Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity - Full text - MIT Libraries
B Kammandel, K Chowdhury, A Stoykova, S Aparicio, … - Dev. Biol, 1999 - fbmc.fcen.uba.ar
Distinct cis-Essential Modules Direct the Time– Space Pattern of the Pax6 Gene Activity ...
Key Words: Pax6; regulatory sequence; enhancer; transgenic mouse. ...
Cited by 66 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The PAX6 gene is activated by the basic helix–loop–helix transcription factor NeuroD/BETA2 - Full text - MIT Libraries
E Marsich, A Vetere, M Di Piazza, G Tell, S … - Biochem J, 2003 - bj.portlandpress.com
... and Fugu (Japanese pufferfish) revealed a sequence in the PAX6 regulatory region ...
This sequence contains potential binding sites for Pbx1, two possible motifs ...
Cited by 4 - View as HTML - Web Search - biochemj.org - biochemj.org - ncbi.nlm.nih.gov - all 5 versions »

The homeodomain Pbx2-Prep1 complex modulates hepatocyte nuclear factor 1 alpha-mediated activation … - Full text - MIT Libraries
PA Gregory, PI Mackenzie - Mol. Pharmacol, 2002 - intl-molpharm.aspetjournals.org
... The G3 enhancer element is composed of two adjacent but distinct binding domains,
A and B, which bind the Pax6 (domain A) and the Pbx1-Prep1 (domain B ...
Cited by 4 - Web Search - molpharm.aspetjournals.org - ncbi.nlm.nih.gov

Pbx genes are required in Xenopus lens development.
R MORGAN, J SOHAL, M PALEJA, R PETTENGELL - Int. J. Dev. Biol, 2004 - ijdb.ehu.es
... and Yasuda, 1998; Vogel-Hopker et al., 2000), and the combination of Pax6 , Sox2 , ...
stage Xenopus embryos and probed with an antibody raised against PBX1, 2 and ...
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Heterodimeric Pbx-Prep 1 Homeodomain Protein Binding to the Glucagon Gene Restricting Transcription … - Full text - MIT Libraries
S Herzig, L Fuezesi, W Knepel - J Biol Chem, 2000 - jbc.org
... The indicated antibodies were directed against Pax6 paired domain ( Pax6), long
Pbx isoforms 1a, 2, and 3a ( Pbx1/2/3), Prep1 ( Prep), Meis1 ( Meis1), Engrailed ...
Cited by 12 - Web Search - intl.jbc.org - jbc.org - ncbi.nlm.nih.gov

Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators
M Wilson, P Koopman - Curr Opin Genet Dev, 2002 - imb.uq.edu.au
... This indicates that SOX2 or PAX6 alone are unable to form a stable protein–DNA ... Hoxb1
and Pbx1 (a Hox cofactor) proteins are both known to bind this enhancer ...
Cited by 41 - View as HTML - Web Search - imb.uq.edu.au - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

Meis homeoproteins directly regulate Pax 6 during vertebrate lens morphogenesis - Full text - MIT Libraries
X Zhang, A Friedman, S Heaney, P Purcell, RL Maas - Genes & Development, 2002 - genesdev.org
... Sections were processed for immunohistochemistry with antibodies against Pax6
(Developmental Hybridoma Bank), AP2 , and Pbx1-3 (both from Santa Cruz). ...
Cited by 12 - Web Search - genesdev.org - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

Hop is an unusual homeobox gene that modulates cardiac development - Full text - MIT Libraries
F Chen, H Kook, R Milewski, AD Gitler, MM Lu, J Li … - Cell, 2002 - imbt.ntou.edu.tw
... Hop is most closely related to homeodomain proteins Pax6 and goosecoid, with 40%
identity and 57% ... paired and engrailed, and human PBX1 and HOX-B1, ...
Cited by 39 - View as HTML - Web Search - uphs.upenn.edu - ingentaconnect.com - all 6 versions »

Advances in islet cell biology: from stem cell differentiation to clinical transplantation: …
F KANDEEL, CV SMITH, I TODOROV, Y MULLEN - Pancreas, 2003 - pancreasjournal.com
... Pbx1 is a member of the TALE class of homeodomain transcription factors that ... 2) islet
cells derive from the cells expressing Ngn3 and Pax6, while exocrine ...
Cited by 2 - Web Search - pancreasjournal.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Hematopoietic, angiogenic and eye defects in Meis 1 mutant animals - Full text - MIT Libraries
T Hisa, SE Spence, RA Rachel, M Fujita, T Nakamura … - The EMBO Journal, 2004 - embojournal.npgjournals.com
... Three additional PBX1-related genes have since been identified (Monica et al, 1991 ...
with a recent report suggesting that MEIS1 regulates Pax6 expression during ...
Cited by 9 - Web Search - nature.com - embojournal.npgjournals.com - ncbi.nlm.nih.gov

