Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice - Full text - MIT Libraries
JJ Moskow, F Bullrich, K Huebner, IO Daar, AM … - Mol. Cell. Biol, 1995 - mcb.asm.org
... Meis1, a PBX1-Related Homeobox Gene Involved in Myeloid ... integration may also be involved
in neoplastic disease in humans, as in the case of Evi1, making murine ...
Cited by 96 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Recurrent chromosomal translocations and fusion genes in leukemia-lymphoma cell lines
HG Drexler, RAF MacLeod, A Borkhardt, JWG Janssen - Leukemia, 1995 - ncbi.nlm.nih.gov
... Cultured. Gene Symbols: ALK; AML-1; BCL1; BCL2; BCL6; BLC3; E2A; EAP; EVI1; HOX11;
IL3; LCK; LYL1; LYT10; MDS; MTCP1; MYC; PBX1; RCK; SIS; TAL1; TAL2; TAN1; TTG11 ...
Cited by 40 - Web Search - Get it from MIT Libraries

Molecular biology of leukemia and lymphoma
AT Look, JR Dowing - Rev Invest Clin, 1994 - ncbi.nlm.nih.gov
... Gene Symbols: AF4; ALL1; E2A; ENL; ETO; EVI1; FEL; HLF; HOX11; HRX; LY1; MLL; MYC;
PBM1; PBX1; PLZF-RAR; PML-RAR; RHOMB1; RHOMB2; SCL; TAL1; TAL2; TCL5; TTG1; TTG2 ...
Cited by 1 - Web Search - Get it from MIT Libraries

Chromosomal Translocations in Hematologic Malignancies
CG Brunstein, SJ Dylla, CM Verfaillie - Current Genomics, 2002 - ingentaconnect.com
... Furthermore, PBX1, a homeodomain protein, has no transforming capacity on its own;
however, when overexpressed with HOXB4 or HOXB3, it enhances the cell ... PBX1 ...
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Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute …
JJ van Dongen, EA Macintyre, JA Gabert, E … - Leukemia, 1999 - nature.com
... A total of nine well-defined chromosome aberrations with fusion gene transcripts
were selected: t(1;19) with E2A-PBX1 , t(4;11) with MLL-AF4 , t(8;21) with AML1 ...
Cited by 213 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

THE AML1 GENE: A TRANSCRIPTION FACTOR INVOLVED IN THE PATHOGENESIS OF MYELOID AND LYMPHOID LEUKEMIAS - Full text - MIT Libraries
FL Coco, S Pisegna, D Diverio - Haematologica, 1997 - haematologica.org
... In this abnormality, three distinct genes EVI1, EAP, MDS1 located on chromosome
band ... of these molecular lesions include the BCR/ABL, PML/RAR , E2A/PBX1, ALL/AF4 ...
Cited by 20 - View as HTML - Web Search - haematologica.org - haematologica.it - ncbi.nlm.nih.gov - all 6 versions »

Estrogen-regulated Conditional Oncoproteins: Tools to Address Open Questions in Normal Myeloid Cell …
DB Sykes, MP Kamps - Leukemia & Lymphoma, 2003 - dx.doi.org
... GM and Ren, R. (2001) “Cooperation of BCR-ABL and AML1/MDS1/EVI1 in blocking ... [30]
Kamps, MP and Wright, DD (1994) “Oncoprotein E2A-Pbx1 immortalizes a ...
Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

DETECTION OF MINIMAL RESIDUAL DISEASE IN ACUTE LEUKEMIA
C Karyotyping, CC Techniques - ishapd.org
... B-lineage ALL t(9;22)(q34;q11) BCR-ABL 15-25 3-5 t(1;19)(q23;p13.3) E2A-PBX1
3-5 5-6 ... inv(16)(p13q22) CBFb-MYHII 3 8-15 inv(3)(q21q26) EVI1 1 < 1 ...
View as HTML - Web Search - haem.nus.edu.sg

The role of TEL fusion genes in pediatric leukemias
JE Rubnitz, CH Pui, JR Downing - Leukemia, 1999 - nature.com
... 2 Several molecular genetic abnor- malities, including the E2A-PBX1, BCR-ABL and
MLL-AF4 ... 46,47 inv(16) (CBF - MYH11), 48 and the t(3;21) (AML1-EVI1) 49–51 ...
Cited by 45 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Blood First Edition Paper, prepublished online August 1, 2002; DOI 10.1182/blood-2002-04-1244
W Count - bloodjournal.org
... translocation which results in a fusion between the AML1, MDS1, and EVI1 genes ... a
typical t(1;19) involving the E2a-PBX1 fusion oncoprotein and a Philadelphia ...
Web Search

Cytogenetics and molecular genetics of childhood leukemia
SK Ma, TSK Wan, LC Chan - Hematological Oncology, 1999 - doi.wiley.com
... t(12;21)(p13;q22) TEL-AML1 B 20±25 t(9;22)(q34;q11) BCR-ABL B 4
t(1;19)(q23;p13) PBX1-E2A B 5 ... t(3;21)(q26;q22) EVI1-AML1 1±2 AML ...
Cited by 15 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Fusion of ETV6 to the caudal-related homeobox gene CDX2 in acute myeloid leukemia with the t (12; 13 … - Full text - MIT Libraries
A Chase, A Reiter, L Burci, G Cazzaniga, A Biondi, … - Blood, 1999 - bloodjournal.org
... that the function of ETV6 in these cases was to drive the inappropriate expression
of MDS1/EVI1. ... T-cell receptor by the t(10;14) in T-ALL 41 and PBX1 is fused ...
Cited by 45 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Prevalence estimates of recurrent balanced cytogenetic aberrations and gene fusions in unselected …
F Mitelman, F Mertens, B Johansson - GENES, CHROMOSOMES & CANCER, 2005 - doi.wiley.com
Page 1. Prevalence Estimates of Recurrent Balanced Cytogenetic Aberrations and
Gene Fusions in Unselected Patients with Neoplastic Disorders ...
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Oncogenic interaction between BCR-ABL and NUP98-HOXA9 demonstrated by the use of an in vitro purging … - Full text - MIT Libraries
N Mayotte, DC Roy, J Yao, E Kroon, G Sauvageau - Blood, 2002 - bloodjournal.org
... translocation, which results in a fusion between the AML1, MDS1, and EVI1 genes
25 ... leukemia with a typical t(1;19) involving the E2a-PBX1 fusion oncoprotein ...
Cited by 6 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov

A comparative analysis of relative occurrence of transcription factor binding sites in vertebrate … - Full text - MIT Libraries
M Stepanova, T Tiazhelova, M Skoblov, A Baranova - Bioinformatics, 2005 - bioinformatics.oxfordjournals.org
... Dang et al., 2000), which may bind to vertebrate SP1 and EVI1 sites with low ... The
same is true for homeobox-containing transcription factor PBX1 with its core ...
Web Search - bioinformatics.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 7 versions »

Multiplex reverse transcription-polymerase chain reaction for simultaneous screening of 29 … - Full text - MIT Libraries
N Pallisgaard, P Hokland, DC Riishoj, B Pedersen, … - Blood, 1998 - bloodjournal.org
... PBX1 (1q23) E2A/PBX1 (1a) R3A 403 ALL 39 ... MLF1 (3q25.1) t(3;21)(q26;q22) AML1
(21q22) AML1ex5/MDS1/(EVI1) R4B 446 SKH1§ CML-BC, AML, MDS 43-45 ...
Cited by 60 - Web Search - bloodjournal.org - bloodjournal.org - ncbi.nlm.nih.gov - all 5 versions »

A statistical analysis of the TRANSFAC database.
GB Fogel, DG Weekes, G Varga, ER Dow, AM Craven, … - Biosystems, 2005 - natural-selection.com
... EVI1 06 Ectopic viral integration site 1 encoded factor Core should be ACAAGAT not
AGAT ... PBX1 02 Homeo domain factor Pbx-1 Core should be CAATC not CAAT ...
View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Sox4 blocks cytokine-induced differentiation of 32Dcl3 cells and is a possible cooperating partner …
KE Boyd, A Poholek, O Mironenko, NG Copeland, NA … - yalepath.org
... Myeloid leukemias arising in AKXD23 mice contain proviral insertions at Evi1, which ...
Evi1 can induce leukemia, arguing that cooperating events are necessary. ...
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12p abnormalities and the TEL gene (ETV6) in childhood acute lymphoblastic leukemia - Full text - MIT Libraries
SC Raimondi, SA Shurtleff, JR Downing, J Rubnitz, … - Blood, 1997 - bloodjournal.org
... of translocations, and fusion transcripts have been identified for ETV6-MDS1/EVI1,
t(3 ... Patient 56, who had the t(1; 19) [E2A-PBX1 fusion], had normal ETV6 genes ...
Cited by 29 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

acquises de la cellule souche hematopoietique ou d’un precurseur deja commis vers les lignees …
S YNTHESE - MEDECINE/SCIENCES, 2003 - ist.inserm.fr
... q22) AML1 (21q22) Sous-unité CBFα du CBF LAM secondaires EVI1 (3q26) Protéine ... 19p13)
Facteur de transcription de type bHLH LAL pré-B PBX1 (1q23) Facteur de ...
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CONSEQUENCES OF CHROMOSOMAL ABNORMALITIES IN TUMOR DEVELOPMENT - Full text - MIT Libraries
I Sanchez-Garcia - Annual Review of Genetics, 1997 - dx.doi.org
... Studies carried out with AML1-ETO (68), AML1-EVI1 (87), and CBFB-MYHI1 (77) suggest ...
homeodomain proteins such as HOX11 in T-ALL (54, 64, 79) or PBX1, which can ...
Cited by 25 - Web Search - wwwlib.bionet.nsc.ru - genet.annualreviews.org - ncbi.nlm.nih.gov - all 6 versions »

Evidence for position effects as a variant ETV6-mediated leukemogenic mechanism in myeloid leukemias … - Full text - MIT Libraries
J Cools, N Mentens, MD Odero, P Peeters, I … - Blood, 2002 - bloodjournal.org
... mechanism is less common in myeloid leukemias, although some examples, such as the
inv (3)(q21q26) with RPN1-mediated ectopic expression of EVI1, have been ...
Cited by 13 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Molecular genetics in acute and chronic leukemias - Full text - MIT Libraries
T Burmeister, E Thiel - Journal of Cancer Research and Clinical Oncology, 2001 - springerlink.com
... AML 1/EAP, AML1/MDS1, AML1/EVI1 t(8;21)(q22;q22) and t(12;21)(p13;q22): favorable
prognosis ... 1984), rarely found in adults E2A/PBX1: PBX1 on 19p13: DNA-binding ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

Pathogenese und Biologie der Leukaemien - Full text - MIT Libraries
M Feuring-Buske, W Hiddemann, C Buske - Der Internist, 2002 - springerlink.com
... t(8;21)(q22;q22) AML1 Transkriptionsfaktor ETO Wahrscheinlich Transkriptionsfaktor
t(3;21)(q26;q22) AML1 Transkriptionsfaktor EVI1 Transkriptionsfaktor t(3;21 ...
Web Search

Translocations, fusion genes, and acute leukemia - Full text - MIT Libraries
V Saha, BD Young, PS Freemont - Journal of Cellular Biochemistry, 1998 - doi.wiley.com
... hCDCrel 22q11.2 CRE-like element Unknown AML E2A partners 19p13.3 TA, LH bHLH PBX1
1q23 HD Unknown ALL HLF 17q22 LZ Unknown ALL ... AML EAP/EVI1 3q26 ZF AML ...
Cited by 16 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t (12; 13 … - Full text - MIT Libraries
VPS Rawat, M Cusan, A Deshpande, W Hiddemann, L … - Proc Natl Acad Sci US A, 2004 - pubmedcentral.nih.gov
... a Cdx2 mutant with an inactivating mutation in the putative PBX1-interacting motif ...
ETV6, in which expression of the putative protooncogene EVI1 is activated by ...
Cited by 6 - Web Search - dx.doi.org - intl.pnas.org - pnas.org - all 8 versions »

Leucemias agudas. Impacto del diagnostico citogenetico en el resultado
I Slavutsky - sam.org.ar
... A nivel de 3q26 se iden- tificó el gen EVI1, cuya desregulación parecería afectar
la ... gen E2A, que mapea a nivel de 19 p13, con el gen PBX1, localizado en ...
View as HTML - Web Search

Sequence analysis of porcine endogenous retrovirus long terminal repeats and identification of … - Full text - MIT Libraries
CA Wilson, S Laeeq, A Ritzhaupt, W Colon-Moran, FK … - J Virol, 2003 - jvi.asm.org
... The Pbx1 binding site is present only in the PERV-C, PERV-NIH, and PERV-NIH ... binding
sites include those for the transcription factors SOX5, Ets-1, Evi1, GATA, v ...
Cited by 6 - Web Search - pubmedcentral.nih.gov - jvi.asm.org - ncbi.nlm.nih.gov

Gene Expression Profiling of Adult Acute Myeloid Leukemia Identifies Novel Biologic Clusters for …
CS Wilson, GS Davidson, SB Martin, E Andries, Y Xu … - hsc.unm.edu
... tyrosine kinase (FLT3), Wilms tumor (WT1), EVI1, RAS, and CEBPA in AML have been ...
Additional genes of interest are PBX1 and serine/threonine protein kinase 17A ...
View as HTML - Web Search - hsc.unm.edu

Molekulargenetik - Full text - MIT Libraries
T Burmeister, J Maurer, E Thiel - Der Onkologe, 1998 - springerlink.com
... II-Inhibitoren [30] entstehen verschiedene Fusionsgene: AML1/EAP,AML1/MDS1,AML1/
EVI1 ... 19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences ...
Web Search

The genes encoding the peripheral cannibinoid receptor and·-l-fucosidase are located near a newly … - Full text - MIT Libraries
P Valk, S Hol, Y Vankan, J Ihle, D Akew, N Jenkins … - J Virol - jvi.asm.org
... These VISs are frequently designated eco- tropic VISs (Evi1 to Evi10), although
other names have been used as well (4, 9, 30, 31, 34, 37, 41). ...
Cited by 1 - Web Search

Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, … - Full text - MIT Libraries
PJ Valk, Y Vankan, M Joosten, NA Jenkins, NG … - J Virol, 1999 - jvi.asm.org
... Activation of EVI1 gene expression in human acute myelogenous leukemias by
translocations ... Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in ...
Cited by 15 - Web Search - pubmedcentral.nih.gov - jvi.asm.org - ncbi.nlm.nih.gov

Oncogenes et leucemies: historique et perspectives
S Gisselbrecht, BG Roussy - M e decine et Science, 2003 - erudit.org
... domaine de fixation à l’ADN de la protéine à homéodomaine PBX1 alors que ... 14Dans les
leucémies myéloïdes, le gène EVI1 est surexprimé dans de rares ...
Cited by 2 - Cached - Web Search

PREPOZNAVANJE ZNAČILNIH KROMOSOMSKIH
PZR KOMPLETOM mD, HVPRIBZ LEVKEMIJO - vestnik.szd.si
... AF4(4q21) PBX1(1q23) t(11;19) (q23;p13.3) MLL1(11q23) ... t(3;21) (q26;q22) AML1(21q22)
TAL1(40kb deletion) SIL1(1p34) T-ALL (10–30%) EVI1(3q26)/MDS1(3q26) ...
View as HTML - Web Search - vestnik.szd.si

Side effects of retroviral gene transfer into hematopoietic stem cells - Full text - MIT Libraries
C Baum, J Dullmann, Z Li, B Fehse, J Meyer, DA … - Blood, 2003 - bloodjournal.org
... Importantly, activation of HOXB4-interacting partners such as PBX1 (possibly by ...
association with retroviral insertional up-regulation of Evi1 in hematopoietic ...
Cited by 71 - Web Search - viro.med.uni-erlangen.de - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Molecular signatures of self-renewal, differentiation, and lineage choice in multipotential … - Full text - MIT Libraries
L Bruno, R Hoffmann, F McBlane, J Brown, R Gupta, … - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... are present in these clusters, including Raf1, ETS2 (a homolog of EVI1), EVI5, LRF1 ...
as a regulator of SCL (9). The expression of the homeoprotein PBX1 and its ...
Cited by 4 - Web Search - mcb.asm.org - ncbi.nlm.nih.gov

[CITATION] MEDICAL PROGRESS
C LEUKEMIAS, R Factors - THE NEW ENGLAND JOURNAL OF MEDICINE, 1995
... Acute lymphoblastic leukemia t(1;19)(q23;p13.3) 5 or 6 E2A-PBX1 fusion Pre–B-cell ...
inv(3)(q21q26) or 1 EVI1 activation Thrombocytosis, abnormal platelets ...
Web Search - indianpediatrics.net - indianpediatrics.net - Get it from MIT Libraries

Abnormalities of the ETV 6 gene occur in the majority of patients with aberrations of the short arm …
HE O’Connor, TA Butler, R Clark, S Swanton, CJ … - Leukemia, 1998 - nature.com
... cloned by rapid amplifi- cation of cDNA ends (RACE-PCR) have described fusions in
which exons 1, or exons 1 and 2 of ETV6, were fused to the EVI1 gene on ...
Cited by 16 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Inaugural-Dissertation zur Erlangung des Doktorgrades der Naturwissenschaftlichen Fakultaet der …
U Fuchs - deposit.ddb.de
Page 1. Charakterisierung der 11q23/MLL-Fusionspartnergene GRAF und FBP17
Inaugural-Dissertation zur Erlangung des Doktorgrades der ...
Web Search - bibl7.hrz.uni-giessen.de - geb.uni-giessen.de - bibd.uni-giessen.de

Molecular genetic analysis of haematological malignancies: I. Acute leukaemias and … - Full text - MIT Libraries
AJ BENCH, WN ERBER, MA SCOTT - Clinical & Laboratory Haematology, 2005 - blackwell-synergy.com
... beneficial. E2A-PBX1 [t(1;19)]. Unbalanced or balanced t(1;19) translocations
give rise to the E2A-PBX1 fusion oncogene (Hunger, 1996). ...
Web Search - ncbi.nlm.nih.gov

CHROMATIN MODIFICATION, LEUKAEMIA AND IMPLICATIONS FOR THERAPY - Full text - MIT Libraries
EIINP MODIFICATION - British Journal of Haematology, 2002 - ingentaconnect.com
... ETO ZF Amann et al (2001) EAP/EVI1 PR Huang et al (1998); Chakraborty et al
(2001); Vinatzer et al (2001) ... PBX1 HD de La Fuente et al (2000) ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov

De la cytogenetique a la cytogenomique des tumeurs: le point en 2004
A Bernheim, JL Huret, M Guillaud-Bataille, O … - Bull Cancer, 2004 - john-libbey-eurotext.fr
... Leucémies aiguës lymphoblastiques LAL L1/L2 Pre-B t(1;19)(q23;p13) PBX1-TCF3 ... LAM,
myélodysplasies t(3;3)(q21;q26) RPN1-EVI1 ou inv(3)(q21;q26) ou ins(3;3 ...
View as HTML - Web Search - john-libbey-eurotext.fr

CLUB ESPANOL DE CITOLOGIA HEMATOLOGICA: EL LINFOBLASTO EN EL CONTEXTO
A DE LA LEUCEMIA LINFOBLASTICA - db2.doyma.es
Page 1. CLUB ESPAÑOL DE CITOLOGÍA HEMATOLÓGICA: EL LINFOBLASTO EN EL CONTEXTO DE
LA LEUCEMIA LINFOBLÁSTICA AGUDA C OORDINADORAS : M.ªC. J IMÉNEZ . ...
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The MN1-TEL fusion protein, encoded by the translocation (12; 22)(p13; q11) in myeloid leukemia, is … - Full text - MIT Libraries
A Buijs, L van Rompaey, AC Molijn, JN Davis, AC … - Mol Cell Biol, 2000 - mcb.asm.org
... fusions with transcription factors such as AML1, MDS1 (or EVI1), and CDX2 (9 ... differences
have been reported for the two alternative E2A-PBX1 chimeric proteins ...
Cited by 22 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Protection and selection for gene therapy in the hematopoietic system - Full text - MIT Libraries
MD Milsom, LJ Fairbairn - The Journal of Gene Medicine, 2004 - doi.wiley.com
Page 1. THE JOURNAL OF GENE MEDICINE REVIEW ARTICLE J Gene Med 2004; 6: 133–146.
Published online in Wiley InterScience (www.interscience.wiley.com). ...
Web Search - angt.net - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Appearance of leukemia in peripheral blood
A Neutropenia, B Anemia, C Thrombocytopenia, C Mac - bloodjournal.org
... Myelomonocytic leukemia. BXH-2 mice. Retroviral transduction with AML1-MDS1-EVI1
fusion. Monocytic leukemia. Retroviral transduction with MLL-ELL fusion. ...
Web Search

Large-scale identification of disease genes involved in acute myeloid leukemia - Full text - MIT Libraries
SJ Erkeland, M Valkhof, C Heijmans-Antonissen, A … - J. Virol, 2004 - pubmedcentral.nih.gov
... Phenotyping of Evi1, Evi11/Cb2, and Evi12 transformed leukemias isolated from a
novel ... Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid ...
Cited by 4 - Web Search - jvi.asm.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Production of high-titer helper-free retroviruses by transient transfection - Full text - MIT Libraries
WS PEAR, GP NOLAN, ML SCOTT, D BALTIMORE - Proc. Nat. Acad. Sci, 1993 - pnas.org
... Home page, Blood Home page I. Nishikata, H. Sasaki, M. Iga, Y. Tateno, S. Imayoshi,
N. Asou, T. Nakamura, and K. Morishita A novel EVI1 gene family, MEL1 ...
Cited by 1223 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - adsabs.harvard.edu - all 5 versions »

Animal models of acute myelogenous leukaemia– development, application and future perspectives
E Mc Cormack, O Bruserud, BT Gjertsen - Leukemia, 2005 - nature.com
... Subsequently, cotransduction and transplantation of doubly BCR/ABL-AML1/MDS1/EVI1,
446 Hoxa9-Meis1 447 and Hoxa9-E2A/Pbx1 448 transfected cells into syngeneic ...
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6 RECURRING CHROMOSOME REARRANGEMENTS IN HUMAN CANCER
OI Olopade, OM Sobulo, JD Rowley - cancer.org
... crisis. The genes cloned at this translocation breakpoint have been AML1,
on band 21q22 fused to EVI1, EAP, or MDS1 on band 3q26. ...
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