Targeted Disruption of Tgif, the Mouse Ortholog of a Human Holoprosencephaly Gene, Does Not Result …
J Shen, CA Walsh - mcb.asm.org
... Multiple modes of repression by the Smad transcriptional corepressor TGIF. ... Meis
homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis. ...
Web Search - mcb.asm.org

Mouse models of holoprosencephaly
M Hayhurst, SK McConnell - Curr Opin Neurol, 2003 - co-neurology.com
... 47], it is conceivable that Shh expression is disrupted after the mutation of TGIF. ...
later expression in the nervous system overlaps with that of Pax6, and is ...
Cited by 4 - Web Search - stanford.edu - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Meis homeoproteins directly regulate Pax 6 during vertebrate lens morphogenesis - Full text - MIT Libraries
X Zhang, A Friedman, S Heaney, P Purcell, RL Maas - Genes & Development, 2002 - genesdev.org
... 1999 ). Antisense probes were generated from cDNAs for Meis1-3 (kindly provided
by Dr. N. Copeland, NCI, Frederick), TGIF, Prep1, and Pax6. ...
Cited by 12 - Web Search - genesdev.org - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

Mechanisms of cerebral cortical patterning in mice and humans - Full text - MIT Libraries
ES Monuki, CA Walsh - Nature Neuroscience, 2001 - nature.com
... Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural ...
DD Regulation of area identity in the mammalian neocortex by Emx2 and Pax6. ...
Cited by 27 - Web Search - walshlab.org - psyweb2.ucdavis.edu - cellbio.wustl.edu - all 11 versions »

SONIC HEDGEHOG mutations causing human holoprosencephaly impair neural patterning activity - Full text - MIT Libraries
C Schell-Apacik, M Rivero, JL Knepper, E Roessler, … - Hum Genet, 2003 - springerlink.com
... 1998), SIX3 (Wallis et al. 1999), TGIF (Gripp et al. ... It also represses the expres-
sion of more dorsally expressed genes, including Pax6. ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Craniofacial anomalies of the cultured mouse embryo induced by inhibition of sonic hedgehog …
T Nagase, M Nagase, N Osumi, S Fukuda, S Nakamura, … - J. Craniofac. Surg, 2005 - jcraniofacialsurgery.com
... it awaits further investigation whether Shh signaling directly controls Pax6 expression
in ... reports indicate that other genes, such as Zic2 and TGIF, are also ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Molecular aspects of vertebrate retinal development
SS Zhang, XY Fu, CJ Barnstable - Mol. Neurobiol, 2002 - biomed.humanapress.com
... Hesx1 TF y (68) TGIF TF – (69) FGF8 GF – (17) Formation of optic cup Pax2 TF y
(70) Vax1 TF y (21) Otx1 TF y (12) Otx2 TF y (12) Pax6 TF y (3, 4) ...
Cited by 9 - Web Search - neurosci.humanapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

A genomewide survey of developmentally relevant genes in Ciona intestinalis - Full text - MIT Libraries
S Wada, M Tokuoka, E Shoguchi, K Kobayashi, A Di … - Dev Genes Evol, 2003 - springerlink.com
... Anf and Mix of the Paired class, POU-I, III, V and VI of the POU class, Lhx6/7 of
the LIM class, TGIF of the ... Pax4/6 Pax6 genewise.337.13.1 32251 P26367 Pax-6 98 ...
Cited by 22 - Web Search - ncbi.nlm.nih.gov

Six family genesÐstructure and function as transcription factors and their roles in development - Full text - MIT Libraries
K Kawakami, S Sato, H Ozaki, K Ikeda - BioEssays - doi.wiley.com
... other genes implicated in HPE, such as Shh, (33) Zic2, (34) and TGIF (35) have ... the
Six3 gene is dependent on Otx2 and is stimulated by over-expression of Pax6. ...
Cited by 55 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Homeobox genes in the developing mouse brain - Full text - MIT Libraries
JY Vollmer, RG Clerc - J Neurochem, 1998 - blackwell-synergy.com
... et al., 1990), MATa2 (Goutte and Johnson, 1988), and TGIF (Bertolino et ... of-function
Ventral inhibition of differentiation of floor plate neurons Pax6 (sey) Loss ...
Cited by 12 - Web Search - ncbi.nlm.nih.gov

Septo-Optic Dysplasia and Related Malformations
MT Dattani - Hypothalamic-pituitary development: genetic and clinical …, 2001 - content.karger.com
... PAX2 (renal-coloboma syndrome), PAX3 (Waardenberg syndrome type I), PAX6 (anir-
idia ... of holoprosencephaly – these are Sonic Hedgehog (SHH), ZIC2, TGIF and SIX3 ...
Cited by 2 - Web Search - content.karger.com

Molecular evolution of the homeodomain family of transcription factors - Full text - MIT Libraries
S Banerjee-Basu, AD Baxevanis - Nucleic Acids Research, 2001 - nar.oupjournals.org
... mouse, and ey of Drosophila are encoded by orthologs of PAX6 suggests that ... Another
atypical class member TGIF is expressed during early brain development in ...
Cited by 25 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

The developmental program of the hypothalamus and its disorders - Full text - MIT Libraries
JL Michaud - Clinical Genetics, 2001 - blackwell-synergy.com
... Shh participates in this process, at least in part, by suppressing Pax6 expression
at ... In humans, four genes, SHH [19], SIX3 [20], ZIC2 [21] and TGIF [22], have ...
Cited by 4 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Expression profiling of lineage differentiation in pluripotential human embryonal carcinoma cells - Full text - MIT Libraries
J Houldsworth, SC Heath, GJ Bosl, L Studer, RS … - Cell Growth Differ, 2002 - cgd.aacrjournals.org
... the differentiation program (CCND1 and MYCN), or up-regulated (CDKN1A, NEFL, PAX6,
and ANXA1 ... cluster O); PROX1 (cluster G); TCF2 (cluster D); and TGIF (cluster P ...
Cited by 6 - Web Search - cgd.aacrjournals.org - ncbi.nlm.nih.gov

Induction of Ectopic Olfactory Structures and Bone Morphogenetic Protein Inhibition by Rossy, a … - Full text - MIT Libraries
I Munoz-Sanjuan, AH Brivanlou - Mol Cell Biol, 2005 - mcb.asm.org
... or through recruitment of transcriptional corepressors (such as Ski, SnoN, and TGIF
[49, 55 ... and NRP-1 and of the anterior neural markers Otx1/2, Pax6, Six3, and ...
Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov

The structure and function of genes causing human holoprosencephaly
G Pediatrics - Gene Funct. Dis, 2000 - doi.wiley.com
... 11,32,34] or for that matter with other HPE genes such as SIX3 or TGIF [35,38 ... of
eya and so are regulated by the eyeless gene [140] which is related to Pax6 . ...
Web Search

Status of the Human Malformation Map: 2002
JC CAREY, DH VISKOCHIL - American Journal of Medical Genetics (Semin. Med. Genet.), 2002 - doi.wiley.com
... Aniridia 106210 106210 11p13 PAX6 Paired box homeotic gene-6 ... Holoprosencephaly-
4 142946 602630 18p11 TGIF TG-interacting factor ...
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Molecular characterization of a familial translocation implicates disruption of HDAC9 and possible … - Full text - MIT Libraries
D David, J Cardoso, B Marques, R Marques, ED Silva … - Genomics, 2003 - insarj.pt
... The PAX6 gene, which is a member of the paired box–containing PAX family of de-
velopmental genes, was implicated in inherited anterior- segment anomalies ...
Cited by 4 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Central Nervous System Embryogenesis and Its Failures - Full text - MIT Libraries
FL Lacbawan, M Muenke - Pediatric and Developmental Pathology, 2002 - springerlink.com
... It also represses properties of the distal optic vesicles (such as expression
of the genes Pax6 and ET) [24–26]. Conversely, loss ...
Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Heterozygous Mutations of OTX2 Cause Severe Ocular Malformations. - Full text - MIT Libraries
NK Ragge, AG Brown, CM Poloschek, B Lorenz, RA … - Am. J. Hum. Genet, 2005 - journals.uchicago.edu
... scans and neuropsychometric testing might be informative, as shown for PAX6 (Sisodiya
et ... individuals carry mutations in two HPE genes (SHH with TGIF [MIM 602630 ...
Web Search - ncbi.nlm.nih.gov

Original Research Report
ESC Differentiation - dx.doi.org
... LASP1; LLGL2; MILD1; MSX1; MSX2; NEUROG1; NKX2B; NSPC1; OLIG2; PAX6; PKNOX1; POU3F2 ...
SOX13; SOX17; SOX18; SOX2; SOX20; SOX3; SOX4; SOX5; SOX6; TGIF; TGIF2; weak ...
Web Search - liebertonline.com - liebertonline.com

Use of targeted array-based CGH for the clinical diagnosis of chromosomal imbalance: Is less more? - Full text - MIT Libraries
BA Bejjani, R Saleki, BC Ballif, EA Rorem, K … - American Journal of Medical Genetics Part A, 2005 - doi.wiley.com
... 3 DiGeorge II DGSII 10p13 Beckwith–Wiedemann IGF2 11p15.5 WAGR PAX6, WT1 11p13 ... SMS
17p11.2 Neurofibromatosis I NF1 17q11.2 Holoprosencephaly 4 TGIF 18p11.3 ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M 3 pharynx motoneuron … - Full text - MIT Libraries
G Aspock, G Ruvkun, TR Burglin - Development, 2003 - dev.biologists.org
... Regulation of area identity in the mammalian neocortex by Emx2 and Pax6. ... Analysis
of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a ...
Cited by 1 - Web Search - dx.doi.org - dev.biologists.org - ncbi.nlm.nih.gov

Prep 1. 1 has essential genetic functions in hindbrain development and cranial neural crest cell … - Full text - MIT Libraries
G Deflorian, N Tiso, E Ferretti, D Meyer, F Blasi, … - Development, 2004 - dev.biologists.org
... was affected severely, as revealed by either loss or defective expression of several
hindbrain markers (foxb1.2/mariposa, krox20, pax2.1 and pax6.1), including ...
Cited by 1 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Genetische Analyse von Conductin durch zielgerichtete Mutagenese in der Maus
BA Jerchow, PDM Linscheid - edoc.hu-berlin.de
Page 1. Institut für Biologie DISSERTATION Genetische Analyse von Conductin durch
zielgerichtete Mutagenese in der Maus zur Erlangung des akademischen Grades ...
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Transcriptional regulation by the MAP kinase signaling cascades - Full text - MIT Libraries
SH Yang, AD Sharrocks, AJ Whitmarsh - Gene, 2003 - www-unix.oit.umass.edu
... HSF-1 ERK, JNK 65, 66 Pax6, TBP ERK, p38 67–69 p53, SMAD3 ... p65 (NFnB) MSK 77 Coregulatory
proteins CBP, p300, SRC-1, GRIP-1, PBP, AIB1, TGIF ERK 77–84 PGC-1 ...
Cited by 48 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Animal models for human contiguous gene syndromes and other genomic disorders - Full text - MIT Libraries
K Walz, P Fonseca, JR Lupski - Genetics and Molecular Biology, 2004 - scielo.br
... tissue-specific targeted mutagenesis (Ashery-Padan et al., 2000); Pax6 transgenesis
(Schedl ... Holoprosencephaly 4 (HPE4) del(18)(p11.3) 142946 TGIF Not available ...
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and Neurogenesis
OOF NERVOUS - eohsi.rutgers.edu
Page 1. 1.3. Neural Development and Neurogenesis 33 E MANUEL D I C ICCO
-B LOOM , MD, AND M ARIANN S ONDELL , P H .D. The diverse ...
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Homeodomain revisited: a lesson from disease-causing mutations - Full text - MIT Libraries
YI Chi - Human Genetics, 2005 - springerlink.com
... Holoprosencephaly TGIF 602630 Homeodomain (35–97) P63R R90C PS/DB DB ... Coloboma of
optic nerve PAX6 607108 Pairedbox-homeodomain (210–269) F258S PS ...
Web Search - ncbi.nlm.nih.gov

Microarray analysis of gene expression in human donor sclera - Full text - MIT Libraries
TL Young, GS Scavello, PC Paluru, JD Choi, EF … - Mol Vis, 2004 - molvis.org
Page 1. Molecular Vision 2004; 10:163-76 <http://www.molvis.org/molvis/v10/a22>
Received 3 October 2003 | Accepted 16 March 2004 | Published 22 March 2004 ...
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Author Index—Volume 13, 2002
DIO CDC42BPB, JAG EIF - springerlink.com
... 3 homology block encodes a potentially functional testis-specific TGIF-like retroposon ...
V.: Characterization of a novel gene adjacent to PAX6, revealing synteny ...
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Mechanisms of non-Mendelian inheritance in genetic disease - Full text - MIT Libraries
V van Heyningen, PL Yeyati - Human Molecular Genetics, 2004 - hmg.oupjournals.org
... A number of causative genes have been identified, with SHH, ZIC2, SIX3 and TGIF
most frequently involved, but only 20% of HPE cases have revealed mutations in ...
Cited by 1 - Web Search - hmg.oupjournals.org - ncbi.nlm.nih.gov

The Iroquois family of genes: from body building to neural patterning - Full text - MIT Libraries
F Cavodeassi, J Modolell, JL Gomez-Skarmeta - Development, 2001 - dev.biologists.org
... Pax6, Pax7, Dbx1, Dbx2, Irx3, Nkx6.1 and Nkx2.2 are expressed in ... Analysis of TALE
superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel ...
Cited by 25 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Limb anomalies and craniofacial syndromes II. Gene regulation of morphogenetic and dysmorphogenetic …
FN Synodinos, MJ Papagrigorakis - grortho.gr
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59 ∞ӈ̷ϛ˜ ÙˆÓ ¿ÎÚˆÓ Î·È Û‡Ó‰ÚÔÌ· ÙÔ ...
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Hox Genes and Their Candidate Downstream Targets in the Developing Central Nervous System
ZN Akin, AJ Nazarali - springerlink.com
Page 1. Cellular and Molecular Neurobiology, Vol. 25, Nos. 3/4, June 2005 (
C 2005) DOI: 10.1007/s10571-005-3971-9 Hox Genes and ...
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Retinoic acid signaling in the brain marks formation of optic projections, maturation of the dorsal … - Full text - MIT Libraries
T Luo, E Wagner, F Gruen, UC Draeger - The Journal of Comparative Neurology, 2004 - doi.wiley.com
Page 1. Retinoic Acid Signaling in the Brain Marks Formation of Optic Projections,
Maturation of the Dorsal Telencephalon, and Function of Limbic Sites ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

Concerted and Birth-and-Death Evolution of Multigene Families' - Full text - MIT Libraries
M Nei, AP Rooney - Annu Rev Genet, 2004 - bio.psu.edu
Page 1. ANRV260-GE39-07 ARI 22 June 2005 22:15 R E V IE W S I N A DV A N C E
Concerted and Birth-and-Death Evolution of Multigene Families ∗ ...
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The Evolution of Transcriptional Regulation in Eukaryotes - Full text - MIT Libraries
GA Wray, MW Hahn, E Abouheif, JP Balhoff, M Pizer, … - Molecular Biology and Evolution, 2003 - mbe.oupjournals.org
... 3–7, 10, and 11 are required to produce the seven embryonic stripes of eve
transcription; K: modules 1 and 4 are required for transcription of PAX6 in the ...
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EVOLUTION OF TWO GENE FAMILIES
MBOXG FAMILY, HG FAMILY - etda.libraries.psu.edu
Page 1. The Pennsylvania State University The Graduate School Eberly College of
Science EVOLUTION OF TWO GENE FAMILIES CONTROLLING THE FUNDAMENTAL PROCESSES OF ...
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