Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 … - Full text - MIT Libraries
M Schwarz, F Cecconi, G Bernier, N Andrejewski, B … - Development, 2000 - dev.biologists.org
... In contrast to Pax6, Pax2 is expressed in the ventral half of the optic vesicle
during early eye morphogenesis (Nornes et al., 1990; Torres et al., 1996). ...
Cited by 48 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by …
JA Epstein, T Glaser, J Cai, L Jepeal, DS Walton, … - Genes Dev, 1994 - genesdev.org
... terminus. This property can be stimulated by deletion of 30 amino-terminal
residues from the Pax6 or Pax2 paired domains. Thus, the ...
Cited by 123 - Web Search - genesdev.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Pax6 defines the di-mesencephalic boundary by repressing En1 and Pax2 - Full text - MIT Libraries
E Matsunaga, I Araki, H Nakamura - Development, 2000 - dev.biologists.org
... Pax6 repressed En1, Pax2 and other tectum (mesencephalon)-related genes such as
En2, Pax5, Pax7, but induced Tcf4, a diencephalon marker gene. ...
Cited by 47 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1 interneurons … - Full text - MIT Libraries
JD Burrill, L Moran, MD Goulding, H Saueressig - Development, 1997 - dev.biologists.org
... Key words: PAX2, PAX6, EN1, spinal cord, interneuron, cell fate, chick SUMMARY PAX2
is expressed in multiple spinal cord interneurons, including a ...
Cited by 72 - Web Search - dev.biologists.org - wwwlib.bionet.nsc.ru - ncbi.nlm.nih.gov

Mutations of the PAX6 gene detected in patients with a variety of optic-nerve malformations - Full text - MIT Libraries
N Azuma, Y Yamaguchi, H Handa, K Tadokoro, A Asaka … - Am J Hum Genet, 2003 - journals.uchicago.edu
... PAX6 and PAX2 are each thought to downregulate the expression of the other.
Four ... d, Effects of PAX6 mutants on PAX2 expression. One ...
Cited by 11 - Web Search - pubmedcentral.nih.gov - journals.uchicago.edu - ncbi.nlm.nih.gov - all 5 versions »

Pax2/5 and Pax6 subdivide the early neural tube into three domains - Full text - MIT Libraries
M Schwarz, G Alvarez-Bolado, G Dressler, P Urbanek … - Mech. Dev, 1999 - ingentaconnect.com
... Pax2/5 and Pax6 subdivide the early neural tube into three domains. Authors:
Schwarz M.; Alvarez-Bolado G.; Dressler G.; Pavel Urbanek ...
Cited by 30 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Midline signalling is required for Pax gene regulation and patterning of the eyes - Full text - MIT Libraries
R Macdonald, KA Barth, Q Xu, N Holder, I Mikkola, … - Development, 1995 - dev.biologists.org
... These include two members of the paired box (Pax) gene family, pax6 and pax2. ... 5.
shh has opposite effects upon Pax2 and Pax6 expression in the optic primordia. ...
Cited by 154 - Web Search - dev.biologists.org - ucl.ac.uk - ncbi.nlm.nih.gov - all 5 versions »

Pax 3 inhibits myogenic differentiation of cultured myoblast cells. - Full text - MIT Libraries
JA Epstein, P Lam, L Jepeal, RL Maas, DN Shapiro - J Biol Chem, 1995 - jbc.org
... from in vitro binding site selection assays, using the isolated Pax3 paired domain
as bait, similar to those performed using the Pax6 and Pax2 paired domains ...
Cited by 58 - Web Search - jbc.org - ncbi.nlm.nih.gov

The Pax2 homolog sparkling is required for development of cone and pigment cells in the Drosophila … - Full text - MIT Libraries
W Fu, M Noll - Genes Dev, 1997 - genesdev.org
... Thus, in wild-type eyes Pax6 and Pax2 expression is mutually exclusive, which results
in a sharp boundary between eye and optic stalk, whereas in the absence ...
Cited by 51 - Web Search - unizh.ch - molbio.unizh.ch - ncbi.nlm.nih.gov - all 7 versions »

Role of Pax genes in eye evolution: a cnidarian PaxB gene uniting Pax2 and Pax6 functions - Full text - MIT Libraries
Z Kozmik, M Daube, E Frei, B Norman, L Kos, LJ … - Dev. Cell, 2003 - ncbi.nlm.nih.gov
Click here to read Role of Pax genes in eye evolution: a cnidarian PaxB gene
uniting Pax2 and Pax6 functions. Kozmik Z, Daube M, Frei ...
Cited by 12 - Web Search - ncbi.nlm.nih.gov

Pax genes and eye organogenesis
F Pichaud, C Desplan - Curr. Opin. Genet. Dev, 2002 - wwworm.biology.uh.edu
... The answer might lie in the understanding of Pax6 function and evolution and we
here describe how various Pax genes, Pax6, Pax2 and Eye gone (Eyg), control eye ...
Cited by 20 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

Mutation of the PAX2 gene in a family with optic nerve colobomas, renal anomalies and vesicoureteral …
P Sanyanusin, LA Schimmenti, LA McNoe, TA Ward, … - Nat Genet, 1995 - nature.com
... RL Genomic structure, evolutionary conservation and aniridia mutations in the human
PAX6 gene. ... Expression of the PAX2 gene in human fetal kidney and Wilms Tumor ...
Cited by 164 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the … - Full text - MIT Libraries
PL Pfeffer, M Bouchard, M Busslinger - Development, 2000 - dev.biologists.org
... Pax2 and Pax5 bound with high affinity to probe A in contrast to Pax3 and Pax6,
which represent two other Pax subfamilies expressed in the developing CNS (Fig. ...
Cited by 21 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Pax2 contributes to inner ear patterning and optic nerve trajectory - Full text - MIT Libraries
M Torres, E Gomez-Pardo, P Gruss - Development, 1996 - dev.biologists.org
... Two of the Pax genes; Pax2 and Pax6, are restrictedly expressed in developing
sense organs (Nornes et al., 1990; Walther and Gruss, 1991). ...
Cited by 176 - Web Search - dev.biologists.org - wwwlib.bionet.nsc.ru - ncbi.nlm.nih.gov

Cooperation of Pax2 and Pax5 in midbrain and cerebellum development - Full text - MIT Libraries
P Urbanek, I Fetka, MH Meisler, M Busslinger - Proc. Natl. Acad. Sci. USA, 1997 - dx.doi.org
... D. Treichel, R. Ashery-Padan, and P. Gruss Retinal pigmented epithelium determination
requires the redundant activities of Pax2 and Pax6 Development, July 1 ...
Cited by 64 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Temporal and Spatial Effects of Sonic Hedgehog Signaling in Chick Eye Morphogenesis - Full text - MIT Libraries
X Zhang, XJ Yang - Developmental Biology, 2001 - ingentaconnect.com
... In addition, Shh signals differentially influenced expression patterns of genes
involved in ocular tissue specification (Pax6, Pax2, and Otx2) and dorsal ...
Cited by 38 - Web Search - ncbi.nlm.nih.gov

Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate eye - Full text - MIT Libraries
M Carl, F Loosli, J Wittbrodt - Development, 2002 - dev.biologists.org
... (D,G,J) Pax2, Six3 and Pax6 expression are not affected in Pax6 morphants. ... In addition,
in Pax6 morphants Pax2 expression remained unchanged (Fig. ...
Cited by 24 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Pax genes and organogenesis
E Dahl, H Koseki, R Balling - BioEssays, 1997 - ncbi.nlm.nih.gov
... PAX6), Peter's anomaly (PAX6), renal coloboma syndrome (PAX2) or spontaneous mouse
mutants (undulated (Pax1), Splotch (Pax3), Small eye (Pax6), Pax2(1)Neu ...
Cited by 109 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Saturation mutagenesis for dominant eye morphological defects in the mouse Mus musculus - Full text - MIT Libraries
J Favor, A Neuh& x 000 E 4 user-Klaus - Mammalian Genome, 2000 - springerlink.com
... The affected genes have been identified for a number of the recovered muta- tions
including Cryga, Crygb, Cgyge, Pax6, Pax2, Mitf, Lim2, and Cx50. ...
Cited by 25 - Web Search - ncbi.nlm.nih.gov

Two tcf 3 genes cooperate to pattern the zebrafish brain - Full text - MIT Libraries
RI Dorsky, M Itoh, RT Moon, A Chitnis - Development, 2003 - dev.biologists.org
... To examine rostral-caudal neural patterning, we compared the expression of pax6,
pax2.1 and gbx1, which respectively mark the future eye field and dorsal ...
Cited by 11 - Web Search - dx.doi.org - dev.biologists.org - ncbi.nlm.nih.gov

Dach1, a vertebrate homologue of Drosophila dachshund, is expressed in the developing eye and ear of … - Full text - MIT Libraries
TA Heanue, RJ Davis, DH Rowitch, A Kispert, AP … - Mech. Dev, 2002 - genetics.med.harvard.edu
... further possibility that a regulatory hierarchy exists between Pax, Eya, and Dach
genes, we have examined the expression of mouse Dach1 in Pax6, Pax2 and Eya1 ...
Cited by 15 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Zebrafish contains two Pax6 genes involved in eye development - Full text - MIT Libraries
S Nornes, M Clarkson, I Mikkola, M Pedersen, A … - Mech. Dev, 1998 - invivo.caltech.edu
... recently, the zebrafish was found to contain an addi- tional Pax2 gene, denoted
Pax2.2. Similar to our findings with the Pax6 genes, the two Pax2 genes differ ...
Cited by 36 - View as HTML - Web Search - cmbn.no - ncbi.nlm.nih.gov

Zebrafish Pax 9 encodes two proteins with distinct C-terminal transactivating domains of different … - Full text - MIT Libraries
S Nornes, I Mikkola, S Krauss, M Delghandi, M … - J Biol Chem, 1996 - jbc.org
... patterns of zebrafish pax[zf-a] and pax[zf-b] (7, 8, 9), now referred to as Pax6
and Pax2, respectively, to relate them to their mammalian homologues. ...
Cited by 27 - Web Search - cmbn.no - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

Pax6 induces ectopic eyes in a vertebrate - Full text - MIT Libraries
RL Chow, CR Altmann, RA Lang, A Hemmati-Brivanlou - Development, 1999 - dev.biologists.org
... Both these phenotypes are observed in Xenopus embryos misexpressing Pax6 and suggest
that Pax2 may function in part by inhibiting the Pax6-directed development ...
Cited by 116 - Web Search - dev.biologists.org - neuron.montana.edu - ncbi.nlm.nih.gov

Identification and expression of zebrafish Iroquois homeobox gene irx 1 - Full text - MIT Libraries
C Cheng, C Hui, U Str& x 000 E 4 hle, S Cheng - Development Genes and Evolution, 2001 - springerlink.com
... To define more precisely the location of irx1 expression in the brain, we performed
double in situ hybridizations using pax6 or pax2.1 probes, which mark the ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Inductive signal and tissue responsiveness defining the tectum and the cerebellum - Full text - MIT Libraries
T Sato, I Araki, H Nakamura - Development, 2001 - dev.biologists.org
... Probes for En1, Pax6, Pax2, Pax5 and Gbx2 were isolated as described previously
(Araki and Nakamura, 1999; Itasaki and Nakamura, 1996; Katahira et al., 2000 ...
Cited by 26 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity - Full text - MIT Libraries
B Kammandel, K Chowdhury, A Stoykova, S Aparicio, … - Dev. Biol, 1999 - fbmc.fcen.uba.ar
Distinct cis-Essential Modules Direct the Time– Space Pattern of the Pax6 Gene Activity ...
Key Words: Pax6; regulatory sequence; enhancer; transgenic mouse. ...
Cited by 66 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Early subdivisions in the neural plate define distinct competence for inductive signals - Full text - MIT Libraries
D Kobayashi, M Kobayashi, K Matsumoto, T Ogura, M … - Development, 2002 - dev.biologists.org
... Broccoli et al., 1999; Millet et al., 1999; Katahira et al., 2000), and similar
interactions were demonstrated between Pax6 and Pax2 or En1 (Araki and Nakamura ...
Cited by 31 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Pax6 is required for the multipotent state of retinal progenitor cells - Full text - MIT Libraries
T Marquardt, R Ashery-Padan, N Andrejewski, R … - Cell, 2001 - blc.arizona.edu
... endogenous Pax2), which binds to a consensus sequence similar to that of
Pax6 or with CMV-Pax3 or CMV-Pax7 (data not Ngn2 expression ...
Cited by 106 - View as HTML - Web Search - chalk.salk.edu - ncbi.nlm.nih.gov

To see or not to see: evolution of eye degeneration in Mexican blind cavefish - Full text - MIT Libraries
WR Jeffery, AG Strickler, Y Yamamoto - Integr. Comp. Biol, 2003 - bioone.org
... The division of the optic vesicle into the optic cup and stalk is controlled by
reciprocal repression between the Pax6 and Pax2 transcription factors (Schwarz ...
Cited by 6 - Web Search - bioone.org - apt.allenpress.com

PAX 6 and Congenital Eye Malformations - Full text - MIT Libraries
IM HANSON - Pediatric Research, 2003 - intl.pedresearch.org
... Competition between Pax6 and Pax2 binding may help to define the sharp boundary
of Pax6 and Pax2 expression between the optic cup and the optic stalk (66). ...
Cited by 3 - Web Search - med.nyu.edu - pedresearch.org - ncbi.nlm.nih.gov - all 5 versions »

Iris hypoplasia in mice that lack the alternatively spliced Pax6 (5a) isoform - Full text - MIT Libraries
S Singh, R Mishra, NA Arango, JM Deng, RR … - Proc Natl Acad Sci USA, 2002 - pnas.org
... Deletion of the 30 amino-terminal residues from PAX6 or PAX2 yields a protein
that mimics the DNA-binding properties of the 5a isoform (16). ...
Cited by 16 - Web Search - pubmedcentral.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

[CITATION] PAX2 is 708 expressed in multiple spinal cord interneurons, including a popula-709 tion of EN1+ … - Full text - MIT Libraries
JD Burrill, L Moran, MD Goulding, H Saueressig - Development, 1997
Cited by 1 - Web Search

Eye development: a view from the retina pigmented epithelium - Full text - MIT Libraries
JR MartınMorales, I Rodrigo, P Bovolenta - BioEssays, 2004 - doi.wiley.com
... (59) Consistentwitha mutually exclusive activity of Pax2 and Pax6, Pax2 expression
domain is expanded in Pax6 mutant mice and vice versa, and Pax2 and Pax6 ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and … - Full text - MIT Libraries
PX Xu, I Woo, H Her, DR Beier, RL Maas - Development, 1997 - dev.biologists.org
... Pax6, a member of the paired box family of transcription factors, has been identified
as a key regulator of eye develop- ment in both vertebrates and ...
Cited by 107 - Web Search - dev.biologists.org - wwwlib.bionet.nsc.ru - ncbi.nlm.nih.gov

Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during … - Full text - MIT Libraries
SH Kim, J Shin, HC Park, SY Yeo, SK Hong, S Han, M … - Development, 2002 - dev.biologists.org
... the stage specific effects of Wnt signalling on the patterning in the anterior
neuroectoderm, we analysed the changes of pax6 and pax2 expression in embryos ...
Cited by 9 - Web Search - tgbio.com - dev.biologists.org - ncbi.nlm.nih.gov

Sonic hedgehog in CNS development: one signal, multiple outputs - Full text - MIT Libraries
E Marti, P Bovolenta - Trends Neurosci, 2002 - nbb.cornell.edu
... eye phenotype is easily explained by the observation that SHH activity regulates
the spatial expression of genes encoding Pax6 and Pax2, which normally ...
Cited by 32 - View as HTML - Web Search - nsm1.utdallas.edu - faculty.evansville.edu - all 7 versions »

Role of Pax6 in development of the cerebellar system - Full text - MIT Libraries
D Engelkamp, P Rashbass, A Seawright, V van … - Development, 1999 - dev.biologists.org
... with expression constructs of individual full length Pax cDNAs (Pax2, 5, 6, 7, 8).
Further tests included staining of primary cells derived from Pax6+ or Pax6 ...
Cited by 50 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Physical mapping of the bovine, caprine and ovine homologues of the paired box gene PAX8
NL Lopez-Corrales, TS Sonstegard, TPL Smith, F … - Cytogenetics and Cell Genetics, 1999 - content.karger.com
... loss-of-func- tion mutations in three different PAX genes, Waardenburg syn- drome
(WS), and kidney and retinal defects (PAX3, PAX6 and PAX2 respectively; Read ...
Cited by 2 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: … - Full text - MIT Libraries
M Schwarz, G Alvarez-Bolado, P Urbanek, M … - Proc. Natl. Acad. Sci. USA, 1997 - dx.doi.org
... D. Treichel, R. Ashery-Padan, and P. Gruss Retinal pigmented epithelium determination
requires the redundant activities of Pax2 and Pax6 Development, July 1 ...
Cited by 51 - Web Search - pnas.org - pubmedcentral.nih.gov - adsabs.harvard.edu - all 6 versions »

Retinal pigmented epithelium determination requires the redundant activities of Pax 2 and Pax 6 - Full text - MIT Libraries
N Baumer, T Marquardt, A Stoykova, D Spieler, D … - Development, 2003 - dev.biologists.org
... Bandshift assays Pax6 and Pax2 proteins were overexpressed using SP6 promoter-coupled
Pax2 and Pax6 cDNA in the TNT in vitro transcription and translation ...
Cited by 9 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Vax 1, a novel homeobox-containing gene, directs development of the basal forebrain and visual … - Full text - MIT Libraries
M Hallonet, T Hollemann, T Pieler, P Gruss - Genes & Development, 1999 - dx.doi.org
... [Key Words: Brain morphogenesis; optic nerve; Pax2; Pax6; Rx; Vax1] 3 Present
address: Institut de Genetique et de Biologie Moleculaire ...
Cited by 38 - Web Search - genesdev.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Dosage requirement and allelic expression of PAX6 during lens placode formation - Full text - MIT Libraries
CD van Raamsdonk, SM Tilghman - Development, 2000 - dev.biologists.org
... The dosage requirement is also evident from the developmental defects caused by
over-expression of Pax2 and Pax6 in transgenic mice (Dressler et al., 1993 ...
Cited by 25 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

PAX 6 in sensory development - Full text - MIT Libraries
V van Heyningen, KA Williamson - Human Molecular Genetics, 2002 - hmg.oupjournals.org
... The latter is illustrated by the Pax6/Six3 interactions (16), and also by the
modulation of Pax6 and Pax2 (20): expression is refined from largely overlapping ...
Cited by 30 - Web Search - hmg.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Functional analysis of the chicken {delta} 1-crystallin enhancer activity in Drosophila reveals … - Full text - MIT Libraries
J Blanco, F Girard, Y Kamachi, H Kondoh, WJ … - Development, 2005 - dev.biologists.org
... As PAX6 and PAX2 proteins derive from the same ancestor, we propose that during
evolution Pax6 function in vertebrate lens development was retained by Pax2 in ...
Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Pax6 defines the di-mesencephalic boundary by repressing En1 and Pax2 - Full text - MIT Libraries
P Pax - Development, 2000 - dev.biologists.org
... Expression pattern of Pax6 and En1, Pax2 Pax6 is repressed when the diencephalon
transdifferentiates into the tectum by En or Pax2 misexpression (Araki and ...
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[CITATION] DEVELOPMENTAL BIOLOGY: Eye Sees Reciprocal Repression
S STKE
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[CITATION] DEVELOPMENTAL BIOLOGY: Eye Sees Reciprocal Repression
E Guides, C Map
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Ancestry of Photic and Mechanic Sensation? - Full text - MIT Libraries
B Fritzsch, J Piatigorsky, K Tessmar-Raible, G … - Science, 2005 - sciencemag.org
... Second, we would like to emphasize that the set of sensory cell types related by
the shared combinatorial code of transcription factors (pax6-pax2/5/8, atonal ...
Web Search - sciencemag.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Macular abnormalities and optic disk anomaly associated with a new PAX2 missense mutation.
T Higashide, T Wada, M Sakurai, H Yokoyama, K … - Am J Ophthalmol, 2005 - ncbi.nlm.nih.gov
... in the left eye. The entire coding regions of PAX2 and PAX6 were screened
for mutations. RESULTS: A heterozygous mutation G755C ...
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