Delineation of Three Functional Domains of the Transcriptional Activator Encoded by the C-myb … - Full text - MIT Libraries
H Sakura, C Kanei-Ishii, T Nagase, H Nakagoshi, TJ … - J. Biol. Chem, 2004 - pnas.org
... deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic
mice ... CS Hofmann, J. Golay, M. Introna, and GE Sonenshein A-myb rescues murine ...
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PBX1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in … - Full text - MIT Libraries
MA van Duk, PM Voorhoeve, C Murre - Proc. Natl. Acad. Sci. USA, 1993 - pnas.org
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Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice - Full text - MIT Libraries
JJ Moskow, F Bullrich, K Huebner, IO Daar, AM … - Mol. Cell. Biol, 1995 - mcb.asm.org
... Meis1, a PBX1-Related Homeobox Gene Involved in Myeloid ... cellular proto-oncogenes
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The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in … - Full text - MIT Libraries
JF DiMartino, L Selleri, D Traver, MT Firpo, J … - Blood, 2001 - bloodjournal.org
... 34-36 The presence of extensive hemorrhages in Aml1, c-Myb, and Rb knockout embryos
also distinguishes them from Pbx1 / embryos, implying that the production ...
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E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when … - Full text - MIT Libraries
X Fu, MP Kamps - Mol. Cell. Biol, 1997 - mcb.asm.org
... that E2a-Pbx1 may also induce the expression of non-B- cell antigens in
t(1;19)-containing pre-B ALL cells. While tar- get genes of the Ras, Myc, Ets, Myb- ...
Cited by 44 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic … - Full text - MIT Libraries
BJ Feldman, T Hampton, ML Cleary… - Blood, 2000 - bloodjournal.org
... of the Notch1 retroviral insertions in accelerated tumors of E2A-PBX1 mice, however ...
mechanism for activation of cellular oncogenes as reported for c-myb 62 and ...
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Estrogen-dependent E2a/Pbx1 myeloid cell lines exhibit conditional differentiation that can be … - Full text - MIT Libraries
DB Sykes, MP Kamps - Blood, 2001 - bloodjournal.org
... it is unlikely that E2a/Pbx1 establishes differentiation arrest by suppressing
PU.1 or c/EBP gene expression, or by maintaining high levels of c-Myb, which has ...
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E2a/Pbx1 induces the rapid proliferation of stem cell factor-dependent murine pro-T cells that cause … - Full text - MIT Libraries
DB Sykes, MP Kamps - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... 2). E2a/Pbx1 pro-T-cell proliferations also expressed c-myb and Egr2 (not shown),
genes required for all early stages of thymocyte development (2, 20). ...
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Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias
N Genetics - Nature Genetics, 1996 - nature.com
... | PubMed | ISI | ChemPort |; Kamps, MP & Wright, DD, E2A–PBX1 immortalizes cultured ...
Klinman, DM, Smith, HR & Mushinski, JF Autoimmunity and c-myb transcription ...
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Transcriptional Profiling During the Early Differentiation of Granulocyte and Monocyte Progenitors …
DB Sykes, J Scheele, M Pasillas, MP Kamps - Leukemia & Lymphoma, 2003 - dx.doi.org
... Down-regulation of c-Myc and c-Myb Mirrors Down Regulation of Other
E2a–Pbx1 Target Genes L-Myc was quantitatively down regulated ...
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Myeloid Leukemia: Disease Genes and Mouse Models
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... 14 Wolf L: Myb-induced transformation ... Nakamura T, Largaespada DA, Shaughnessy JD,
Jenkins NA, Copeland NG: Cooperative activation of Hoxa and Pbx1-related genes ...
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DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t (17 … - Full text - MIT Libraries
SP Hunger, R Brown, ML Cleary - Mol. Cell. Biol, 1994 - pubmedcentral.nih.gov
... Synergistic activation of the chicken mim-1 gene by v-myb and C/EBP transcription ...
1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences ...
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Computational analysis of composite regulatory elements - Full text - MIT Libraries
P Qiu, W Ding, Y Jiang, JR Greene, L Wang - Mammalian Genome, 2002 - springerlink.com
... COUP HNF4 1698.5 NFY PBX1 170.4 NFKAPPAB50 SP1 57.6 CEBP GATA1 28.9 AHRARNT
MYCMAX 1424.3 HSF2 NFAT 170.3 BRN2 HNF1 56.6 ISRE MYB 28.7 ...
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Estrogen-regulated Conditional Oncoproteins: Tools to Address Open Questions in Normal Myeloid Cell …
DB Sykes, MP Kamps - Leukemia & Lymphoma, 2003 - dx.doi.org
... Myb [42], Hoxa9 [27] and E2a-Pbx1 [30,43] are oncoproteins that immortalize primary
GM-CSF or IL-3-dependent myeloblasts and have been rendered estrogen ...
Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Application of Ingenuity Pathways Analysis to Identify Putative Biomarkers of Childhood Leukemia …
IA Spectrum - Cancer - ingenuity.com
... HOXB9, HOXD12,Malic Enzyme,PBX, PBX1,RB1,Sst, TR ALPHA CHD4,CPSF3, Creb,CREB1,
CREBBP,HDAC1, HDAC2,HOXA9, HOXC8, KIAA0601, MBD3,MTA2, MYB,PPIE, PPP1R15A ...
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Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a … - Full text - MIT Libraries
JD Shaughnessy Jr, DA Largaespada, E Tian, CF … - Oncogene, 1999 - nature.com
... the Myb proto-oncogene (Buchberg et al., 1990; our unpublished results), two class
I homeobox genes (Hox7 and Hox9) (Nakamura et al., 1996), and a Pbx1-related ...
Cited by 9 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Control of Self-Renewal and Differentiation of Hematopoietic Stem Cells: HOXB4 on the Threshold - Full text - MIT Libraries
H KLUMP, B SCHIEDLMEIER, C BAUM - Ann. NY Acad. Sci, 2005 - annalsnyas.org
... stages of haemopoiesis is dependent on distinct threshold levels of c-Myb. ... Differential
expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout ...
Web Search - annalsnyas.org - ncbi.nlm.nih.gov

