Neurofibromin Deficiency in Mice Causes Exencephaly and Is a Modifier for Splotch Neural Tube … - Full text - MIT Libraries
M Lakkis, JA Golden, KS O’Shea, JA Epstein - Developmental Biology, 1999 - uphs.upenn.edu
... The thinned and abnormally formed forebrain of some Nf1 mutants led us to test for
expression of the Pax6 gene, which is normally transcribed in the developing ...
Cited by 13 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

The joys of reverse biology.
P Child, F Chromosomes, M Cloning, TS Genes, H … - Nat Genet, 1993 - ncbi.nlm.nih.gov
... Repetitive Sequences, Nucleic Acid; Sequence Homology*. Gene Symbols: BRCA1;
FMR-1; NF1; PAX6; PMP-22; Pit-1; SRY; Skn-1; WT1. PMID: 8099840 [PubMed - indexed ...
Web Search - Get it from MIT Libraries

Online Mendelian Inheritance in Man
C Fields, N Limit - anatomy.med.unsw.edu.au
... MEMBER 4; SLC4A4 249420 MELNICK-NEEDLES SYNDROME *106210 PAIRED BOX GENE 6; PAX6
*162200 NEUROFIBROMATOSIS, TYPE I; NF1 177650 PSEUDOEXFOLIATION OF THE LENS ...
View as HTML - Web Search

Ophthalmic genetics/inherited eye disease.
TL Young - Current Opinion in Ophthalmology, 2003 - co-ophthalmology.com
... MFS Marfan syndrome, MRI magnetic resonance imaging, NF1 neurofibromatosis type
1 ... chromosomal DNA segments) encompassing the aniridia-associated PAX6 gene, the ...
Web Search - co-ophthalmology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Sox21 promotes the progression of vertebrate neurogenesis - Full text - MIT Libraries
M Sandberg, M Kaellstroem, J Muhr - Nature Neuroscience, 2005 - nature.com
... 3a) were maintained in a proliferative and Pax6 + progenitor state and failed to
upregulate the expression of Lim2, NeuN or NF1, even 45 h after transfection ( ...
Web Search - nature.com

From insect eye to vertebrate muscle: redeployment of a regulatory network - Full text - MIT Libraries
F Relaix, M Buckingham - Development, 1999 - dx.doi.org
... Dach expression is not affected in the mouse Small eye (Pax6) mutation (Hammond ... Another
model, based on interaction between NF1 transcription factors and Ski ...
Cited by 44 - Web Search - genesdev.org - genesdev.org - ncbi.nlm.nih.gov - all 5 versions »

Developmental Neurogenetics and Neuro-Ophthalmology.
JL Bennett - Journal of Neuro-Ophthalmology, 2002 - jneuro-ophthalmology.com
... Mutations in the Pax6 gene are also associated with congenital central corneal ... The
diagnostic criteria for neurofibromatosis Type 1 (NF1) includes two or more ...
Cited by 3 - Web Search - jneuro-ophthalmology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Gene-targeting approaches in the study of cellular processes involved in growth or differentiation
KS Gen YAMADA, ET STUART - Eur. J. Biochem, 1994 - blackwell-synergy.com
... NF1 -/-mice show many developmental abnormali- ties in heart and neural crest ... three
mouse mutants, undulated (Paxl), splotch (Pax3) and small eye (Pax6) and two ...
Web Search - ingentaconnect.com - Get it from MIT Libraries

Management of childhood glaucoma.
CL Ho, DS Walton - Current Opinion in Ophthalmology, 2004 - co-ophthalmology.com
... relating the outcome of glaucoma care to the R317X PAX6 mutation demonstrated ... Glaucoma
complicating neurofibromatosis (NF1) is rare and NF1 is a rare cause of ...
Web Search - co-ophthalmology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Sources and Evolution of Human Alu Repeated Sequences - Full text - MIT Libraries
RJ Britten, WF Baron, DB Stout, EH Davidson - Genetics, 2004 - pnas.org
... JB Zheng, X. Gu, GF Saunders, and WKA Yung Novel PAX6 Binding Sites ... Tract Blocks
Nucleosome Formation Over the Human Neurofibromatosis Type 1 (NF1)-Alu Element ...
Cited by 110 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