Pancreatic transcription factors: implications for diabetes therapy. - Full text - MIT Libraries
MD Walker - Isr Med Assoc J, 2004 - ima.org.il
... some of the effects require heterodimerization with the homeodomain protein Pbx1
[10]. ... reduced islet cell number [7]. Several other factors (Pax4, Pax6, Nkx2.2 ...
View as HTML - Web Search - ncbi.nlm.nih.gov

The third helix of the homeodomain of paired class homeodomain proteins acts as a recognition helix … - Full text - MIT Libraries
JA Bruun, EIS Thomassen, K Kristiansen, G Tylden, … - Nucleic Acids Research, 2005 - nar.oxfordjournals.org
... have previously shown that Pax6 PD as well as other homeodomain proteins, such as
Rax, Chx10, HoxB1, Pbx1 and Lhx2, can enhance Pax6-mediated transactivation ...
Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of … - Full text - MIT Libraries
A Rattner, JC Hsieh, PM Smallwood, DJ Gilbert, NG … - Proc. Natl. Acad. Sci. USA, 1997 - dx.doi.org
... E. Boncinelli, P. Gruss, and A. Mallamaci Emx2 and Pax6 Control Regionalization
of ... and C. Murre Oncogenic homeodomain transcription factor E2A-Pbx1 activates a ...
Cited by 152 - Web Search - pnas.org - pubmedcentral.nih.gov - adsabs.harvard.edu - all 7 versions »

BMP4 is essential for lens induction in the mouse embryo - Full text - MIT Libraries
Y Furuta, BLM Hogan - Genes Dev, 1998 - genesdev.org
... No change in Pax6 expression is seen in Bmp4 tm1 mutant eyes, and Bmp4 expression
appears unaffected in the eyes of homozygous Pax6 Sey-1Neu , suggesting that ...
Cited by 91 - Web Search - genesdev.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Eye development: a view from the retina pigmented epithelium - Full text - MIT Libraries
JR MartınMorales, I Rodrigo, P Bovolenta - BioEssays, 2004 - doi.wiley.com
... Here, we have outlined many recent findings that suggest that a limited number of
transcription factors, including Otx2, Mitf and Pax6 and a few signalling ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

Patterning defects in the primary axonal scaffolds caused by the mutations of the extradenticle and … - Full text - MIT Libraries
T Nagao, K Endo, H Kawauchi, U Walldorf, K … - Development Genes and Evolution, 2000 - springerlink.com
... In ad- dition, expression of a Drosophila Pax6 gene, eyeless, is significantly
suppressed in the mutants except for the most anterior region. ...
Cited by 6 - Web Search - uniklinik-saarland.de - med-rz.uni-sb.de - biol.tsukuba.ac.jp - all 7 versions »

Hox regulation of normal and leukemic hematopoietic stem cells.
C Abramovich, RK Humphries - Current Opinion in Hematology, 2005 - co-hematology.com
... not show hematopoietic phenotypes, despite similarities between these genes and
Pbx1 in their ... of Meis1 to bind and activate the promoter of Pax6 and platelet ...
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Molecular Characterisation of Three Murine HOXI I-Related Homeobox Genes, Tlx-I,-2, and-3, and …
SH Cheng, TW Mak - blackwell-synergy.com
... Small eye mouse mutants have indicated that Pax-3 and Pax6 are involved ... It appears
that the translocation results in the deregulation of PBX1, which normally ...
Web Search

Transgenic Tagging Defining Pancreatic Pedigrees - Full text - MIT Libraries
P Cancer, G Expression, E Tumors - Ann. NY Acad. Sci, 2004 - annalsnyas.org
... Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes ...
Pax6 is required for differentiation of glucagon-producing alpha-cells in ...
Web Search - annalsnyas.org - ncbi.nlm.nih.gov

A duodenum-specific enhancer regulates expression along three axes in the small intestine - Full text - MIT Libraries
MR Dusing, AG Brickner, SY Lowe, MB Cohen, DA … - Am. J. Physiol. Gastrointest. Liver Physiol, 2000 - ajpgi.physiology.org
... In studies of some genes expressed in the pancreas, PDX-1 has been shown to require
other homeodomain proteins as partners (such as Pbx1 or Pax6) bound at ...
Cited by 10 - Web Search - ajpgi.physiology.org - ncbi.nlm.nih.gov

Development and diseases of the pancreas. - Full text - MIT Libraries
KA Johansson, A Grapin-Botton - Clinical Genetics, 2002 - ingentaconnect.com
... extent, a and d cells (51) and IAPP (73) PAX6 Numbers of all ... Several genes involved
in pancreas development encode proto-oncogenes (PBX1, MEIS, SHH), tumor ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov

Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and … - Full text - MIT Libraries
M Nguyen, H Arnheiter - Development, 2000 - dev.biologists.org
... needed for optic vesicle formation (Mathers et al., 1997), the lim-homeodomain protein
LHX2 (Porter et al., 1997) and the paired-domain protein PAX6 (Hill et al ...
Cited by 33 - Web Search - milkpa.idv.tw - dev.biologists.org - ncbi.nlm.nih.gov

Development and diseases of the pancreas Section Editors: Roderick R McInnes, e-mail: mcinnes@ … - Full text - MIT Libraries
KAJ andA Grapin-Botton - Clinical Genetics, 2002 - blackwell-synergy.com
... genes involved in pancreas development encode proto-oncogenes (PBX1, MEIS, SHH ... malignant
metaplastic ductal epithelium, and focal expression of Pax6 is observed ...
Web Search

Phylogenetic analyses alone are insufficient to determine whether genome duplication (s) occurred … - Full text - MIT Libraries
AC Horton, NR Mahadevan, I Ruvinsky, JJ Gibson- … - Journal of Experimental Zoology (Molecular and Developmental …, 2003 - doi.wiley.com
... Pax3/7 AF165886 PAX3 AAH08826 2 PAX7 NP___039236 Pax6 CAA11368 PAX6 AAA59962 1 ... Otx
2 Williams and Holland, 1998 PBX1/2/3/4 (AAM18882) 4 Abi-Rached et al., 2002 ...
Cited by 7 - Web Search - zoo.ufl.edu - ncbi.nlm.nih.gov

Developmental Biology of the Pancreas
PLH Merino - Cell Biochemistry and Biophysics, 2004 - biomed.humanapress.com
... (71) Pbx1 Hypoplasia (16) Nkx2.2 Immature β-cells (72) Page 10. as well as Pax6
and Pax4, are necessary for the differentiation of islet endocrine cells. ...
Web Search - neurosci.humanapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

Xpbx 1 b and Xmeis 1 b play a collaborative role in hindbrain and neural crest gene expression in … - Full text - MIT Libraries
R Maeda, A Ishimura, K Mood, EK Park, AM Buchberg, … - Proceedings of the National Academy of Sciences, 2002 - pnas.org
... mouse (39), Hth or Meis are required to retain Exd or Pbx1 in the ... Heaney, P. Purcell,
and RL Maas Meis homeoproteins directly regulate Pax6 during vertebrate ...
Cited by 9 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Original Contributions
DJ Symula, Y Zhu, JC Schimenti, EM Rubin - springerlink.com
... 1.24 0.04 differentiation 94804_at 18514 Pbx1: pre B-cell leukemia transcription
factor 1 1.18 0.01 96075_at 22388 Wdr1: WD repeat domain 1 1.19 0.05 ...
Web Search

Ectopic expression of the beta-cell specific transcription factor Pdx 1 inhibits glucagon gene … - Full text - MIT Libraries
B Ritz-Laser, BR Gauthier, A Estreicher, A Mamin, … - Diabetologia, 2003 - springerlink.com
... still repressed transcriptional activation of the glucagon gene promoter by Pax6
and Cdx-2 ... In acinar cells, Pdx1 associates with Pbx1 and Meis2 on the B element ...
Cited by 1 - Web Search - medecine.unige.ch - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

FGF signaling through FGFR 1 is required for olfactory bulb morphogenesis - Full text - MIT Libraries
JM Hebert, M Lin, J Partanen, J Rossant, SK … - Development, 2003 - dev.biologists.org
... For example, Emx2 and Pax6 are expressed in counter-gradients along the
anteroposterior (AP) axis of the cerebral cortex in mice. ...
Cited by 17 - Web Search - stanford.edu - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

The role of homeobox genes in hematopoiesis
MC Magli - Biotherapy, 1998 - ingentaconnect.com
... is also required and suffi- cient for the oncogenic potential of E2A-PBX1 [61 ... and
Aniridia can be correlated with molecular alterations of PAX2, PAX3 and PAX6. ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Septo-Optic Dysplasia and Related Malformations
MT Dattani - Hypothalamic-pituitary development: genetic and clinical …, 2001 - content.karger.com
... PAX2 (renal-coloboma syndrome), PAX3 (Waardenberg syndrome type I), PAX6 (anir-
idia ... Recent structural studies of the Pbx1 class homeodomains [78, 79] highlight ...
Cited by 2 - Web Search - content.karger.com

Transcriptional profile analysis of in vivo adult subventricular zone (SVZ) neurogenesis
DA Lim, M Suarez-Farinas, F Naef, C Hacker, B Menn … - asterion.rockefeller.edu
... or St. Transcription factors Meis1, Mrg1/Meis2, Pbx1, Pbx3, Pax6, Madh1/Smad1,
Runx2, and Dlx5 were found in this group. These transcription ...
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Fgf receptor signaling plays a role in lens induction - Full text - MIT Libraries
SC Faber, P Dimanlig, HP Makarenkova, S Shirke, K … - Development, 2001 - dev.biologists.org
... used: (1) using small-molecule inhibitors of Fgfr kinase activity, we showed that
both the transcription level and protein expression of Pax6, a transcription ...
Cited by 23 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the … - Full text - MIT Libraries
PL Pfeffer, M Bouchard, M Busslinger - Development, 2000 - dev.biologists.org
... EMSA analysis The mouse Pax2b, Pax3, Pax5, Pax6, Oct1, Otx2, Gbx2, En2 and Xenopus
HoxD1 cDNAs were cloned into the expression vector pKW2T, and proteins were ...
Cited by 21 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

FGF19-FGFR4 signaling elaborates lens induction with the FGF8-L-Maf cascade in the chick embryo - Full text - MIT Libraries
H Kurose, M Okamoto, M Shimizu, T Bito, C Marcelle … - Development Growth & Differentiation, 2005 - blackwell-synergy.com
... 2002). It is likely that transcription factors such as Pax6 and Sox2 would also ... system
is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1. ...
Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

HESX1 and Septo-Optic Dysplasia
MT Dattani, IC Robinson - Reviews in Endocrine & Metabolic Disorders, 2002 - springerlink.com
... renal- coloboma syndrome), PAX3 (Waardenberg syndrome type I), PAX6 (aniridia),
MSX1 ... Recent structural studies of the Pbx1 class homeodomains [82,83] highlight ...
Cited by 3 - Web Search - kluweronline.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Evidence for a direct functional antagonism of the selector genes proboscipedia and eyeless in … - Full text - MIT Libraries
C Benassayag, S Plaza, P Callaerts, J Clements, Y … - Development, 2003 - dev.biologists.org
... afford a sensitive and delicate measure of the balance of Pax6 level, permitting ...
a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes ...
Cited by 4 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic … - Full text - MIT Libraries
M Ishibashi, AP McMahon - Development, 2002 - dev.biologists.org
... text, Table1). (EJ) Expression patterns of Emx2, En1 and Pax6. A ... Pax6 expression
provides a third useful landmark. Pax6 is expressed ...
Cited by 22 - Web Search - note.cellbio.duke.edu - cellbio.duke.edu - ncbi.nlm.nih.gov - all 5 versions »

Development of cell markers for the identification and expansion of islet progenitor cells
YQ Zhang, N Sarvetnick - Diabetes/Metabolism Research and Reviews, 2003 - doi.wiley.com
... Tran- scription factors expressed in pancreatic progenitor cells include PDX-1,
Hlxb9 PTF1-p48 PBX1, Nkx2.2, Nkx6.1, Isl-1, Pax4, Pax6, Ngn3 and Beta2/NeuroD. ...
Cited by 7 - Web Search - joplink.net - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Progenitor cells in the adult pancreas
AM Holland, LJ Gonez, LC Harrison - Diabetes/Metabolism Research and Reviews, 2004 - doi.wiley.com
... [22] Pax6 Loss of α -cell development and disorganization of islets ... Pbx1 Multiple
developmental abnormalities including hypoplasia of foregut-endoderm-derived ...
Cited by 7 - Web Search - pi.be - ncbi.nlm.nih.gov - Get it from MIT Libraries

Meis family proteins are required for hindbrain development in the zebrafish - Full text - MIT Libraries
SK Choe, N Vlachakis, CG Sagerstrom - Development, 2002 - dev.biologists.org
... 4Q). Expression of pax6 reveals six boundaries in control embryos (Fig. ... Meis1 and
pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface ...
Cited by 12 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Expression profiling of lineage differentiation in pluripotential human embryonal carcinoma cells - Full text - MIT Libraries
J Houldsworth, SC Heath, GJ Bosl, L Studer, RS … - Cell Growth Differ, 2002 - cgd.aacrjournals.org
... differentiation program (CCND1 and MYCN), or up-regulated (CDKN1A, NEFL, PAX6, and
ANXA1 ... identified [MEIS1, MRG1, and ATBF1 (cluster E); DLX5 and PBX1 (cluster C ...
Cited by 6 - Web Search - cgd.aacrjournals.org - ncbi.nlm.nih.gov

[BOOK] Role of epidermal and fibroblast growth factors in pancreatic development
MA Pulkkinen, B Helsinki - 2003 - ethesis.helsinki.fi
... development. These belong to the homeodomain family (Pdx1, Hb9, Pbx1, HNF6,
Pax4, Pax6, Nkx2.2, Nkx6.1, Isl1, HNF1a, HNF4a, Brn4 ...
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The last common bilaterian ancestor - Full text - MIT Libraries
DH Erwin, EH Davidson - Development, 2002 - dev.biologists.org
... at the terminus of the developmental process, just as is the case of pax6. ... transcription
factors to specify proximal regions (meis1/2 and pbx1 in vertebrates ...
Cited by 37 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

The roles of an ephrin and a semaphorin in patterning cell–cell contacts in C. elegans sensory … - Full text - MIT Libraries
AC Hahn, SW Emmons - Dev. Biol, 2002 - worms.aecom.yu.edu
... ray identity genes include the Hox genes mab-5 and egl-5, the Pax6 homolog mab ... ng/
l PvuII-digested N2-genomic DNA and 2 ng/ l XhoI-digested pBX1, which carries ...
Cited by 4 - View as HTML - Web Search - worms.aecom.yu.edu - ncbi.nlm.nih.gov

Unique and combinatorial functions of Fgf 3 and Fgf 8 during zebrafish forebrain development - Full text - MIT Libraries
J Walshe, I Mason - Development, 2003 - dev.biologists.org
... using markers of the hypothalamus [shh, nk2.1b (titf1b - Zebrafish Information Network),
fgf3], ventral thalamus [nk2.1b, shh, twhh, dlx2, pax6.1 (pax6a ...
Cited by 8 - Web Search - dx.doi.org - dev.biologists.org - ncbi.nlm.nih.gov

Departement de Genetique Humaine–CNRS UMR 8090
G des Maladies Multifactorielles - mail-good.pasteur-lille.fr
... Several candidate genes have been screened (including PBX1, LMX1, RXR , PAI-I)
and ... led to the identification of a common SNP variant in a PAX6 binding site ...
View as HTML - Web Search - www-good.pasteur-lille.fr - www-good.pasteur-lille.fr - jaba.pasteur-lille.fr - all 5 versions »

The Development of Beta-cell Mass: Recent Progress and Potential Role of GLP-1 - Full text - MIT Libraries
DA Stoffers - Hormone and Metabolic Research, 2004 - thieme-connect.com
... Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes
diabetes ... Onge L, Sosa-Pineda B, Chowdhury K, Gruss P. Pax6 is required for ...
Cited by 2 - Web Search - thieme-connect.com - ncbi.nlm.nih.gov

Prep 1. 1 has essential genetic functions in hindbrain development and cranial neural crest cell … - Full text - MIT Libraries
G Deflorian, N Tiso, E Ferretti, D Meyer, F Blasi, … - Development, 2004 - dev.biologists.org
... 3T) but a pax6.1 probe revealed a strong reduction of the forebrain ... PREP1 homeodomain
might enhance the transcriptional activity of mammalian PBX1-HOXB1-PREP1 ...
Cited by 1 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Gene expression in the developing mouse retina by EST sequencing and microarray analysis - Full text - MIT Libraries
X Mu, S Zhao, R Pershad, TF Hsieh, A Scarpa, SW … - Nucleic Acids Research, 2001 - nar.oupjournals.org
... N., Scardigli,R., Guillermot,F. and Gruss,P. (2001) Pax6 is required ... nervous system
is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1. ...
Cited by 22 - Web Search - nar.oupjournals.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »