Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax … - Full text - MIT Libraries
PL Pfeffer, T Gerster, K Lun, M Brand, M … - Development, 1998 - dev.biologists.org
... The rate of divergence (Pax8>Pax5>Pax2) suggests that Pax2 most closely resembles
the ancestral gene that gave rise to the three members of the Pax2/5/8 family ...
Cited by 99 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Cooperation of Pax2 and Pax5 in midbrain and cerebellum development - Full text - MIT Libraries
P Urbanek, I Fetka, MH Meisler, M Busslinger - Proc. Natl. Acad. Sci. USA, 1997 - dx.doi.org
Proc. Natl. Acad. Sci. USA Vol. 94, pp. 5703-5708, May 1997 Developmental Biology.
Cooperation of Pax2 and Pax5 in midbrain and cerebellum development. ...
Cited by 64 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development - Full text - MIT Libraries
M Bouchard, P Pfeffer, M Busslinger - Development, 2000 - dev.biologists.org
... Interestingly, a twofold reduction of Pax5 expression in Pax2 5ki/− embryos resulted
in enlargement and fusion of the utricle and saccule compartments at the ...
Cited by 41 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the … - Full text - MIT Libraries
PL Pfeffer, M Bouchard, M Busslinger - Development, 2000 - dev.biologists.org
... Cross-regulation of Pax5 by Pax2 during mhb development The discovery of an essential
Pax2/5/8-binding site in the mhb enhancer of Pax5 raised the question of ...
Cited by 21 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The mouse Pax2 (1Neu) mutation is identical to a human PAX2 mutation in a family with renal-coloboma … - Full text - MIT Libraries
J Favor, R Sandulache, A Neuhauser-Klaus, W … - Proc Natl Acad Sci USA, 1996 - dx.doi.org
... Home page M Bouchard, P Pfeffer, and M Busslinger Functional equivalence of the
transcription factors Pax2 and Pax5 in mouse development Development, January 9 ...
Cited by 145 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Pax2 contributes to inner ear patterning and optic nerve trajectory - Full text - MIT Libraries
M Torres, E Gomez-Pardo, P Gruss - Development, 1996 - dev.biologists.org
... We have analysed the expression of Wnt-1, En-1 and Pax5 in mutant embryos in order
to establish whether Pax2 activates the expression of these genes in this ...
Cited by 176 - Web Search - dev.biologists.org - wwwlib.bionet.nsc.ru - ncbi.nlm.nih.gov

Deregulation of PAX-5 by translocation of the Eµ enhancer of the IgH locus adjacent to two … - Full text - MIT Libraries
M Busslinger, N Klix, P Pfeffer, PG Graninger, Z … - Cancer Res, 2003 - dx.doi.org
... Home page M Bouchard, P Pfeffer, and M Busslinger Functional equivalence of the
transcription factors Pax2 and Pax5 in mouse development Development, January 9 ...
Cited by 46 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

A series of no isthmus (noi) alleles of the zebrafish pax2. 1 gene reveals multiple signaling events … - Full text - MIT Libraries
K Lun, M Brand - Development, 1998 - dev.biologists.org
... the function of zebrafish pax2.1 (formerly pax(zf-b); Krauss et al., 1991), a member
of the family of transcription factors that includes pax2, pax5 and pax8 ...
Cited by 85 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

The expression of PAX5 in human transitional cell carcinoma of the bladder: relationship with de- … - Full text - MIT Libraries
JM ADSHEAD, CW OGDEN, MA PENNY, ET STUART, AM … - BJU International, 1999 - ingentaconnect.com
... ulloblastoma, non-Hodgkin lymphoma (PAX5), RCC (PAX2), Wilms’ tumour (PAX2 and 8)
and rhabdomyos- arcoma (PAX3 and 7) [11]. PCR amplification of PAX5 cDNA ...
Cited by 7 - Web Search - bjui.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The Pax2 homolog sparkling is required for development of cone and pigment cells in the Drosophila … - Full text - MIT Libraries
W Fu, M Noll - Genes Dev, 1997 - genesdev.org
... A new Drosophila Pax gene, sparkling (spa), implicated in eye development, was isolated
and shown to encode the homolog of the vertebrate Pax2, Pax5, and Pax8 ...
Cited by 51 - Web Search - unizh.ch - molbio.unizh.ch - ncbi.nlm.nih.gov - all 7 versions »

Two Pax2/5/8-binding sites in Engrailed2 are required for proper initiation of endogenous mid- … - Full text - MIT Libraries
DL Song, AL Joyner - Mech. Dev, 2000 - saturn.med.nyu.edu
... A growing number of genes, including those that encode the transcription factors
Engrailed1 and 2 (En1 and 2), Pax2, Pax5, Pax8, Otx2 and Gbx2, as well as the ...
Cited by 13 - View as HTML - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov

Pax6 defines the di-mesencephalic boundary by repressing En1 and Pax2 - Full text - MIT Libraries
E Matsunaga, I Araki, H Nakamura - Development, 2000 - dev.biologists.org
... Pax6 repressed En1, Pax2 and other tectum (mesencephalon)-related genes such as
En2, Pax5, Pax7, but induced Tcf4, a diencephalon marker gene. ...
Cited by 47 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Independent regulation of the two Pax5 alleles during B-cell development - Full text - MIT Libraries
SL Nutt, S Vambrie, P Steinlein, Z Kozmik, A … - Nat. Genet, 1999 - nature.com
... Mutation of the PAX2 gene in a family with optic nerve colombomas, renal anomalies ...
and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. ...
Cited by 72 - Web Search - nature.com - ncbi.nlm.nih.gov

pax2. 1 is required for the development of thyroid follicles in zebrafish - Full text - MIT Libraries
T Wendl, K Lun, M Mione, J Favor, M Brand, SW … - Development, 2002 - dev.biologists.org
... During evolution of tetrapods, pax5 and either pax2 or pax8 have subsequently lost
this function, while in zebrafish both pax2 and pax8 have maintained a role ...
Cited by 7 - Web Search - ucl.ac.uk - dev.biologists.org - ncbi.nlm.nih.gov

THE DEVELOPMENTAL AND ONCOGENIC GENES PAX2, 5 & 8 ARE EXPRESSED IN TRANSITIONAL CELL CARCINOMA OF …
JM Adshead, B Khoubehi, AM Kessling, CW Ogden - The Journal of Urology, 1999 - jurology.com
... Results: Cell lines; RT112, HT1376, MGH-U1 and 74.3% of primary TCCs express
PAX5. Cell line; MGH-U1 and 6/35 TCCs express PAX2. ...
Web Search

The activation and maintenance of Pax2 expression at the mid-hindbrain boundary is controlled by … - Full text - MIT Libraries
PL Pfeffer, B Payer, G Reim, MP di Magliano, M … - Development, 2002 - dev.biologists.org
... Subsequently, the transcription factors Pax2, Pax5 and Pax8, and En1 and En2 are
expressed across the Otx2-Gbx2 boundary in the mid-hindbrain region and ...
Cited by 12 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Rabbit anti-phospho-Pax2 (Ser393)
S Western - zytomed.de
... SPECIFICITY This antibody identifies the Pax2 protein when phosphorylated at Ser393.
Based on amino acid sequence homology with Pax5 and Pax8, cross-reactivity ...
View as HTML - Web Search - zymed.com

Homonucleotide expansion and contraction mutations of PAX2 and inclusion of Chiari 1 malformation as … - Full text - MIT Libraries
LA Schimmenti, HH Shim, JD Wirtschafter, VA … - Hum Mutat, 1999 - doi.wiley.com
... The seven-guanine tract sequence is only conserved between two of the nine human
PAX genes, PAX2 and PAX5 [Adams et al., 1992; Sanyanusin et al., 1996]. ...
Cited by 8 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: … - Full text - MIT Libraries
M Schwarz, G Alvarez-Bolado, P Urbanek, M … - Proc. Natl. Acad. Sci. USA, 1997 - dx.doi.org
... Home page M Bouchard, P Pfeffer, and M Busslinger Functional equivalence of the
transcription factors Pax2 and Pax5 in mouse development Development, January 9 ...
Cited by 51 - Web Search - pnas.org - pubmedcentral.nih.gov - adsabs.harvard.edu - all 6 versions »

Pax2 in development and renal disease
GR Dressler, AS Woolf - Int J Dev Biol, 1999 - ijdb.ehu.es
... Surprisingly, Pax2 also contains a repressor motif, the octapeptide sequence, that
is ... For example, Pax5 can recruit members of the Ets family of proteins to a B ...
Cited by 20 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - ijdb.ehu.es - Get it from MIT Libraries

Zebrafish no isthmus reveals a role for pax2. 1 in tubule differentiation and patterning events in … - Full text - MIT Libraries
A Majumdar, K Lun, M Brand, IA Drummond - Development, 2000 - dev.biologists.org
... In vertebrates, the pax2, pax5 and pax8 genes have been grouped into a common subfamily
based on their sequence similarity and expression pattern. ...
Cited by 24 - Web Search - receptor.mgh.harvard.edu - danio.mgh.harvard.edu - ncbi.nlm.nih.gov - all 6 versions »

Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes
SL Nutt, M Busslinger - Biol. Chem, 1999 - degruyter.com
... The main reasons for this apparent discrepancy are the functional redundancy of
Pax2 and Pax5 in the developing midbrain (Urbánek et al., 1997; Schwarz et al ...
Cited by 17 - Web Search - extenza-eps.com - degruyter.de - ncbi.nlm.nih.gov - all 9 versions » - Get it from MIT Libraries

The zebrafish buttonhead-like factor Bts1 is an early regulator of pax2. 1 expression during mid- … - Full text - MIT Libraries
A Tallafuss, TP Wilm, M Crozatier, P Pfeffer, M … - Development, 2001 - dev.biologists.org
... Whether pax5 and eng3 expressions are directly regulated by Bts1 cannot be immediately
concluded from our data, as pax5 and eng3 expressions require Pax2.1 at ...
Cited by 11 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 … - Full text - MIT Libraries
M Schwarz, F Cecconi, G Bernier, N Andrejewski, B … - Development, 2000 - dev.biologists.org
... The early and dynamic expression of Pax2 and Pax6 during eye formation suggests
a potential role for these genes in eye regionalization (Nornes et al., 1990 ...
Cited by 48 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Distinct regulators control the expression of the mid-hindbrain organizer signal FGF8 - Full text - MIT Libraries
W Ye, M Bouchard, D Stone, X Liu, F Vella, J Lee, … - Nat. Neurosci, 2001 - nature.com
... | PubMed | ISI | ChemPort |; Bouchard, M., Pfeffer, P. & Busslinger, M. Functional
equivalence of the transcription factors Pax2 and Pax5 in mouse development. ...
Cited by 25 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The deltaA gene of zebrafish mediates lateral inhibition of hair cells in the inner ear and is … - Full text - MIT Libraries
BB Riley, M Chiang, L Farmer, R Heck - Development, 1999 - dev.biologists.org
... In addition, deltaA dx2/dx2 mutants show an increased number of cells expressing
pax2.1 in regions where hair cells are normally produced. ... and Pax2. ...
Cited by 43 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic … - Full text - MIT Libraries
PD Brophy, L Ostrom, KM Lang, GR Dressler - Development, 2001 - dev.biologists.org
... 1994); the consensus sequence from chromatin immunoprecipitation studies (Phelps
and Dressler, 1996); the Pax2-binding site from the Pax5 enhancer (Pfeffer et ...
Cited by 31 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Les genes Pax et la specification cellulaire
M Bouchard - erudit.org
... 2. Bouchard M, Pfeffer P, Busslinger M. Functional equivalence of the transcription
factors Pax2 and Pax5 in mouse development. Development 2000; 127: 3703-13. ...
View as HTML - Web Search - ist.inserm.fr - erudit.org

A novel positive transcriptional feedback loop in midbrain-hindbrain boundary development is … - Full text - MIT Libraries
A Picker, S Scholpp, H Bohli, H Takeda, M Brand - Development, 2002 - dev.biologists.org
... tested. The Pax5 enhancer similarly activates expression at later stages through
Pax2 and Pou homeodomain binding sites. These enhancers ...
Cited by 11 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Loss of p53 function through PAX-mediated transcriptional repression - Full text - MIT Libraries
ET Stuart, R Haffner, M Oren, P Gruss - J. Biol. Chem, 2004 - embojournal.npgjournals.com
... PAX5 and its paralogues PAX2 and PAX8 are capable of inhibiting both the p53 promoter
and transactivation of a p53- responsive reporter in cell culture. ...
Cited by 76 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

PAX2 suppresses apoptosis in renal collecting duct cells - Full text - MIT Libraries
E Torban, MR Eccles, J Favor, PR Goodyer - Am J Pathol, 2000 - ajp.amjpathol.org
... 32 Moreover, PAX2, PAX5, and PAX8 all inhibit transcription of p53, a pivotal molecule
regulating entry into the final common apoptotic pathway. ...
Cited by 18 - Web Search - ajp.amjpathol.org - ncbi.nlm.nih.gov

shaven and sparkling are mutations in separate enhancers of the Drosophila Pax2 homolog - Full text - MIT Libraries
W Fu, H Duan, E Frei, M Noll - Development, 1998 - dev.biologists.org
... sparkling (spa) gene of Drosophila and shown it to encode a paired-domain transcription
factor most closely related to the vertebrate Pax2/Pax5/Pax8 proteins ...
Cited by 22 - Web Search - unizh.ch - molbio.unizh.ch - ncbi.nlm.nih.gov - all 6 versions »

PAX genes in development and disease: The role of PAX2 in urogenital tract development
MR Eccles, S He, M Legge, R Kumar, J Fox, C Zhou, … - Int J Dev Biol, 2002 - ijdb.ehu.es
... expression in certain tissues. This has been observed for the PAX5 gene,
but not for PAX2 (Nutt et al., 1999, Porteous et al., 2000). ...
Cited by 5 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - ijdb.ehu.es - Get it from MIT Libraries

Integrity of the Midbrain Region Is Required to Maintain the Diencephalic–Mesencephalic Boundary … - Full text - MIT Libraries
S Scholpp, M Brand - Dev. Dyn, 2003 - doi.wiley.com
... Full inactivation of Pax2 and Pax5, however, results in a reliably strong phenotype,
sug- gesting a partial functional redun- dancy of these two factors ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Pax2 mutant mice display increased number and size of islets of Langerhans but no change in insulin … - Full text - MIT Libraries
M Zaiko, A Estreicher, B Ritz-Laser, P Herrera, J … - European Journal of Endocrinology, 2004 - eje.org
... 5, 6). Pax2, Pax5 and Pax8 form group II which is specified by a paired domain,
an octapeptide motif and a partial paired-class DNA-binding homeodomain. ...
View as HTML - Web Search - eje-online.org - eje.org - ncbi.nlm.nih.gov - all 5 versions »

Pax6 defines the di-mesencephalic boundary by repressing En1 and Pax2 - Full text - MIT Libraries
P Pax - Development, 2000 - dev.biologists.org
... Probes for En1, Pax2, Pax5 and Pax6 were described previously (Funahashi et
al., 1999; Okafuji et al., 1999; Araki and Nakamura, 1999). ...
Web Search

A novel paired domain DNA recognition motif can mediate Pax2 repression of gene transcription - Full text - MIT Libraries
B Havik, E Ragnhildstveit, JB Lorens, K Saelemyr, … - Biochem Biophys Res Commun, 1999 - ingentaconnect.com
... sequence was found to be conserved in known natural Pax5 repressor elements ... affinity
binding sites in potential target genes of the Pax2 protein, including the ...
Cited by 3 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

An essential role for the Drosophila Pax2 homolog in the differentiation of adult sensory organs - Full text - MIT Libraries
J Kavaler, W Fu, H Duan, M Noll, JW Posakony - Development, 1999 - dev.biologists.org
... Here we show that D-Pax2, the Drosophila homolog of the vertebrate Pax2 gene,
has an essential role in the differentiation of the shaft cell. ...
Cited by 21 - Web Search - www-biology.ucsd.edu - unizh.ch - ncbi.nlm.nih.gov - all 6 versions »

The midbrain–hindbrain boundary organizer - Full text - MIT Libraries
M Rhinn, M Brand - Curr. Opin. Neurobiol, 2001 - cbs.montana.edu
... functional Pax2 binding sites are nevertheless present in the murine Pax5 promoter
and Pax2 partially regulates Pax5 also in mice [76 • ]; the regulatory ...
Cited by 69 - View as HTML - Web Search - cbs.montana.edu - ncbi.nlm.nih.gov

Morpholino-induced knockdown of zebrafish engrailed genes eng2 and eng3 reveals redundant and unique … - Full text - MIT Libraries
S Scholpp, M Brand - Genesis, 2001 - doi.wiley.com
... As molecular markers, we used pax2.1 and pax5 for the MHB, fgf8 for the forebrain
and the poste- rior part of the MHB, and wnt1 for the dorsal midbrain and the ...
Cited by 13 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Anteroposterior patterning of the epidermis by inductive influences from the vegetal hemisphere … - Full text - MIT Libraries
S Wada, Y Katsuyama, H Saiga - Development, 1999 - dev.biologists.org
... The single ascidian homologue of the Pax2, Pax5 and Pax8 genes is expressed
in between (Wada et al., 1998). Expression pattern of ...
Cited by 21 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b - Full text - MIT Libraries
MP Smidt, CH Asbreuk, JJ Cox, H Chen, RL Johnson, … - Nat. Neurosci, 2000 - nature.com
... | Article | PubMed | ChemPort |; Urbanek, P., Fetka, I., Meisler, MH & Busslinger,
M. Cooperation of Pax2 and Pax5 in midbrain and cerebellum development. Proc. ...
Cited by 82 - Web Search - nature.com - cellbio.wustl.edu - ncbi.nlm.nih.gov

Identification of DNA recognition sequences for the Pax3 paired domain - Full text - MIT Libraries
G Chalepakis, P Gruss - Gene, 1995 - ncbi.nlm.nih.gov
... Pax1 and Pax9 constitute one subfamily, Pax2, Pax5 and Pax8 another, Pax3
and Pax7 another one and Pax4 and Pax6 the fourth subfamily. ...
Cited by 19 - Web Search

Altered mRNA expression of Pax5 and Blimp-1 in B cells in multiple myeloma - Full text - MIT Libraries
ND Borson, MQ Lacy, PJ Wettstein - Blood, 2002 - bloodjournal.org
Page 1. NEOPLASIA Altered mRNAexpression of Pax5 and Blimp-1 in B cells in multiple
myeloma ... Our finding of this unique isoform prompted us to investigate Pax5 ...
Cited by 9 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Ce sont la des questions cruciales qui vont necessiter un effort considerable. Heureusement, … - Full text - MIT Libraries
BM Functional, M Schebesta, M Busslinger, K … - Development, 1995 - ist.inserm.fr
... 2. Bouchard M, Pfeffer P, Busslinger M. Functional equivalence of the transcription
factors Pax2 and Pax5 in mouse development. Development 2000; 127: 3703-13. ...
View as HTML - Web Search

A Distinct Preisthmic Histogenetic Domain Is Defined by Overlap of Otx2 and Pax2 Gene Expression in … - Full text - MIT Libraries
RM ALVARADO-MALLART, L PUELLES - THE JOURNAL OF COMPARATIVE NEUROLOGY, 2005 - doi.wiley.com
... These data in the chick are on the whole consistent with observations reported on
expression of Pax2 and Pax5 in the mouse (Stoykova and Gruss, 1994). ...
Web Search

DEV01833 Supplementary Material
S Figure, S Figure, S Figure - dev.biologists.org
... Brn4 was only weakly expressed in a Pax2-independent manner in the mid-hindbrain
region, whereas Tst1 ... Brn1 expression in wild-type and Pax5 –/– embryos. ...
Web Search

The PAX5 oncogene is expressed in N-type neuroblastoma cells and increases tumorigenicity of a S- … - Full text - MIT Libraries
FBB Kubetzko, C di Paolo, C Maag, R Meier, BW … - Carcinogenesis, 2004 - carcin.oupjournals.org
... Dev., 6, 1589–1607.[Abstract]; Urbanek,P., Fetka,I., Meisler,MH and Busslinger,M.
(1997) Cooperation of Pax2 and Pax5 in midbrain and cerebellum development. ...
Cited by 2 - Web Search - carcin.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 7 versions »

Transcriptional repression by Pax 5(BSAP) through interaction with corepressors of the Groucho … - Full text - MIT Libraries
D Eberhard, G Jimenez, B Heavey, M Busslinger - The EMBO Journal, 2000 - embojournal.npgjournals.com
... Pax5 cooperates with Pax2 in development of the midbrain and cerebellum, in agreement
with the overlapping expression patterns of the two genes at the midbrain ...
Cited by 64 - Web Search - nature.com - emboj.org - pubmedcentral.nih.gov - all 6 versions »

The developmental genetics of auditory hair cells - Full text - MIT Libraries
RD Hawkins, M Lovett - Human Molecular Genetics, 2004 - hmg.oupjournals.org
... However, the relationship of Pax genes to Six and Eya expression is less clear.
This may reflect functional redundancy in Pax genes [eg Pax5 and Pax2 (31)]. ...
Cited by 1 - Web Search - hmg.oupjournals.org - hg.wustl.edu - ncbi.nlm.nih.gov