A Fundamental Division in the Alu Family of Repeated Sequences - Full text - MIT Libraries
J Jurka, T Smith - Genetics, 2004 - pnas.org
... JB Zheng, X. Gu, GF Saunders, and WKA Yung Novel PAX6 Binding Sites ... Tract Blocks
Nucleosome Formation Over the Human Neurofibromatosis Type 1 (NF1)-Alu Element ...
Cited by 112 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Frequent Chromosome Aberrations Revealed by Molecular Cytogenetic Studies in Patients with Aniridia - Full text - MIT Libraries
JA Crolla, V van Heyningen - The American Journal of Human Genetics, 2002 - journals.uchicago.edu
... Prosser J, van Heyningen V (1998) PAX6 mutations reviewed. ... Segmental neurofibromatosis
is caused by somatic mutation of the neurofibromatosis type 1 (NF1) gene ...
Cited by 13 - Web Search - pubmedcentral.nih.gov - journals.uchicago.edu - ncbi.nlm.nih.gov

The protein truncation test: A review - Full text - MIT Libraries
JT Den Dunnen, GJB Van Ommen - Human Mutation, 1999 - doi.wiley.com
... cancer (FAP, HNPCC), breast cancer (BRCA1 and BRCA2), tuberous sclerosis (TSC1 and
TSC2), and neurofibromatosis (NF1 and NF2 ... PAX6 106210 Axton et al., 1997 ...
Cited by 18 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Insertions, substitutions, and the origin of microsatellites - Full text - MIT Libraries
Y ZHU, JE STRASSMANN, DC QUELLER - Genetical Research, 2000 - journals.cambridge.org
... (1996) 11 NF1 AGTTttACTG No Ainsworth et al. (1993) ... (1996) 20 PAX6 GCCccGTGC No Davis
& Cowell (1993) 21 MSH2 ATAtgTGTACGA Yes (1) Nystrom-Lahti et al. (1996) ...
Cited by 9 - Web Search - ruf.rice.edu - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Grundlagen der Tumoren des Kindesalters–das Beispiel Wilms-Tumor - Full text - MIT Libraries
G fuer die Entstehung - Der Onkologe, 2000 - springerlink.com
... der Bande 11p13 bei WAGR-Patienten waren der erste Hin- weis für eine Gen-Suche
und aus dieser Region wurden später das WT1- und das PAX6-Gen isoliert [5, 7 ...
Web Search

Status of the Human Malformation Map: 2002
JC CAREY, DH VISKOCHIL - American Journal of Medical Genetics (Semin. Med. Genet.), 2002 - doi.wiley.com
... Sonic hedgehog), ligands (FGFR1-3), signal transduction pathway genes (NF1),
extracellular matrix ... Aniridia 106210 106210 11p13 PAX6 Paired box homeotic gene-6 ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Recognition and Management of Childhood Cancer Syndromes: A Systems Approach
CL CLERICUZIO - AMERICAN JOURNAL OF MEDICAL GENETICS (SEMIN. MED. GENET.), 1999 - doi.wiley.com
... Most neo- plasms associated with NF1 are benign, but a number of malignancies occur ...
with autosomal domi- nant aniridia due to mutations of the PAX6 gene, and ...
Cited by 6 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Chapter Four: The Protein Truncation Test
C Page - promega.com
... hMSH2 30 hMLH1 31 Neurofibromatosis Type 1 NF1 32 Neurofibromatosis Type 2 NF2 33
Aniridia PAX6 34 Paroxysmal Nocturnal Haemoglobinuria PIG-A 35 ...
View as HTML - Web Search - shpromega.cn - shpromega.com.cn - promega.com

NEUROSCIENCE
V Semaphorin, N Neuropilin, V Semaphorin, N … - woongbee.com
... of Pax6, Irx3, Dbx2, Dbx1, Pax3, and Pax7 is repressed by Shh signals (Class I),
whereas Shh stimulates the expression of Nkx2.2, Nkx2.9, Olig2, Nkx6.1, and ...
View as HTML - Web Search - rndsystems.com - rndsystems.com

Direct estimates of human per nucleotide mutation rates at 20 loci causing mendelian diseases - Full text - MIT Libraries
AS Kondrashov - Human Mutation, 2003 - doi.wiley.com
... 2000] detected NF1 mutations in ... PAX6, Aniridia The incidence of aniridia was reported
to be between 1:64,000 and 1:96,000, with B1/3 of cases being sporadic, ie ...
Cited by 27 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Theatre: a software tool for detailed comparative analysis and visualization of genomic sequence - Full text - MIT Libraries
YJK Edwards, TJ Carver, T Vavouri, M Frith, MJ … - Nucleic Acids Research, 2003 - nar.oupjournals.org
... NF1 is critical for basal expression of the mouse p53 gene whilst the NFkB ... Complete
sequencing of the Fugu WAGR region from WT1 to PAX6: dramatic compaction ...
Cited by 1 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Pax3 and the splotch mutations: structure, function, and relationship to teratogenesis, including …
AF Machado, LJ Martin, MD Collins - Curr. Pharm. Design, 2001 - ingentaconnect.com
... Further evidence for evolutionary conservation in the Pax family is the observation
that ectopic expression of an ascidian Pax6 induces supernumerary eye ...
Cited by 7 - Web Search - bentham.org - bentham.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

A New ssA1-Crystallin Splice Junction Mutation in Autosomal Dominant Cataract - Full text - MIT Libraries
JB Bateman, DD Geyer, P Flodman, M Johannes, J … - Investigative Ophthalmology and Visual Science, 2000 - iovs.org
... 26 Although mutations in the homeobox DNA-binding PAX6 gene usually cause ... D17S805;
additionally, they found linkage with a neurofibromatosis-1 (NF1) marker (Z ...
Cited by 17 - Web Search - iovs.org - iovs.org - ncbi.nlm.nih.gov - all 6 versions »

BMC Bioinformatics - Full text - MIT Libraries
SD Mooney, TE Klein - BMC Bioinformatics, 2002 - biomedcentral.com
... ATP7A 0.62 GALE 0.75 NAGA 1.01 SLC2A2 0.58 ATP7B 0.36 GALK1 1.18 NF1 1.05
SLC3A1 0.89 AVP ... 0.55 CBS 0.57 GP9 0.66 PAX6 0.99 TH 0.84 ...
View as HTML - Web Search - bmc.ub.uni-potsdam.de - gdrs-intranet.ath.cx - smi-web.stanford.edu - all 6 versions »

Transgenic rescue of congenital heart disease and spina bifida in Splotch mice - Full text - MIT Libraries
J Li, KC Liu, F Jin, MM Lu, JA Epstein - Development, 1999 - dev.biologists.org
... A gene dosage effect for PAX6 in humans has been reported (Glaser et al., 1994)
and transgenic over expression of Pax6 in mice results in ocular defects ...
Cited by 38 - Web Search - hunterlab.med.tufts.edu - uphs.upenn.edu - ncbi.nlm.nih.gov - all 5 versions »

Animal models for human contiguous gene syndromes and other genomic disorders - Full text - MIT Libraries
K Walz, P Fonseca, JR Lupski - Genetics and Molecular Biology, 2004 - scielo.br
... Disease, HNPP: Hereditary Neuropathy with Liability to Pressure Palsies, NF1: Neuro-
fibromatosis I ... del(11)(p12p14) 194072 PAX6 for aniridia (AN2), WT1 for and ...
View as HTML - Web Search - scielo.br

