Mammalian Groucho homologs: Redundancy or specificity? - Full text - MIT Libraries
M Gasperowicz, F Otto - Journal of Cellular Biochemistry, 2005 - doi.wiley.com
... The other transcription factors, such as RUNX1, Pax5, and BF-1 were also shown to
induce Grg/TLE hyperphosphorylation [Eberhard et al., 2000; Nuthall et al ...
Web Search - ncbi.nlm.nih.gov

Oligo GEArray® Human Hematopoietic Stem Cells and Hematopoiesis Microarray
S Conditions - search.cosmobio.co.jp
... HDAC5, HDAC7A, HDAC9, HOXB4, IFI16, IL31RA, IRF4, IRF8, KLF6, LEF1, MAFB, MYC, NCOA6,
NFYA, NOTCH1, NOTCH2, NOTCH4, PAX5, RBPSUH, RHOH, RUNX1, SCAND1, STAT1 ...
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Eukaryotic transcriptional regulatory complexes: cooperativity from near and afar - Full text - MIT Libraries
K Ogata, K Sato, T Tahirov, T Tahirov - Curr Opin Struct Biol, 2003 - cm.utexas.edu
... F, Levanon D, Groner Y, Shakked Z: DNA recognition by the RUNX1 transcription factor ...
Hagman J, Wolberger C: Structural studies of Ets-1/ Pax5 complex formation ...
Cited by 17 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Role for Hes1-induced phosphorylation in Groucho-mediated transcriptional repression - Full text - MIT Libraries
HN Nuthall, J Husain, KW McLarren, S Stifani - Mol. Cell. Biol, 2002 - mcb.asm.org
... Taken together with the demonstration that other Gro/TLE-binding factors, such as
RUNX1 (this study), Pax5 (14), and BF-1 (H. Nuthall and S. Stifani ...
Cited by 16 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Upstream and downstream targets of RUNX proteins - Full text - MIT Libraries
F Otto, M Luebbert, M Stock - Journal of Cellular Biochemistry, 2003 - doi.wiley.com
... D nuclear receptors, albeit with the regulatory effect being positive for RUNX1
and RUNX3 ... fac- tors c/EBPalpha, c/EBPbeta, c/EBPdelta, ets-1, MEF, PAX5 and Mi ...
Cited by 16 - Web Search - ncbi.nlm.nih.gov

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila … - Full text - MIT Libraries
E Ogawa, M Maruyama, H Kagoshima, M Inuzuka, J Lu, … - Proceedings of the National Academy of Sciences - pnas.org
... Nakase, Y. Fujita, M. Nakao, S. Toda, N. Kitamura, T. Abe, and T. Okuda VWRPY
motif-dependent and -independent roles of AML1/Runx1 transcription factor in ...
Cited by 272 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

t (8; 21) Breakpoints on Chromosome 21 in Acute Myeloid Leukemia are Clustered within a Limited … - Full text - MIT Libraries
H Miyoshi, K Shimizu, T Kozu, N Maseki, Y Kaneko, … - Proceedings of the National Academy of Sciences - pnas.org
... Nakase, Y. Fujita, M. Nakao, S. Toda, N. Kitamura, T. Abe, and T. Okuda VWRPY
motif-dependent and -independent roles of AML1/Runx1 transcription factor in ...
Cited by 241 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and … - Full text - MIT Libraries
Q Wang, T Stacy, M Binder, M Marin-Padilla, AH … - Developmental Biology, 1996 - dx.doi.org
... Sci. USA Home page FM Theriault, P. Roy, and S. Stifani AML1/Runx1 is important
for the development of hindbrain cholinergic branchiovisceral motor neurons and ...
Cited by 368 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 7 versions »

Research Paper Prospective gene expression analysis accurately subtypes acute leukaemia in children …
FW van Delft, T Bellotti, Z Luo, LK Jones, N Patel … - blackwell-synergy.com
... a box plot (Fig 5). The mean expression of TERF2 in ETV6 RUNX1 and hyperdiploidy ...
The expression levels for TCL1, PAX5, EPOR and APLP2 by RQ-PCR were correlated ...
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Gene Expression Profiling and Microarrays Gene expression profiling of leukemic cell lines reveals …
A Andersson, P Eden, D Lindgren, J Nilsson, C … - Leukemia, 2005 - nature.com
... The B-cell regulator PAX5 was upregulated in B-lineage ALL. ... genes discriminating
cell lines with identical genetic aberrations (P 0.002): RUNX1/CBFA2T1, 35 ...
Web Search - nature.com

Loss of Runx 3 function in leukocytes is associated with spontaneously developed colitis and gastric … - Full text - MIT Libraries
O Brenner, D Levanon, V Negreanu, O Golubkov, O … - Proceedings of the National Academy of Sciences - pnas.org
... was performed as described (24) by using the murine Runx1 region spanning ... intestine
was characterized by immunostaining with anti-CD45R and Pax5 (B lymphocytes ...
Cited by 4 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

ORIGINAL PAPER ES02. 01 Transcriptional regulation of haematopoiesis - Full text - MIT Libraries
B Goettgens - Vox Sanguinis, 2004 - blackwell-synergy.com
... The knock-out phenotypes for runx1 and cbf are very similar, consistent with the
fact that their protein ... v Ets-1, C/EBP v FOG-1, C/EBP v PU.1 and Pax5 v Notch1 ...
Web Search - ncbi.nlm.nih.gov

Core-binding factors in haematopoiesis and leukaemia - Full text - MIT Libraries
NA Speck, DG Gilliland - Nature Reviews Cancer, 2002 - nature.com
... 12. Huang, G. et al. Dimerization with PEBP2 protects RUNX1/AML1 from
ubiquitin-proteosome-mediated degradation. EMBO J. 20, 723-733 (2001). ...
Cited by 60 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Loss of C/EBP {alpha} cell cycle control increases myeloid progenitor proliferation and transforms … - Full text - MIT Libraries
BT Porse, D Bryder, K Theilgaard-Moench, MS … - J Exp Med, 2005 - jem.org
... two categories: factors generally required for definitive hematopoiesis, including
AML1/Runx1 and GATA-2 ... C/EBP) , GATA-1, GATA-3, friend of GATA, Pax5, and E2A ...
Cited by 1 - Web Search - jem.org

Transcription Factors: Normal and Malignant Development of Blood Cells
IJ Hematol - Int J Hematol, 2001 - cardenjennings.metapress.com
... which focuses on myeloid differentiation,consists of the topics RUNX1(AML1)/CBFB ...
eight chapters, and includes information about Ikaros, PU.1, Pax5(BSAP), Janus ...
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Transcriptional regulation of haematopoiesis - Full text - MIT Libraries
B Goettgens - Vox Sanguinis, 2004 - ingentaconnect.com
... The knock-out phenotypes for runx1 and cbfβ are very similar, consistent with the
fact that their ... v Ets-1, C/EBPβ v FOG-1, C/EBPα v PU.1 and Pax5 v Notch1). ...
Web Search

Analysis of the interaction of TIP60β and PIN1 with the ets family transcription factor ETV6
CD Zhang - edoc.ub.uni-muenchen.de
... SYK, and FGFR3, to transcription factors, such as AML1/RUNX1, EVI1, HLXB9, MN1
or PAX5, to genes of various or unknown functions, such as ...
View as HTML - Web Search

Hematopoietic stem cells and their precursors: developmental diversity and lineage relationships - Full text - MIT Libraries
E Dzierzak - Immunological Reviews, 2002 - blackwell-synergy.com
... Thus, Runx1 is thought to be important in the generation of adult HSCs and ... Pax5 is
a transcription factor important in the differentiation of the B-cell lineage ...
Cited by 8 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

The bloody fate of endothelial stem cells - Full text - MIT Libraries
H Kubo, K Alitalo - Development, 2003 - dx.doi.org
... Runx1 is essential for hematopoietic commitment at the hemangioblast stage of
development in vitro. ... Reversion of B cell commitment upon loss of Pax5 expression ...
Cited by 10 - Web Search - genesdev.org - genesdev.org - ncbi.nlm.nih.gov - all 5 versions »

The‘definitive’(and‘primitive’) guide to zebrafish hematopoiesis - Full text - MIT Libraries
AJ Davidson, LI Zon - Oncogene, 2004 - nature.com
... (2000) runx1 Core binding factor Morphant Kalev-Zylinska et al. (2002) ...
(1998) pax5 Paired domain, homeobox — Pfeffer et al. (1998) ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

[PS] CITATIONS FOR PROTEIN/DNA (REGULATORY) - Full text - MIT Libraries
PDA White, X Ding, JC Vanderspek, JR Murphy, D … - J. Biol. Chem, 2004 - aist.go.jp
... PD0210 J.Bravo, Z.Li, NA.Speck, AJ.Warren The Leukemia-Associated Aml1 (Runx1)-Cbfbeta
Complex Functions as a DNA-Induced Molecular Clamp Nat.Struct.Biol., 8 ...
Cited by 10 - View as HTML - Web Search - ndbserver.rutgers.edu - ndbserver.rutgers.edu

Fusion of the TEL Gene on 12p13 to the AML1 Gene on 21q22 in Acute Lymphoblastic Leukemia - Full text - MIT Libraries
TR Golub, GF Barker, SK Bohlander, SW Hiebert, DC … - Proceedings of the National Academy of Sciences, 1995 - pnas.org
... Home page Z. Li, J. Yan, CJ Matheny, T. Corpora, J. Bravo, AJ Warren, JH Bushweller,
and NA Speck Energetic Contribution of Residues in the Runx1 Runt Domain ...
Cited by 349 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

A Role for Cell Cycle-regulated Phosphorylation in Groucho-mediated Transcriptional Repression - Full text - MIT Libraries
HN Nuthall, K Joachim, A Palaparti, S Stifani - J Biol Chem, 2002 - jbc.org
... 39). Third, they become phosphorylated in response to interaction with
DNA-binding partners like Hes1 and RUNX1 (17) or Pax5 (22). ...
Cited by 6 - Web Search - dx.doi.org - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

Cellular Immune Response to Parasitization in Drosophila Requires the EBF Orthologue Collier - Full text - MIT Libraries
M Crozatier, JM Ubeda, A Vincent, M Meister - PLoS Biol, 2004 - dx.doi.org
... GATA factor, and Lozenge (Lz), a transcription factor related to Runx1/AML1, are ...
basic helix-loop-helix protein E2A), commitment depends on another gene, Pax5. ...
Cited by 5 - Web Search - medicine.plosjournals.org - plbi.allenpress.com - plosbiology.org - all 9 versions »

Comprehensive genotypic analysis of leukemia: clinical and therapeutic implications
L Kelly, J Clark, DG Gilliland - Curr. Opin. Oncol, 2002 - co-oncology.com
... In addition, the PAX5-paired box domain is retained in the fusion. ... AML1 (also known
as RUNX1, CBFA2) is a frequent target of translocations in human leukemias. ...
Cited by 11 - Web Search - siteman.wustl.edu - co-oncology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

TRANSCRIPTION FACTORS
OFB CELLS - doi.wiley.com
... 85 6 RUNX1(AML1) and CBFB: Genes Required for the Development of All Definitive
Hematopoietic ... 14 The Role of Pax5 (BSAP) in Early and Late B-Cell Development ...
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Chromosome Rearrangement Breakpoint Clustering: The Role of Clonal Selection
ON Umanskaya, AA Bystritskiy, SV Razin - MOLECULAR BIOLOGY, 2005 - springerlink.com
... MTGR1 ETO EAP BCR JAK2 ABL BTL FGFR3 ETV6 PAX5 NTRK3 ... 13. Okuda T., Nishimura M.,
Nakao M., Fujita Y. 2001. RUNX1/AML1: A central player in hematopoiesis. Int. ...
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Genetic networks that regulate B lymphopoiesis.
KL Medina, H Singh - Current Opinion in Hematology, 2005 - co-hematology.com
... Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated
with mb-1 ... M. Reversion of B cell commitment upon loss of Pax5 expression. ...
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AML1 interconnected pathways of leukemogenesis
J Michaud, HS Scott, R Escher - Cancer Invest, 2003 - taylorandfrancis.metapress.com
... The official designation for AML1 is RUNX1 (the Human Gene Nomenclature Committee;
http ... lymphocyte specific tyro- sine kinase B cells Experimental [44] Pax5 [44 ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Evolutionary Origins of Lymphocytes: Ensembles of T Cell and B Cell Transcriptional Regulators in a … - Full text - MIT Libraries
MK Anderson, R Pant, AL Miracle, X Sun, CA Luer, … - The Journal of Immunology, 2004 - jimmunol.org
... EV Rothenberg, unpublished data); however, the possibility that a skate Runx1 also
exists ... cells in the adult epigonal and Leydig organs do not express Pax5. ...
Cited by 3 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Clinical and biological importance of cytogenetic abnormalities in childhood and adult acute …
B Johansson, F Mertens, F Mitelman - Annals of Medicine, 2004 - dx.doi.org
Page 1. Clinical and biological importance of cytogenetic abnormalities
in childhood and adult acute lymphoblastic leukemia Bertil ...
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Issues in Development
MAS MOORE - dx.doi.org
... The Runx1/AML1 gene plays a critical role in estab- lishment of definitive
hematopoiesis in the AGM. Runx1 expression is initiated ...
Web Search - liebertonline.com - liebertonline.com

MOLECULAR GENETICS OF T CELL DEVELOPMENT - Full text - MIT Libraries
EV Rothenberg, T Taghon - Annual Review of Immunology, 2005 - arjournals.annualreviews.org
... transcriptional effector RBPSuh (CSL);GATA-3;thebHLHfactorsE2AandHEBandtheiranta
gonistsId2andId3; Runx1 and Runx3 ... to the B cell factors EBF and Pax5 (7), which ...
Cited by 2 - Web Search - arjournals.annualreviews.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice - Full text - MIT Libraries
C Schessl, VPS Rawat, M Cusan, A Deshpande, TM … - J. Clin. Invest, 2005 - jci.org
... The translocation targets AML1 (RUNX1), a member of the RUNX family ... or surface antigens
but extends to the transcriptional apparatus, since PAX5 is selectively ...
Web Search - pubmedcentral.nih.gov - jci.org

Production of high-titer helper-free retroviruses by transient transfection - Full text - MIT Libraries
WS PEAR, GP NOLAN, ML SCOTT, D BALTIMORE - Proc. Nat. Acad. Sci, 1993 - pnas.org
... Home page BA Hug, N. Ahmed, JA Robbins, and MA Lazar A Chromatin Immunoprecipitation
Screen Reveals Protein Kinase C{beta} as a Direct RUNX1 Target Gene J. Biol ...
Cited by 1223 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - adsabs.harvard.edu - all 5 versions »

Dynamic repositioning of CD4 and CD8 genes during T cell development - Full text - MIT Libraries
S Delaire, YH Huang, SW Chan, EA Robey - J. Exp. Med, 2004 - jem.org
... 2003. Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis.
Proc. ... 2002. Reversion of B cell commitment upon loss of Pax5 expression. ...
Cited by 3 - Web Search - dx.doi.org - jcb.org - ncbi.nlm.nih.gov - all 5 versions »

Autoinhibitory Domains: Modular Effectors - Full text - MIT Libraries
MA Pufall, BJ Graves - Annu. Rev. Cell Dev. Biol, 2002 - cellbio.annualreviews.org
Page 1. Annu. Rev. Cell Dev. Biol. 2002. 18:421–62 doi: 10.1146/annurev.cellbio.
18.031502.133614 Copyright c 2002 by Annual Reviews. ...
Cited by 18 - Web Search - astro.annualreviews.org - ncbi.nlm.nih.gov

Annual Review of Cell and Developmental Biology - Full text - MIT Libraries
MA Pufall, BJ Graves - Annual Review of Cell and Developmental Biology, 2002 - cellbio.annualreviews.org
... A protein partnership with RUNX1 counteracts the inhibitory mechanism by interacting
with the autoinhibitory module (Goetz et al. 2000) (lower right). ...
Web Search - astro.annualreviews.org - nutr.annualreviews.org

A developing picture of lymphopoiesis in bone marrow - Full text - MIT Libraries
J Hirose, T Kouro, H Igarashi, T Yokota, N … - Immunological Reviews, 2002 - blackwell-synergy.com
... Their first appearance in intraembryonic sites is marked by dependence on the
Runx1(AML1) transcription factor as well as by expression of endothelial cell ...
Cited by 13 - Web Search - ncbi.nlm.nih.gov

Characterization of a Novel Mammalian Groucho Isoform and Its Role in Transcriptional Regulation - Full text - MIT Libraries
M Lepourcelet, RA Shivdasani - J Biol Chem, 2002 - jbc.org
... 13); (ii) interaction of Grg4 with Pax5 is associated with altered Grg4 phosphorylation
states (53); and (iii) interaction between Hes1 and RUNX1 leads to ...
Cited by 2 - Web Search - research.dfci.harvard.edu - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

PEBP2 and c-myb sites crucial for oe 5 core enhancer activity in pre-B cells
A Maartensson, XQ Xie, C Persson, M Holm, T … - doi.wiley.com
Page 1. 0014-2980/01/1111-3165$17.50+.50/0 © WILEY-VCH Verlag GmbH, D-69451
Weinheim, 2001 PEBP2 and c-myb sites crucial for ø 5 core ...
Web Search - doi.wiley.com

Growth defect in Grg5 null mice is associated with reduced Ihh signaling in growth plates - Full text - MIT Libraries
WF Wang, YG Wang, AM Reginato, S Plotkina, T … - DEVELOPMENTAL DYNAMICS, 2002 - doi.wiley.com
... Grg5 is also reported to interact with Aml1/Cbfa2/Runx1 and mod- ulate its
transcriptional activity in vitro (Imai et al., 1998; Levanon et al., 1998 ...
Cited by 4 - Web Search - stat.nus.edu.sg - stat.nus.edu.sg - ncbi.nlm.nih.gov

Gene Targeting and Transgenic Strategies for the Analysis of Hematopoietic Development in the Mouse
HKA Mikkola, SH Orkin - Methods Mol Med, 2005 - neurosci.humanapress.com
... (2002) Runx1 expression marks long-term repopulating hematopoietic stem cells
in the midgestation mouse embryo. Immunity 16, 661–672. 30. ...
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Progress in Hematology
S Koschmieder, F Rosenbauer, U Steidl, BM Owens, … - Int J Hematol, 2005 - cardenjennings.metapress.com
... Heavey B, Charalambous C, Cobaleda C, Busslinger M. Myeloid lineage switch of Pax5
mutant but not wild-type B cell progenitors by C/EBPalpha and GATA factors. ...
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Hematopoietic stem cells
D Bonnet - Birth Defects Research Part C Embryo Today Reviews, 2003 - doi.wiley.com
... Using Runx1 LacZ knock-in embryos, HSC activity could be found in AGM cells express-
ing hematopoietic (CD45 CD31 , CD45 VE-Cadherin ) markers or endothelial ...
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Phosphorylation of Serine 239 of Groucho/TLE1 by Protein Kinase CK2 Is Important for Inhibition of … - Full text - MIT Libraries
HN Nuthall, K Joachim, S Stifani - Mol Cell Biol, 2004 - mcb.asm.org
... 2000. Transcriptional repression by Pax5 (BSAP) through interaction with
corepressors of the Groucho family. EMBO J. 19:2292-2303. ...
Cited by 2 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov

Jun Hirose A developing picture of Taku Kouro lymphopoiesis in bone marrow - Full text - MIT Libraries
H Igarashi, T Yokota, N Sakaguchi, PW Kincade - Immunological Reviews, 2002 - ingentaconnect.com
Page 1. Jun Hirose A developing picture of Taku Kouro lymphopoiesis in bone marrow
Hideya Igarashi Takafumi Yokota Nobuo Sakaguchi Paul W. Kincade ...
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Bibliography Current World Literature
LE Abrey, CH Moskowitz, WP Mason… - Current Opinion in Hematology, 2005 - co-hematology.com
July 2005, 12:4 > Bibliography Current World Literature. ...
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