Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide- … - Full text - MIT Libraries
Q Lu, MP Kamps - Mol. Cell. Biol, 1996 - mcb.asm.org
... Binding studies with chimeric HoxA5-Pbx1 fusion proteins suggest that the homeodomains
of Pbx1 and HoxA5 are docked on the representative element, TTGATTGAT ...
Cited by 52 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Constitutive HOXA5 expression inhibits erythropoiesis and increases myelopoiesis from human … - Full text - MIT Libraries
GM Crooks, J Fuller, D Petersen, P Izadi, P Malik, … - Blood, 1999 - bloodjournal.org
... 35. Lobe C: Activation of Hox gene expression by Hoxa5. ... Lu Q, Knoepfler P, Scheele
J, Wright DD, Kamps MP: Both Pbx1 and E2APbx1 bind the DNA motif ATCAATCAA ...
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Estrogen-dependent E2a/Pbx1 myeloid cell lines exhibit conditional differentiation that can be … - Full text - MIT Libraries
DB Sykes, MP Kamps - Blood, 2001 - bloodjournal.org
... E2a/Pbx1 arrests myeloid differentiation in a DNA binding-dependent manner ... are
implicated in myeloid differentiation, 33 no expression of Hoxa5, Hoxa7, or Hoxa9 ...
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Rapid Generation of de novo Biological Pathways from Large-Scale Gene Expression Data Using the …
DC Siu - ingenuity.com
... HOXA5, PBX1, HOXB7, HOXC8, PKNOX1, ISL1, NEUROG3, SST, COL5A2, REN, HOXB6, HOXB1,
COL1A1 FOS Ras, Erk, NADPH Oxidase, IFNGR1, IFNGR2, Erk1/2, CD3Z ...
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A Conserved C-terminal Domain in PBX Increases DNA Binding by the PBX Homeodomain and Is Not a … - Full text - MIT Libraries
NC Green, I Rambaldi, J Teakles, MS Featherstone - J Biol Chem, 1998 - jbc.org
... PBX 233-319 and 233-294 are derived from wild-type PBX1. ... The second model is supported
by data showing that HOXA5 can weakly interact with the isolated ...
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Homeobox genes and gut development - Full text - MIT Libraries
F Beck, F Tata, K Chawengsaksophak - BioEssays, 2000 - doi.wiley.com
... Hoxa5 (23) Hoxc5 (23) hi ... gut morphology cannot easily be explained by reference to
the normal expression of the wild-type gene or to the Pbx1 transgene driven ...
Cited by 33 - Web Search - dx.doi.org - gutjnl.com - gut.bmjjournals.com - all 8 versions »

Cellular proliferation and transformation induced by HOXB 4 and HOXB 3 proteins involves cooperation … - Full text - MIT Libraries
J Krosl, S Baban, G Krosl, S Rozenfeld, C Largman, … - Oncogene, 1998 - nature.com
... homolog) and extradenticle (exd, a homolog of PBX1) (Sun et al., 1995; Chan et al.,
1994). Furthermore, it was shown that the YPWM motif of Hoxa5 is essential ...
Cited by 34 - Web Search - nature.com - ncbi.nlm.nih.gov

Functional and Cooperative Interactions between the Homeodomain PDX 1, Pbx, and Prep 1 Factors on … - Full text - MIT Libraries
G Goudet, S Delhalle, F Biemar, JA Martial, B … - J Biol Chem, 1999 - jbc.org
... the somatostatin gene by using the two ubiquitous factors Pbx1 and Prep1 ... Competitions
with the Hoxa5 peptide (QPQIYPWMRKLH) were carried out by preincubating ...
Cited by 33 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Differences in Gene Expression between Wild Type and Hoxa 1 Knockout Embryonic Stem Cells after … - Full text - MIT Libraries
E Martinez-Ceballos, P Chambon, LJ Gudas - Journal of Biological Chemistry - jbc.org
... a 637-bp fragment was excised with EcoRI-BglII from pUC18-Hoxa5 (formerly known
as ... A Pbx1 cDNA fragment (750 bp) was obtained by restriction digestion of the ...
Web Search - jbc.org - ncbi.nlm.nih.gov