Summary of ocular genetic disorders and inherited systemic conditions with eye findings
IM MacDonald, PM Haney, MA Musarella - Ophthalmic Genetics, 1998 - taylorandfrancis.metapress.com
... Peters’ anomaly 106210 PAX6 11p13 21 ... 302350 Xp22.3-p22.2 233 Neurofibromatosis:
NF1- von Recklinghausen 162200 neurofibromin 17q11.2 234,235 ...
Cited by 8 - Web Search - ingentaconnect.com - extenza-eps.com - szp.swets.nl - all 6 versions »

Mutations of VMD 2 Splicing Regulators Cause Nanophthalmos and Autosomal Dominant … - Full text - MIT Libraries
J Yardley, BP Leroy, N Hart-Holden, BA Lafaut, B … - Investigative Ophthalmology & Visual Science, 2004 - iovs.org
... Identification of a mutation that perturbs NF1 gene splicing using genomic DNA samples ...
Mutations at the PAX6 locus are found in heterogeneous anterior segment ...
Cited by 1 - Web Search - dx.doi.org - iovs.org - ncbi.nlm.nih.gov

Context of deletions and insertions in human coding sequences - Full text - MIT Libraries
AS Kondrashov, IB Rogozin - Human Mutation, 2004 - doi.wiley.com
... Sets of deletions and insertions were updated, in December 2002, for the following
loci: PAX6 (pax6.hgu.mrc.ac.uk ... NF1 M82814.1 706 6 aggaattaacTGTTtgttcagaaga ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The transcription factor Sp3 interacts with promoter elements of the lens specific MIP gene - Full text - MIT Libraries
S Kim, H Ge, C Ohtaka-Maruyama, AB Chepelinsky - Mol Vis, 1999 - molvis.org
... located at position -69/-83 of the MIP gene, containing an NF1 element and a CAT ...
In fact, non lens-specific tran- scription factors such as Pax6, Sox1, Nrl are ...
Cited by 3 - View as HTML - Web Search - molvis.org - ncbi.nlm.nih.gov

Growth of a Rat Neuroblastoma Cell Line in Serum-Free Supplemented Medium - Full text - MIT Libraries
JE Bottenstein, GH Sato - Mol. Biol. Cell, 2004 - pnas.org
... Home page, Development Home page A Stoykova, M Gotz, P Gruss, and J Price
Pax6-dependent regulation of adhesive patterning, R-cadherin expression and boundary ...
Cited by 630 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Evidence for a Novel Osteosarcoma Tumor-Suppressor Gene in the Chromosome 18 Region Genetically … - Full text - MIT Libraries
MJ Nellissery, SS Padalecki, Z Brkanac, FR Singer, … - The American Journal of Human Genetics, 1998 - journals.uchicago.edu
... 1991); mutations in the NF1 gene have been linked to both von Recklinghausen ... in which
multigenic deletions inactivate both the WT1 gene and the PAX6 gene and ...
Cited by 38 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Regulation of the poly (ADP-ribose) polymerase-1 gene expression by the transcription factors Sp1 … - Full text - MIT Libraries
K Zaniolo, A Rufiange, S Leclerc, S Desnoyers, SL … - Biochem J, 2005 - biochemj.org
... nuclear factor 1 (NF1) family to the rPARP-1 promoter [7,8]. Studies performed
on established cell lines or transformed cells showed ...
Cited by 1 - View as HTML - Web Search - biochemj.org - ncbi.nlm.nih.gov

Expression of the {alpha} 4 Integrin Subunit Gene Promoter Is Modulated by the Transcription Factor … - Full text - MIT Libraries
K Zaniolo, S Leclerc, A Cvekl, L Vallieres, R … - Investigative Ophthalmology and Visual Science, 2004 - iovs.org
... The regulatory influence exerted by Pax6 on the 4 promoter was studied by ... corresponding
to a binding site for the unrelated transcription factor NF1 could not ...
Cited by 1 - Web Search - intl.iovs.org - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

Faithful expression of a tagged Fugu WT 1 protein from a genomic transgene in zebrafish: efficient … - Full text - MIT Libraries
CG Miles, L Rankin, SI Smith, M Niksic, G Elgar, … - Nucleic Acids Research, 2003 - nar.oupjournals.org
... 1998) Complete sequencing of the Fugu WAGR region from WT1 to PAX6: dramatic compaction ...
insertion of a cryptic exon in the neurofibromatosis type 1 (NF1) mRNA. ...
Cited by 3 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 7 versions »

Use of targeted array-based CGH for the clinical diagnosis of chromosomal imbalance: Is less more? - Full text - MIT Libraries
BA Bejjani, R Saleki, BC Ballif, EA Rorem, K … - American Journal of Medical Genetics Part A, 2005 - doi.wiley.com
... 9q22.3 DiGeorge II DGSII 10p13 Beckwith–Wiedemann IGF2 11p15.5 WAGR PAX6, WT1 11p13 ...
LIS1 17p13.3 Smith–Magenis SMS 17p11.2 Neurofibromatosis I NF1 17q11.2 ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

Conditional alleles in mice: Practical considerations for tissue-specific knockouts - Full text - MIT Libraries
KM Kwan - genesis, 2002 - doi.wiley.com
... c-Myc 15 (32.0) F de Alboran et al., 2001 Nf1 (neurofibromatosis type 1) ... Pax6 2
(58.0) ✚ Ashery-Padan et al., 2000; Marquardt et al., 2001 Pex5 ...
Cited by 27 - Web Search - tagc.univ-mrs.fr - biochem.wisc.edu - ncbi.nlm.nih.gov - all 6 versions »

Summary of heritable ocular disorders and selected systemic conditions with eye findings
IM MacDonald, DY Mah - Ophthalmic Genetics, 2000 - taylorandfrancis.metapress.com
... Microcoria 156600 13q31-q32 36 Peters’ anomaly 106210 PAX6 11p13 37 PITX2 (601542)
4q25 38 ... 302350 Xp22.3-p22.2 328 Neurofibromatosis: NF1- von Recklinghausen ...
Cited by 2 - Web Search - ingentaconnect.com - extenza-eps.com - szp.swets.nl - all 6 versions »

List of genes screened entirely or partly by DHPLC (last updated August 20, 2002) Gene MIM# Disease …
SGT Center - parma.co.kr
... Benit et al. [2001b] NF1 162200 Neurofibromatosis type 1 O’Donovan et al. ... [2000]
PAX6 106210 Microphthalmia, anophthalmia, coloboma Morrison et al. [2002] ...
Web Search

[BOOK] PCR mutation detection protocols
BDM Theophilus, R Rapley, BDM Theophilus, R Rapley - 2002 - now.humanapress.com
... 15 Cystic fibrosis CFTR ggatccTAATACGACTCACTATAGGaacagaCCACCATG 16
Neurofibromatosis 1 NF1 ggatccTAATACGACTCACTATAGGGagaCCACCATG 17 ...
Web Search - neurosci.humanapress.com - journals.humanapress.com - all 9 versions » - Get it from MIT Libraries - Library Search

A statistical analysis of the TRANSFAC database.
GB Fogel, DG Weekes, G Varga, ER Dow, AM Craven, … - Biosystems, 2005 - natural-selection.com
... MEF-2 MINI20 B Muscle initiator sequence-20 MUSCLE INI B Muscle initiator NF1 Q6
Nuclear ... PAX4 03 Pax-4 binding sites PAX4 04 Pax-4 binding sites PAX6 01 Pax-6 ...
View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

MOLECULAR MECHANISMS FOR GENOMIC DISORDERS - Full text - MIT Libraries
K Inoue, JR Lupski - Annual Review of Genomics and Human Genetics, 2002 - genom.annualreviews.org
... 161, 221). Deletion of NF1 on 17q11.2 accounts for 5%-22% of patients with
neurofibromatosis type 1 (30, 168, 217, 222). The deletion ...
Cited by 42 - Web Search - nutr.annualreviews.org - 128.194.251.107 - ncbi.nlm.nih.gov - all 7 versions »

2004
A Report, U Guide - Occupational Health & Safety - sanraffaele.org
... ME- BA may function by competing with nuclear factor 1(NF1)—a transcription
factor present ubiquitously that re- presses the MBP promoter. ...
Cited by 4 - View as HTML - Web Search - ing.pl - inglife.co.kr - jaarverslag.info - all 430 versions » - Get it from MIT Libraries

Genetic control of growth - Full text - MIT Libraries
PE Mullis - European Journal of Endocrinology - eje-online.org
... 11.5), transcription factors such as Prop1 and Pax6 are preferentially ... specific
transcription factor); USF, upstream stimulatory factor; NF1, nuclear factor 1 ...
Web Search - eje-online.org - ncbi.nlm.nih.gov

Xiphophorus Genetic Linkage Map: Beginnings of Comparative Gene Mapping in Fishes - Full text - MIT Libraries
DC Morizot, RS Nairn, P Simhambhatla, L Della … - Marine Biotechnology - springerlink.com
... avian myelocytomatosis oncogene homolog; MYH2—myosin heavy chain-2; NF1—
neurofibromatosis-1 ... of the Fugu WAGR region from WT1 to PAX6: dramatic compaction ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

Mouse models of human disease. Part II: recent progress and future directions - Full text - MIT Libraries
MA Bedell, DA Largaespada, NA Jenkins, NG Copeland - Genes Dev, 1997 - genesdev.org
... Pax6 Sev, Paired box homeotic gene 6, C,R,S, Aniridia type II, 106210, ... Nf1,
Neurofibromatosis type 1, K, Neurofibromatosis type 1, 162200, *Gutmann and Collins ( ...
Cited by 52 - Web Search - genesdev.org - cshl.org - ncbi.nlm.nih.gov

The river buffalo(Bubalus bubalis, 2 n= 50) cytogenetic map: assignment of 64 loci by fluorescence … - Full text - MIT Libraries
L Iannuzzi, GP Di Meo, A Perucatti, L Schibler, D … - Cytogenetic and Genome Research, 2003 - content.karger.com
Page 1. Cytogenet Genome Res 102:65–75 (2003) DOI: 10.1159/000075727 The river buffalo (
Bubalus bubalis , 2n = 50) cytogenetic map: assignment of 64 loci by ...
Cited by 1 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions »

Clinical pharmacology of human growth hormone and its secretagogues
AW Root, MJ Root - Curr Drug Targets Immune Endocr Metabol Disord, 2002 - ingentaconnect.com
... Nkx3.1, Six3, P-Frk, GATA2, Islet1, Pax6, and Brn4 further the formation of the
definitive pouch which closes off from the oral cavity by e12 in the mouse. ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Meta-analysis of indels causing human genetic disease: mechanisms of mutagenesis and the role of … - Full text - MIT Libraries
NA Chuzhanova, EJ Anassis, EV Ball, M Krawczak, DN … - Human Mutation, 2003 - doi.wiley.com
Page 1. RESEARCH ARTICLE Meta-Analysis of Indels Causing Human Genetic Disease:
Mechanisms of Mutagenesis and the Role of Local DNA Sequence Complexity ...
Cited by 13 - Web Search - csb.yale.edu - ncbi.nlm.nih.gov

Histone deacetylase inhibitors decrease reelin promoter methylation in vitro - Full text - MIT Libraries
CP Mitchell, Y Chen, M Kundakovic, E Costa, DR … - Journal of Neurochemistry, 2005 - blackwell-synergy.com
... binding sites for several transcription factors, including Tbr-1, Sp1 and Pax6,
to examine ... PJ (2001) Allele-specific non-CpG methylation of the Nf1 gene during ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov