Getting your Pax straight: Pax proteins in development and disease
N Chi, JA Epstein - Trends Genet, 2002 - instruct.uwo.ca
... Adding to this complexity, several Pax proteins, including Pax3, Pax4, Pax6 and
Pax7, possess an additional DNA-binding domain – a homeodomain (HD). ...
Cited by 54 - View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Transcriptional regulation of the human PAX 6 gene promoter. - Full text - MIT Libraries
ZP Xu, GF Saunders - J Biol Chem, 1997 - jbc.org
... the pax genes contain a 128-amino acid N-terminal paired box that can be present
alone (as in Pax1 and Pax9) or with a full-length (as in Pax3, Pax4, Pax6, and ...
Cited by 13 - Web Search - jbc.org - ncbi.nlm.nih.gov

Identification of DNA recognition sequences for the Pax3 paired domain - Full text - MIT Libraries
G Chalepakis, P Gruss - Gene, 1995 - ncbi.nlm.nih.gov
... Pax1 and Pax9 constitute one subfamily, Pax2, Pax5 and Pax8 another, Pax3
and Pax7 another one and Pax4 and Pax6 the fourth subfamily. ...
Cited by 19 - Web Search

Genetic and biochemical diversity in the Pax gene family - Full text - MIT Libraries
DA Underhill - Biochem Cell Biol, 2000 - article.pubs.nrc-cnrc.gc.ca
... 1991). In addition, Drosophila paired contains a homeodomain that defines a distinct
subclass, which includes the mammalian Pax3, Pax4, Pax6 and Pax7 ...
Cited by 11 - Web Search - dx.doi.org - pubs.nrc-cnrc.gc.ca - ncbi.nlm.nih.gov - all 6 versions »

Regulation of retrograde signaling at neuromuscular junctions by the novel C2 domain protein AEX-1 - Full text - MIT Libraries
M Doi, K Iwasaki - Neuron, 2002 - upp.so-net.ne.jp
... not genes (pAX4 and pAX3, Figure 2A) into animals. Al- Page 4. Neuron
252 entire body using both pAX3 and pAX4 (Figure 3D). The ...
Cited by 13 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic … - Full text - MIT Libraries
SB Smith, HC Ee, JR Conners, MS German - Mol. Cell. Biol, 1999 - mcb.asm.org
... may alter the specificity of each, as is the case for PAX3 (40 ... from islet genes that
demonstrate different relative affinities for the full-length PAX4 and PAX6 ...
Cited by 34 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

The role of PAX 2 in normal and abnormal development of the urinary tract - Full text - MIT Libraries
MR Eccles - Pediatric Nephrology, 1998 - springerlink.com
... PAX3 and PAX7 are in group III, with PAX4 and PAX6 in group IV [8]. All the PAX
genes contain the characteristic paired box domain (PD), whereas octapeptide ...
Cited by 13 - Web Search - ncbi.nlm.nih.gov

Pax genes and eye organogenesis
F Pichaud, C Desplan - Curr. Opin. Genet. Dev, 2002 - wwworm.biology.uh.edu
... palindromic DNA sequence [8]. The nine human Pax genes can be placed into five
phylogenetic groups [9]: (1) Pax1 and Pax9; (2) Pax3 and Pax7; (3) Pax4 and Pax6 ...
Cited by 20 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker … - Full text - MIT Libraries
HE Xu, MA Rould, W Xu, JA Epstein, RL Maas, CO … - Genes Dev, 1999 - genesdev.org
... Like Pax3, Pax4, and Pax7 proteins, the intact Pax6 protein contains a paired-type
homeodomain, which is located about 80 residues downstream of the paired ...
Cited by 61 - Web Search - uphs.upenn.edu - 128.95.44.130 - pubmedcentral.nih.gov - all 8 versions »

Progressive loss of PAX 9 expression correlates with increasing malignancy of dysplastic and … - Full text - MIT Libraries
JK Gerber, T Richter, E Kremmer, J Adamski, H … - The Journal of Pathology, 2002 - doi.wiley.com
... homeodomain, it is tempting to speculate that the oncogenic potential of PAX9 is
less strong than that of PAX genes that contain a full (PAX3, PAX4, PAX6, PAX7 ...
Cited by 3 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Identification of a portable repression domain and an E1A-responsive activation domain in Pax4: a … - Full text - MIT Libraries
Y Fujitani, Y Kajimoto, T Yasuda, TA Matsuoka, H … - Mol Cell Biol, 1999 - mcb.asm.org
... While the HD of Pax3 appears to mediate transcriptional suppression by interacting
with corepressors such as pRb (60) and HIRA (31), the HD of Pax4 may also ...
Cited by 16 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

The diabetes-linked transcription factor PAX4 promotes ß-cell proliferation and survival in rat and … - Full text - MIT Libraries
T Brun, I Franklin, L St-Onge, A Biason-Lauber, EJ … - The Journal of Cell Biology - jcb.org
... proliferative role of Pax4, other members of the Pax family were shown to stimulate
cell replication. For instance, increased levels of Pax3 were observed in ...
Cited by 1 - Web Search - jcb.org - jem.org - ncbi.nlm.nih.gov

Exclusion of a disease relevant role of PAX4 in the aetiology of Silver-Russell syndrome: screening …
JM Genet - dx.doi.org
... PAX4 is a member of a highly conserved gene family, 10 and has ... by human diseases
(PAX2, kidney abnormalities, optic nerve coloboma; PAX3, Waardenburg syndrome ...
Web Search - jmedgenet.com - jmg.bmjjournals.com

TranSignal™ Protein/DNA Arrays
PU Manual - panomics.com
Page 1. TranSignal ™ Protein/DNA Arrays Catalog Nos. MA1010 & MA1011 Product
User Manual Version 1.11 Panomics, Inc. • 2003 East ...
View as HTML - Web Search - panomics.com

Synteny-defined candidate genes for congenital and idiopathic scoliosis - Full text - MIT Libraries
PF Giampietro, CL Raggio, RD Blank - American Journal of Medical Genetics, 1999 - doi.wiley.com
... Dbf (Pax3, Ihh) 1, 40 2q35 PAX3, IHH Waardenburg, CFDH Gli2 1, 65 2q14
GLI2 ... hop 6, 13 7q22-qter PTN, PAX4 tc 6, 38 2p13-p11 TGFA ...
Cited by 9 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Pax3 and the splotch mutations: structure, function, and relationship to teratogenesis, including …
AF Machado, LJ Martin, MD Collins - Curr. Pharm. Design, 2001 - ingentaconnect.com
... Aniridia [243] , Peter's anomaly [111] , Isolated foveal hypoplasia [7] Pax4 knockout
[225] Small eye [118] ... details. Page 3. Pax3 and the Splotch Mutations ...
Cited by 7 - Web Search - bentham.org - bentham.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

TranSignal TM GR-TF Interaction Arrays
PU Manual - panomics.com
Page 1. TranSignal TM GR-TF Interaction Arrays GR-TFCat. # MA5061, MA5062 &
MA5063 Product User Manual Released 07/29/04 Panomics, Inc. ...
View as HTML - Web Search - biocat.de

TranSignal TM Protein/DNA Arrays
PU Manual, MA MA1014 - panomics.com
Page 1. TranSignal TM Protein/DNA Arrays Cat. # MA1010, MA1011, MA1012 Product User
Manual, MA1013 & MA1014, MA1015 Released 09/28/04 Panomics, Inc. ...
View as HTML - Web Search - biocat.de

Missense Mutations of Human Homeoboxes: A Review - Full text - MIT Libraries
G Damante - HUMAN MUTATION, 2001 - doi.wiley.com
... Only a fraction of PAX proteins have a functional HD (PAX3, PAX4, PAX6, PAX7); in
these proteins the additional DNA-binding domain is constituted by the paired ...
Web Search - doi.wiley.com - geocities.com

TranSignal TM Protein/DNA Arrays
CS Version - panomics.com
Page 1. TranSignal TM Protein/DNA Arrays (Column Separation Version) Cat. #
MA1210, MA1211, MA1212l, MA1213 & MA1214, MA1215 Product ...
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Transcription factors in dysmorphology - Full text - MIT Libraries
D Lacombe - Clinical Genetics, 1999 - blackwell-synergy.com
... PAX genes are characterized by a paired box sequence encoding a DNA-binding domain
with two helix-turn-helix structures, and for some (PAX3/PAX7, PAX4/PAX6) a ...
Web Search - ncbi.nlm.nih.gov