Analysis of HOX Homeodomain Proteins and Gene Transcripts in the Epidermis
LG Koemueves, C Largman - now.humanapress.com
... Several of these, such as PBX1, 2, and 3, exhibit substantial degrees of amino acid
sequence ... scbt@scbt.com): HOXA1 (N-20, C-20); HOXA2 (N-20, P-20); HOXA5 (N-20 ...
Web Search - journals.humanapress.com - biomed.humanapress.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Progress in Hematology
Y Hayashi - cardenjennings.metapress.com
... involved in chromosomal translocations of ALL, such as the E2A-PBX1 chimeric gene
in t ... sistent differences in expression [13].The genes HOXA9 and HOXA5 were not ...
Web Search

Homeodomain Sequences
SD Subsets, V Plots - pnas.org
... H6, HB9, HB24, HD1, Hesx1, HEX, HOX11L1, HOX11L2, HOXA1, HOXA2, HOXA3, HOXA4, HOXA5,
HOXA6, HOXA7 ... 6, Og-2, Og-9, Otp, OTX1, OTX2, Pax-3, Pax-7, PBX1, PBX2, PBX3 ...
Web Search

HOX Homeobox Genes Exhibit Spatial and Temporal Changes in Expression During Human Skin Development - Full text - MIT Libraries
EJ Stelnicki, LG Komuves, AO Kwong, D Holmes, P … - Journal of Investigative Dermatology, 1998 - blackwell-synergy.com
... individuals for supplying human HOX cDNA clones: Dr. Judy Gasson (HOXA5), Dr. Debbie ...
C. Hox gene products modulate the DNA binding activity of Pbx1 and Pbx2. ...
Cited by 33 - Web Search - ingentaconnect.com - jidonline.org - all 4 versions »

Homeobox genes: a molecular link between development and cancer
I PhD, II Dentist, TIIID Student - scielo.br
... malignant transformation, may be primarily due to lack of expression of HOXA5 29 . ...
Other fusions, as PBX1 to E2A and HRX to nuclear proteins, alter the sequence ...
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Hox regulation of normal and leukemic hematopoietic stem cells.
C Abramovich, RK Humphries - Current Opinion in Hematology, 2005 - co-hematology.com
... show hematopoietic phenotypes, despite similarities between these genes and Pbx1
in their ... p53 [71] and the progesterone receptor [72] for HOXA5), a complete ...
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Uterine receptivity and implantation: The regulation and action of insulin-like growth factor … - Full text - MIT Libraries
J Kim, A Fazleabas - Reproductive Biology and Endocrinology, 2004 - dx.doi.org
... Hoxa5 [45] and HOXA10 [46] stimulate the p53 promoter in breast cancer cells
and promote the expression of the progesterone receptor [47]. ...
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The role of HOX homeobox genes in normal and leukemic hematopoiesis - Full text - MIT Libraries
HJ Lawrence, G Sauvageau, RK Humphries, C Largman - Stem Cells, 1996 - stemcells.alphamedpress.org
... colony formation [64, 65], whereas treatment with ASOs against HOXA5 simultaneously
inhibits ... has been the recent discovery that the proto-oncogene Pbx1 acts as ...
Cited by 79 - Web Search - stemcells.alphamedpress.org - ncbi.nlm.nih.gov

Differential Expression of Homeobox Genes in Functionally Distinct CD34 Subpopulations of Human Bone … - Full text - MIT Libraries
G Sauvageau, PM Lansdorp, CJ Eaves, DE Hogge, WH … - Proceedings of the National Academy of Sciences - pnas.org
... JF DiMartino, L. Selleri, D. Traver, MT Firpo, J. Rhee, R. Warnke, S. O'Gorman,
IL Weissman, and ML Cleary The Hox cofactor and proto-oncogene Pbx1 is required ...
Cited by 174 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The neuronal microtubule-associated protein 1B is under homeoprotein transcriptional control - Full text - MIT Libraries
ML Montesinos, I Foucher, M Conradt, G Mainguy, L … - J. Neurosci, 2001 - jneurosci.org
... However, the possibility that added purified En2 binds Pbx1 or other cofactors ... Second,
Hoxa5, another member of the Q50 homeoprotein family, also regulates ...
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Ho me o box genes: a mole cu lar link betwe en deve lop ment and cancer Ge nes home o box: uma rela …
IDUCTI ON - Pesqui Odontol Bras, 2003 - scielo.br
... ma tion, may be primar ily due to lack of expres sion of HOXA5 29 . ... Other fusions,
as PBX1 to E2A and HRX to nuclear proteins, alter the se- quence-specific ...
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HOX and Non-HOX Homeobox Genes in Leukemic Hematopoiesis - Full text - MIT Libraries
BM Owens, RG Hawley - Stem Cells, 2002 - stemcells.alphamedpress.org
... effector of p53, no specific association between loss of HOXA5 expression (or ...
E2A-PBX1 is constitutively nuclear and acts as a transcriptional activator in ...
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Regulation of insulin-like growth factor binding protein-1 promoter activity by FKHR and HOXA10 in … - Full text - MIT Libraries
JJ Kim, HS Taylor, GE Akbas, I Foucher, A … - Biol Reprod, 2003 - biolreprod.org
... and postnatal dwarfism: evidence for an interaction between Hoxa5 and Forkhead ... proteins
is required for cooperative DNA binding with Pbx1, physically contacts ...
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Joint regulation of the MAP1B promoter by HNF3ss/Foxa2 and Engrailed is the result of a highly … - Full text - MIT Libraries
I Foucher, ML Montesinos, M Volovitch, A … - Development, 2003 - dev.biologists.org
... Finally, Foxa2 not only binds Engrailed but also Lim1, Gsc and Hoxa5 homeoproteins
and ... of the PBC class (Drosophila Exd and its vertebrate homologs Pbx1, 2, 3 ...
Cited by 3 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Identification of novel functional regions important for the activity of HOXB7 in mammalian cells - Full text - MIT Libraries
Y Yaron, JK McAdara, M Lynch, E Hughes, JC Gasson - J. Immunol, 2001 - jimmunol.org
... pBluescript (pBluescript (pBSK); Stratagene, La Jolla, CA), releasing the HOXA5
coding sequence ... This family includes three known members, Pbx1, Pbx2, and Pbx3. ...
Cited by 10 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 6 versions »

PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins - Full text - MIT Libraries
K Shanmugam, NC Green, I Rambaldi, HU Saragovi, MS … - Mol Cell Biol, 1999 - mcb.asm.org
... nor has this been observed by other groups with HOXB7 (16) and HOXA5 (26 ... fusion of
the transcriptional activation domain of E2A with residues 89 to 430 of PBX1. ...
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HOX genes: not just myeloid oncogenes any more.
HJ Lawrence, NA Fischbach, C Largman - Leukemia, 2005 - nature.com
... of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B ...
Compromised HOXA5 function can limit p53 expression in human breast tumours. ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

MOLECULAR TARGETS FOR THERAPY (MTT)
J Roche, C Zeng, A Baron, S Gadgil, RM Gemmill, I … - Leukemia, 2004 - nature.com
... 4–11 How- ever, other homeodomain genes, that is, HOXA5, 23 HoxB3 24,25 ... Cooperative
activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias. ...
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Human Homeobox HOXA 7 Regulates Keratinocyte Transglutaminase Type 1 and Inhibits Differentiation - Full text - MIT Libraries
PT La Celle, RR Polakowska - J Biol Chem, 2001 - jbc.org
... (32) identified predominantly HOXA4, HOXA5, and HOXA7 ... DNA sequence recognition and
cooperative DNA binding with either of two homeodomain proteins, PBX1 (34, 35 ...
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Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells - Full text - MIT Libraries
C Buske, M Feuring-Buske, C Abramovich, K … - Blood, 2002 - bloodjournal.org
... interact directly with Meis1 but only with Pbx1 in contrast to HOXA10, which can
interact directly with both proteins. 13 , 18 HOXA5 overexpression, also in ...
Cited by 23 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Meis1-mediated apoptosis is caspase-dependent and can be suppressed by coexpression of HoxA9 in … - Full text - MIT Libraries
PJ Wermuth, AM Buchberg - Blood, 2005 - bloodjournal.org
... Pbx1, another Meis1 cofactor, also induces apoptosis; however, coexpressing
HoxA9 is incapable of rescuing Pbx-mediated apoptosis. ...
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Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with … - Full text - MIT Libraries
N Pineault, C Abramovich, H Ohta, RK Humphries - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias. ...
Compromised HOXA5 function can limit p53 expression in human breast tumours ...
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Changes in HOXB 6 homeodomain protein structure and localization during human epidermal development … - Full text - MIT Libraries
LG Koemueves, WF Shen, A Kwong, E Stelnicki, S … - Developmental Dynamics, 2000 - doi.wiley.com
... PBX1 protein expression was weak and not co-localized with HOXB6, while PBX3 ... The
HOXA1 and HOXA5 genes are also expressed as alternative tran- scripts which ...
Cited by 15 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa 7 and Hoxa 9 - Full text - MIT Libraries
PM Ayton, ML Cleary - Genes & Development, 2003 - genesdev.org
... were variably expressed with periodicity, as evidenced by low levels of Hoxa1, higher
levels of Hoxa3 and Hoxa5, and complete ... 1992 ) or E2A-PBX1 (Nourse et al. ...
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HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and … - Full text - MIT Libraries
NA Fischbach, S Rozenfeld, W Shen, S Fong, D … - Blood, 2005 - bloodjournal.org
... effect on HSC expansion independent of interaction with PBX1 via the ... with overexpression
of HOX genes, including impaired erythropoiesis with HOXA5, impaired B ...
Cited by 1 - Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov

Full Article - Full text - MIT Libraries
FR Goodman, PJ Scambler - Clinical Genetics, 2001 - blackwell-synergy.com
... Interestingly, HOXA5 has recently been shown to activate transcription of the key
tumour suppressor gene p53, and loss of p53 expression occurs secondary to ...
Web Search - blackwell-synergy.com

Enforced expression of HOX 11 is associated with an immature phenotype in J 2 E erythroid cells - Full text - MIT Libraries
WK Greene, J Ford, D Dixon, PA Tilbrook, PM Watt, … - British Journal of Haematology, 2002 - ingentaconnect.com
... factors that includes other human oncoproteins such as HOXA9 and PBX1 (Hatano et ...
For example, overexpression of either HOXB6 or HOXA5 has been shown to inhibit ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

Altered HOX and WNT 7 A expression in human lung cancer - Full text - MIT Libraries
R Calvo, J West, W Franklin, P Erickson, L Bemis, … - Proceedings of the National Academy of Sciences - pnas.org
... in acute lymphoblastic leukemia results in overexpression of HOX11 (7) and the
pre-B cell (1;19) transloca- tion fuses the homeodomain of PBX1 with E2A proteins ...
Cited by 28 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

Analysis in Drosophila melanogaster of the interaction between Sex combs reduced and extradenticle … - Full text - MIT Libraries
A Percival-Smith, DJ Hayden - Genetics, 1998 - genetics.org
... suggesting that the mechanism of tarsus induction by SCR and HOXA5 may be ... gene activity,
is a homolog of the homeobox-containing human proto-oncogene pbx1. ...
Cited by 4 - Web Search - genetics.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The pathophysiology of HOX genes and their role in cancer - Full text - MIT Libraries
DG Grier, A Thompson, A Kwasniewska, GJ McGonigle, … - J Pathol, 2005 - doi.wiley.com
... Hoxa5 does not decrease significantly during lung development and remains highly
expressed in the lungs of newborn animals, suggesting that Hox genes have ...
Cited by 1 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Comparative genomics provides evidence for an ancient genome duplication event in sh
JS Taylor, Y Van de Peer, I Braasch, A Meyer - Phil. Trans. R. Soc. Lond. B, 2001 - journals.royalsoc.ac.uk
Page 1. Comparative genomics provides evidence for an ancient genome duplication
event in sh John S. Taylor, Yves Van de Peer, Ingo Braasch and Axel Meyer * ...
Cited by 102 - Web Search - evolutionsbiologie.uni-konstanz.de - mit.edu - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Protein Kinase C-Mediated Phosphorylation of the Leukemia-Associated HOXA9 Protein Impairs Its DNA … - Full text - MIT Libraries
U Vijapurkar, N Fischbach, W Shen, C Brandts, D … - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... The Drosophila SCR protein, which is homologous to HOXA5, is both activated and
repressed by ... PBX1 appeared to be a component in all of the complexes formed by ...
Cited by 1 - Web Search - mcb.asm.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Proliferation of primitive myeloid progenitors can be reversibly induced by HOXA10 - Full text - MIT Libraries
JM Bjornsson, E Andersson, P Lundstrom, N Larsson, … - Blood, 2001 - bloodjournal.org
... period can be shortened dramatically if the Hox cofactors, Pbx1 or Meis1 ... Hox
transcription factors in various other pathways; that is, HoxA5 affects expression ...
Cited by 15 - Web Search - dx.doi.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Children and adults with acute lymphoblastic leukaemia have similar gene expression profiles. - Full text - MIT Libraries
E Kuchinskaya, M Heyman, D Grander, M Linderholm, … - European Journal Of Haematology, 2005 - blackwell-synergy.com
... Cancer Institute, Buffalo, USA: PAC569O5 is located at the 5 end of PBX1, and ...
BCR/ABL, 3 with high hyperdiploidy and 1 with PBX1/TCF3. Microarray analysis ...
Web Search - blackwell-synergy.com - ejh.dk - ncbi.nlm.nih.gov

Transcriptional Control of the Cell Cycle in Mammary Gland Development and Tumorigenesis
RD Coletta, P Jedlicka, A Gutierrez-Hartmann, HL … - Journal of Mammary Gland Biology and Neoplasia, 2004 - springerlink.com
... While HOXA5 expression has been detected in normal mammary cells in culture
(37,43), its expres- sion throughout normal mammary gland develop- ment has not ...
Web Search - kluweronline.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Deregulated homeobox gene expression in cancer: cause or consequence? - Full text - MIT Libraries
C Abate-Shen - Nature Reviews Cancer, 2002 - nature.com
... | PubMed | ISI | ChemPort |. 50. Raman, V. et al. Compromised HOXA5 function can
limit p53 expression in human breast tumours. Nature 405, 974-978 (2000). ...
Cited by 38 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The intracrine hypothesis and intracellular peptide hormone action - Full text - MIT Libraries
RN Re - BioEssays, 2003 - doi.wiley.com
... analogue of LHRH)/LHRH Receptor Insulin/Nuclear Insulin Receptor Homeodomain protein
feed-back loops and intracrine interactions Hoxb-4/Hoxb-4 HOXA5/HOXA Gene ...
Cited by 10 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Use of Heterologous cDNA Array Screening to Analyze Bovine Oocyte Transcriptome and its Evolution …
R DALBIES-TRAN, P MERMILLOD - biolreprod.org
Page 1. Use of Heterologous cDNA Array Screening to Analyze Bovine Oocyte
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Effects of HOX homeobox genes in blood cell differentiation - Full text - MIT Libraries
MC Magli, C Largman, HJ Lawrence - J Cell Physiol, 1997 - doi.wiley.com
... human bone marrow cells exposed to antisense HOXA5 oligonucleotides also ... Given that
the various translocations main’’ in Pbx1 and demonstrated that this ...
Cited by 57 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Proliferation of primitive myeloid progenitors can be reversibly induced by HOXA10 - Full text - MIT Libraries
R studies show that several Hox - Blood, 2001 - bloodjournal.org
... This latency period can be shortened dramatically if the Hox cofactors,
Pbx1 or Meis1, are co-overexpressed with their Hox partner. ...
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Development of a murine hematopoietic progenitor complementary DNA microarray using a subtracted … - Full text - MIT Libraries
X Ma, T Husain, H Peng, S Lin, O Mironenko, N Maun … - Blood, 2002 - bloodjournal.org
... 1.2 0.4 2.0 0.05 Hmga1 High-mobility group AT-hook 1 — — Hoxa5 Homeobox A5 — — Jun
Jun oncogene, part of AP1 transcriptional complex with Fos — — ...
Cited by 6 - Web Search - info.med.yale.edu - dx.doi.org - ncbi.nlm.nih.gov - all 8 versions »