PAX genes
T Strachan, AP Read - Curr. Opin. Genet. Dev, 1994 - ncbi.nlm.nih.gov
... Mutations in three of the nine mouse genes (Pax1, Pax3 and Pax6) and two of the
nine human genes (PAX3 and PAX6) are known to cause developmental defects. ...
Cited by 92 - Web Search - Get it from MIT Libraries

Expression pattern of PAX3 and PAX6 genes during human embryogenesis
J Terzic, M Saraga-Babic - Int J Dev Biol, 1999 - ijdb.ehu.es
... During early human development, PAX6 and PAX3 genes seem to be involved in the brain
regionalization and establishment of dorso-ventral polarity of the spinal ...
Cited by 7 - View as HTML - Web Search - ncbi.nlm.nih.gov - ijdb.ehu.es - Get it from MIT Libraries

Anti-apoptotic role of Sonic hedgehog protein at the early stages of nervous system organogenesis - Full text - MIT Libraries
JB Charrier, F Lapointe, NM Le Douarin, MA Teillet - Development, 2001 - dev.biologists.org
... and structures: HNF3ß (Ruiz i Altaba et al., 1995) and Shh (Riddle et al., 1993)
for Hensen’s node, floor plate and notochord; Pax6 and Pax3 (Goulding et al ...
Cited by 23 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1 interneurons … - Full text - MIT Libraries
JD Burrill, L Moran, MD Goulding, H Saueressig - Development, 1997 - dev.biologists.org
... Previously, we have shown that signals from the notochord and floor plate regulate
the spatial expression of three transcription factors, PAX3, PAX6 and PAX7 ...
Cited by 72 - Web Search - dev.biologists.org - wwwlib.bionet.nsc.ru - ncbi.nlm.nih.gov

Missense mutations in the most ancient residues of the PAX 6 paired domain underlie a spectrum of … - Full text - MIT Libraries
I Hanson, A Churchill, J Love, R Axton, T Moore, M … - Human Molecular Genetics, 1999 - hmg.oupjournals.org
... In PAX6 and PAX3, there is further complexity, with evidence for additional
interactions between the paired domain and the homeodomain (25,27,28). ...
Cited by 38 - Web Search - hmg.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

FGF signalling controls the timing of Pax6 activation in the neural tube - Full text - MIT Libraries
N Bertrand, F Medevielle, F Pituello - Development, 2000 - dev.biologists.org
... In situ hybridisation Pax6 and Pax3 transcripts were analysed using the antisense
RNA probe prepared as described (Pituello et al., 1995). ...
Cited by 11 - Web Search - www-cbd.ups-tlse.fr - dev.biologists.org - ncbi.nlm.nih.gov

Identification of DNA recognition sequences for the Pax3 paired domain - Full text - MIT Libraries
G Chalepakis, P Gruss - Gene, 1995 - ncbi.nlm.nih.gov
... Pax1 and Pax9 constitute one subfamily, Pax2, Pax5 and Pax8 another, Pax3
and Pax7 another one and Pax4 and Pax6 the fourth subfamily. ...
Cited by 19 - Web Search

Control of dorsoventral pattern in the chick paraxial mesoderm - Full text - MIT Libraries
S Dietrich, FR Schubert, A Lumsden - Development, 1997 - dev.biologists.org
... signalling structures to ectopic sites and analysed the spatiotemporal expression
of MyoD, Pax1, Pax3 in the paraxial mesoderm, and Shh, Pax6, Pax3, Wnt4 and ...
Cited by 66 - Web Search - wwwlib.bionet.nsc.ru - dev.biologists.org - ncbi.nlm.nih.gov - all 5 versions »

The specification of noradrenergic locus coeruleus (LC) neurones depends on bone morphogenetic … - Full text - MIT Libraries
A Vogel-Hopker, H Rohrer - Development, 2002 - dev.biologists.org
... compare Fig. 5AC). After Noggin application at stage 10 to 11, Pax6 and
Pax3 expression was shifted to the dorsal midline (Fig. 5 ...
Cited by 13 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Role of Pax3/7 in the tectum regionalization - Full text - MIT Libraries
E Matsunaga, I Araki, H Nakamura - Development, 2001 - dev.biologists.org
... take it into consideration that detection of repression is much more difficult than
that of induction, induction of Fgf8 and repression of Pax6 by Pax3/7 may ...
Cited by 7 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: a role for FGFR1 in … - Full text - MIT Libraries
BG Ciruna, L Schwartz, K Harpal, TP Yamaguchi, J … - Development, 1997 - dev.biologists.org
... Herrmann, 1991), Shh (Echelard et al., 1993), Sox-1 and Sox-2 (unpublished, obtained
from Robin Lovell- Badge), Pax3 (Goulding et al., 1991), Pax6 (Walther and ...
Cited by 110 - Web Search - dev.biologists.org - wwwlib.bionet.nsc.ru - ncbi.nlm.nih.gov

Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the … - Full text - MIT Libraries
A Mansouri, P Gruss - Mech. Dev, 1998 - invivo.caltech.edu
... G and H indicate schematically the expression of En1, Evx1 and Pax6 in control
(G) and mutant (H) embryos as compared to Pax3 and Pax7 expression domain in the ...
Cited by 41 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker … - Full text - MIT Libraries
HE Xu, MA Rould, W Xu, JA Epstein, RL Maas, CO … - Genes Dev, 1999 - genesdev.org
... The only variation occurs at position 121, where Pax6 has an asparagine,
but Pax3 and about half of the paired domains have a serine. ...
Cited by 61 - Web Search - uphs.upenn.edu - 128.95.44.130 - pubmedcentral.nih.gov - all 8 versions »

Gscl, a gene within the minimal DiGeorge critical region, is expressed in primordial germ cells and … - Full text - MIT Libraries
N Galili, JA Epstein, I Leconte, S Nayak, CA Buck - Developmental Dynamics, 1998 - doi.wiley.com
... Pax6 and Pax3 are expressed by subpopulations of migrating neural crest
cells (Walther and Gruss, 1991; Goulding et al., 1991). ...
Cited by 5 - Web Search - doi.wiley.com - uphs.upenn.edu - ncbi.nlm.nih.gov - all 5 versions »

Synergistic regulation of vertebrate muscle development by Dach 2, Eya 2, and Six 1, homologs of … - Full text - MIT Libraries
TA Heanue, R Reshef, RJ Davis, G Mardon, G Oliver, … - Genes & Development, 1999 - dx.doi.org
... rather than eye development, and has been expanded to include gene family members
that are not directly homologous, for example Pax3 instead of Pax6. ...
Cited by 104 - Web Search - genesdev.org - genetics.med.harvard.edu - pubmedcentral.nih.gov - all 9 versions »

Pax3 modulates expression of the c-Met receptor during limb muscle development - Full text - MIT Libraries
JA Epstein, DN Shapiro, J Cheng, PYP Lam, RL Maas - Developmental Biology, 1996 - dx.doi.org
... microarrays detect activation of a myogenic transcription program by the PAX3-FKHR
fusion ... RL Maas, and CO Pabo Crystal structure of the human Pax6 paired domain ...
Cited by 94 - Web Search - uphs.upenn.edu - pnas.org - ncbi.nlm.nih.gov - all 6 versions »

Genetic and biochemical diversity in the Pax gene family - Full text - MIT Libraries
DA Underhill - Biochem Cell Biol, 2000 - article.pubs.nrc-cnrc.gc.ca
... In contrast with the activities of Pax6 and Pax3, per- sistent and widespread
expression of Pax2 does not perturb the developmental potential of other cell ...
Cited by 11 - Web Search - dx.doi.org - pubs.nrc-cnrc.gc.ca - ncbi.nlm.nih.gov - all 6 versions »

Potential roles for BMP and Pax genes in the development of iris smooth muscle - Full text - MIT Libraries
AM Jensen - Dev. Dyn, 2004 - doi.wiley.com
... The developing iris smooth muscle coexpresses Pax6 and Pax3. ... Key words: BMP4;
BMP7; HNK1; Pax6; Pax3; anterior chamber; ciliary epithelium ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

Pax genes and organogenesis
E Dahl, H Koseki, R Balling - BioEssays, 1997 - ncbi.nlm.nih.gov
... nine characterized Pax genes have been associated with either congenital human diseases
such as Waardenburg syndrome (PAX3), Aniridia (PAX6), Peter's anomaly ...
Cited by 109 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Inhibition of floor plate differentiation by Pax3: evidence from ectopic expression in transgenic … - Full text - MIT Libraries
P Tremblay, F Pituello, P Gruss - Development, 1996 - dev.biologists.org
... made in the spinal cord, we examined the dorsoventral patterning of the mesencephalon
by characterizing the expression pattern of Pax3, Pax7, Pax5, Pax6 and Shh ...
Cited by 28 - Web Search - wwwlib.bionet.nsc.ru - www-cbd.ups-tlse.fr - ncbi.nlm.nih.gov - all 5 versions »

Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and … - Full text - MIT Libraries
PX Xu, I Woo, H Her, DR Beier, RL Maas - Development, 1997 - dev.biologists.org
... Pax6, a member of the paired box family of transcription factors, has been identified
as a key regulator of eye develop- ment in both vertebrates and ...
Cited by 107 - Web Search - dev.biologists.org - wwwlib.bionet.nsc.ru - ncbi.nlm.nih.gov

The PAX3-FKHR fusion protein created by the t (2; 13) translocation in alveolar rhabdomyosarcomas is … - Full text - MIT Libraries
WJ Fredericks, N Galili, S Mukhopadhyay, G Rovera, … - Mol Cell Biol, 1995 - mcb.asm.org
... mutants and human syn- dromes (38) are associated with genetic lesions in different
PAX genes, notably, Pax-1 (2, 13) and PAX6 (48, 78, 79), as well as PAX3. ...
Cited by 84 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Molecular anatomy of placode development in Xenopus laevis - Full text - MIT Libraries
G SCHLOSSER, K Ahrens - Developmental Biology, 2004 - ncbi.nlm.nih.gov
... gschloss@uni-bremen.de We analyzed the spatiotemporal pattern of expression of 15
transcription factors (Six1, Six4, Eya1, Sox3, Sox2, Pax6, Pax3, Pax2, Pax8 ...
Cited by 3 - Web Search

Pax3 is required for enteric ganglia formation and functions with Sox10 to modulate expression of c- … - Full text - MIT Libraries
D Lang, F Chen, R Milewski, J Li, MM Lu, JA … - J. Clin. Invest, 2000 - jci.org
... (c) The response of construct 615 (depicted in b) is specific for Pax3 and
is activated to a much lesser degree by Pax2, Pax6, and Pax9. ...
Cited by 29 - Web Search - jci.org - pubmedcentral.nih.gov - uphs.upenn.edu - all 7 versions »

Activation of Pax6 depends on somitogenesis in the chick embryo cervical spinal cord - Full text - MIT Libraries
F Pituello, F Medevielle, F Foulquier, AM Duprat - Development, 1999 - dev.biologists.org
... chicken embryo. The neural plate positioned caudally to Hensen’s node
displays a Pax3-on, Pax6-off state (Fig. 7A; Goulding et ...
Cited by 14 - Web Search - www-cbd.ups-tlse.fr - dev.biologists.org - ncbi.nlm.nih.gov

Isabel Hanson, Amanda Churchill 2, James Love, Richard Axton, Tony Moore 3, - Full text - MIT Libraries
M Clarke, F Meire, V van Heyningen - Human Molecular Genetics, 1999 - med.nyu.edu
... In PAX6 and PAX3, there is further complexity, with evidence for additional
interactions between the paired domain and the homeodomain (25,27,28). ...
Web Search - med.nyu.edu

Pax6 is required for the multipotent state of retinal progenitor cells - Full text - MIT Libraries
T Marquardt, R Ashery-Padan, N Andrejewski, R … - Cell, 2001 - blc.arizona.edu
... endogenous Pax2), which binds to a consensus sequence similar to that of
Pax6 or with CMV-Pax3 or CMV-Pax7 (data not Ngn2 expression ...
Cited by 106 - View as HTML - Web Search - chalk.salk.edu - ncbi.nlm.nih.gov

Paired-Type Homeodomain Transcription Factors Are Imported into the Nucleus by Karyopherin 13 - Full text - MIT Libraries
JE Ploski, MK Shamsher, A Radu - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... The consensus between Pax6, Pax3, and Crx consists of residues that are conserved
between the three factors based on physical and chemical properties. ...
Cited by 2 - Web Search - dx.doi.org - mcb.asm.org - ncbi.nlm.nih.gov

BMP signaling patterns the dorsal and intermediate neural tube via regulation of homeobox and helix- … - Full text - MIT Libraries
JR Timmer, C Wang, L Niswander - Development, 2002 - dev.biologists.org
... One of the earliest signs of distinct regional identity in spinal neural tissue
is the expression of Pax genes, specifically Pax6 and Pax3/7 (Liem et al., 1995 ...
Cited by 28 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Functional interactions between alternatively spliced forms of Pax 6 in crystallin gene regulation … - Full text - MIT Libraries
BK Chauhan, Y Yang, K Cveklova, A Cvekl - Nucleic Acids Research, 2004 - pubmedcentral.nih.gov
... from cultured αTN4-1 lens cells (40) and mouse melanoma B16 cells (Geneka, Montreal,
Canada) were used as positive controls for Pax6 and Pax3, respectively. ...
Cited by 2 - Web Search - nar.oxfordjournals.org - nar.oupjournals.org - ingentaconnect.com - all 7 versions »

Determination of functional domains of the human transcription factor PAX8 responsible for its …
EJ Biochem - Eur. J. Biochem, 1997 - blackwell-synergy.com
... Mutations in PAX6 affecting the car- boxy-terminal region which possibly lead ...
Intrachromosomal translocations, involving PAX3 or PAX7 and the FKHR gene of the ...
Cited by 19 - Web Search - ejbiochem.org - content.febsjournal.org - ingentaconnect.com - all 6 versions » - Get it from MIT Libraries

Dosage requirement and allelic expression of PAX6 during lens placode formation - Full text - MIT Libraries
CD van Raamsdonk, SM Tilghman - Development, 2000 - dev.biologists.org
... Loss-of-function heterozygous mutations in Pax1, Pax2, Pax3, Pax6, Pax8, and possibly
Pax9 cause semi-dominant phenotypes in either the mouse or human, or both ...
Cited by 25 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Msx 1 is required for dorsal diencephalon patterning - Full text - MIT Libraries
A Bach, Y Lallemand, MA Nicola, C Ramos, L Mathis, … - Development, 2003 - dev.biologists.org
... GTA TTA AGT GTC AGA GC); Otx2, 408 bp (coding for amino-acids 110 to 243); Lim1,
441 bp (coding for amino-acids 259 to 406); Pax7, Pax6 and Pax3 (complete cDNA ...
Cited by 11 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Mutations in the PAX 3 gene causing Waardenburg syndrome type 1 and type 2
M Tassabehji, AP Read, VE Newton, M Patton, P … - Nature Genetics, 1993 - nature.com
... Here we describe a further three PAX3 mutations which cause WS; one alters the
octapeptide motif ... The human PAX6 gene is mutated in two patients with aniridia. ...
Cited by 56 - Web Search - nature.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Pax3 functions in cell survival and in pax7 regulation - Full text - MIT Libraries
AG Borycki, J Li, F Jin, CP Emerson, JA Epstein - Development, 1999 - dev.biologists.org
... Another key regulatory gene in myogenesis is Pax3, which is a member of the Paired
Box transcription factor family (Borycki and Emerson, 1997; Goulding et al ...
Cited by 62 - Web Search - dev.biologists.org - uphs.upenn.edu - ncbi.nlm.nih.gov

Role of Pax6 in development of the cerebellar system - Full text - MIT Libraries
D Engelkamp, P Rashbass, A Seawright, V van … - Development, 1999 - dev.biologists.org
... Here we assess the role of the Pax6 gene in development of cerebellar structures,
by comparing normal and Pax6-mutant Small eye mice at different gestational ...
Cited by 50 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Identification and expression of the lamprey Pax6 gene: evolutionary origin of the segmented brain … - Full text - MIT Libraries
Y Murakami, M Ogasawara, F Sugahara, S Hirano, N … - Development, 2001 - dev.biologists.org
... or five groups (Pax1/9, Pax2/5/8, Pax3/7, Pax4/6 and PaxA) (Miller et al., 2000;
Breitling and Gerber, 2000). Of those, duplication of Pax4 and Pax6 appears to ...
Cited by 21 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

1 Embed in an iodinated polymer: a new paradigm for histology via backscattered electron imaging. By … - Full text - MIT Libraries
D Dyn - J. Anat, 2001 - journals.cambridge.org
... Here, we present expression patterns for the transcription factors PAX6, PAX3 and
OTX2, the ventralising signalling molecule sonic hedgehog (SHH) and ...
Web Search - blackwell-synergy.com - journals.cambridge.org - blackwell-synergy.com

Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 … - Full text - MIT Libraries
M Schwarz, F Cecconi, G Bernier, N Andrejewski, B … - Development, 2000 - dev.biologists.org
... The early and dynamic expression of Pax2 and Pax6 during eye formation suggests
a potential role for these genes in eye regionalization (Nornes et al., 1990 ...
Cited by 48 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Retinoic acid mediates Pax6 expression during in vitro differentiation of embryonic stem cells - Full text - MIT Libraries
P Gruss - Differentiation, 1997 - blackwell-synergy.com
... axis of the neural tube, as shown using Shh, islet1, and Pax3 as dorsal ... For example,
activins which inhibit Pax6 expression were down-regulat- ed during the ...
Cited by 28 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Msx2 is an immediate downstream effector of Pax3 in the development of the murine cardiac neural … - Full text - MIT Libraries
SJ Kwang, SM Brugger, A Lazik, AE Merrill, LY Wu, … - Development, 2002 - dev.biologists.org
... The Splotch phenotype is caused by a loss-of-function mutation in Pax3 (Epstein
et al., 1993; Goulding et al., 1993), 527 ... negatively regulated by Pax3. ...
Cited by 19 - Web Search - note.cellbio.duke.edu - cellbio.duke.edu - ncbi.nlm.nih.gov - all 5 versions »

Pax3 acts cell autonomously in the neural tube and somites by controlling cell surface properties - Full text - MIT Libraries
A Mansouri, P Pla, L Larue, P Gruss - Development, 2001 - dev.biologists.org
... wild-type cells suggests that Pax3 may control cell surface properties. Similar
observations have been made in chimeras generated with mutant Pax6 Sey cells ...
Cited by 12 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

PAX6 expression in the developing human eye - Full text - MIT Libraries
S Nishina, S Kohsaka, Y Yamaguchi, H Handa, A … - Br. J. Ophthalmol, 1999 - bjophthalmol.com
... showed that the PAX6 antibody detected Pax6 isoforms specifically but did not detect
proteins of other Pax gene family members including Pax7 and Pax3. ...
Cited by 11 - Cached - Web Search - bjo.bmjjournals.com - bjophthalmol.com - ncbi.nlm.nih.gov - all 5 versions »

Transcription factors in dysmorphology - Full text - MIT Libraries
D Lacombe - Clinical Genetics, 1999 - blackwell-synergy.com
... characterized by a paired box sequence encoding a DNA-binding domain with two
helix-turn-helix structures, and for some (PAX3/PAX7, PAX4/PAX6) a homeodomain ...
Web Search - ncbi.nlm.nih.gov

Pax3 and the splotch mutations: structure, function, and relationship to teratogenesis, including …
AF Machado, LJ Martin, MD Collins - Curr. Pharm. Design, 2001 - ingentaconnect.com
... Each of the three aforementioned cysteine residues is conserved in all of the Pax
proteins, including Pax3, and the structural data from Pax6 and Pax8 are ...
Cited by 7 - Web Search - bentham.org - bentham.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

Molecular Basis of Splotch and Waardenburg Pax-3 Mutations - Full text - MIT Libraries
G Chalepakis, M Goulding, A Read, T Strachan, P … - Proceedings of the National Academy of Sciences - pnas.org
... GF Saunders Missense mutation at the C-terminus of PAX6 negatively modulates ... Herlyn,
JR Friedman, and FJ Rauscher III An Engineered PAX3-KRAB Transcriptional ...
Cited by 25 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

The genetic network of prototypic planarian eye regeneration is Pax6 independent - Full text - MIT Libraries
D Pineda, L Rossi, R Batistoni, A Salvetti, M … - Development, 2002 - dev.biologists.org
... The analysis includes: human Pax 3, 4, 6 (Aniridia) and 7; mouse Pax3, 4, 6 and
7; zebrafish Pax6; sea urchin suPax6; chordate PmPax6 and Amphi-Pax6; mollusc Lo ...
Cited by 18 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Getting your Pax straight: Pax proteins in development and disease
N Chi, JA Epstein - Trends Genet, 2002 - instruct.uwo.ca
... binding characteristics. For instance, alternative splicing within the
PD can result in forms of Pax3, Pax6 or Pax8 with altered ...
Cited by 54 - View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Tumor-specific PAX3-FKHR transcription factor, but not PAX3, activates the platelet-derived growth … - Full text - MIT Libraries
JA Epstein, B Song, M Lakkis, C Wang - Mol. Cell. Biol, 1998 - mcb.asm.org
... in PAX3-dependent gene regulation. The only known functional P3 site is that identified
in the rhodopsin 1 promoter which mediates transactivation by the PAX6 ...
Cited by 25 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov - all 5 versions »

Untersuchung des PAX6-Gens bei Aniridie-Patienten - Full text - MIT Libraries
M Wolf, B Zabel, B Lorenz, A Blankenagel, MB … - Ophthalmologe, 1998 - springerlink.com
... Veränderungen der PAX-Gene korreliert: das ¹renal-colo- bomaª-Syndrom mit PAX2,
das Waar- denburg-Syndrom Typ I und III mit PAX3 und die Aniridie mit PAX6. ...
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