Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPalpha and GATA … - Full text - MIT Libraries
B Heavey, C Charalambous, C Cobaleda, M Busslinger - EMBO J, 2003 - embojournal.npgjournals.com
... control by its own protein in erythroblasts (Tsai et al., 1991), which may also
explain its cross-regulation by GATA2 and GATA3 in Pax5 –/– pro-B cells. ...
Cited by 10 - Web Search - nature.com - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Analysis of Notch1 Function by In Vitro T Cell Differentiation of Pax5 Mutant Lymphoid Progenitors - Full text - MIT Libraries
S Hoeflinger, K Kesavan, M Fuxa, C Hutter, B … - The Journal of Immunology, 2004 - jimmunol.org
... Interestingly, both the GATA3 and Tcf1 genes were also induced in a Notch1-dependent
manner following OP9-DL1 stimulation of Pax5 –/– pro-B cells (Fig. 8). ...
Cited by 3 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Transcription factor expression in cell lines derived from natural killer-cell and natural killer- …
Y Matsuo, HG Drexler, A Harashima, A Okochi, N … - Hum Cell, 2004 - ncbi.nlm.nih.gov
... The present study analyzed the expression of the following 13 TFs: AML1, CEBPA,
E2A, ETS1, GATA1, GATA2, GATA3, IKAROS, IRF1, PAX5, PU1, TBET and TCF1 in 7 ...
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The origin of hematopoietic cell type diversity - Full text - MIT Libraries
T Hoang - Oncogene, 2004 - nature.com
... B G M Meg Ery T Ery P LMO2 E2A E2A, Pax5 HEB, GATA3 Pro-B Pro-T PU.1 C/EBPα C/EBPβ
SCL, GATA-1 FOG SCL Figure 2 Transcription factors discussed in the review ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

RAGs and Regulation of Autoantibodies - Full text - MIT Libraries
M Jankovic, R Casellas, N Yannoutsos, H Wardemann, … - Annual Review of Immunology, 2004 - phyto.annualreviews.org
... the murine RAG2 promoter is active in transient transfection experiments in B and
T cell lines, and the activity is dependent on PAX5 and GATA3 (127, 128). ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

BMC Genomics - Full text - MIT Libraries
JJ Hutton, AG Jegga, S Kong, A Gupta, C Ebert, S … - BMC Genomics, 2004 - biomedcentral.com
... Examples include PU.1/Ets, Ikaros, E2A, EBF, PAX5, GATA3, NFAT, cMYB, and OCT-2
[1-4]. These pro- teins bind to clusters of cis-regulatory elements in multi ...
Cited by 1 - View as HTML - Web Search - dx.doi.org - pubmedcentral.nih.gov - bmc.ub.uni-potsdam.de - all 8 versions »

Annual Review of Immunology - Full text - MIT Libraries
M Jankovic, R Casellas, N Yannoutsos, H Wardemann, … - Annual Review of Immunology, 2004 - phyto.annualreviews.org
... In contrast, the murine RAG2 promoter is active in transient transfection experiments
in B and T cell lines, and the activity is dependent on PAX5 and GATA3 ( ...
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The role of recombination activating gene (RAG) reinduction in thymocyte development in vivo - Full text - MIT Libraries
N Yannoutsos, P Wilson, W Yu, HT Chen, A … - J. Exp. Med, 2001 - jem.org
... In contrast, the RAG2 promoter displayed preferential activity in lymphoid cell
lines that was PAX5 and GATA3 dependent but the activity was not ...
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Table 1. Ets1 interacting proteins
H GM-CSF - pubmedcentral.nih.gov
... VEGFR-2 (Flk-1). [64]. HTLV-I Tax. PTHrP (P3 promoter), interleukin-5. Tax forms
ternary complex with Ets1 and Sp1, enhances GATA3/Ets1 cooperation. ... Pax5. mb-1. ...
Web Search

Summary: Signals and Beyond
RA Flavell - cshl-symposium.org
... B-cell receptor com- ponents, and therefore act earlier in development than Pax5. ...
The key transcription factor for Th2 develop- ment is likely GATA3 (Zheng and ...
Web Search - cshl-symposium.org

Active form of Notch members can enforce T lymphopoiesis on lymphoid progenitors in the monolayer … - Full text - MIT Libraries
K Hozumi, N Abe, S Chiba, H Hirai, S Habu - J. Immunol, 2003 - jimmunol.org
... For B cells, the products of E2A and Pax5 are specifically required at the ... The
oligonucleotides used to detect GATA3, pT , and 2 -microglobulin ( 2 m) were the ...
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Expression of the transcription factors GATA 3 and Pax 2 during development of the mammalian inner … - Full text - MIT Libraries
G Lawoko-Kerali, MN Rivolta, M Holley - The Journal of Comparative Neurology, 2002 - doi.wiley.com
... GATA3 and Pax2 during Development of ... ABSTRACT The transcription factors GATA3 and
Pax2 are expressed throughout development of the mouse inner ear. ...
Cited by 24 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

A target selection of somatic hypermutations is regulated similarly between T and B cells upon … - Full text - MIT Libraries
A Kotani, I Okazaki, M Muramatsu, K Kinoshita, NA … - Proceedings of the National Academy of Sciences, 2005 - pnas.org
... extensively investigated, and their expression in lymphocyte is not reported, whereas
GATA3 and c ... far, nine genes (Ig , IgH, MB-1(Ig ), B29(Ig ), PAX5, BCL6, c ...
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Expression of Sox3 throughout the developing central nervous system is dependent on the combined … - Full text - MIT Libraries
S Brunelli, ES Casey, D Bell, R Harland, R Lovell- … - Genesis, 2003 - doi.wiley.com
... neural cell types (Isl1/2, HB9, En1, Chx10, Lim3, and GATA3) (green) together ... FGF8)
and transcription factors (OTX2, GBX2, EN1, EN2, PAX2, PAX5) (Simeone, 2000 ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov

Dynamic repositioning of CD4 and CD8 genes during T cell development - Full text - MIT Libraries
S Delaire, YH Huang, SW Chan, EA Robey - J. Exp. Med, 2004 - jem.org
... have been implicated in CD4 and CD8 T cell development including GATA3, which is ...
example of a late, reinforcing event is the expression of Pax5 in developing B ...
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Determination of lymphoid cell fate is dependent on the expression status of the IL-7 receptor - Full text - MIT Libraries
SJ Purohit, RP Stephan, HG Kim, BR Herrin, L … - The EMBO Journal, 2003 - embojournal.npgjournals.com
... with observations that enforced expression of either EBF or Pax5 in hematopoietic ...
signaling molecules (like Notch1) and transcription factors (like GATA3 and c ...
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The role of Six 1 in mammalian auditory system development - Full text - MIT Libraries
W Zheng, L Huang, ZB Wei, D Silvius, B Tang, PX Xu - Development, 2003 - dev.biologists.org
... Furthermore, loss of Six1 function alters the expression pattern of Nkx5.1 and Gata3,
indicating that Six1 is required for regional specification of the otic ...
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Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor … - Full text - MIT Libraries
Y Fujiwara, CP Browne, K Cunniff, SC Goff, SH … - Developmental Biology, 1996 - dx.doi.org
... Rigden, J. Sampson, AJ Williams, and RV Thakker Characterization of GATA3 Mutations
in ... C. Cobaleda, and M. Busslinger Myeloid lineage switch of Pax5 mutant but ...
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Blood First Edition Paper, prepublished online November 18, 2004; DOI 10.1182/blood-2004-07-2947
S Monti, KJ Savage, JL Kutok, F Feuerhake, P … - broad.mit.edu
... Transcription factors PAX5 FOXO1A BCL6 POU2AF1 (BOB-1/OBF-1/OCAB) STAT6 TCF3 (E2A)
NFAT SPI ... receptor α and β CD2 CD3 δ, ε and γ CD6 CD28 GATA3 cMAF CXCR6 ...
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The Biology of the Ets 1 Proto-Oncogene - Full text - MIT Libraries
J Dittmer - Molecular Cancer, 2003 - dx.doi.org
... In the Th2 subtype of T-helper cells, Th2-specific transcription factor GATA3 is
able to ... action of Ets1 with the B-cell specific activator protein Pax5 [71,72 ...
Cited by 18 - Web Search - pubmedcentral.nih.gov - molecular-cancer.com - citebase.eprints.org - all 11 versions »

The‘definitive’(and‘primitive’) guide to zebrafish hematopoiesis - Full text - MIT Libraries
AJ Davidson, LI Zon - Oncogene, 2004 - nature.com
... pax5 Paired domain, homeobox — Pfeffer et al. ... 3–4 dpf, these cells can be detected
by examining the expression of genes such as ikaros, gata3, lck, and ...
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Transcriptional control of kidney development - Full text - MIT Libraries
M Bouchard - Differentiation, 2004 - blackwell-synergy.com
... difficult to understand the molecular nature of the Gata3 differentiation block ... 2000)
Functional equivalence of the transcription factors Pax2 and Pax5 in mouse ...
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Transcriptional regulation of lymphocyte lineage commitment - Full text - MIT Libraries
EV Rothenberg, JC Telfer, MK Anderson - BioEssays, 1999 - doi.wiley.com
... arrest of B-cell development at an early stage (Table 1). The three factors involved,
E2A (ie, E12 and E47 products of the E2A gene), EBF, and Pax5, are not ...
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An epigenetic view of helper T cell differentiation - Full text - MIT Libraries
KM Ansel, DU Lee, A Rao - Nature Immunology, 2003 - nature.com
References 1. Ahmad, K. & Henikoff, S. The histone variant H3.3 marks active
chromatin by replication-independent nucleosome assembly. Mol. ...
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The link between chromatin structure, protein acetylation and cellular differentiation
V Sartorelli, PL Puri - Front. Biosci, 2001 - xylian.igh.cnrs.fr
... Examples of genes repressed by Pax5 are those encoding for the M-CSF receptor,
myeloperoxidase ... (286) have expressed a non-acetylatable (KRR-GATA3) form in the T ...
Cited by 8 - Cached - Web Search - bioscience.org - bioscience.org - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Report A Dynamic Switch in the Replication Timing of Key Regulator Genes in Embryonic Stem Cells …
P Perry, S Sauer, N Billon, WD Richardson, M … - landesbioscience.com
... Gata3 (2; A1) Nkx2.2 (2; H1) Foxd3 (4; C6) T-bet (11; D) Nkx2.9 (12; C2) Esg1 (X;
A1.2) Ebf (11; B1.1) Msx1 (5; B2) Cripto (9; F2) Pax5 (4; B2) Pax3 (1 ...
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T lymphoid differentiation in human bone marrow - Full text - MIT Libraries
F Klein, N Feldhahn, S Lee, H Wang, F Ciuffi, M … - Proceedings of the National Academy of Sciences, 2003 - pnas.org
... T cell lineage-specific transcription factors including HES, NOTCH1, GATA3, TCF,
and ... light chains), B cell-specific transcription factors (OBF1, PAX5, EBF, and ...
Cited by 6 - Web Search - pubmedcentral.nih.gov - uni-duesseldorf.de - dx.doi.org - all 6 versions »

Molecular Cancer - Full text - MIT Libraries
J Dittmer - Molecular Cancer, 2003 - bmc.ub.uni-potsdam.de
... Pax5 (paired box containing gene 5), a transcription factor that contacts the Ets ...
and ionomycin are needed for the cooperative effect of Ets1 with GATA3 on the ...
View as HTML - Web Search - gdrs-intranet.ath.cx

Genomic Structure and Transcriptional Regulation of the Early B Cell Gene chB1 - Full text - MIT Libraries
R Goitsuka, H Mamada, D Kitamura, MD Cooper, H … - The Journal of Immunology, 2001 - jimmunol.org
... transcription of chB1, whereas PU.1 and B cell-specific activator protein/Pax5 have
been ... to -683), AP-1 (-564 to -556), Ets-1 (-391 to -384), GATA3 (-369 to ...
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A statistical analysis of the TRANSFAC database.
GB Fogel, DG Weekes, G Varga, ER Dow, AM Craven, … - Biosystems, 2005 - natural-selection.com
Page 1. BioSystems xxx (2005) xxx–xxx A statistical analysis of the TRANSFAC database
Gary B. Fogel a , Dana G. Weekes a , Gabor Varga b , Ernst R. Dow b , ...
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Genes, pathways and checkpoints in lymphocyte development and homeostasis - Full text - MIT Libraries
LA MIOSGE, CC GOODNOW - Immunology and Cell Biology, 2005 - ingentaconnect.com
... The transcription factor Pax5 is required for B cell commit- ment and maturation. ...
15 B cells in pax5- deficient mice undergo arrest at the pro-B/pre-BI stage. ...
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PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila … - Full text - MIT Libraries
E Ogawa, M Maruyama, H Kagoshima, M Inuzuka, J Lu, … - Proceedings of the National Academy of Sciences - pnas.org
... M. Kubo, and M. Satake The Runx1 Transcription Factor Inhibits the Differentiation
of Naive CD4+ T Cells into the Th2 Lineage by Repressing GATA3 Expression J ...
Cited by 272 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

PERSPECTIVES IN BASIC SCIENCE Ear and kidney syndromes: Molecular versus clinical approach - Full text - MIT Libraries
H Izzedine, F Tankere, V Launay-Vacher, G Deray - Kidney International, 2004 - blackwell-synergy.com
... GATA3 (OMIM 131320), Go to: Choose, ...
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Gene Expression Profiling and Microarrays Gene expression profiling of leukemic cell lines reveals …
A Andersson, P Eden, D Lindgren, J Nilsson, C … - Leukemia, 2005 - nature.com
... regulator GATA3 and the signal transducer CD3G were expressed in T-cell ALL, the
latter gene involved in the T-cell receptor complex. The B-cell regulator PAX5 ...
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Notch signaling controls the generation and differentiation of early T lineage progenitors - Full text - MIT Libraries
A Sambandam, I Maillard, VP Zediak, L Xu, RM … - Nature Immunology, 2005 - nature.com
... Bone marrow (BM) LSK, Flt3 + ETP, Flt3 lo ETP and DN2 cells were sorted and analyzed
by RT-PCR for expression of Flt3, Cd25, Gata3 and Hprt1 and the Notch ...
Web Search - nature.com - ncbi.nlm.nih.gov

Determination of the embryonic inner ear - Full text - MIT Libraries
S Noramly, RM Grainger - Journal of Neurobiology, 2002 - doi.wiley.com
... In situ hybridiza- tion studies by Wada et al (1998) revealed that the ascidian
homologue of the vertebrate Pax2, Pax5, and Pax8 genes, Hr-Pax258, is expressed ...
Cited by 14 - Web Search - ncbi.nlm.nih.gov

Molecular characterization of early human T/NK and B-lymphoid progenitor cells in umbilical cord … - Full text - MIT Libraries
R Haddad, P Guardiola, B Izac, C Thibault, J … - Blood, 2004 - bloodjournal.org
... expression of stem cell-associated transcription factors TAL1, GATA3, HLF, and MLLT3 ...
factors involved in BL lineage commitment (E2A/TCF3, PAX5, POU2AF1), which ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

E2a/Pbx1 induces the rapid proliferation of stem cell factor-dependent murine pro-T cells that cause … - Full text - MIT Libraries
DB Sykes, MP Kamps - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... SCF receptor), Scl/tal1, IL-7 receptor α, E2A, Ikaros, PU.1, GATA3, and ID2 ... 2) nor
the early B-cell differentiation genes Pax5, λ5, or VpreB (data not shown ...
Cited by 4 - Web Search - mcb.asm.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Variation of serotonergic gene expression: neurodevelopment and the complexity of response to …
KP Lesch - Eur Neuropsychopharmacol, 2001 - uni-wuerzburg.de
Page 1. European Neuropsychopharmacology 11 (2001) 457–474 www.elsevier.com/
locate/euroneuro Variation of serotonergic gene expression ...
Cited by 13 - View as HTML - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one … - Full text - MIT Libraries
S Monti, KJ Savage, JL Kutok, F Feuerhake, P … - Blood, 2005 - bloodjournal.org
... and additional B-cell–specific or essential transcription factors (including PAX5,
OBF-1 ... cells) 40 ; the T helper 2 (TH 2 ) transcription factors, GATA3 and c ...
Cited by 4 - Web Search - broad.mit.edu - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

The psychopharmacogenetic-neurodevelopmental interface in serotonergic gene pathways
KP Lesch, J Benninghoff, A Schmitt - Pharmacogenetics of psychotropic drugs, 2002 - uni-wuerzburg.de
Page 1. 6 The psychopharmacogenetic– neurodevelopmental interface in serotonergic
gene pathways K. Peter Lesch, Jens Benninghoff and Angelika Schmitt ...
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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and … - Full text - MIT Libraries
Q Wang, T Stacy, M Binder, M Marin-Padilla, AH … - Developmental Biology, 1996 - dx.doi.org
... M. Kubo, and M. Satake The Runx1 Transcription Factor Inhibits the Differentiation
of Naive CD4+ T Cells into the Th2 Lineage by Repressing GATA3 Expression J ...
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Transcriptional Control of T Lymphocyte Differentiation - Full text - MIT Libraries
FJT Staal, F Weerkamp, AW Langerak, RW Hendriks, … - Stem Cells, 2001 - stemcells.alphamedpress.org
... Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the ...
Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. ...
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Use of Heterologous cDNA Array Screening to Analyze Bovine Oocyte Transcriptome and its Evolution …
R DALBIES-TRAN, P MERMILLOD - biolreprod.org
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THE ROLE OF THE IKAROS GENE IN LYMPHOCYTE DEVELOPMENT AND HOMEOSTASIS - Full text - MIT Libraries
K Georgopoulos, S Winandy, N Avitahl - Annual Review of Immunology, 1997 - immunol.annualreviews.org
Annual Reviews tagline graphic, ...
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MOLECULAR GENETICS OF T CELL DEVELOPMENT - Full text - MIT Libraries
EV Rothenberg, T Taghon - Annual Review of Immunology, 2005 - arjournals.annualreviews.org
... These factors can be viewed as central to T cell identity, somewhat analogous to
the B cell factors EBF and Pax5 (7), which are compared in more detail below. ...
Cited by 2 - Web Search - arjournals.annualreviews.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Gradient of E2A activity in B-cell development - Full text - MIT Libraries
S Herblot, PD Aplan, T Hoang - Mol Cell Biol, 2002 - mcb.asm.org
MCB EC Online 2003 Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Abstract of this Article ( ). Reprint (PDF) Version of this Article. ...
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Anxiety-related traits in mice with modified genes of the serotonergic pathway - Full text - MIT Libraries
KP Lesch, Y Zeng, A Reif, L Gutknecht - Eur J Pharmacol, 2003 - uni-wuerzburg.de
Page 1. Anxiety-related traits in mice with modified genes of the serotonergic pathway
Klaus Peter Lesch * , Yong Zeng, Andreas Reif, Lise Gutknecht ...
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S tem C ells
FJT Staal, F Weerkamp, AW Langerak, RW Hendriks, … - immuneweb.xxmc.edu.cn
Page 1. Transcriptional Control of T Lymphocyte Differentiation F RANK
JT S TAAL , a F LOOR W EERKAMP , a A NTON W. L ANGERAK , a ...
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Evolutionary Origins of Lymphocytes: Ensembles of T Cell and B Cell Transcriptional Regulators in a … - Full text - MIT Libraries
MK Anderson, R Pant, AL Miracle, X Sun, CA Luer, … - The Journal of Immunology, 2004 - jimmunol.org
... GATA primers were as follows: 3'-degGATA-YHKMN and 5'-deg-GATA3 (36). ... the Ig-expressing
cells in the adult epigonal and Leydig organs do not express Pax5. ...
Cited by 3 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »