Deregulated Expression of PAX5 in Medulloblastoma - Full text - MIT Libraries
Z Kozmik, U Sure, D Ruedi, M Busslinger, A Aguzzi - Proceedings of the National Academy of Sciences - pnas.org
... Of all nine PAX genes investigated, only PAX5 and PAX6 were consistently expressed
in most medulloblastomas (70 and 78% of all cases, respectively), as were ...
Cited by 46 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker … - Full text - MIT Libraries
HE Xu, MA Rould, W Xu, JA Epstein, RL Maas, CO … - Genes Dev, 1999 - genesdev.org
... These isoforms can recognize the extended sites identified for Pax5 and Pax6, and
optimal binding to these extended sites also requires the intact C subdomains ...
Cited by 61 - Web Search - uphs.upenn.edu - 128.95.44.130 - pubmedcentral.nih.gov - all 8 versions »

Getting your Pax straight: Pax proteins in development and disease
N Chi, JA Epstein - Trends Genet, 2002 - instruct.uwo.ca
... activity. In addition, Pax2, Pax3, Pax4, Pax5 and Pax6 can repress transcription
of some reporter constructs. Transcriptional function ...
Cited by 54 - View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Identification of DNA recognition sequences for the Pax3 paired domain - Full text - MIT Libraries
G Chalepakis, P Gruss - Gene, 1995 - ncbi.nlm.nih.gov
... has been performed [Xu et al., Cell 80 (1995) 639-650] and the DNA-binding
characteristics of members of two Pax subfamilies (Pax2, Pax5 and Pax6) have been ...
Cited by 19 - Web Search

Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the … - Full text - MIT Libraries
PL Pfeffer, M Bouchard, M Busslinger - Development, 2000 - dev.biologists.org
... EMSA analysis The mouse Pax2b, Pax3, Pax5, Pax6, Oct1, Otx2, Gbx2, En2 and Xenopus
HoxD1 cDNAs were cloned into the expression vector pKW2T, and proteins were ...
Cited by 21 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region - Full text - MIT Libraries
A Liu, AL Joyner - Development, 2001 - dev.biologists.org
... Table 1. Gene expression profiles in brain explants cultured with FGF8b-soaked beads
(A) Diencephalic explants En1 En2 Pax5 Pax6 Gbx2 Otx2 Wnt1 i i i r i r i/r ...
Cited by 35 - Web Search - dev.biologists.org - saturn.med.nyu.edu - ncbi.nlm.nih.gov

Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and … - Full text - MIT Libraries
PX Xu, I Woo, H Her, DR Beier, RL Maas - Development, 1997 - dev.biologists.org
... Pax6, a member of the paired box family of transcription factors, has been identified
as a key regulator of eye develop- ment in both vertebrates and ...
Cited by 107 - Web Search - dev.biologists.org - wwwlib.bionet.nsc.ru - ncbi.nlm.nih.gov

Expression of Alcaligenes eutrophus flavohemoprotein and engineered Vitreoscilla hemoglobin- … - Full text - MIT Libraries
AD Frey, JE Bailey, PT Kallio - Applied and Environmental Microbiology, 2000 - aem.asm.org
... Thus, E. coli MG1655 cells expressing VHb (pPPC1), FHPg (pAX1), or separate
globin-reductase fusions (pAX5, pAX6, pAX4, pAX9, pAX12, and pAX14) were cultivated ...
Cited by 13 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - csa.com - all 5 versions »

Functional analysis of paired box missense mutations in the PAX6 gene - Full text - MIT Libraries
HK Tang, LY Chao, GF Saunders - Nucleic Acids Res, 2004 - hmg.oupjournals.org
... The C-terminal subdomains of the paired regions of PAX5 (29 ) and PAX6 (31 )
have been shown to have a role in DNA binding in vitro. ...
Cited by 29 - Web Search - hmg.oupjournals.org - molgen.gla.ac.uk - ncbi.nlm.nih.gov - all 5 versions »

