Oscillation between B-lymphoid and myeloid lineages in Myc-induced hematopoietic tumors following … - Full text - MIT Libraries
D Yu, D Allman, MH Goldschmidt, ML Atchison, JG … - Blood, 2003 - bloodjournal.org
... This failure could be at least partly explained by inappropriate expression of
several oncogenic transcription factors, such as Pax5 and Myc. ...
Cited by 5 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Transcriptional repression by Pax 5(BSAP) through interaction with corepressors of the Groucho … - Full text - MIT Libraries
D Eberhard, G Jimenez, B Heavey, M Busslinger - The EMBO Journal, 2000 - embojournal.npgjournals.com
... To test this hypothesis, we co-expressed mutant Pax5 proteins with Myc-tagged Grg4
in transiently transfected COP-8 cells, followed by Western blot analysis. ...
Cited by 64 - Web Search - nature.com - emboj.org - pubmedcentral.nih.gov - all 6 versions »

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5 - Full text - MIT Libraries
SL Nutt, B Heavey, AG Rolink, M Busslinger - Nature, 1999 - nature.com
... Long-term in vivo reconstitution of T cell development by Pax5-deficient B ...
Adams,JM Hematopoietic lineage switch: v-raf oncogene converts Eµ-myc transgenic ...
Cited by 235 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Oscillation between B-lymphoid and myeloid lineages in Myc-induced hematopoietic tumors following …
N CD19, MB Unexpectedly - BLOOD, 2003 - mail.vet.upenn.edu
... This failure could be at least partly explained by inappropriate expression of
several oncogenic transcription factors, such as Pax5 and Myc. ...
Web Search - phl.vet.upenn.edu - Get it from MIT Libraries

Pax5 determines the identity of B cells from the beginning to the end of B-lymphopoiesis
SL Nutt, D Eberhard, M Horcher, AG Rolink, M … - Int Rev Immunol, 2001 - ncbi.nlm.nih.gov
... Once committed to the B-lineage, B cells require Pax5 function to ... Gene Rearrangement,
B-Lymphocyte; Genes, Immunoglobulin; Genes, myc; Hematopoiesis/genetics*; ...
Cited by 27 - Web Search - Get it from MIT Libraries

PAX5 expression correlates with increasing malignancy in human astrocytomas
ET Stuart, C Kioussi, A Aguzzi, P Gruss - Clin Cancer Res, 1995 - clincancerres.aacrjournals.org
... Expression of PAX5 was limited to those cells which also expressed the
oncogenes myc, fos, or jun singularly or in combination. ...
Cited by 21 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Expression of the PAX5/BSAP transcription factor in haematological tumour cells and further … - Full text - MIT Libraries
T Hamada, N Yonetani, C Ueda, Y Maesako, H Akasaka … - Br J Haematol, 1998 - ingentaconnect.com
... an effect on PAX5 (Iida et al, 1996). Analogous molecular features were observed
in the Burkitt’s lymphoma Manca cell line, in which the c-MYC coding exons 2 ...
Cited by 12 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Primary diffuse large B-cell lymphomas of the central nervous system are targeted by aberrant … - Full text - MIT Libraries
M Montesinos-Rongen, D Van Roost, C Schaller, OD … - Blood, 2004 - bloodjournal.org
... We have addressed whether aberrant ongoing hypermutation can be detected in the
proto-oncogenes PIM1, c-MYC, RhoH/TTF, PAX5, and the tumor-suppressor gene CD95 ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Control of pre-BCR signaling by Pax5-dependent activation of the BLNK gene - Full text - MIT Libraries
M Schebesta, PL Pfeffer, M Busslinger, V Biocenter - Immunity, 2002 - lsic.ucla.edu
... Control of Pre-BCR Signaling by Pax5-Dependent Activation of the BLNK Gene ... Although
some of these proteins have the transcription factor Pax5 (BSAP). ...
Cited by 28 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Rabbit anti-Pax5
SI Western - zytomed.de
... Pax5 fulfills a dual role in early B-cell development, as it functions as ... of gene
transcription because it positively controls CD19, mb-1 (Iga), N-myc, and Lef ...
View as HTML - Web Search - zymed.com - zytomed.de - zymed.com

Altered mRNA expression of Pax5 and Blimp-1 in B cells in multiple myeloma - Full text - MIT Libraries
ND Borson, MQ Lacy, PJ Wettstein - Blood, 2002 - bloodjournal.org
Page 1. NEOPLASIA Altered mRNAexpression of Pax5 and Blimp-1 in B cells in multiple
myeloma ... Our finding of this unique isoform prompted us to investigate Pax5 ...
Cited by 9 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

The Epstein-Barr virus promoter initiating B-cell transformation is activated by RFX proteins and … - Full text - MIT Libraries
R Tierney, H Kirby, J Nagra, A Rickinson, A Bell - J. Virol, 2000 - jvi.asm.org
... B and D both bind the B-cell-specific activator protein BSAP/Pax5. ... In addition, another
cellular factor, MIBP1 (myc intron binding factor 1), first identified ...
Cited by 15 - Web Search - pubmedcentral.nih.gov - jvi.asm.org - ncbi.nlm.nih.gov

The paired box domain gene PAX5 is fused to ETV6/TEL in an acute lymphoblastic leukemia case - Full text - MIT Libraries
G Cazzaniga, M Daniotti, S Tosi, G Giudici, A … - Cancer Res, 2001 - cancerres.aacrjournals.org
... a repressor, because it positively controls CD19, mb-1 (Iga), N-myc, and Lef-1
expression and negatively regulates PD-1 transcription (2) . The PAX5 gene was ...
Cited by 11 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Repression of c-myc is necessary but not sufficient for terminal differentiation of B lymphocytes in … - Full text - MIT Libraries
KI Lin, Y Lin, K Calame - Mol. Cell. Biol, 2000 - mcb.asm.org
... Repression of c-myc Is Necessary but Not Sufficient for Terminal Differentiation
of B Lymphocytes In Vitro. ... Role of c-Myc in terminal B-cell differentiation. ...
Cited by 24 - Web Search - pubmedcentral.nih.gov - eastwin.com.cn - dx.doi.org - all 6 versions »

The PAX5 oncogene is expressed in N-type neuroblastoma cells and increases tumorigenicity of a S- … - Full text - MIT Libraries
FBB Kubetzko, C di Paolo, C Maag, R Meier, BW … - Carcinogenesis, 2004 - carcin.oupjournals.org
... Mason,KL and Parysek,LM (1991) Differential expression of N-myc in phenotypically ...
Meisler,MH and Busslinger,M. (1997) Cooperation of Pax2 and Pax5 in midbrain ...
Cited by 2 - Web Search - carcin.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 7 versions »

Pax5 expression in Non-Hodgkin’s Lymphomas and Acute Leukemias - Full text - MIT Libraries
X Zhang, Z Lin, I Kim - J Korean Med Sci, 2003 - jkms.kams.or.kr
... in plasma cells (5, 6). It activates expression of mb-1, LEF-1, N-myc, and also ...
associated with t(9;14) (p13;q32), which leads to juxtaposition of Pax5 gene to ...
Cited by 2 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - jkms.kams.or.kr

THE ROLE OF Pax5 (BSAP) IN EARLY AND LATE B-CELL DEVELOPMENT
M HORCHER, D EBERHARD, M BUSSLINGER - doi.wiley.com
... for the cell surface proteins CD19 and Ig (mb-1) and the transcription factors
LEF-1 and N-myc were thus shown to be posi- tively regulated by Pax5, while the ...
Web Search

Reconstitution and assay of the activity of the caspase-9±Apaf-1 holoenzyme complexes - Full text - MIT Libraries
MJ Humphreys - J. Biol. Chem, 2000 - nature.com
... 412 191 173 chromo shadow HP1α HP1γ b Myc 3 –Pax5 Myc 3 –mPC1 Myc 3 –SUV39H1 Myc
3 –HP1 β Myc 3 –HP1 α Myc 3 –HP1 γ 84K 32K 52K chromo shadow ...
Web Search - nature.com

Id2 Is Dispensable for Myc-Induced Lymphomagenesis - Full text - MIT Libraries
JA Nilsson, LM Nilsson, U Keller, Y Yokota, K Boyd … - Cancer Research, 2004 - cancerres.aacrjournals.org
... Medline]; Gonda H, Sugai M, Nambu Y, et al The balance between Pax5 and Id2 ... critical
for cellular proliferation and is the oncogenic effector of N-myc in human ...
Cited by 1 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

B cell–specific loss of histone 3 lysine 9 methylation in the VH locus depends on Pax 5 - Full text - MIT Libraries
K Johnson, DL Pflugh, D Yu, DGT Hesslein, KI Lin, … - Nature Immunology, 2004 - nature.com
... Oscillation between B-lymphoid and myeloid lineages in Myc-induced hematopoietic
tumors following spontaneous silencing/reactivation of the EBF/Pax5 pathway. ...
Cited by 7 - Web Search - nature.com - mail.vet.upenn.edu - ncbi.nlm.nih.gov

Direct Repression of FLIP Expression by c-myc Is a Major Determinant of TRAIL Sensitivity - Full text - MIT Libraries
MS Ricci, Z Jin, M Dews, D Yu, A Thomas-Tikhonenko … - Mol. Cell. Biol, 2004 - pubmedcentral.nih.gov
... Direct Repression of FLIP Expression by c-myc Is a Major Determinant of
TRAIL Sensitivity. ... (i) Constitutive c-myc expression model. ...
Cited by 2 - Web Search - mail.vet.upenn.edu - dx.doi.org - mcb.asm.org - all 5 versions »

Inactivation of Myc in Murine Two-Hit B lymphomas Causes Dormancy with Elevated Levels of … - Full text - MIT Libraries
D Yu, M Dews, A Park, JW Tobias, A Thomas- … - Cancer Research, 2005 - cancerres.aacrjournals.org
... Oscillation between B-lymphoid and myeloid lineages in Myc-induced hematopoietic
tumors following spontaneous silencing/reactivation of the EBF/Pax5 pathway. ...
Web Search - mail.vet.upenn.edu - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

THE FUNCTION OF E- AND ID PROTEINS IN LYMPHOCYTE DEVELOPMENT - Full text - MIT Libraries
I Engel, C Murre - Nature Reviews Immunology, 2001 - nature.com
... and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and
myc proteins. ... patterning of the posterior midbrain in mice lacking Pax5/BSAP ...
Cited by 41 - Web Search - nature.com - ncbi.nlm.nih.gov

A target selection of somatic hypermutations is regulated similarly between T and B cells upon … - Full text - MIT Libraries
A Kotani, I Okazaki, M Muramatsu, K Kinoshita, NA … - Proceedings of the National Academy of Sciences, 2005 - pnas.org
... So far, nine genes (Ig , IgH, MB-1(Ig ), B29(Ig ), PAX5, BCL6, c-MYC, PIM1,
and RhoH/TTF) are known to have SHM in B cells (3–5, 33). ...
Web Search - dx.doi.org - pnas.org - ncbi.nlm.nih.gov - all 5 versions »

Molecular biology
N User - Neuron, 1995 - nature.com
... 3), being especially evident in the case of MYC and PAX5, where two distinct
promoters correspond to separate mutation clusters (Fig. ...
Web Search - nature.com - Get it from MIT Libraries

STAT 5 regulates the self-renewal capacity and differentiation of human memory B cells and controls … - Full text - MIT Libraries
FA Scheeren, M Naspetti, S Diehl, R Schotte, M … - Nature Immunology, 2005 - nature.com
Page 1. STAT5 regulates the self-renewal capacity and differentiation of
human memory B cells and controls Bcl-6 expression Ferenc ...
Web Search - nature.com - hawaii.edu - ncbi.nlm.nih.gov

Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression … - Full text - MIT Libraries
AL Shaffer, KI Lin, TC Kuo, X Yu, EM Hurt, A … - Immunity, 2002 - cumicro2.cpmc.columbia.edu
... tion in levels of the target gene proteins c-Myc, PAX5, expressing ... et identified
direct targets, c-myc, PAX5, and CIITA, and al., 2001). ...
Cited by 75 - View as HTML - Web Search - lymphochip.nih.gov - ncbi.nlm.nih.gov - all 4 versions »

This Week IN Science
M from Dmanisi, QD Molecules, BT Catch, SM Water - sciencemag.org
... sarcoma cells differen- tiated into bone cells; re-expres- sion of MYC did not ... in
some cases, may be re- versible.The transcription factor Pax5, is required ...
Web Search - sciencemag.org

Decision making in the immune system: Lymphoid Malignancies: the dark side of B-cell differentiation - Full text - MIT Libraries
AL Shaffer, A Rosenwald, LM Staudt - Nature Reviews Immunology, 2002 - nature.com
... 12. Pelicci, PG, Knowles, DM 2nd, Magrath, I. & Dalla-Favera, R. Chromosomal
breakpoints and structural alterations of the c-myc locus differ in endemic and ...
Cited by 31 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Rapid amplification of immunoglobulin heavy chain switch(IGHS) translocation breakpoints using long- …
T Sonoki, TG Willis, DG Oscier, EL Karran, R … - Leukemia, 2004 - ncbi.nlm.nih.gov
... we have succeeded in amplifying IGHS translocation breakpoints involving FGFR3/MMSET
on 4p16, BCL6 on 3q27, MYC on 8q24, IRTA1 on 1q21 and PAX5 on 9p13 as well ...
Web Search - Get it from MIT Libraries

Somatic hypermutation of the B cell receptor genes B29 (Igb, CD79b) and mb1 (Iga, CD79a) - Full text - MIT Libraries
MS Gordon, CM Kanegai, JR Doerr, R Wall - Proc. Natl. Acad. Sci. USA, 2003 - pnas.org
... Deletions and insertions accounted for only 2 - 9% of total mutations in the Bcl6,
c-myc, Pax5, Pim1, and RhoHTTF oncogenes in DLBCL (5). However, deletions ...
Cited by 2 - Web Search - pubmedcentral.nih.gov

Oligo GEArray® Human Hematopoietic Stem Cells and Hematopoiesis Microarray
S Conditions - search.cosmobio.co.jp
... GATA2, GFI1, HDAC4, HDAC5, HDAC7A, HDAC9, HOXB4, IFI16, IL31RA, IRF4, IRF8, KLF6,
LEF1, MAFB, MYC, NCOA6, NFYA, NOTCH1, NOTCH2, NOTCH4, PAX5, RBPSUH, RHOH ...
View as HTML - Web Search

Transcriptional regulatory cascades controlling plasma cell differentiation - Full text - MIT Libraries
KI Lin, C Tunyaplin, K Calame - Immunological Reviews, 2003 - blackwell-synergy.com
... over 10% of the named genes identified were transcription factors, and the five
known direct targets of Blimp-1 in B cells, c-myc, CIITA, Pax5, SpiB and Id3 ...
Cited by 8 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Plasma cells: finding new light at the end of B cell development - Full text - MIT Libraries
KL Calame - Nat Immunol, 2001 - nature.com
... Lin, Y., Wong, K. & Calame, K. Repression of c-myc transcription by Blimp-1 ... KW &
Koshland, ME An interleukin-2 signal relieves BSAP (Pax5)-mediated repression ...
Cited by 72 - Web Search - cumicro2.cpmc.columbia.edu - hora.cpmc.columbia.edu - ncbi.nlm.nih.gov - all 7 versions »

Regulation of E 2 A Activities by Histone Acetyltransferases in B Lymphocyte Development - Full text - MIT Libraries
C Bradney, M Hjelmeland, Y Komatsu, M Yoshida, TP … - J Biol Chem, 2003 - jbc.org
... pro-B cell stage (2-5). Although the expression of EBF and Pax5 are relatively ... For
transfections, a Myc-tagged E2-5 was generated by adding six repeats of Myc ...
Cited by 15 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Control of Self-Renewal and Differentiation of Hematopoietic Stem Cells: HOXB4 on the Threshold - Full text - MIT Libraries
H KLUMP, B SCHIEDLMEIER, C BAUM - Ann. NY Acad. Sci, 2005 - annalsnyas.org
... concentration levels has also been shown for many transcription factors that organize
hematopoiesis, for example AML1 (CBFA2), 14 PU.1, 15,16 Pax5, c-Myc 17 or ...
Web Search - annalsnyas.org - ncbi.nlm.nih.gov

An interfering form of Blimp-1 increases IgM secreting plasma cells and blocks maturation of … - Full text - MIT Libraries
C Angelin-Duclos, K Johnson, J Liao, KI Lin, K … - European Journal of Immunology, 2002 - doi.wiley.com
... PCR products were obtained from sequential dilutions of cDNA amplified with specific
primers for TBlimp, c-myc, PAX5, CIITA and BCL-6 and GAPDH (control), as ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov

Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a) - Full text - MIT Libraries
MS Gordon, CM Kanegai, JR Doerr, R Wall - Proc. Natl. Acad. Sci, 2003 - pnas.org
... Deletions and insertions accounted for only 2 - 9% of total mutations in the Bcl6,
c-myc, Pax5, Pim1, and RhoHTTF oncogenes in DLBCL (5). However, deletions ...
Cited by 14 - Web Search - dx.doi.org - pnas.org - ncbi.nlm.nih.gov - all 5 versions »

B Cell Heterogeneity in the Teleost Kidney: Evidence for a Maturation Gradient from Anterior to … - Full text - MIT Libraries
P Zwollo, S Cole, E Bromage, S Kaattari - The Journal of Immunology, 2005 - jimmunol.org
... B, EMSA using Pax-5-specific (CD19/Pax5) and Blimp-1-specific (c-myc/Blimp-
1) probes. ... 2B using labeled CD19/Pax5 or c-myc/Blimp-1 probes. ...
Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Activation-induced Cytosine Deaminase(AID) Is Actively Exported out of the Nucleus but Retained by … - Full text - MIT Libraries
SS Brar, M Watson, M Diaz - J Biol Chem, 2004 - jbc.org
... subsets of germinal center-derived B cell lymphomas display untargeted AID-mediated
hypermutation in multiple protooncogenes such as C-MYC and PAX5 (29, 30). ...
Cited by 11 - Web Search - biol.sc.edu - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

Kuo-I Lin Chainarong Tunyaplin Kathryn Calame - Full text - MIT Libraries
KI Lin - Immunological Reviews, 2003 - ingentaconnect.com
... over 10% of the named genes identi- fied were transcription factors, and the five
known direct targets of Blimp-1 in B cells, c-myc, CIITA, Pax5, SpiB and Id3 ...
Web Search

Plasma cell ontogeny defined by quantitative changes in Blimp-1 expression - Full text - MIT Libraries
A Kallies, J Hasbold, DM Tarlinton, W Dietrich, LM … - J. Exp. Med, 2004 - jem.org
... expression (20, 21). Direct promoter analyses have suggested that Blimp-1
represses Pax5 (17), c-myc (16), and CIITA (36). This paper ...
Cited by 8 - Web Search - dx.doi.org - jem.org - ncbi.nlm.nih.gov

Transcription factor regulation of B lineage commitment - Full text - MIT Libraries
BL Kee, C Murre - Curr Opin Immunol, 2001 - www-biology.ucsd.edu
... In the absence of Pax5, B lin- eage progenitors are able to rearrange the D–J ... associated
genes are expressed normally with the exception of CD19, N-myc, mb-1 ...
Cited by 18 - View as HTML - Web Search - inv.his.se - ncbi.nlm.nih.gov

Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the … - Full text - MIT Libraries
CS Seet, RL Brumbaugh, BL Kee - J. Exp. Med, 2004 - jem.org
... We are grateful to C. Murre for the E47 –/– mice, L. Penn for the N-myc retrovirus,
H. Singh for the Pax5 retrovirus and for use of the FACSCalibur TM ...
Cited by 10 - Web Search - dx.doi.org - jem.org - ncbi.nlm.nih.gov

HLS 5, a Novel RBCC(Ring Finger, B Box, Coiled-coil) Family Member Isolated from a Hemopoietic … - Full text - MIT Libraries
JP Lalonde, R Lim, E Ingley, PA Tilbrook, MJ … - J Biol Chem, 2004 - intl.jbc.org
... the conversion of B lymphoma cells overexpressing the raf and myc oncogenes into ...
The recent data with Pax5-/- mice are particularly noteworthy as committed B ...
Web Search - dx.doi.org - jbc.org - ncbi.nlm.nih.gov - all 6 versions »

Paediatrische Onkologie
P Onkologie - Monatsschrift Kinderheilkunde, 2002 - springerlink.com
... Bei Veränderungen des Transkriptionsfak- tors PAX5 bleibt hingegen die B-Zellent-
wicklung auf der etwas ... t(8;14)(q24;q32) t(10;14))(q24;11) c-myc, Hox11 B-ALL ...
Web Search

BIOTECHNICAL METHODS SECTION (BTS)
T Sonoki, TG Willis, DG Oscier, EL Karran, R … - Leukemia, 2004 - nature.com
... we have succeeded in amplifying IGHS translocation breakpoints involving FGFR3/MMSET
on 4p16, BCL6 on 3q27, MYC on 8q24, IRTA1 on 1q21 and PAX5 on 9p13 as well ...
Web Search

ISOTYPE SWITCH-MEDIATED C - Full text - MIT Libraries
TINPPIN MICE - Int. J. Cancer, 2002 - doi.wiley.com
... Translo- cation breakpoints in S regions were first detected in MYC-acti- vating
t(8 ... q32), MUC1], lymphoplasmacytoid lymphoma [t(9;14)(p13;q32), PAX5] and, with ...
Web Search

Antibody regulation of B cell development - Full text - MIT Libraries
E Meffre, R Casellas, MC Nussenzweig - Nat. Immunol, 2000 - nature.com
... P., Rolink, A. & Busslinger, M. Essential functions of Pax5 (BSAP) in ... human
immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic ...
Cited by 77 - Web Search - nature.com - lsic.ucla.edu - ncbi.nlm.nih.gov - all 5 versions »

Multicolour fluorescence in situ hybridization analysis of t (14; 18)-positive follicular lymphoma … - Full text - MIT Libraries
VS Lestou, RD Gascoyne, L Sehn, O Ludkovski, M … - British Journal of Haematology, 2003 - blackwell-synergy.com
... Such balanced chromosomal translocations may characteristically result in deregulated
expression of oncogenes, such as PIM1, PAX5, BCL6, MYC and RhoH/TTF, and ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov