Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic … - Full text - MIT Libraries
SB Smith, HC Ee, JR Conners, MS German - Mol. Cell. Biol, 1999 - mcb.asm.org
... Several transcription factors (PDX1, ISL1, PAX6, PAX4, BETA2/NeuroD, and NKX2.2)
are required for normal pancreatic endocrine development, and many of these ...
Cited by 34 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Getting your Pax straight: Pax proteins in development and disease
N Chi, JA Epstein - Trends Genet, 2002 - instruct.uwo.ca
... Pax6, Pax4 and the endocrine pancreas Within the pancreas, small clusters of endocrine
cells are located among the more abundant exocrine tissue. ...
Cited by 54 - View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Identification of a portable repression domain and an E1A-responsive activation domain in Pax4: a … - Full text - MIT Libraries
Y Fujitani, Y Kajimoto, T Yasuda, TA Matsuoka, H … - Mol Cell Biol, 1999 - mcb.asm.org
... 7, Pax6 stimulated the promoter activity containing the Pax6 and Pax4 binding sites
in HIT-T15 cells and 293T cells (lanes 2 to 4 in both panels). ...
Cited by 16 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Pax 6 is required for differentiation of glucagon-producing α-cells in mouse pancreas - Full text - MIT Libraries
L St-Onge, B Sosa-Pineda, K Chowdhury, A Mansouri, … - Nature, 1997 - nature.com
... As mice lacking Pax4 and Pax6 fail to develop any mature endocrine cells, we conclude
that both Pax genes are required for endocrine fate in the pancreas. ...
Cited by 242 - Web Search - ncbi.nlm.nih.gov

Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription … - Full text - MIT Libraries
SE Samaras, MA Cissell, K Gerrish, CV Wright, M … - Mol. Cell. Biol, 2002 - pubmedcentral.nih.gov
... Pax6 and Pax4 represent the only known members of the paired-box, homeodomain
transcription factor family involved in pancreatic islet development (10). ...
Cited by 12 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Single-cell transcript analysis of pancreas development - Full text - MIT Libraries
MK Chiang, DA Melton - Dev Cell, 2003 - note.cellbio.duke.edu
... It was also noted that cells expressing Pax4 always express Pax6. Pax4 null mutant
mice have few or no ... A model has been proposed in which Pax4 causes Pax6- ...
Cited by 39 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

A missense mutation of Pax4 gene (R121W) is associated with type 2 diabetes in Japanese - Full text - MIT Libraries
Y Shimajiri, T Sanke, H Furuta, T Hanabusa, T … - Diabetes, 2001 - diabetes.diabetesjournals.org
... We recently showed that Pax4 functioned as a repressor of transcription and that
Pax4 inhibited Pax6-induced transcriptional activation by competing for the ...
Cited by 14 - Web Search - diabetes.diabetesjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Pax4 represses pancreatic glucagon gene expression - Full text - MIT Libraries
HV Petersen, MC Jorgensen, FG Andersen, J Jensen, … - Mol Cell Biol Res Commun, 2000 - ingentaconnect.com
... The paired box and homeodomain containing transcription factors Pax4 and Pax6 are
known to be essential for development of the pancreatic endocrine cells. ...
Cited by 7 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Expression of Alcaligenes eutrophus flavohemoprotein and engineered Vitreoscilla hemoglobin- … - Full text - MIT Libraries
AD Frey, JE Bailey, PT Kallio - Applied and Environmental Microbiology, 2000 - aem.asm.org
... Thus, E. coli MG1655 cells expressing VHb (pPPC1), FHPg (pAX1), or separate
globin-reductase fusions (pAX5, pAX6, pAX4, pAX9, pAX12, and pAX14) were cultivated ...
Cited by 13 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - csa.com - all 5 versions »

IFN-gamma overexpression within the pancreas is not sufficient to rescue Pax4, Pax6, and Pdx-1 …
M Krakowski, B Yeung, R Abdelmalik, A Good, L … - Pancreas, 2000 - pancreasjournal.com
... Pax6 and Pax4 mutant mice were received on the outbred NMRI background.
Pdx-1 ... Fig. 1 shows Pax4 ins-IFN-γ and Pax6 ins-IFN-γ). We ...
Cited by 3 - Web Search - pancreasjournal.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Bio-engineering insulin-secreting cells from embryonic stem cells: a review of progress
E Roche, MP Sepulcre, R Ensenat-Waser, I Maestre, … - Med Biol Eng Comput, 2003 - iee.org
... or several endocrine pancreas precursor markers, such as the specific transcription
factors Neurogenin3, NeuroD=Beta2, Isl-1, Nkx2.2, Nkx6.1, Pax6, Pax4, Pdx-1 ...
Cited by 4 - View as HTML - Web Search - conferences.iee.org.uk - ncbi.nlm.nih.gov - link.aip.org - Get it from MIT Libraries

Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic … - Full text - MIT Libraries
A Grapin-Botton, AR Majithia, DA Melton - Genes & Development, 2001 - genesdev.org
... 1). Paired homeodomain proteins Pax4 (Sosa-Pineda et al. 1997 ) and Pax6 (Sander
et al. ... Mouse Pax6 and Pax4 coding sequences (Genbank accession no. ...
Cited by 65 - Web Search - pubmedcentral.nih.gov - dx.doi.org - joplink.net - all 7 versions »

The PAX6 gene is activated by the basic helix–loop–helix transcription factor NeuroD/BETA2 - Full text - MIT Libraries
E Marsich, A Vetere, M Di Piazza, G Tell, S … - Biochem J, 2003 - bj.portlandpress.com
... Several transcription factors (ie Pdx1, ISL1, PAX6, PAX4, NeuroD/BETA2 and
NKX2.2) are required for normal pancreatic endocrine development [28–31]. ...
Cited by 4 - View as HTML - Web Search - biochemj.org - biochemj.org - ncbi.nlm.nih.gov - all 5 versions »

Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature … - Full text - MIT Libraries
H Kojima, T Nakamura, Y Fujita, A Kishi, M … - Diabetes, 2002 - diabetes.diabetesjournals.org
... RT-PCR was used to probe for the presence of NeuroD, Isl-1, Nkx6.1, Pax6, Pax4,
and G3PDH in total RNA isolated from neonatal rat pancreas (lane 1), IEC-6 ...
Cited by 34 - Web Search - diabetes.diabetesjournals.org - ncbi.nlm.nih.gov

Neurogenin3 triggers β-cell differentiation of retinoic acid-derived-endoderm cells - Full text - MIT Libraries
A Vetere, E Marsich, M Di Piazza, R Koncan, F … - Biochem. J, 2003 - biochemj.org
... Paired homeodomain proteins Pax4 [6-8] and Pax6 [7-10], LIM ... pancreas development
transcription factors NeuroD, Pax6, Pax4, Nkx2.2, Pdx1 and Isl1 and ...
Cited by 5 - View as HTML - Web Search - biochemj.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Pax genes and the differentiation of hormone-producing endocrine cells in the pancreas - Full text - MIT Libraries
C Dohrmann, P Gruss, L Lemaire - Mech. Dev, 2000 - ingentaconnect.com
... focuses on the specification of the endocrine pancreas lineage and in particular
on the role of the developmental control genes Pax4 and Pax6 in the generation ...
Cited by 35 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Lineage Commitment and Cellular Differentiation in Exocrine Pancreas
AL Means, SD Leach, SD Leach, F Alert - Pancreatology, 2001 - content.karger.com
... These include Ngn3, NeuroD/Neta2, Pax6, Pax4, and Nkx6.1 [18–25]. Table
1 provides a summary of islet phenotypes associat- Page 4. ...
Cited by 3 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Promoter elements in endocrine pancreas development and hormone regulation - Full text - MIT Libraries
C Brink - Cell Mol Life Sci, 2003 - ncbi.nlm.nih.gov
... Transcription factors such as Pdx1, Hnf6, ngn3, NeuroD/BETA2, Pax6 or Pax4 act within
regulatory cascades and networks of transcriptional regulations that ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

Conserved Sequences in a Tissue-Specific Regulatory Region of the pdx-1 Gene Mediate Transcription …
SE Samaras, MA Cissell, K Gerrish, CVE Wright, M … - mcb.asm.org
... FIG. 7. Pax6 binds to B8 in vitro. (A) [ 35 S]methionine was used to label
IVT Pax6, Pax4, Nkx6.1, and Hb9. The positions of the ...
Web Search - dx.doi.org - mcb.asm.org

ELSEVIER: UNCORRECTED PROOF
GG Expression - glucagon.com
... Both Pax6 and Pax4 are expressed in the endocrine pancreas and play divergent roles
in the control of cell lineage formation and proglucagon gene transcription ...
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DNA Sequence Motifs Conserved in Endocrine Promoters Are Essential for Pax4 Expression
C Brink, P Gruss - Key words, 2003 - doi.wiley.com
... transcription factors Pax4 and Pax6 are required for endocrine cell iden- tities
(Naya et al, 1997; St-Onge et al., 1997; Gradwohl et al., 2000). ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker … - Full text - MIT Libraries
HE Xu, MA Rould, W Xu, JA Epstein, RL Maas, CO … - Genes Dev, 1999 - genesdev.org
... The four groups include Pax1 and Pax9; Pax2, Pax5, and Pax8; Pax3 and Pax7;
and Pax4 and Pax6 (for review, see Stuart et al. 1994 ). ...
Cited by 61 - Web Search - uphs.upenn.edu - 128.95.44.130 - pubmedcentral.nih.gov - all 8 versions »

Isolation of full-length cDNA of mouse PAX4 gene and identification of its human homologue - Full text - MIT Libraries
H Inoue, J Nomiyama, K Nakai, A Matsutani, Y … - Biochem. Biophys. Res. Commun, 1998 - ingentaconnect.com
... homology with PAX6 (71.2%, 65.0%, respectively), another member of the PAX gene
family. However, the sequence of the C-terminal segment of PAX4 diverged and ...
Cited by 10 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Transgenic Tagging Defining Pancreatic Pedigrees - Full text - MIT Libraries
P Cancer, G Expression, E Tumors - Ann. NY Acad. Sci, 2004 - annalsnyas.org
... of both pancreatic rudiments, (3) ptf1-p48 activity is required for exocrine pancreas
differentiation, and (4) Ngn3 as well as Pax6 and Pax4 are necessary for ...
Web Search - annalsnyas.org - ncbi.nlm.nih.gov

The gene Pax4 is an essential regulator of pancreatic beta-cell development. - Full text - MIT Libraries
B Sosa-Pineda - Mol Cells, 2004 - ncbi.nlm.nih.gov
... One of these subclasses comprises two close homologues, Pax4 and Pax6, that contain
a second DNA-binding domain: the homeodomain (Dahl et al., 1997; Dohrman et ...
Cited by 1 - Web Search

Identification and expression of the lamprey Pax6 gene: evolutionary origin of the segmented brain … - Full text - MIT Libraries
Y Murakami, M Ogasawara, F Sugahara, S Hirano, N … - Development, 2001 - dev.biologists.org
... Gerber, 2000). Of those, duplication of Pax4 and Pax6 appears to date back
to the origin of metazoans (Breitling and Gerber, 2000). In ...
Cited by 21 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription - Full text - MIT Libraries
ME Hill, SL Asa, DJ Drucker - Mol Endocrinol, 1999 - mend.endojournals.org
... Intriguingly, pax4-/- mice have increased numbers of islet A cells, consistent with
a ... islets from mice with a targeted inactivation in the Pax6 gene contain ß ...
Cited by 29 - Web Search - mend.endojournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity - Full text - MIT Libraries
B Kammandel, K Chowdhury, A Stoykova, S Aparicio, … - Dev. Biol, 1999 - fbmc.fcen.uba.ar
Distinct cis-Essential Modules Direct the Time– Space Pattern of the Pax6 Gene Activity ...
Key Words: Pax6; regulatory sequence; enhancer; transgenic mouse. ...
Cited by 66 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Developmental Biology of the Pancreas
PLH Merino - Cell Biochemistry and Biophysics, 2004 - biomed.humanapress.com
... (71) Pbx1 Hypoplasia (16) Nkx2.2 Immature β-cells (72) Page 10. as well as Pax6
and Pax4, are necessary for the differentiation of islet endocrine cells. ...
Web Search - neurosci.humanapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

PAX6 mutation as a genetic factor common to aniridia and glucose intolerance - Full text - MIT Libraries
T Yasuda, Y Kajimoto, Y Fujitani, H Watada, S … - Diabetes, 2002 - diabetes.diabetesjournals.org
... and an E1A-responsive activation domain in Pax4: a possible role of Pax4 as a ... LC,
Ferrell RE, Saunders GF: Three novel aniridia mutations in the human PAX6 gene ...
Cited by 14 - Web Search - diabetes.diabetesjournals.org - ncbi.nlm.nih.gov

Regulation of pancreatic cell differentiation and morphogenesis - Full text - MIT Libraries
RK Humphrey, MS Smith, BE Tuch, A Hayek - Pediatric Diabetes, 2002 - blackwell-synergy.com
... Paired box class. The adult islet is characterized by expression of the
paired box transcription factors Pax6 and Pax4 (57, 58). ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Tissue-specific transcriptional activity of a pancreatic islet cell-specific enhancer sequence/Pax6- … - Full text - MIT Libraries
S Beimesche, A Neubauer, S Herzig, R Grzeskowiak, … - Mol Endocrinol, 1999 - mend.endojournals.org
... Pax4 expression seems to be restricted largely to ß-cells, whereas Pax6 is expressed
in mature -, ß-, -, and - endocrine cells (8). However, the role of all ...
Cited by 9 - Web Search - mend.endojournals.org - ncbi.nlm.nih.gov

The diabetes-linked transcription factor PAX4 promotes ß-cell proliferation and survival in rat and … - Full text - MIT Libraries
T Brun, I Franklin, L St-Onge, A Biason-Lauber, EJ … - The Journal of Cell Biology - jcb.org
... Antibodies generated against Pax4 and Pax6 were provided by MS German (University
of California, San Francisco, San Francisco, CA) and S. Saule (Institut Curie ...
Cited by 1 - Web Search - jcb.org - jem.org - ncbi.nlm.nih.gov

The genetic network of prototypic planarian eye regeneration is Pax6 independent - Full text - MIT Libraries
D Pineda, L Rossi, R Batistoni, A Salvetti, M … - Development, 2002 - dev.biologists.org
... The subsequent screening of a cDNA library using Pax4-6 fragment as a probe, allowed
us to isolate a second Pax6 gene, GtPax6A, in addition to the previously ...
Cited by 18 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Regulation of insulin gene transcription - Full text - MIT Libraries
D Melloul, S Marshak, E Cerasi - Diabetologia, 2002 - springerlink.com
... PAX6 and PAX4 are transcription factors that play an important role in
pancreatic development (re- viewed in [81]). Whilst PAX6 ...
Cited by 37 - Web Search - ncbi.nlm.nih.gov

Changes in the expression of transcription factors in pancreatic AR42J cells during differentiation … - Full text - MIT Libraries
YQ Zhang, H Mashima, I Kojima - Diabetes, 2001 - diabetes.diabetesjournals.org
... pmol/l HGF and 2 nmol/l activin A (H+A). mRNA expression of Pdx-1, Pax4, Pax6,
Nkx6.1, Nkx2.2, Beta-2, neurogenin3 (ngn-3), and GAPDH was mea- sured by RT-PCR. ...
Cited by 8 - Web Search - ncbi.nlm.nih.gov

Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell … - Full text - MIT Libraries
BR Gauthier, TBCB Wollheim, EJ Schoenle - Diabetologia, 2005 - springerlink.com
... The differentiation of endo- derm-derived endocrine pancreas is mediated through
Pax4 and Pax6 [6]. Inactivation of pax4 by homologous recom- bination in mice ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

Regulation of pancreatic cell differentiation and morphogenesis - Full text - MIT Libraries
A Hayek - Pediatric Diabetes, 2002 - ingentaconnect.com
... Paired box class The adult islet is characterized by expression of the
paired box transcription factors Pax6 and Pax4 (57, 58). ...
Web Search

Isolation and characterization of the human PAX4 gene - Full text - MIT Libraries
T Tao, J Wasson, E Bernal-Mizrachi, PS Behn, S … - Diabetes, 1998 - diabetes.diabetesjournals.org
... 2 . Sosa-Pineda B, Chowdhury K, Torres M, Oliver G, Gruss P: The Pax4 gene is ... 3 .
St-Onge L, Sosa-Pineda B, Chowdhury K, Mansouri A, Gruss P: Pax6 is required ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Exclusion of a disease relevant role of PAX4 in the aetiology of Silver-Russell syndrome: screening …
JM Genet - dx.doi.org
... PAX4 is a member of a highly conserved gene family, 10 and has been ... Waardenburg syndrome
types I and III; PAX5, small lymphotic lymphomas; PAX6, aniridia; PAX9 ...
Web Search - jmedgenet.com - jmg.bmjjournals.com

Role of Homeodomain Transcription Factor IPF-1 in the Pathogenesis of Diabetes mellitus
P Froguel - content.karger.com
... of defective -cell development, it is tempting to speculate that mutations in genes
encoding the transcription factors Isl-1, Beta2/NeuroD, Pax6, Pax4, Nkx 2.2 ...
Web Search - content.karger.com

Bedeutung der Homoeodomaene des Transkriptionsfaktors Pax6 fuer die Aktivierung des Glukagon-Gens …
S TEICHLER - webdoc.sub.gwdg.de
... Transkriptionsfaktors Pax6 für die Aktivierung des Glukagon-Gens durch Pax6
DISSERTATION ... von Glukagon-Promotorfragmenten durch Pax6 im heterologen Zellsystem ...
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Genetic analysis of genes found on the 4th chromosome of Drosophila-emphasizing the developmental …
J Kronhamn - publications.uu.se
... Miller also place the nine human Pax genes in four phylogenetic groups: (1) Pax1
and Pax9; (2) Pax3 and Pax7; (3) Pax4 and Pax6; (4) Pax2, Pax5 and Pax8. ...
Web Search

Regulation of the pancreatic pro-endocrine gene neurogenin3 - Full text - MIT Libraries
JC Lee, SB Smith, H Watada, J Lin, D Scheel, J … - Diabetes, 2001 - diabetes.diabetesjournals.org
... days postnatally from diabetes (6). The pancreata of the ngn3-null mice fail to
express islet transcription factors isl1, pax4, pax6, and neuroD1 (6), whereas ...
Cited by 34 - Web Search - diabetes.diabetesjournals.org - ncbi.nlm.nih.gov

Identification of DNA recognition sequences for the Pax3 paired domain - Full text - MIT Libraries
G Chalepakis, P Gruss - Gene, 1995 - ncbi.nlm.nih.gov
... Pax1 and Pax9 constitute one subfamily, Pax2, Pax5 and Pax8 another, Pax3
and Pax7 another one and Pax4 and Pax6 the fourth subfamily. ...
Cited by 19 - Web Search

A case of novel de novo paired box gene 6(PAX 6) mutation with early-onset diabetes mellitus and … - Full text - MIT Libraries
M Nishi, M Sasahara, T Shono, S Saika, Y Yamamoto, … - Diabetic Medicine, 2005 - blackwell-synergy.com
... We thought her early-onset diabetes was partly as a result of PAX6 mutation and ...
mutations in HNF-1 , -1 , -4 , IPF-1, ISL-1, BEAT2/NeuroD1, PAX4, and amylin ...
Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Fundamentals of Transcription Factors and Their Impact on Pancreatic Development and Cancer
JAKR Urrutia - Pancreatology, 2003 - content.karger.com
... subpopulation of pancreatic cells relies on the expression of a cell fate-spe- cific
set of transcription factors, including Isl-1 [26], Pax4 [28], Pax6 [65, 68 ...
Web Search - content.karger.com

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas - Full text - MIT Libraries
G Gradwohl, A Dierich, M LeMeur, F Guillemot - Developmental Biology, 2000 - dx.doi.org
... Recent genetic studies have identified a network of transcription factors, including
Pdx1, Isl1, Pax4, Pax6, NeuroD, Nkx2.2, and Hlxb9, regulating the ...
Cited by 148 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Targeted oncogenesis of hormone-negative pancreatic islet progenitor cells - Full text - MIT Libraries
TL Jetton, JM Moates, J Lindner, CVE Wright, MA … - Developmental Biology, 1998 - pnas.org
... noninsulinomas are often periductal in location, express none of the four major
islet peptide hormones, Glut-2, Pdx1, tyrosine hydroxylase, Pax4, Pax6, or Nkx6 ...
Cited by 5 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Stem cell technologies in regenerative medicine
KK Jain - Expert Opinion on Biological Therapy, 2002 - dx.doi.org
... Two genes critical for the control of pancreatic cell differentiation have been
dis- covered: Pax6 for formation of islets of Langerhans and Pax4 for β cell ...
Web Search - ashley-pub.com - ingentaconnect.com - ijp-online.com - all 8 versions »