Overexpression of Pax 5 is not sufficient for neoplastic transformation of mouse neuroectoderm - Full text - MIT Libraries
JP Steinbach, Z Kozmik, P Pfeffer, A Aguzzi - International Journal of Cancer, 2001 - doi.wiley.com
... MATERIAL AND METHODS Plasmid construction The mouse Pax5 and Pax6 cDNAs were cloned
into the BamHI site of the pM48 retrovirus vector 21 in sense and antisense ...
Cited by 4 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Cooperation of Pax2 and Pax5 in midbrain and cerebellum development - Full text - MIT Libraries
P Urbanek, I Fetka, MH Meisler, M Busslinger - Proc. Natl. Acad. Sci. USA, 1997 - dx.doi.org
... 7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Alters the Regulation of Pax5 in
Lipopolysaccharide ... requires the redundant activities of Pax2 and Pax6 Development, ...
Cited by 64 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Inhibition of floor plate differentiation by Pax3: evidence from ectopic expression in transgenic … - Full text - MIT Libraries
P Tremblay, F Pituello, P Gruss - Development, 1996 - dev.biologists.org
... made in the spinal cord, we examined the dorsoventral patterning of the mesencephalon
by characterizing the expression pattern of Pax3, Pax7, Pax5, Pax6 and Shh ...
Cited by 28 - Web Search - wwwlib.bionet.nsc.ru - www-cbd.ups-tlse.fr - ncbi.nlm.nih.gov - all 5 versions »

Pax6 defines the di-mesencephalic boundary by repressing En1 and Pax2 - Full text - MIT Libraries
E Matsunaga, I Araki, H Nakamura - Development, 2000 - dev.biologists.org
... Pax6 repressed En1, Pax2 and other tectum (mesencephalon)-related genes such as
En2, Pax5, Pax7, but induced Tcf4, a diencephalon marker gene. ...
Cited by 47 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The transcription factor Pax6 is required for development of the diencephalic dorsal midline … - Full text - MIT Libraries
G Estivill-Torrus, T Vitalis, P Fernandez-Llebrez, … - Mech. Dev, 2001 - uma.es
... and the underlying SCO are tightly related to one another and that these structures
are under the control of regulatory genes such as Pax2, Pax5, Pax6 and Msx1 ...
Cited by 10 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Clinical and genetic aspects of the Joubert syndrome: a disorder characterised by cerebellar vermian …
CL Bennett, J Meuleman, PF Chance, IA Glass - Current Genomics, 2003 - ingentaconnect.com
... Specifically, the isthmus has been shown to induce the expression of genes
such as Fgf8, En1, En2, Wnt, Pax2, Pax5, Pax6, Otx1 and Otx2. ...
Cited by 2 - Web Search

Independent regulation of the two Pax5 alleles during B-cell development - Full text - MIT Libraries
SL Nutt, S Vambrie, P Steinlein, Z Kozmik, A … - Nat. Genet, 1999 - nature.com
... Influence of PAX6 gene dosage on development: overexpression causes severe eye
abnormalities. ... patterning of the posterior midbrain in mice lacking Pax5/BSAP. ...
Cited by 72 - Web Search - nature.com - ncbi.nlm.nih.gov

Zebrafish Pax 9 encodes two proteins with distinct C-terminal transactivating domains of different … - Full text - MIT Libraries
S Nornes, I Mikkola, S Krauss, M Delghandi, M … - J Biol Chem, 1996 - jbc.org
... Several Pax genes, including Pax2, Pax3, Pax5, Pax6, Pax7, and Pax8 are expressed
in dorsoventrally restricted domains along the hindbrain and spinal cord (ie ...
Cited by 27 - Web Search - cmbn.no - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

Alternatively spliced insertions in the paired domain restrict the DNA sequence specificity of Pax 6 … - Full text - MIT Libraries
Z Kozmik, T Czerny, M Busslinger - The EMBO Journal, 1997 - embojournal.npgjournals.com
... The differential recognition of this divergent position by Pax5 and Pax6 is achieved
by three distinct amino acid residues which are located within a ...
Cited by 41 - Web Search - emboj.org - nature.com - ncbi.nlm.nih.gov - all 6 versions »

Pax6 defines the di-mesencephalic boundary by repressing En1 and Pax2 - Full text - MIT Libraries
P Pax - Development, 2000 - dev.biologists.org
... Probes for En1, Pax2, Pax5 and Pax6 were described previously (Funahashi et
al., 1999; Okafuji et al., 1999; Araki and Nakamura, 1999). ...
Web Search

Nervous system tumors: Medulloblastoma
C Morphological, C Molecular - caroll.vjf.cnrs.fr
... Expression of PAX5 and PAX6 mRNA was shown in 70 % of medulloblastomas. The precise
mechanism by which these genes are involved remains unknown. ...
Cached - Web Search

Pax2 mutant mice display increased number and size of islets of Langerhans but no change in insulin … - Full text - MIT Libraries
M Zaiko, A Estreicher, B Ritz-Laser, P Herrera, J … - European Journal of Endocrinology, 2004 - eje.org
... GCGGTCATAGGCAGC-3 0 (reverse, exon 11) and their specificity for Pax2 was tested
in control amplifications using cDNAs from Pax4, Pax5, Pax6 and Pax8 (data not ...
View as HTML - Web Search - eje-online.org - eje.org - ncbi.nlm.nih.gov - all 5 versions »

Dosage requirement and allelic expression of PAX6 during lens placode formation - Full text - MIT Libraries
CD van Raamsdonk, SM Tilghman - Development, 2000 - dev.biologists.org
... The expression of Pax6 is biallelic It was recently reported that another member
of the Pax gene family, Pax5 (BSAP), is expressed in a stochastic and ...
Cited by 25 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Functional analysis of paired box missense mutations in the PAX6 gene - Full text - MIT Libraries
HMG Pages - Nucleic Acids Res, 2004 - hmg.oupjournals.org
... The C-terminal subdomains of the paired regions of PAX5 (29 ) and PAX6 (31 )
have been shown to have a role in DNA binding in vitro. ...
Web Search

Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes
SL Nutt, M Busslinger - Biol. Chem, 1999 - degruyter.com
... a similar phenotype as inacti- vation of one of the two Pax6 alleles (Schedl ... Our
recent data on the allele-specific regulation of Pax5 (Nutt et al., 1999) raise ...
Cited by 17 - Web Search - extenza-eps.com - degruyter.de - ncbi.nlm.nih.gov - all 9 versions » - Get it from MIT Libraries

PAX-genes expression during human embryonic development, a preliminary report
M Gerard, M Abitbol, AL Delezoide, JL Dufier, J … - CR Acad Sci III, 1995 - ncbi.nlm.nih.gov
... We report in the present paper a preliminary in situ hybridization study of PAX3-,
PAX5- and PAX6-gene expression during human embryonic development. ...
Cited by 15 - Web Search - Get it from MIT Libraries

Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 … - Full text - MIT Libraries
M Schwarz, F Cecconi, G Bernier, N Andrejewski, B … - Development, 2000 - dev.biologists.org
... The early and dynamic expression of Pax2 and Pax6 during eye formation suggests
a potential role for these genes in eye regionalization (Nornes et al., 1990 ...
Cited by 48 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Identification of an enhancer region in the mouse ephA 8 locus directing expression to the anterior … - Full text - MIT Libraries
J Koo, S Shim, C Gu, O Yoo, S Park - Developmental Dynamics, 2003 - doi.wiley.com
... In contrast, the 1-kb ephA8 enhancer region specific for the anterior re- gion of
the tectum did not contain binding sites for En, Pax2, Pax5, Pax6, and Grg4 ...
Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Role of Pax6 in development of the cerebellar system - Full text - MIT Libraries
D Engelkamp, P Rashbass, A Seawright, V van … - Development, 1999 - dev.biologists.org
... Here we assess the role of the Pax6 gene in development of cerebellar structures,
by comparing normal and Pax6-mutant Small eye mice at different gestational ...
Cited by 50 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development - Full text - MIT Libraries
M Bouchard, P Pfeffer, M Busslinger - Development, 2000 - dev.biologists.org
... The vertebrate Pax2, Pax5 and Pax8 genes constitute one such subclass, which has
been even further diversified during zebrafish evolution by a recent Pax2 gene ...
Cited by 41 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Zebrafish contains two Pax6 genes involved in eye development - Full text - MIT Libraries
S Nornes, M Clarkson, I Mikkola, M Pedersen, A … - Mech. Dev, 1998 - invivo.caltech.edu
Page 1. Zebrafish contains two Pax6 genes involved in eye development 1 Svanhild ...
We have previously cloned a Pax6 cDNA from zebrafish. Here ...
Cited by 36 - View as HTML - Web Search - cmbn.no - ncbi.nlm.nih.gov

Identification and expression of the lamprey Pax6 gene: evolutionary origin of the segmented brain … - Full text - MIT Libraries
Y Murakami, M Ogasawara, F Sugahara, S Hirano, N … - Development, 2001 - dev.biologists.org
... Emx and Pax6 are expressed in the pallium, and Dlx in the subpallium (Puelles et
al ... Pax5 is expressed at the midbrain-hindbrain boundary during mouse development ...
Cited by 21 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The activation and maintenance of Pax2 expression at the mid-hindbrain boundary is controlled by … - Full text - MIT Libraries
PL Pfeffer, B Payer, G Reim, MP di Magliano, M … - Development, 2002 - dev.biologists.org
... The mouse Pax2b, Pax3, Pax5, Pax6, En1, Gbx2, Oct1, Otx2 and Xenopus HoxD1 cDNAs
were cloned into pKW2T, and proteins were synthesized by a coupled in vitro ...
Cited by 12 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Expression of Pax5 gene in human haematopoietic cells and tissues: comparison with immunodeficient … - Full text - MIT Libraries
H Kaneko, T Ariyasu, R Inoue, T Fukao, K Kasahara, … - Clin Exp Immunol, 1998 - ingentaconnect.com
... of B cell development at early proB cell stage, which showed that Pax5 cDNA was
normal [37]. It is known that lesions in human Pax3 and Pax6 genes cause ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov

Expression pattern of PAX3 and PAX6 genes during human embryogenesis
J Terzic, M Saraga-Babic - Int J Dev Biol, 1999 - ijdb.ehu.es
... rostral limit of expression of the late Pax genes –Pax2, Pax5, Pax8 (Nornes et al.,
1990; Asano and Gruss, 1992). Genetic lesions in Pax3and Pax6 genes lead ...
Cited by 7 - View as HTML - Web Search - ncbi.nlm.nih.gov - ijdb.ehu.es - Get it from MIT Libraries

Growth and specification: fly Pax6 homologs eyegone and eyeless have distinct functions - Full text - MIT Libraries
AB Rodrigues, K Moses - Bioessays, 2004 - doi.wiley.com
... of the PD, (34,38) so that like Pax6(5a) it binds DNA through the RED subdomain.
Furthermore, Eyg binds to the same ‘‘5aCON-like’’ site as does Pax5(5a ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate - Full text - MIT Libraries
A Liu, K Losos, AL Joyner - Development, 1999 - dev.biologists.org
... 1995), Fgf8 (Crossley and Martin, 1995), Gbx2 (Bouillet et al., 1995), Wnt1 (Parr
et al., 1993), Pax2, Pax5, Pax8 (Asano and Gruss, 1992), Pax6 (Grindley et al ...
Cited by 55 - Web Search - saturn.med.nyu.edu - homepage.mac.com - ncbi.nlm.nih.gov - all 6 versions »

Paired-Type Homeodomain Transcription Factors Are Imported into the Nucleus by Karyopherin 13 - Full text - MIT Libraries
JE Ploski, MK Shamsher, A Radu - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... A previous study reported that Kap α2 binds in vitro to Pax2, Pax3, Pax5,
Pax6, and Pax8 (51). The binding was tested by using ...
Cited by 2 - Web Search - dx.doi.org - mcb.asm.org - ncbi.nlm.nih.gov

Polyomaviruses and Cancer-Interplay between Viral Proteins and Signal Transduction Pathways
JY Wang, L Del Valle, F Peruzzi, J Trojanek, A … - J Exp Clin Cancer Res, 2004 - 193.109.105.24
... tion factors PAX5 and PAX6, detection of JCV T-anti- gen and Agnoprotein, TrkC elevated
expression, and the activation of IGF-IR signaling system (37). ...
View as HTML - Web Search - 193.109.105.24 - ncbi.nlm.nih.gov - Get it from MIT Libraries

Genetic analysis of genes found on the 4th chromosome of Drosophila-emphasizing the developmental …
J Kronhamn - publications.uu.se
... Miller also place the nine human Pax genes in four phylogenetic groups: (1) Pax1
and Pax9; (2) Pax3 and Pax7; (3) Pax4 and Pax6; (4) Pax2, Pax5 and Pax8. ...
Web Search

Mutational analysis of PAX 6: 16 novel mutations including 5 missense mutations with a mild aniridia …
K Groenskov, T Rosenberg, A Sand, K Broendum- … - European Journal of Human Genetics, 1999 - nature.com
... However, in a comparison of the paired domains from 14 representative Pax genes
(PAX1, PAX2, PAX3, Pax-4, PAX5, PAX6, PAX7, PAX8, PAX9, prd, Gsbn, Gsb, Poxmeso ...
Cited by 18 - Web Search - nature.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Search for genes involved in Joubert syndrome: evidence that one or more major loci are yet to be … - Full text - MIT Libraries
IP Blair, RR Gibson, CL Bennett, PF Chance - Am J Med Genet, 2002 - doi.wiley.com
... These other molecules include PAX2, PAX5, PAX6, PAX8, OTX1, OTX2, GBX2, WNT5a, and
NKX2.2, several of which encode proteins that either act up- stream or ...
Cited by 16 - Web Search - ncbi.nlm.nih.gov

Pax5-Deficient Mice Exhibit Early Onset Osteopenia with Increased Osteoclast Progenitors - Full text - MIT Libraries
MC Horowitz, Y Xi, DL Pflugh, DGT Hesslein, DG … - The Journal of Immunology, 2004 - jimmunol.org
... which results in skeletal changes in the vertebrae and Pax6 mutations result in
Small eye, which fail to develop eyes and nose (5, 6). The Pax5 gene codes for ...
Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Antagonizing Activity of Chick Grg 4 against Tectum-Organizing Activity - Full text - MIT Libraries
S Sugiyama, J Funahashi, H Nakamura - Developmental Biology, 2000 - ingentaconnect.com
... After Grg4 overexpression, expression of En-2, Pax5, Fgf8, and EphrinA2 was
repressed, and Pax6 was upregulated in the mesencephalic region. ...
Cited by 20 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: … - Full text - MIT Libraries
M Schwarz, G Alvarez-Bolado, P Urbanek, M … - Proc. Natl. Acad. Sci. USA, 1997 - dx.doi.org
... and M Busslinger Functional equivalence of the transcription factors Pax2 and Pax5
in mouse ... Home page E Matsunaga, I Araki, and H Nakamura Pax6 defines the di ...
Cited by 51 - Web Search - pnas.org - pubmedcentral.nih.gov - adsabs.harvard.edu - all 6 versions »

Optimizing the detection of nascent transcripts by RNA fluorescence in situ hybridization - Full text - MIT Libraries
CD van Raamsdonk, SM Tilghman - Nucleic Acids Research, 2001 - nar.oupjournals.org
... Based on these and other results they argued that the Pax5 gene was ... While examining
the expression of Pax6 in embryonic cells (11) we investigated the ...
Cited by 2 - Web Search - nar.oupjournals.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Bedeutung der Homoeodomaene des Transkriptionsfaktors Pax6 fuer die Aktivierung des Glukagon-Gens …
S TEICHLER - webdoc.sub.gwdg.de
... Transkriptionsfaktors Pax6 für die Aktivierung des Glukagon-Gens durch Pax6
DISSERTATION ... von Glukagon-Promotorfragmenten durch Pax6 im heterologen Zellsystem ...
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Insulin-like growth factor-I receptor- a potential therapeutic target in medulloblastomas
K Reiss - Expert Opinion on Therapeutic Targets, 2002 - dx.doi.org
... Elevated expression of neuronal transcription factors PAX5 and PAX6 70 and 78%,
respectively Detected mostly in undifferentiated medulloblastomas [47] ...
Cited by 4 - Web Search - ashley-pub.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

Testing for genetic associations with the PAX gene family in a spina bifida population - Full text - MIT Libraries
KA Volcik, SH Blanton, MC Kruzel, IT Townsend, GH … - Am J Med Genet, 2002 - doi.wiley.com
... ETDT Analysis of PAX2, PAX3, PAX5, and PAX6 Dinucleotide Marker Alleles A total
of eight dinucleotide markers located within and/or flanking the PAX2, PAX3 ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

Cloning and Characterization of the Human PAX7 Promoter
OV Murmann, F Niggli, BW Schaefer - Biological Chemistry, 2000 - degruyter.com
... Thus, the PAX7 promoter is very similar to the TATA-less PAX2 promoter (Stayner
et al., 1998), whereas other PAX-pro- moters, such as PAX3, PAX5, PAX6 and PAX8 ...
Cited by 2 - Web Search - extenza-eps.com - degruyter.de - ncbi.nlm.nih.gov - all 8 versions » - Get it from MIT Libraries

Deregulation of PAX-5 by translocation of the Eµ enhancer of the IgH locus adjacent to two … - Full text - MIT Libraries
M Busslinger, N Klix, P Pfeffer, PG Graninger, Z … - Cancer Res, 2003 - dx.doi.org
... 2) Cooperates with B Cell-specific Activating Protein (BSAP/PAX5) in Activation
of ... in the paired domain restrict the DNA sequence specificity of Pax6 and Pax8 ...
Cited by 46 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »