Pax6 defines the di-mesencephalic boundary by repressing En1 and Pax2 - Full text - MIT Libraries
E Matsunaga, I Araki, H Nakamura - Development, 2000 - dev.biologists.org
... Pax6 repressed En1, Pax2 and other tectum (mesencephalon)-related genes such as
En2, Pax5, Pax7, but induced Tcf4, a diencephalon marker gene. ...
Cited by 47 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1 interneurons … - Full text - MIT Libraries
JD Burrill, L Moran, MD Goulding, H Saueressig - Development, 1997 - dev.biologists.org
... Key words: PAX2, PAX6, EN1, spinal cord, interneuron, cell fate, chick SUMMARY ...
population of EN1 + interneurons that require PAX6 for their development ...
Cited by 72 - Web Search - dev.biologists.org - wwwlib.bionet.nsc.ru - ncbi.nlm.nih.gov

Pax6 and engrailed 1 regulate two distinct aspects of renshaw cell development - Full text - MIT Libraries
T Sapir, EJ Geiman, Z Wang, T Velasquez, S Mitsui, … - J Neurosci, 2004 - jneurosci.org
... Together, these results show that Pax6 and En1 have essential roles in establishing
the recurrent inhibitory circuit between motor neurons and Renshaw cells. ...
Cited by 12 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

[CITATION] Pax6 and EN1 regulate sequential steps in the development of Renshaw Cells
T Sapir, EG Geiman, T Velasqueez, FJ Alvarez, M … - Abstr. Soc. Neurosci, 2002
Cited by 2 - Web Search

Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the … - Full text - MIT Libraries
A Mansouri, P Gruss - Mech. Dev, 1998 - invivo.caltech.edu
... 178 Page 3. associated with a function for neuronal subtypes in the spinal
cord (including Pax6, En1, Isl1 and Lim1). 2.2. Pax3 and ...
Cited by 41 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region - Full text - MIT Libraries
A Liu, AL Joyner - Development, 2001 - dev.biologists.org
... The changes in expression of Pax5 and Pax6 in En1/2 mutants could be due to the
early decrease in Fgf8 expression and a factor other than FGF8 could be ...
Cited by 35 - Web Search - dev.biologists.org - saturn.med.nyu.edu - ncbi.nlm.nih.gov

Regionalisation and acquisition of polarity in the optic tectum
H Nakamura - Prog. Neurobiol, 2001 - ncbi.nlm.nih.gov
... tectum. The anterior border of the tectum may be determined as a result
of repressive interactions between Pax6 and En1/Pax2. Along ...
Cited by 6 - Web Search - Get it from MIT Libraries

Inductive signal and tissue responsiveness defining the tectum and the cerebellum - Full text - MIT Libraries
T Sato, I Araki, H Nakamura - Development, 2001 - dev.biologists.org
... et al., 2000), the interface of Pax6 and En1 expression domains corresponded to
the boundary between the diencephalon and the tectum on the experimental side. ...
Cited by 26 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Pax6 regulates specification of ventral neurone subtypes in the hindbrain by establishing progenitor … - Full text - MIT Libraries
M Takahashi, N Osumi - Development, 2002 - dev.biologists.org
... En1 expression is first detected at E12.0. In the Pax6 mutant, En1 is transiently
expressed in a small number of cells at r3-6 levels of E13.0-13.25 embryo. ...
Cited by 15 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic … - Full text - MIT Libraries
M Ishibashi, AP McMahon - Development, 2002 - dev.biologists.org
... The anterior midbrain, a gap between the Pax6 and En1 expression domains, was also
reduced in Shh mutants (I,J). Arrowheads in I,J indicate the forebrain ...
Cited by 22 - Web Search - note.cellbio.duke.edu - cellbio.duke.edu - ncbi.nlm.nih.gov - all 5 versions »

Expression of neurogenic and region specific genes during the in vitro induced neurogenesis of NE-4C …
BV Varga, B Herberth, M Bence, N Hadinger, E … - Meeting abstract, International Society for Developmental …, 2004 - angel.elte.hu
... 2) Emx2 (empty spiracles homolog 2) Pax6 (paired box gene 6) Otx2 (orthodenticle
homolog 2) Otx3 (orthodenticle homolog 3) (Dmbx1) En1 (engrailed1) Gbx2 ...
Cited by 1 - View as HTML - Web Search - angel.elte.hu

Functional integration of embryonic stem cell-derived neurons in vivo - Full text - MIT Libraries
M Wernig, F Benninger, T Schmandt, M Rade, KL … - The Journal of Neuroscience, 2004 - jneurosci.org
... chain, clone BD17; 1:50; Chemicon), synaptophysin (1:40), pan-cytokeratin (clone
Lu-5; 1:50; both from DAKO, Hamburg, Germany), Pax6, En1, and Nestin (1:10, 1 ...
Cited by 4 - Web Search - jneurosci.org - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Dmbx1 is a paired-box containing gene specifically expressed in the caudal most brain structures - Full text - MIT Libraries
V Broccoli, E Colombo, G Cossu - Mech. Dev, 2002 - ingentaconnect.com
IngentaConnect. ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

Pax6 defines the di-mesencephalic boundary by repressing En1 and Pax2 - Full text - MIT Libraries
P Pax - Development, 2000 - dev.biologists.org
... Pax6 repressed En1, Pax2 and other tectum (mesencephalon)-related genes such as
En2, Pax5, Pax7, but induced Tcf4, a diencephalon marker gene. ...
Web Search

Isthmus organizer and regionalization of the mesencephalon and metencephalon.
H Nakamura, Y Watanabe - ncbi.nlm.nih.gov
... The di-mesencephalic boundary is determined by repressive interaction between Pax6
and En1/Pax2 and the mes-metencephalic boundary is defined by repressive ...
Web Search - Get it from MIT Libraries

Polarity and laminar formation of the optic tectum in relation to retinal projection - Full text - MIT Libraries
H Nakamura, S Sugiyama - Journal of Neurobiology, 2004 - doi.wiley.com
... The di-mesence- phalic and mes-metencephalic boundaries are deter- mined by repressive
interaction of Pax6 and En1/Pax2 and of Otx2 and Gbx2, respectively. ...
Web Search - ncbi.nlm.nih.gov

FunctionalIntegrationofEmbryonicStemCell-Derived NeuronsInVivo
M Wernig, F Benninger, T Schmandt, M Rade, KL … - ntp.neuroscience.wisc.edu
... chain, clone BD17; 1:50; Chemicon), synaptophy- sin (1:40), pan-cytokeratin (clone
Lu-5; 1:50; both from DAKO, Hamburg, Germany), Pax6, En1, and Nestin (1:10, 1 ...
View as HTML - Web Search - neuroscience.iastate.edu

Pax6 modulates the dorsoventral patterning of the mammalian telencephalon - Full text - MIT Libraries
A Stoykova, D Treichel, M Hallonet, P Gruss - J. Neurosci, 2000 - jneurosci.org
... Pax6 Modulates the Dorsoventral Patterning of the Mammalian Telencephalon. ... The Pax6
gene plays a crucial role in the development of the vertebrate CNS. ...
Cited by 75 - Web Search - jneurosci.org - ncbi.nlm.nih.gov

Emx2 directs the development of diencephalon in cooperation with Otx2 - Full text - MIT Libraries
Y Suda, ZM Hossain, C Kobayashi, O Hatano, M … - Development, 2001 - dev.biologists.org
... The interaction between Pax6, En1 and Pax2 at this stage is believed to establish
the boundary between the diencephalon and mesencephalon (Araki and Nakamura ...
Cited by 15 - Web Search - cdb.riken.go.jp - cdb.riken.jp - ncbi.nlm.nih.gov - all 5 versions »

Pax6 regulates granule cell polarization during parallel fiber formation in the developing … - Full text - MIT Libraries
T Yamasaki, K Kawaji, K Ono, H Bito, T Hirano, N … - Development, 2001 - dev.biologists.org
... Matsunaga, E., Araki, I. and Nakamura, H. (2000). Pax6 defines the dimesencephalic
boundary by repressing En1 and Pax2. Development 127,2357 -2365. ...
Cited by 12 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Identification of an enhancer region in the mouse ephA 8 locus directing expression to the anterior … - Full text - MIT Libraries
J Koo, S Shim, C Gu, O Yoo, S Park - Developmental Dynamics, 2003 - doi.wiley.com
... Con- versely, the repressive interaction of Pax6 with En1 and Pax2 may de- termine
the anterior border of the tectum (Araki and Nakamura, ...
Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Deregulated Expression of PAX5 in Medulloblastoma - Full text - MIT Libraries
Z Kozmik, U Sure, D Ruedi, M Busslinger, A Aguzzi - Proceedings of the National Academy of Sciences - pnas.org
... EN1, EN2, and PAX6 genes were also expressed in normal cerebellar tissue, and their
expression in medulloblastoma is consistent with the hypothesis that this ...
Cited by 46 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Activation of Pax6 depends on somitogenesis in the chick embryo cervical spinal cord - Full text - MIT Libraries
F Pituello, F Medevielle, F Foulquier, AM Duprat - Development, 1999 - dev.biologists.org
... paired-type homeobox), particularly those coding for proteins harbouring both a
paired domain and a paired-type homeodomain, such as Pax6, exhibit patterns of ...
Cited by 14 - Web Search - www-cbd.ups-tlse.fr - dev.biologists.org - ncbi.nlm.nih.gov

Search for genes involved in Joubert syndrome: evidence that one or more major loci are yet to be … - Full text - MIT Libraries
IP Blair, RR Gibson, CL Bennett, PF Chance - Am J Med Genet, 2002 - doi.wiley.com
... PAX2, PAX5, PAX6, PAX8, OTX1, OTX2, GBX2, WNT5a, and NKX2.2, several of which encode
proteins that either act up- stream or regulate the expression of EN1, EN2 ...
Cited by 16 - Web Search - ncbi.nlm.nih.gov

FGF signalling controls the timing of Pax6 activation in the neural tube - Full text - MIT Libraries
N Bertrand, F Medevielle, F Pituello - Development, 2000 - dev.biologists.org
... inhibitory activity acting in the caudal region of the embryo on Pax6 expression ...
Anterior neuroepithelium markers such as Otx2, Fgf8, En1 and Krox20 do not seem ...
Cited by 11 - Web Search - www-cbd.ups-tlse.fr - dev.biologists.org - ncbi.nlm.nih.gov

[CITATION] PAX2 is 708 expressed in multiple spinal cord interneurons, including a popula-709 tion of EN1+ … - Full text - MIT Libraries
JD Burrill, L Moran, MD Goulding, H Saueressig - Development, 1997
Cited by 1 - Web Search

The transcription factor Pax6 is required for development of the diencephalic dorsal midline … - Full text - MIT Libraries
G Estivill-Torrus, T Vitalis, P Fernandez-Llebrez, … - Mech. Dev, 2001 - uma.es
... Matsunaga, E., Araki, I., Nakamura, H., 2000. Pax6 defines the di-mesen- cephalic
boundary by repressing En1 and Pax2. Development 127, 2357–2365. ...
Cited by 10 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Emx2 and Pax6 Function in Cooperation with Otx2 and Otx1 to Develop Caudal Forebrain Primordium That … - Full text - MIT Libraries
J Kimura, Y Suda, D Kurokawa, ZM Hossain, M … - The Journal of Neuroscience, 2005 - jneurosci.org
... In the neural plate rostral to this sulcus, a series of transcriptional factors,
Otx2, Gbx2, Pax2, En1, Pax6, Irx3, and Six3, are expressed in a nested pattern ...
Web Search - jneurosci.org - ncbi.nlm.nih.gov

Selective Requirement of Pax6, But Not Emx2, in the Specification and Development of Several Nuclei … - Full text - MIT Libraries
S Tole, R Remedios, B Saha, A Stoykova - The Journal of Neuroscience, 2005 - jneurosci.org
... Development/Plasticity/Repair Selective Requirement of Pax6, But Not Emx2, in the
Specification and Development of Several Nuclei of the Amygdaloid Complex. ...
Web Search - jneurosci.org - ncbi.nlm.nih.gov

Evolution of transcription factor function
CC Hsia, W McGinnis - Curr Opin Genet Dev, 2003 - www-biology.ucsd.edu
... the Drosophila engrailed allele did not rescue the En1 mutant phenotype ... in the imaginal
disc primordia of adult Drosophila structures, mouse Pax6 protein can ...
Cited by 9 - View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: … - Full text - MIT Libraries
M Schwarz, G Alvarez-Bolado, P Urbanek, M … - Proc. Natl. Acad. Sci. USA, 1997 - dx.doi.org
... Home page, Development Home page E Matsunaga, I Araki, and H Nakamura Pax6 defines
the di-mesencephalic boundary by repressing En1 and Pax2 Development, January ...
Cited by 51 - Web Search - pnas.org - pubmedcentral.nih.gov - adsabs.harvard.edu - all 6 versions »

Towards the comprehension of genetic mechanisms controlling brain morphogenesis - Full text - MIT Libraries
A Simeone - Trends Neurosci, 2002 - courses.bio.psu.edu
... (2000) Pax6 defines the di-mesencephalic boundary by repressing En1 and
Pax2. Development 127, 2357–2365 18 Mastick, GS et al. ...
Cited by 2 - View as HTML - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov

Specification of neuronal fates in the ventral neural tube - Full text - MIT Libraries
J Briscoe, J Ericson - Curr. Opin. Neurobiol, 2001 - retinotectal.med.umn.edu
... 24. Matsunaga E, Araki I, Nakamura H: Pax6 defines the di- mesencephalic boundary
by repressing En1 and Pax2. Development 2000, 127:2357-2365. ...
Cited by 93 - View as HTML - Web Search - healthsystem.virginia.edu - neurobio.arizona.edu - all 5 versions »

Neural plate patterning: upstream and downstream of the isthmic organizer - Full text - MIT Libraries
W Wurst, L Bally-Cuif - Nat. Rev. Neurosci, 2001 - nature.com
... 29. Davis, CA & Joyner, AL Expression patterns of the homeobox containing genes
En1 and En2 and the proto-oncogene int-1 diverge during mouse development. ...
Cited by 98 - Web Search - nature.com - nbb.cornell.edu - ncbi.nlm.nih.gov - all 5 versions »

Evx1 is a postmitotic determinant of v0 interneuron identity in the spinal cord - Full text - MIT Libraries
L Moran-Rivard, T Kagawa, H Saueressig, MK Gross, … - Neuron, 2001 - chalk.salk.edu
... cord showing Evx1 (red) is not expressed in divid- ing Pax6 cells (green). ... velop
ventral to Lbx1 dorsal interneurons (green) (F), dorsal to En1 V1 interneurons ...
Cited by 52 - View as HTML - Web Search - ncbi.nlm.nih.gov

The activation and maintenance of Pax2 expression at the mid-hindbrain boundary is controlled by … - Full text - MIT Libraries
PL Pfeffer, B Payer, G Reim, MP di Magliano, M … - Development, 2002 - dev.biologists.org
... The mouse Pax2b, Pax3, Pax5, Pax6, En1, Gbx2, Oct1, Otx2 and Xenopus HoxD1 cDNAs
were cloned into pKW2T, and proteins were synthesized by a coupled in vitro ...
Cited by 12 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms’ tumor - Full text - MIT Libraries
GR Dressler, EC Douglass - Proceedings of the National Academy of Sciences - pnas.org
... Home page, Development Home page D Engelkamp, P Rashbass, A Seawright, and V van
Heyningen Role of Pax6 in development of the cerebellar system Development ...
Cited by 115 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

The formation of sensorimotor circuits - Full text - MIT Libraries
M Goulding, G Lanuza, T Sapir, S Narayan - Curr Opin Neurobiol, 2002 - chalk.salk.edu
... Embryo MN V1 V0 V2 V3 Evx1/2 Evx1/2 En1 En1 Chx10 Chx10 Isl1 Isl1 Sim1 Sim1 Dbx2
Pax6 Dbx1 Dbx2 Pax6 Nkx6.2 Pax6 Nkx6.1 Irx3 Nkx6.1 Olig2 Nkx2.2 Pax3/7 (a) (b) ...
Cited by 18 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Neuronal specification in the spinal cord: inductive signals and transcriptional codes - Full text - MIT Libraries
TM Jessell, FA White, CR Keller-Peck, CM Knudson, … - Nat. Rev. Genet, 2000 - nature.com
... 34. Matsunaga, E., Araki, I. & Nakamura, H. Pax6 defines the di-mesencephalic boundary
by repressing En1 and pax2. Development 127, 2357-2365 (2000). ...
Cited by 280 - Web Search - mc.vanderbilt.edu - bioweb.usc.edu - staging.healthsystem.virginia.edu - all 13 versions »

Gene silencing in chick embryos with a vector-based small interfering RNA system - Full text - MIT Libraries
T Katahira, H Nakamura - Development Growth and Differentiation, 2003 - blackwell-synergy.com
... Pax6 defines the di-mesencephalic boundary by repressing En1 and Pax2.
Development 127, 2357-2365. MEDLINE Abstract ISI Abstract. ...
Cited by 16 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Molecular Control Of Cell Type Diversity In The Developing Spinal Cord - Full text - MIT Libraries
T Yamada, A Karunaratne, M Hargrave - Clinical and Experimental Pharmacology and Physiology, 1999 - blackwell-synergy.com
... 7 Interestingly, in Pax6 mutant, other ventral interneurons adjacent to the
En1-expressing interneurons whose DV positions overlap with that of Pax6-expressing ...
Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Topographical and physiological characterization of interneurons that express engrailed-1 in the … - Full text - MIT Libraries
P Wenner, MJ O'Donovan, MP Matise, P Wenner, MJ O' … - J Neurophysiol, 2000 - jn.physiology.org
... studies of ventral interneuron connectivity in animals in which En1 function has
been ... including a population of en1+ interneurons that require pax6 for their ...
Cited by 19 - Web Search - intl-jn.physiology.org - ncbi.nlm.nih.gov

Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli … - Full text - MIT Libraries
Y Litingtung, C Chiang - Nature Neuroscience, 2000 - nature.com
... | Article | PubMed | ISI | ChemPort | Ericson, J. et al. Pax6 controls progenitor
cell identity and neuronal fate in response to graded Shh signaling. ...
Cited by 88 - Web Search - nature.com - ncbi.nlm.nih.gov

Early subdivisions in the neural plate define distinct competence for inductive signals - Full text - MIT Libraries
D Kobayashi, M Kobayashi, K Matsumoto, T Ogura, M … - Development, 2002 - dev.biologists.org
... Broccoli et al., 1999; Millet et al., 1999; Katahira et al., 2000), and similar
interactions were demonstrated between Pax6 and Pax2 or En1 (Araki and Nakamura ...
Cited by 31 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Emx 2 patterns the neocortex by regulating FGF positional signaling - Full text - MIT Libraries
T Fukuchi-Shimogori, EA Grove - Nature Neuroscience, 2003 - nature.com
... Emx2 and Pax6 control regionalization of the pre-neuronogenic cortical primordium. ...
Sequential roles for Fgf4, En1 and Fgf8 in specification and regionalisation ...
Cited by 18 - Web Search - nature.com - info.med.yale.edu - ncbi.nlm.nih.gov - all 6 versions »

Half a century of neural prepatterning: the story of a few bristles and many genes - Full text - MIT Libraries
JL Gomez-Skarmeta, S Campuzano, J Modolell - Nature Reviews Neuroscience, 2003 - nature.com
1. Stern, C. Two or three bristles. American Scientist 42, 213-247 (1954).
A seminal genetic study of the pattern of bristles on ...
Cited by 2 - Web Search - nature.com - ncbi.nlm.nih.gov

Manipulating gene expressions by electroporation in the developing brain of mammalian embryos - Full text - MIT Libraries
M Takahashi, K Sato, T Nomura, N Osumi - Differentiation, 2002 - blackwell-synergy.com
... 4D; see also Takahashi and Osumi, 2002). Previous studies reported that expression
of Wnt7b and En1 is missing in the Pax6 mutant hindbrain (left side in Fig. ...
Cited by 7 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - joplink.net

Engrailed and Fgf 8 act synergistically to maintain the boundary between diencephalon and … - Full text - MIT Libraries
S Scholpp, C Lohs, M Brand - Development, 2003 - dev.biologists.org
... Mis-expression of En1 in the anterior neural tube represses Pax6 expression, resulting
in a rostral shift of the DMB (Araki and Nakamura, 1999). ...
Cited by 4 - Web Search - dx.doi.org - dev.biologists.org - ncbi.nlm.nih.gov

A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor … - Full text - MIT Libraries
M Wijgerde, JA McMahon, M Rule, AP McMahon - Genes & Development, 2002 - genesdev.org
... B), Nkx2.2 and Olig2 (C,D), Nkx6.1 (C,D) and Pax6, (G,H) HNF3 . (I-N) MNR2, MN,
and Chox10, v2 interneuron precursors. (O-T) Evx1/2, v0 and En1, v1 interneuron ...
Cited by 34 - Web Search - genesdev.org - pubmedcentral.nih.gov - dx.doi.org - all 8 versions »

The mouse Pax2 (1Neu) mutation is identical to a human PAX2 mutation in a family with renal-coloboma … - Full text - MIT Libraries
J Favor, R Sandulache, A Neuhauser-Klaus, W … - Proc Natl Acad Sci USA, 1996 - dx.doi.org
... Home page, Development Home page E Matsunaga, I Araki, and H Nakamura Pax6 defines
the di-mesencephalic boundary by repressing En1 and Pax2 Development, January ...
Cited by 145 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »