Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the … - Full text - MIT Libraries
PL Pfeffer, M Bouchard, M Busslinger - Development, 2000 - dev.biologists.org
... organizer critically depends on the mhb-specific expression of secreted proteins
(Wnt1, Fgf8) and transcription factors (Otx2, Gbx2, En1, En2, Pax2, Pax5). ...
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E2a/Pbx1 induces the rapid proliferation of stem cell factor-dependent murine pro-T cells that cause … - Full text - MIT Libraries
DB Sykes, MP Kamps - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... 2) nor the early B-cell differentiation genes Pax5, λ5, or VpreB (data not shown)
were expressed in E2a/Pbx1-induced pro-T-cell proliferations. ...
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The role of homeobox genes in hematopoiesis
MC Magli - Biotherapy, 1998 - ingentaconnect.com
... murine myeloid leukemias Pax1∗ Paired 20p11.2 early stages of thymus development;
cortical thymic stromal cells PAX5 Paired 9p13 Early B cells PBX1 PBC 1q23 ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Distinct regulators control the expression of the mid-hindbrain organizer signal FGF8 - Full text - MIT Libraries
W Ye, M Bouchard, D Stone, X Liu, F Vella, J Lee, … - Nat. Neurosci, 2001 - nature.com
... I., Meisler, MH & Busslinger, M. Cooperation of Pax2 and Pax5 in midbrain ... growth
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Molecular portraits of B cell lineage commitment - Full text - MIT Libraries
M Muschen, S Lee, G Zhou, N Feldhahn, VS Barath, J … - Proceedings of the National Academy of Sciences - uni-duesseldorf.de
... CGLB 0 31 p300 CBPAF 13 0 E2A 2 164 ICAPA1 13 0 PAX5 1 67 NAP1L4 13 0 EBF 2 131
AP3 24 1 ... E2F 2 39 CDC2L1 6 0 PBX1 4 68 DNM1L 6 0 C EBPB 4 66 ELAV1 6 0 ...
Cited by 11 - View as HTML - Web Search - pubmedcentral.gov - ncbi.nlm.nih.gov

Paediatrische Onkologie
P Onkologie - Monatsschrift Kinderheilkunde, 2002 - springerlink.com
... Bei Veränderungen des Transkriptionsfak- tors PAX5 bleibt hingegen die B-Zellent-
wicklung auf der etwas differenzierte ... t(1;19)(q23;p13) E2A-PBX1 Prä-B-ALL ...
Web Search

Table 3. Verification of SAGE tags matching to multiple UniGene clusters by GLGI
ID UniGene - pnas.org
... PAX5. 2. Hs. 22030. 0. 4. CATTTTGCTT. PAX5. 2. Hs. 22599. 1. 29. GCTCACCCTT. AIP1.
2. Hs. ... RAD30. 3. Hs. 155691. 0. 68. TTATCAGCCA. PBX1. 2. Hs. 156114. 1. 14. AGTCCTGGAG ...
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Transcription factor regulation of B lineage commitment - Full text - MIT Libraries
BL Kee, C Murre - Curr Opin Immunol, 2001 - www-biology.ucsd.edu
... Consistent with role of BSAP in B lineage commitment, the Pax5 gene is expressed
mono ... that Wnt16 was identified as a target of the E2A–Pbx1 oncoprotein which ...
Cited by 18 - View as HTML - Web Search - inv.his.se - ncbi.nlm.nih.gov

Molecular portraits of B cell lineage commitment
S Table - pnas.org
... factors such as OBF1 (174 tags), E2A (164 tags), EBF (131 tags), PAX5 (67 tags),
and ... 26; 39 tags), a target gene of the B lineage leukemia fusion E2A-PBX1. ...
Web Search

Comparative genomics provides evidence for an ancient genome duplication event in sh
JS Taylor, Y Van de Peer, I Braasch, A Meyer - Phil. Trans. R. Soc. Lond. B, 2001 - journals.royalsoc.ac.uk
Page 1. Comparative genomics provides evidence for an ancient genome duplication
event in sh John S. Taylor, Yves Van de Peer, Ingo Braasch and Axel Meyer * ...
Cited by 102 - Web Search - evolutionsbiologie.uni-konstanz.de - mit.edu - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

The incidence of clonal T-cell receptor rearrangements in B-cell precursor acute lymphoblastic … - Full text - MIT Libraries
C Brumpt, E Delabesse, K Beldjord, F Davi, JM … - Blood, 2000 - bloodjournal.org
... development under appropriate condition, 52 , 53 suggests that assessment of PAX5
status may ... use of TCRG will lead to underrepresentation of E2A-PBX1, MLL-AF4 ...
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Identification of a novel molecular partner of the E2A gene in childhood leukemia
F Brambillasca, G Mosna, M Colombo, A Rivolta, C … - Leukemia, 1999 - nature.com
... B cell differentiation: role of E2A and Pax5/BSAP transcription factors. ... Trans-
formation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is ...
Cited by 5 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Homeobox genes: a molecular link between development and cancer
I PhD, II Dentist, TIIID Student - scielo.br
... 26 ; PAX3 has a role in rhabdomyosarcomas 2 and melanomas 31 ; PAX5 determines the ...
Other fusions, as PBX1 to E2A and HRX to nuclear proteins, alter the sequence ...
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MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia - Full text - MIT Libraries
SA Armstrong, JE Staunton, LB Silverman, R Pieters … - Nature Genetics, 2002 - nature.com
... Jenkins, NA & Copeland, NG Cooperative activation of Hoxa and Pbx1-related genes ...
Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. ...
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Research Paper Prospective gene expression analysis accurately subtypes acute leukaemia in children …
FW van Delft, T Bellotti, Z Luo, LK Jones, N Patel … - blackwell-synergy.com
... ETV6 RUNX1 and hyperdiploidy was greater than in patients with E2A PBX1, MLL
rearrangements ... The expression levels for TCL1, PAX5, EPOR and APLP2 by RQ-PCR were ...
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Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies.
H Nagai, Y Li, S Hatano, O Toshihito, M Yuge, E … - Genes Chromosomes Cancer, 2003 - doi.wiley.com
... Homeobox genes such as PAX5 (Ohno et al., 1990), MLL/ALL1 (Gu et al., 1992; Tkachuk
et al., 1992), and PBX1 (Kamps et al., 1990) are the targets of chromosomal ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Gene Expression Profiling and Microarrays Gene expression profiling of leukemic cell lines reveals …
A Andersson, P Eden, D Lindgren, J Nilsson, C … - Leukemia, 2005 - nature.com
... The B-cell regulator PAX5 was upregulated in B-lineage ALL. ... genetic aberrations
(P 0.002): RUNX1/CBFA2T1, 35 genes; CBF-leukemias, 62; TCF3/PBX1, 10; and IGH ...
Web Search - nature.com

Lymphoid precursors - Full text - MIT Libraries
K Akashi, T Reya, D Dalma-Weiszhausz, IL Weissman - Curr Opin Immunol, 2000 - unb.br
... because IL-7R-mediated signals are necessary for the rearrangement of immunoglobulin
heavy chain V segments through the activation of the Pax5 gene [17 ...
Cited by 36 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Ho me o box genes: a mole cu lar link betwe en deve lop ment and cancer Ge nes home o box: uma rela …
IDUCTI ON - Pesqui Odontol Bras, 2003 - scielo.br
... I Hox prote ins – eviden ce for se - lec ti ve target ting of E2a-Pbx1 to a ... Nutt
SL, Eberhard D, Horcher M. Pax5 deter mi nes the iden tity of B cells from ...
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Control of Self-Renewal and Differentiation of Hematopoietic Stem Cells: HOXB4 on the Threshold - Full text - MIT Libraries
H KLUMP, B SCHIEDLMEIER, C BAUM - Ann. NY Acad. Sci, 2005 - annalsnyas.org
... hematopoiesis, for example AML1 (CBFA2), 14 PU.1, 15,16 Pax5, c-Myc 17 ... By altering
the dosage of its interaction partner Pbx1, the repopulation efficiency of ...
Web Search - annalsnyas.org - ncbi.nlm.nih.gov

Notch regulation of lymphocyte development and function - Full text - MIT Libraries
F Radtke, A Wilson, SJC Mancini, HR MacDonald - Nature Immunology, 2004 - nature.com
... 34. Feldman, BJ, Hampton, T. & Cleary, ML A carboxy-terminal deletion mutant of
Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice. ...
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Role for Homodimerization in Growth Deregulation by E2a Fusion Proteins - Full text - MIT Libraries
R Bayly, DP LeBrun - Mol Cell Biol, 2000 - mcb.asm.org
... B cell differentiation: role of E2A and Pax5/BSAP transcription factors. ... derepressed
by pbx, hox, and Meis/Prep1 partners regulates DNA-binding by pbx1 and E2a ...
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Restricted expression of E2A protein in primary human tissues correlates with proliferation and … - Full text - MIT Libraries
MN Rutherford, DP LeBrun - Am. J. Pathol, 1998 - ajp.amjpathol.org
... differentiation and altered patterning of the posterior midbrain in mice lacking
Pax5/BSAP. ... 1994, 179:1099-1108[Abstract]; Kamps MP, Baltimore D: E2A-Pbx1, the t ...
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E PROTEIN FUNCTION IN LYMPHOCYTE DEVELOPMENT - Full text - MIT Libraries
MW Quong, WJ Romanow, C Murre - Annual Review of Immunology, 2002 - immunol.annualreviews.org
... Consistent with these observations is the recent finding that the Pax5 promoter
contains ... is fused to the homeodomain-containing region of the pbx1 gene (112). ...
Cited by 25 - Web Search - phyto.annualreviews.org - phyto.annualreviews.org - ncbi.nlm.nih.gov

Examination of POU homeobox gene expression in human breast cancer cells - Full text - MIT Libraries
T Jin, DR Branch, X Zhang, S Qi, B Youngson, PE … - Int. J. Cancer, 1999 - doi.wiley.com
... in an altered form, such as the expression of E2A-PBX1 fusion protein ... In primary
human diffuse astrocyto- mas, the expression of PAX5 correlates inversely with ...
Cited by 16 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

High incidence of proviral integrations in the Hoxa locus in a new model of E 2 a-PBX 1-induced B- … - Full text - MIT Libraries
J Bijl, M Sauvageau, A Thompson, G Sauvageau - Genes & Development, 2005 - genesdev.org
... was more accelerated than that seen in our single E2a–PBX1.23 transgenics ... 3A, right
panels) and they expressed Pax5 (Supplementary Tables S2, S3), indicating ...
Cited by 1 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of … - Full text - MIT Libraries
J Xu, Z Liu, DM Ornitz - Development, 2000 - dev.biologists.org
... Wnt1, Engrailed2 (En2) and Pax5 are essential for specifying midbrain and hindbrain
fate before embryonic day 9.5 (E9.5). Wnt1 null mice, Pax2/5 double ...
Cited by 69 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

[PS] CITATIONS FOR PROTEIN/DNA (REGULATORY) - Full text - MIT Libraries
PDA White, X Ding, JC Vanderspek, JR Murphy, D … - J. Biol. Chem, 2004 - aist.go.jp
... PD0075 DE.Piper, AH.Batchelor, C.-P.Chang, ML.Cleary, C.Wolberger Structure of a
Hoxb1-Pbx1 Heterodimer Bound to DNA: Role of the Hexapeptide and a Fourth ...
Cited by 10 - View as HTML - Web Search - ndbserver.rutgers.edu - ndbserver.rutgers.edu

Cytogenetics and molecular genetics of acute lymphoblastic leukemia - Full text - MIT Libraries
CJ Harrison, L Foroni - Reviews in Clinical and Experimental Hematology, 2002 - blackwell-synergy.com
... In the PAX5/ETV6 fusion gene, the paired-box domain of PAX5 and both the ... the E2A
gene on chromosome 19 with the homeobox-containing gene, PBX1, on chromosome 1 ...
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The roles of transcription factors in B lymphocyte commitment, development, and transformation
E Smith, M Sigvardsson - Journal of Leukocyte Biology, 2004 - jleukbio.org
... EF, Busslinger, M. (1994) Complete block of early B cell differentiation and altered
patterning of the posterior midbrain in mice lacking Pax5/BSAP Cell 79,901 ...
Cited by 1 - Web Search - dx.doi.org - ncbi.nlm.nih.gov - lu-research.lub.lu.se - all 9 versions » - Get it from MIT Libraries

Transcriptional control of kidney development - Full text - MIT Libraries
M Bouchard - Differentiation, 2004 - blackwell-synergy.com
... modulation of this pathway by BF-2, Pod1, and Pbx1, preliminary evidence ... M. (2000)
Functional equivalence of the transcription factors Pax2 and Pax5 in mouse ...
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Expression of B-Lymphocyte-Associated Transcription Factors in Human T-Cell Neoplasms - Full text - MIT Libraries
T Marafioti, S Ascani, K Pulford, E Sabattini, M … - American Journal of Pathology, 2003 - ajp.amjpathol.org
... to B-cell neoplasms (eg, the Reed-Sternberg cells express PAX5/BSAP 15 ... a fusion protein
gene that encodes an oncogenic hybrid E2A-PBX1 transcription factor]. ...
Cited by 6 - Web Search - ajp.amjpathol.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Fates of human B-cell precursors - Full text - MIT Libraries
TW LeBien - Blood, 2000 - bloodjournal.org
Institution: Google Indexer Sign In as Individual. Abstract of this Article ( ).
PDF Version of this Article. Citation Map. Email this article to a friend. ...
Cited by 60 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Deregulated homeobox gene expression in cancer: cause or consequence? - Full text - MIT Libraries
C Abate-Shen - Nature Reviews Cancer, 2002 - nature.com
... | Article | PubMed | ISI | ChemPort |. 30. Kozmik, Z., Sure, U., Ruedi, D., Busslinger,
M. & Aguzzi, A. Deregulated expression of PAX5 in medulloblastoma. Proc. ...
Cited by 38 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Phylogenetic analyses alone are insufficient to determine whether genome duplication (s) occurred … - Full text - MIT Libraries
AC Horton, NR Mahadevan, I Ruvinsky, JJ Gibson- … - Journal of Experimental Zoology (Molecular and Developmental …, 2003 - doi.wiley.com
... PAX9 NP___006185 Pax2 AAC12734 PAX2 NP___003981 3 PAX5 NP___057953 PAX8 Q06710 ... Otx
2 Williams and Holland, 1998 PBX1/2/3/4 (AAM18882) 4 Abi-Rached et al., 2002 ...
Cited by 7 - Web Search - zoo.ufl.edu - ncbi.nlm.nih.gov

The World Health Organization Classification of Lymphomas
J Jakiae-Razumoviae, I Aurer - cmj.hr
... Lymphoplasmacytic lymphoma (t9;14)(p13;q32) PAX5 ... precursor B lymphoblastic neoplasms
t(9;22), q(34;q11), BCR/ ABL, 11q23, MLL, t(1;19)(q23;p13), E2A/PBX1, t(12 ...
View as HTML - Web Search - cmj.hr

A statistical analysis of the TRANSFAC database.
GB Fogel, DG Weekes, G Varga, ER Dow, AM Craven, … - Biosystems, 2005 - natural-selection.com
... SF1 B SF1 steroidogenic factor 1 Core should be CAAGG not AAGG PBX1 02 Homeo
domain factor Pbx-1 Core should be CAATC not CAAT MAX ...
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Expression of B-Lymphocyte-Associated Transcription Factors in Human T-Cell Neoplasms
T Samples - American Journal of Pathology, 2003 - ajp.amjpathol.org
... to B-cell neoplasms (eg, the Reed-Sternberg cells ex- press PAX5/BSAP 15 but ... a fusion
protein gene that encodes an oncogenic hybrid E2A-PBX1 tran- scription ...
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A novel positive transcriptional feedback loop in midbrain-hindbrain boundary development is … - Full text - MIT Libraries
A Picker, S Scholpp, H Bohli, H Takeda, M Brand - Development, 2002 - dev.biologists.org
... can however act as activators, for instance as heterodimers with Pbx1 in regulating ...
1999 ; Kuschert et al., 2001 ; Pfeffer et al., 2002 ) and Pax5 (Pfeffer et ...
Cited by 11 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Expression profiling of lineage differentiation in pluripotential human embryonal carcinoma cells - Full text - MIT Libraries
J Houldsworth, SC Heath, GJ Bosl, L Studer, RS … - Cell Growth Differ, 2002 - cgd.aacrjournals.org
... were identified [MEIS1, MRG1, and ATBF1 (cluster E); DLX5 and PBX1 (cluster C ... identity
such as GBX2 and PAX8 (transcripts present); or PAX2, PAX5, EN2, DLX2 ...
Cited by 6 - Web Search - cgd.aacrjournals.org - ncbi.nlm.nih.gov

Homeobox genes in normal and malignant cells - Full text - MIT Libraries
C Cillo, M Cantile, A Faiella, E Boncinelli - Journal of Cellular Physiology, 2001 - doi.wiley.com
... Homeoproteins of paralogy groups 1 to 10 are stabilised in their binding by the
PBX1 protein (Knoep¯er and Kamps, 1997), whereas AbdB-like Hox proteins ...
Cited by 30 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets - Full text - MIT Libraries
D Traver, T Miyamoto, J Christensen, J Iwasaki- … - Blood, 2001 - bloodjournal.org
... 55 Supporting a critical role of FL CMPs in the generation of erythroid progeny
are our recent findings in Pbx1-deficient mice (see accompanying article by ...
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p 53 regulates thymic Notch 1 activation - Full text - MIT Libraries
AM Laws, BA Osborne - European Journal of Immunology, 2004 - doi.wiley.com
... mice exhibit low levels of thymoma for- mation or leukemia [10, 20], N IC accelerates
the develop- ment of T cell tumors in E2A-PBX1 transgenic mice [31]. ...
Web Search - ncbi.nlm.nih.gov

Clinical and biological importance of cytogenetic abnormalities in childhood and adult acute …
B Johansson, F Mertens, F Mitelman - Annals of Medicine, 2004 - dx.doi.org
Page 1. Clinical and biological importance of cytogenetic abnormalities
in childhood and adult acute lymphoblastic leukemia Bertil ...
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Hematopoietic stem cells
D Bonnet - Birth Defects Research Part C Embryo Today Reviews, 2003 - doi.wiley.com
... More recently, Sau- vageau’s group showed that further increase in HSC expansion
could be achieved by knocking down the ex- pression of PBX1 in HOX-B4 over ...
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The use of genetic microarray analysis to classify and predict prognosis in haematological … - Full text - MIT Libraries
AP Levene, GJ Morgan, FE Davies - Clinical and Laboratory Haematology, 2003 - blackwell-synergy.com
... the known prognostically important leukaemic cell types (T-ALL, E2A-PBX1, BCR-ABL ...
essential B cell transcription factors including c-MYC, CIITA, Id3 PAX5 and Spi ...
Cited by 2 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Production of high-titer helper-free retroviruses by transient transfection - Full text - MIT Libraries
WS PEAR, GP NOLAN, ML SCOTT, D BALTIMORE - Proc. Nat. Acad. Sci, 1993 - pnas.org
PDF Version of this Article. Similar articles found in: PNAS Online PubMed. PubMed
Citation. This Article has been cited by: other online articles. ...
Cited by 1223 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - adsabs.harvard.edu - all 5 versions »

Functional equivalence of Hox gene products in the specification of the tritocerebrum during … - Full text - MIT Libraries
F Hirth, T Loop, B Egger, DFB Miller, TC Kaufman, … - Development, 2001 - dev.biologists.org
... Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development. ...
Structure of a HoxB1-Pbx1 heterodimer bound to DNA: Role of the ...
Cited by 8 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Cytogenetic and FISH Studies in Myelodysplasia, Acute Myeloid Leukemia, Chronic Lymphocytic Leukemia …
II Supplement - Genetic Testing - ishapd.org
... TAL1, MLL AF1r, MLL TAL1, TCRad ?, RARa PBX1, E2A Igk, BCL6 ALK, NPM Igk, c-MYC ... ZNF198
c-MYC, IgH c-MYC, TCRad ETO, AML1 c-MYC, Ig1 AF9, MLL PAX5, IgH ABL, BCR ...
View as HTML - Web Search - haem.nus.edu.sg

Cytogenetic and molecular delineation of a region of chromosome 3q commonly gained in marginal zone … - Full text - MIT Libraries
S Gazzo, L Baseggio, L Coignet, C Poncet, D Morel, … - Haematologica, 2003 - haematologica.org
... 88(01):January 2003 t(14;19) (q32;q13.1) aberration (case #10). In those two later
cases, PAX5/IgH and BCL3 rearrange- ments were not studied. ...
Cited by 4 - View as HTML - Web Search - haematologica.it - ncbi.nlm.nih.gov - haematologica.org - all 8 versions »