E 2 A-PBX 1 Interacts Directly with the KIX Domain of CBP/p 300 in the Induction of Proliferation in … - Full text - MIT Libraries
R Bayly, L Chuen, RA Currie, BD Hyndman, R … - J Biol Chem, 2004 - jbc.org
... 2, and the most C-terminal E2A position (483) before the fusion point with PBX1. ...
N termini of metazoan E2A orthologs and the CBP-interactive domain of c-Myb. ...
Web Search - jbc.org - ncbi.nlm.nih.gov

Drosophila in cancer research
CJ Potter, GS Turenchalk, T Xu - Trends Genet, 2000 - botany.utoronto.ca
... D.E2F (D.E2F DP) E2F patched ptch l(1)malignant ? extradenticle Pbx1 PP2A-29B
PPP2RIB l(2)k07918 ? ... D.myb myb spellchecker hMSH2 l(2)talc ? ...
Cited by 33 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia - Full text - MIT Libraries
LH Castilla, P Perrat, NJ Martinez, SF Landrette, … - Proc Natl Acad Sci US A, 2004 - pubmedcentral.nih.gov
... oncogenes associated with lymphomagenesis, including CD2-myc (14), E2A-PBX1 (15),
Pim1 and ... is reported suggesting that misexpression of known (ie, Myb and Runx2 ...
Cited by 8 - Web Search - dx.doi.org - pnas.org - ncbi.nlm.nih.gov - all 5 versions »

Retroviral integration at the Epi1 locus cooperates with Nf1 gene loss in the progression to acute … - Full text - MIT Libraries
SM Blaydes, SC Kogan, BT Truong, DJ Gilbert, NA … - J. Virol, 2001 - jvi.asm.org
... activation of Hoxa and Pbx1-related genes in murine myeloid leukemias. Nat. Genet.
12:149-153[Medline]. 27. Oh, IH, and EP Reddy. 1999. The myb gene family in ...
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The role of TEL fusion genes in pediatric leukemias
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... Several molecular genetic abnor- malities, including the E2A-PBX1, BCR-ABL ... binding
sites for lineage-restricted transcription factors including myb, CEBP , and ...
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High-throughput retroviral tagging to identify components of specific signaling pathways in cancer - Full text - MIT Libraries
H Mikkers, J Allen, P Knipscheer, L Romeyn, A Hart … - Nature Genetics, 2002 - nature.com
... PIM-1 kinase and P100 cooperate to enhance c-Myb activity. ... Shaughnessy, JD Jr Jenkins,
NA & Copeland, NG Cooperative activation of Hoxa and Pbx1-related genes ...
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Molecular portraits of B cell lineage commitment - Full text - MIT Libraries
M Muschen, S Lee, G Zhou, N Feldhahn, VS Barath, J … - Proceedings of the National Academy of Sciences - uni-duesseldorf.de
... MYB 0 13 CD46 16 1 HK3 1 32 H2KBF2 16 1 DLEU1 1 31 HSP70IP 16 1 IL4R 1 29 MAEA 31
2 CASP8 3 83 NUP62 15 1 CD83 2 55 p300TED 6 0 E2F 2 39 CDC2L1 6 0 PBX1 4 68 ...
Cited by 11 - View as HTML - Web Search - pubmedcentral.gov - ncbi.nlm.nih.gov

An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation - Full text - MIT Libraries
GW Klappacher, VV Lunyak, DB Sykes, D Sawka- … - Cell, 2002 - rosenfeldlab.ucsd.edu
... of METS results in significant repression of the c-Myc, c-Myb, and Cdc2 ... (D) Retroviral
expression of METS blocks proliferation of E2A-Pbx1-transformed myeloid ...
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Genome-based identification of cancer genes by proviral tagging in mouse retrovirus-induced T-cell … - Full text - MIT Libraries
R Kim, A Trubetskoy, T Suzuki, NA Jenkins, NG … - J Virol, 2003 - jvi.asm.org
... Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias ...
Importance of a c-Myb binding site for lymphomagenesis by the retrovirus SL3-3 ...
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Luciferase Reporters: Less is More
A Paguio, B Almond, F Fan, P Stecha, D Garvin, M … - promega.com
... GFI1 MESI1 MIBP-1/RFX1 v-Myb v-Myb v-Myb PAX2/5/8 c-Myb C-Myb c-Myb c-Myb v-Myb
v-Myb Pbx1/Meis1 RFX1 TATA Brn3 CHOP CCAAT CCAAT CCAAT VIS1 CDE/CHR ...
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Chromosomal abnormalities and tumor development: from genes to therapeutic mechanisms - Full text - MIT Libraries
C Cobaleda, J Perez-Losada, I Sanchez-Garcia - BioEssays, 1998 - doi.wiley.com
... 19p13 alterations t(1;19)(q23;p13) pre-B-ALL PBX1, E2A t(17;19)(q22;p13) pro-B-ALL
HLF, E2A 9q34 alterations t(9;22)(q34;q11) CML, B-ALL ABL, BCR t(9;12)(q34 ...
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Bibliography Current world literature
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... PA, Lutwyche JK, Gonda TJ: Identification and validation of candidate Myb target
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The role of homeobox genes in hematopoiesis
MC Magli - Biotherapy, 1998 - ingentaconnect.com
... is also required and suffi- cient for the oncogenic potential of E2A-PBX1 [61]. ... might
be mediated by nuclear proto- oncogenes (c-myc, c-myb), or, alternatively ...
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Promotion of cell cycle progression by basic helix-loop-helix E2A - Full text - MIT Libraries
F Zhao, A Vilardi, RJ Neely, JK Choi - Mol Cell Biol, 2001 - mcb.asm.org
... in normal human T-lymphocytes requires the nuclear protein encoded by c-myb. ... 19)
translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins ...
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CONSEQUENCES OF CHROMOSOMAL ABNORMALITIES IN TUMOR DEVELOPMENT - Full text - MIT Libraries
I Sanchez-Garcia - Annual Review of Genetics, 1997 - dx.doi.org
... but that the PBX1 DNA-binding homeodomain is dispensable, indicating that E2A-PBX1
need not ... Other examples of this phenomenon are illustrated by v-Myb, which up ...
Cited by 25 - Web Search - wwwlib.bionet.nsc.ru - genet.annualreviews.org - ncbi.nlm.nih.gov - all 6 versions »

DNA microarray analysis in malignant lymphomas - Full text - MIT Libraries
C Schwaenen, S Wessendorf, HA Kestler, H Doehner, … - Annals of Hematology, 2003 - springerlink.com
... widely recognized, clinically distinct leukemia subtypes (T-ALL, E2A-PBX1, BCR-ABL ...
2001) [34] ZAP70, galectin-1, KIAA0808, LC13076, ckshs, B-MYB, LC23393, LC9883 ...
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Oncogene activation in myeloid leukemias by Graffi murine leukemia virus proviral integration - Full text - MIT Libraries
C Denicourt, E Edouard, E Rassart - J Virol, 1999 - jvi.asm.org
... Structural organization and nucleotide sequence of the mouse c-myb oncogene. ... Meis1,
a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. ...
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pGL3 Luciferase Reporter Vectors
I Description, IIIP Components, IVC Methods, I … - promega.com
... GFI1 MESI1 MIBP-1/RFX1 v-Myb v-Myb v-Myb PAX2/5/8 c-Myb C-Myb c-Myb c-Myb v-Myb
v-Myb Pbx1/Meis1 RFX1 TATA Brn3 CHOP CCAAT CCAAT CCAAT VIS1 CDE/CHR ...
Web Search - genomics.sbg.ac.at - sci.sdsu.edu - shpromega.cn - all 8 versions »

HOX and Non-HOX Homeobox Genes in Leukemic Hematopoiesis - Full text - MIT Libraries
BM Owens, RG Hawley - Stem Cells, 2002 - stemcells.alphamedpress.org
... Hoxb8 requires interaction with Pbx1 to arrest myeloid differentiation [96]. ... GBX2
has also been identified as a downstream target of the Myb oncogene; therefore ...
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Compilation of vertebrate-encoded transcription factors - Full text - MIT Libraries
S Faisst, S Meyer - Nucleic Acids Res, 1992 - pubmedcentral.nih.gov
... The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1
fusion proteins ... PubMed]; Ness SA, Marknell A, Graf T. The v-myb oncogene product ...
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CANCER ET GENETIQUE: DETERMINATION DES SUJETS A RISQUE
IAT RISK - adfcongres.com
... de l’acide rétinoïque) et des facteurs de transcription (familles des gènes myc,
myb, fos, jun ... L. aiguë lymphoblastique t(1;19)(q23;p13.3) E2A-PBX1 F. de ...
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The Transcription Factor CCAAT-binding Factor CBF/NF-Y and Two Repressors Regulate the Core Promoter … - Full text - MIT Libraries
H Nagato, N Matsuo, H Sumiyoshi, K Sakata-Takatani … - J Biol Chem, 2004 - jbc.org
... indicate that members of the homeotic complex and TALE class of homeoproteins,
PBX1/2, PREP1, and HOXB1, were involved in regulation of COL5A2. B-myb, a member ...
Web Search - jbc.org - ncbi.nlm.nih.gov

[PS] CITATIONS FOR PROTEIN/DNA (REGULATORY) - Full text - MIT Libraries
PDA White, X Ding, JC Vanderspek, JR Murphy, D … - J. Biol. Chem, 2004 - aist.go.jp
... PD0075 DE.Piper, AH.Batchelor, C.-P.Chang, ML.Cleary, C.Wolberger Structure of a
Hoxb1-Pbx1 Heterodimer Bound to DNA: Role of the Hexapeptide and a Fourth ...
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Coordinate expression and proliferative role of HOXB genes in activated adult T lymphocytes - Full text - MIT Libraries
A Care, U Testa, A Bassani, E Tritarelli, E … - Mol Cell Biol, 1994 - pubmedcentral.nih.gov
... 19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins ...
C, Mattia G, Gewirtz AM, Calabretta B, Peschle C. Antisense myb inhibition of ...
Cited by 27 - Web Search - mcb.asm.org - ncbi.nlm.nih.gov

Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets - Full text - MIT Libraries
D Traver, T Miyamoto, J Christensen, J Iwasaki- … - Blood, 2001 - bloodjournal.org
... Both c-myb and PU.1 were expressed in HSCs, CLP counterparts, and all ... in the generation
of erythroid progeny are our recent findings in Pbx1-deficient mice ...
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acquises de la cellule souche hematopoietique ou d’un precurseur deja commis vers les lignees …
S YNTHESE - MEDECINE/SCIENCES, 2003 - ist.inserm.fr
... la famille Ras, Harvey et Kirsten Ras, des oncogènes nucléaires Myc, Myb, et de ... 19p13)
Facteur de transcription de type bHLH LAL pré-B PBX1 (1q23) Facteur ...
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Fundamental Concepts of the Angiogenic Process
TDCANR FROM, B ANGIOGENESIS - Current Molecular Medicine, 2003 - dx.doi.org
... 1 downregulation v-src VEGF upregulation, TSP-1 downregulation c-myb TSP-2 ... ODC novel
angiogenic factor PTTG1 VEGF and bFGF upregulation E2a-Pbx1 Induction of ...
Web Search - ingentaconnect.com - mcdb.colorado.edu - colorado.edu - all 5 versions »

A statistical analysis of the TRANSFAC database.
GB Fogel, DG Weekes, G Varga, ER Dow, AM Craven, … - Biosystems, 2005 - natural-selection.com
... not AAAG VMYB 02 v-Myb Core should be AACGG not AACG MYT1 ... not AAGG PBX1 02
Homeo domain factor Pbx-1 Core should be CAATC not CAAT MAX ...
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4 ONCOGENES
MA Pierotti, SA Schichman, G Sozzi, CM Croce - cancer.org
... by weakly oncogenic retroviruses, first demon- strated in bursal lymphomas of chickens,
frequently involves the same oncogenes (such as myc, myb, and erb B ...
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Transgenic and gene knockout mice in cancer research
JL Viney - Cancer and Metastasis Reviews, 1995 - springerlink.com
... It has been thought for some while that the nuclear oncoproteins, such as rnyc,
myb, los, jun ... cation is t(1;19), which causes fusion of the E2A and PBX1 genes. ...
Cited by 13 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Gene expression profiles of poor-prognosis primary breast cancer correlate with survival - Full text - MIT Libraries
F Bertucci, V Nasser, S Granjeaud, F Eisinger, J … - Human Molecular Genetics, 2002 - hmg.oupjournals.org
... Examples are mucin 1 (MUC1) (27), the proto-oncogene MYB (28), BCL2 (29) and ... has
been previously associated with ER status), ILF1, ELF1, BS69, GLI3 and PBX1. ...
Cited by 41 - Web Search - hmg.oupjournals.org - ncbi.nlm.nih.gov

Oncogenes and Angiogenesis: Signaling Three-Dimensional Tumor Growth - Full text - MIT Libraries
J Rak, JL Yu, G Klement, RS Kerbel - Journal of Investigative Dermatology Symposium Proceedings, 2000 - blackwell-synergy.com
... 1999; Meitar et al. 1996; Fotsis et al. 1999), myb (Bein et al. 1998), HPV-16 (Le
Buanec et al. 1999), E2a-Pbx1 (Fu et al. 1999), PTTG (Heaney et al. ...
Cited by 47 - Web Search - ncbi.nlm.nih.gov

I. I ntroduction
IV References - promega.com
... GFI1 MESI1 MIBP-1/RFX1 v-Myb v-Myb v-Myb PAX2/5/8 c-Myb C-Myb c-Myb c-Myb v-Myb
v-Myb Pbx1/Meis1 RFX1 TATA Brn3 CHOP CCAAT CCAAT CCAAT VIS1 CDE/CHR ...
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