Origin of the paired domain - Full text - MIT Libraries
R Breitling, JK Gerber - Development Genes and Evolution, 2000 - springerlink.com
... Page 2. 645 an evolutionary tree (Fig. 2A), in which PaxC is the sister group
of Pax1–9/meso, Pax3–7/gooseberry/paired and Pax4–6/eyeless. ...
Cited by 8 - Web Search - brc.dcs.gla.ac.uk - ncbi.nlm.nih.gov

The Pax 3-FKHR oncoprotein is unresponsive to the Pax 3-associated repressor hDaxx - Full text - MIT Libraries
AD Hollenbach, JE Sublett, CJ McPherson, G … - The EMBO Journal, 1999 - embojournal.npgjournals.com
... To quantitatively determine -galactosidase activity Pax3, the indicated Pax3 deletion
mutants, Pax7, Pax4 or Pax3-FKHR, were co-transformed into the yeast ...
Cited by 82 - Web Search - nature.com - emboj.org - ncbi.nlm.nih.gov - all 7 versions »

Dissection of the Transactivation Function of the Transcription Factor Encoded by the Eye … - Full text - MIT Libraries
HK Tang, S Singh, GF Saunders - J Biol Chem, 1998 - jbc.org
... Such a structural organization is found in proteins produced by other Pax
genes with dual DNA-binding domains (Pax3, Pax4, and Pax7). ...
Cited by 24 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Les genes Pax et la specification cellulaire
M Bouchard - erudit.org
... En se fondant sur les homologies de séquence, on peut distinguer quatre classes
parmi les neuf membres de la famille Pax: Pax3/7, Pax4/6, Pax1/9 et finalement ...
View as HTML - Web Search - ist.inserm.fr - erudit.org

Phosphorylation of the Transactivation Domain of Pax 6 by Extracellular Signal-regulated Kinase and … - Full text - MIT Libraries
I Mikkola, JA Bruun, G Bjoerkoey, T Holm, T … - J Biol Chem, 1999 - jbc.org
... 22). Pax6, like Pax3, Pax4, and Pax7, also harbors a second DNA-binding
domain, the paired-type home- odomain (2, 7, 23). In Pax6 ...
Cited by 19 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

A statistical analysis of the TRANSFAC database.
GB Fogel, DG Weekes, G Varga, ER Dow, AM Craven, … - Biosystems, 2005 - natural-selection.com
... 01 N-Myc OCT1 02 Octamer factor 1 OCT1 03 Octamer factor 1 OCT1 04 Octamer factor
1 OCT1 Q6 Octamer factor 1 P300 01 p300 PAX3 B Pax3 binding sites PAX4 01 Pax ...
View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

A genomewide survey of developmentally relevant genes in Ciona intestinalis - Full text - MIT Libraries
S Wada, M Tokuoka, E Shoguchi, K Kobayashi, A Di … - Dev Genes Evol, 2003 - springerlink.com
... 8 93% $ Pax3/7 Pax3/7 genewise.209.17.1 36362 Q96H85 Pax-3 99% $ Pax4/6
Pax6 genewise.337.13.1 32251 P26367 Pax-6 98% $ orphan Pax3 ...
Cited by 22 - Web Search - ncbi.nlm.nih.gov

Identification and expression of the lamprey Pax6 gene: evolutionary origin of the segmented brain … - Full text - MIT Libraries
Y Murakami, M Ogasawara, F Sugahara, S Hirano, N … - Development, 2001 - dev.biologists.org
... By amino acid sequence analysis, the vertebrate Pax genes have been classified into
four or five groups (Pax1/9, Pax2/5/8, Pax3/7, Pax4/6 and PaxA) (Miller et ...
Cited by 21 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Isolation and expression analysis of a Pax group III gene from the crustacean Cherax destructor - Full text - MIT Libraries
RBWTM Lamey, M Ziman, A Koenders - Dev Genes Evol, 2005 - springerlink.com
... sequences (and their accession numbers) used for phylogenetic analysis include:
Mus musculus Pax1 (M69222), Pax2 (NM011037), Pax3 (X59358), Pax4 (P321 15 ...
Web Search - ncbi.nlm.nih.gov

Eyg and Ey Pax proteins act by distinct transcriptional mechanisms in Drosophila development - Full text - MIT Libraries
JG Yao, YH Sun - The EMBO Journal, 2005 - embojournal.npgjournals.com
... Pax2, Pax3, Pax4, Pax5, and Pax8 can also function as repressors, in addition
to being activators (reviewed in Underhill, 2000). ...
Web Search - pubmedcentral.nih.gov - embojournal.npgjournals.com - ncbi.nlm.nih.gov

The COOH-terminal Transactivation Domain Plays a Key Role in Regulating the in Vitro and in Vivo … - Full text - MIT Libraries
Y Cao, C Wang - J Biol Chem, 2000 - jbc.org
... Pax3 contains two DNA binding domains: a paired box domain common to all members
of the ... factors and a Prd-type homeodomain that is also found in Pax4 and Pax6 ...
Cited by 7 - Web Search - jbc.org - dx.doi.org - ncbi.nlm.nih.gov

Institut fuer Experimentelle Genetik GSF-Forschungszentrum fuer Umwelt und Gesundheit, Neuherberg
DBR Breitling - tumb1.biblio.tu-muenchen.de
Page 1. Institut für Experimentelle Genetik GSF-Forschungszentrum für Umwelt und
Gesundheit, Neuherberg Phylogenetische und bioinformatische Untersuchung der ...
View as HTML - Web Search - deposit.ddb.de

The Trichoplax PaxB Gene: a Putative Proto-PaxA/B/C Gene Predating the Origin of Nerve and Sensory … - Full text - MIT Libraries
T Hadrys, R DeSalle, S Sagasser, N Fischer, B … - Molecular Biology and Evolution, 2005 - mbe.oupjournals.org
... but it has been proposed that cnidarian PaxB genes are related to triploblast
Pax2/5/8 genes, PaxC genes to Pax4-6, and PaxD genes to Pax1-9 and Pax3-7 genes ...
Web Search - mbe.oxfordjournals.org - mbe.oxfordjournals.org - ncbi.nlm.nih.gov

Six family genesÐstructure and function as transcription factors and their roles in development - Full text - MIT Libraries
K Kawakami, S Sato, H Ozaki, K Ikeda - BioEssays - doi.wiley.com
... the metanephros at E12.5, (6,57,58) and expression of Pax3, Six (Six1,
Six4) and Eya (Eya1, Eya2) is observed in somites. (58±60)
Cited by 55 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Developmental expression of Pax1/9 genes in urochordate and hemichordate gills: insight into … - Full text - MIT Libraries
M Ogasawara, H Wada, H Peters, N Satoh - Development, 1999 - dev.biologists.org
... However, Group II (Pax2, Pax5 and Pax8), Group III (Pax3 and Pax7) and Group
IV (Pax4 and Pax6) encode the paired domain and homeodomain. ...
Cited by 29 - Web Search - staff.washington.edu - dev.biologists.org - ncbi.nlm.nih.gov

Testing for genetic associations with the PAX gene family in a spina bifida population - Full text - MIT Libraries
KA Volcik, SH Blanton, MC Kruzel, IT Townsend, GH … - Am J Med Genet, 2002 - doi.wiley.com
... PAX4 and PAX9 were not analyzed due to their lack of expression during the formation
of ... Mutations within the murine Pax3 gene result in the splotch mouse mutant ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

Embryonic development of heads, skeletons and amphioxus: Edwin S. Goodrich revisited
PWH Holland - Int. J. Dev. Biol, 2000 - ijdb.ehu.es
... genes; the nine mouse Pax genes are divisible into four subfamilies each with two
or three genes (Pax1/Pax9; Pax3/Pax7; Pax2/Pax5/Pax8; possibly Pax4 with Pax6 ...
Cited by 18 - View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Noriko Osumi Department of Developmental Neurobiology, Tohoku University Graduate School of Medicine …
TM Lectureat73 … - journal.med.tohoku.ac.jp
... Pax8 4 9p13 Yes Pax3 1 2q35 Splotch Waadenburg syndromeI,III Pax7 4 1p36.2 Yes Pax4
6 7q32 Yes Pax6 2 11p13 Small eye Yes Aniridia Petersanomaly ...
Web Search

A More Complete TLA.
S Merz - World Congress on Formal Methods, 1999 - springerlink.com
... (ax3) 2 [F ⇒ d F] F ⇒ (F ⇒ 2 F) (pax3) |∼ 2 F ⇒ d 2 F (ax4) 2 [P ⇒ Q] v ⇒ (
2 [P] v ⇒ 2 [Q] v ) (pax4) |∼ 2 [P] v ≡ [P] v ∧ d 2 [P] v ...
Cited by 5 - Web Search - webloria.loria.fr - dc.exa.unrc.edu.ar - pst.informatik.uni-muenchen.de - all 8 versions »

Pax2 mutant mice display increased number and size of islets of Langerhans but no change in insulin … - Full text - MIT Libraries
M Zaiko, A Estreicher, B Ritz-Laser, P Herrera, J … - European Journal of Endocrinology, 2004 - eje.org
... Group III, represented by Pax3 and Pax7, contains a second DNA-binding motif ... Finally,
the fourth group which includes Pax4 and Pax6 is characterized by the ...
View as HTML - Web Search - eje-online.org - eje.org - ncbi.nlm.nih.gov - all 5 versions »

Zebrafish Pax 9 encodes two proteins with distinct C-terminal transactivating domains of different … - Full text - MIT Libraries
S Nornes, I Mikkola, S Krauss, M Delghandi, M … - J Biol Chem, 1996 - jbc.org
... Pax4 is excluded. Thus, the four classes may differ in their DNA-binding specificities
and/or affinities with Pax2, -5, and -8 in one, Pax6 in a second, Pax3 ...
Cited by 27 - Web Search - cmbn.no - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

PAX genes in development and disease: The role of PAX2 in urogenital tract development
MR Eccles, S He, M Legge, R Kumar, J Fox, C Zhou, … - Int J Dev Biol, 2002 - ijdb.ehu.es
... abnormalities, absent chiasma, absent cochlea PAX3 Waardenburg Dystophia ... muscle and
neuromuscular development, hypopigmentation PAX4 - - Pax4 knockout (+/-) No ...
Cited by 5 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - ijdb.ehu.es - Get it from MIT Libraries

Genetic analysis of genes found on the 4th chromosome of Drosophila-emphasizing the developmental …
J Kronhamn - publications.uu.se
... Miller also place the nine human Pax genes in four phylogenetic groups: (1) Pax1
and Pax9; (2) Pax3 and Pax7; (3) Pax4 and Pax6; (4) Pax2, Pax5 and Pax8. ...
Web Search

The genetic network of prototypic planarian eye regeneration is Pax6 independent - Full text - MIT Libraries
D Pineda, L Rossi, R Batistoni, A Salvetti, M … - Development, 2002 - dev.biologists.org
... The subsequent screening of a cDNA library using Pax4-6 fragment as a probe, allowed
us ... analysis includes: human Pax 3, 4, 6 (Aniridia) and 7; mouse Pax3, 4, 6 ...
Cited by 18 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Identification of A Pax Paired Domain Recognition Sequence and Evidence for DNA-dependent …
N Genet - uphs.upenn.edu
... 41, and a translocation involving the paired box portion of PAX3 has been ... the protein
was prepared and analyzed in either buffer, and the Pax4 paired domain ...
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ON THE EVOLUTION OF CNIDARIAN EYES
M Stierwald - unibas.ch
Page 1. ON THE EVOLUTION OF CNIDARIAN EYES Inauguraldissertation zur Erlangung
der Würde eines Doktors der Philosophie vorgelegt der ...
View as HTML - Web Search - pages.unibas.ch

pax2. 1 is required for the development of thyroid follicles in zebrafish - Full text - MIT Libraries
T Wendl, K Lun, M Mione, J Favor, M Brand, SW … - Development, 2002 - dev.biologists.org
... development. Pax2, Pax5 and Pax8 form a paralogue group of genes, like
Pax1/9, Pax4/6 and Pax3/7 (reviewed by Dahl et al., 1997 ). ...
Cited by 7 - Web Search - ucl.ac.uk - dev.biologists.org - ncbi.nlm.nih.gov

Were vertebrates octoploid - Full text - MIT Libraries
RF Furlong, PWH Holland - Philos Trans R Soc Lond B Biol Sci, 2002 - journals.royalsoc.ac.uk
... Pax1/9 1 2 1 to 2 ND Holland et al. (1995) Wada et al. (1998) Pax3/7 1 2 1 to 2
Holland et al. (1999) as cloning PTPN3 1 2 1 to 2 Ono-Koyanagi et al. ...
Cited by 42 - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov

[PS] Logic-based analysis of reactive systems: hiding, composition and abstraction
S Merz - loria.fr
Page 1. Logic-Based Analysis of Reactive Systems: Hiding, Composition, and
Abstraction Stephan Merz Institut fur Informatik, Ludwig ...
Cited by 2 - View as HTML - Web Search