The oncogenic potential of the Pax3-FKHR fusion protein requires the Pax3 homeodomain recognition … - Full text - MIT Libraries
PY Lam, JE Sublett, AD Hollenbach, MF Roussel - Mol. Cell. Biol, 1999 - mcb.asm.org
... domain must be present for efficient transformation by Pax3-FKHR. ... by which another
homeodomain-containing fusion protein, E2a-Pbx1, induces transformation (26 ...
Cited by 37 - Web Search - pubmedcentral.nih.gov - sfu.ca - ncbi.nlm.nih.gov - all 7 versions »

Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but … - Full text - MIT Libraries
K Monica, DP LeBrun, DA Dedera, R Brown, ML Cleary - Mol Cell Biol, 1994 - pubmedcentral.nih.gov
... Fusion of PAX3 to a member of the forkhead family of transcription factors in human
alveolar ... [PubMed]; Van Dijk MA, Voorhoeve PM, Murre C. Pbx1 is converted ...
Cited by 51 - Web Search - mcb.asm.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The PAX3-FKHR fusion protein created by the t (2; 13) translocation in alveolar rhabdomyosarcomas is … - Full text - MIT Libraries
WJ Fredericks, N Galili, S Mukhopadhyay, G Rovera, … - Mol Cell Biol, 1995 - mcb.asm.org
... The PAX3-FKHR Fusion Protein Created by the t(2;13) Translocation in Alveolar
Rhabdomyosarcomas Is a More Potent Transcriptional Activator than PAX3 ...
Cited by 84 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Computational analysis of composite regulatory elements - Full text - MIT Libraries
P Qiu, W Ding, Y Jiang, JR Greene, L Wang - Mammalian Genome, 2002 - springerlink.com
... CEBP CHOP 559.1 CREB PAX3 125.3 GATA1 PBX1 46.3 AP2 MYCMAX 24.8 ATF WHN
546.3 CEBPA HLF 124.0 MZF1 NFKAPPAB 46.0 CREL MZF1 24.7 ...
Cited by 10 - Web Search - ncbi.nlm.nih.gov

DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t (17 … - Full text - MIT Libraries
SP Hunger, R Brown, ML Cleary - Mol. Cell. Biol, 1994 - pubmedcentral.nih.gov
... Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar ...
1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences ...
Cited by 23 - Web Search - mcb.asm.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Molecular genetics of childhood cancer: implications for pathogenesis, diagnosis, and treatment - Full text - MIT Libraries
JE Rubnitz, WM Crist - Pediatrics, 1997 - pediatrics.org
... Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain
is ... J, Biegel JA, Rovera G, Emanuel BS Rearrangement of the PAX3 paired box ...
Cited by 10 - Cached - Web Search - pediatrics.aappublications.org - pediatrics.org - ncbi.nlm.nih.gov - all 6 versions »

Homeobox genes: a molecular link between development and cancer
I PhD, II Dentist, TIIID Student - scielo.br
... been implicated in breast cancer 34 , renal hypoplasia and renal disease 26 ; PAX3
has a ... Other fusions, as PBX1 to E2A and HRX to nuclear proteins, alter the ...
Cached - Web Search - scielo.br

Paediatrische Onkologie
P Onkologie - Monatsschrift Kinderheilkunde, 2002 - springerlink.com
... t(1;19)(q23;p13) E2A-PBX1 Prä-B-ALL t(8;21) (q22;q22) AML1-ETO AML (FAB
M2) ... t(2;13)(q35;q14) PAX3-FKHR Rhabdomyosarkom,alveol. ...
Web Search

Chromosomal abnormalities and tumor development: from genes to therapeutic mechanisms - Full text - MIT Libraries
C Cobaleda, J Perez-Losada, I Sanchez-Garcia - BioEssays, 1998 - doi.wiley.com
... homeodomain proteins, such as HOX11 in T-ALL (10–12) and PBX1 in pre-B- cell leukemias;
(13,14) paired homeobox domains, including PAX3 in rhabdomyosarcoma ...
Cited by 13 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Ho me o box genes: a mole cu lar link betwe en deve lop ment and cancer Ge nes home o box: uma rela …
IDUCTI ON - Pesqui Odontol Bras, 2003 - scielo.br
... I Hox prote ins – eviden ce for se - lec ti ve target ting of E2a-Pbx1 to a ... PAX3
is expres sed in human me - la no mas and contri bu tes to tumor cell survi ...
View as HTML - Web Search - scielo.br

Deregulated homeobox gene expression in cancer: cause or consequence? - Full text - MIT Libraries
C Abate-Shen - Nature Reviews Cancer, 2002 - nature.com
1. Duboule, D. (ed.) Guidebook to the Homeobox Genes (Oxford Univ. Press,
New York, 1994). 2. Stein, S., Fritsch, R., Lemaire, L ...
Cited by 38 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

CONSEQUENCES OF CHROMOSOMAL ABNORMALITIES IN TUMOR DEVELOPMENT - Full text - MIT Libraries
I Sanchez-Garcia - Annual Review of Genetics, 1997 - dx.doi.org
... such as HOX11 in T-ALL (54, 64, 79) or PBX1, which can be fused to E2A in preB-cell
leukemias (61, 93); paired box domains like PAX3 in rhabdomyosarcoma (5, 31 ...
Cited by 25 - Web Search - wwwlib.bionet.nsc.ru - genet.annualreviews.org - ncbi.nlm.nih.gov - all 6 versions »

Six and Eya expression during human somitogenesis and MyoD gene family activation
F Fougerousse, M Durand, S Lopez, L Suel, J … - Journal of Muscle Research and Cell Motility, 2002 - springerlink.com
... that Six1 could be a direct or indirect target of Pax3 in these cells ... stimulation
(Macfarlane et al., 1999), and in Drosophila for exd (Pbx1) during patterning ...
Cited by 2 - Web Search - kluweronline.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Homeodomain revisited: a lesson from disease-causing mutations - Full text - MIT Libraries
YI Chi - Human Genetics, 2005 - springerlink.com
... Waardenburg syndrome PAX3 606597 193500 Paired box-homeodomain (219–278) F238S V265F
W266C R270C ... PBX1 Mouse Homeodomain 1PUF N3 on A O2 on T O4¢ on T O4 ...
Web Search - ncbi.nlm.nih.gov

Phylogenetic analyses alone are insufficient to determine whether genome duplication (s) occurred … - Full text - MIT Libraries
AC Horton, NR Mahadevan, I Ruvinsky, JJ Gibson- … - Journal of Experimental Zoology (Molecular and Developmental …, 2003 - doi.wiley.com
... PAX5 NP___057953 PAX8 Q06710 Pax3/7 AF165886 PAX3 AAH08826 2 PAX7 NP___039236 ... Otx
2 Williams and Holland, 1998 PBX1/2/3/4 (AAM18882) 4 Abi-Rached et al., 2002 ...
Cited by 7 - Web Search - zoo.ufl.edu - ncbi.nlm.nih.gov

The role of homeobox genes in hematopoiesis
MC Magli - Biotherapy, 1998 - ingentaconnect.com
... is also required and suffi- cient for the oncogenic potential of E2A-PBX1 [61]. ... and
Aniridia can be correlated with molecular alterations of PAX2, PAX3 and PAX6 ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Fibroblast Growth Factors In The Developing Central Nervous System - Full text - MIT Libraries
M Ford-Perriss, H Abud, M Murphy - Clinical and Experimental Pharmacology and Physiology, 2001 - blackwell-synergy.com
... expression in neural precursor cells demonstrated a requirement for Pax3 in neuronal ...
discovered as a downstream target of the homeodomain oncoprotein E2A-Pbx1. ...
Cited by 37 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators
M Wilson, P Koopman - Curr Opin Genet Dev, 2002 - imb.uq.edu.au
... they showed that the SOX2/Oct1 complex was able to increase the transcriptional
activity of the Hox/Pbx1 complex. ... SOX10 Pax3 N/D c-ret Neural crest [52,53] ...
Cited by 41 - View as HTML - Web Search - imb.uq.edu.au - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

A statistical analysis of the TRANSFAC database.
GB Fogel, DG Weekes, G Varga, ER Dow, AM Craven, … - Biosystems, 2005 - natural-selection.com
... 1 OCT1 04 Octamer factor 1 OCT1 Q6 Octamer factor 1 P300 01 p300 PAX3 B Pax3 binding
sites PAX4 ... PBX1 02 Homeo domain factor Pbx-1 Core should be CAATC not CAAT ...
View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Sox genes and cancer - Full text - MIT Libraries
C Dong, D Wilhelm, P Koopman, F Alert - Cytogenetic and Genome Research, 2004 - content.karger.com
... E, Le Caignec C, Wegner M, Goossens M: Interaction among SOX10, PAX3 and MITF ... M:
The Hox cooperativity motif of the chimeric oncoprotein E2a-Pbx1 is necessary ...
Cited by 1 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions »

Genetics of childhood cancer
H Ganjavi, D Malkin - Clinical Orthopaedics & Related Research, 2002 - corronline.com
... PAX3 = paired box 3 gene (associated with t(2;13) translocation of alveolar ... PBX1 =
paired box 1 gene (associated with pre-B acute lymphoblastic leukemia). ...
Cited by 4 - Web Search - corronline.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

The MN1-TEL fusion protein, encoded by the translocation (12; 22)(p13; q11) in myeloid leukemia, is … - Full text - MIT Libraries
A Buijs, L van Rompaey, AC Molijn, JN Davis, AC … - Mol Cell Biol, 2000 - mcb.asm.org
... because similar differences have been reported for the two alternative E2A-PBX1
chimeric proteins ... by the fusion of EWS to FLI1 (37) or of FKHR to PAX3 (2). Due ...
Cited by 22 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Septo-Optic Dysplasia and Related Malformations
MT Dattani - Hypothalamic-pituitary development: genetic and clinical …, 2001 - content.karger.com
... and combined hormone deficiencies), PAX2 (renal-coloboma syndrome), PAX3 (Waardenberg
syndrome ... Recent structural studies of the Pbx1 class homeodomains [78, 79 ...
Cited by 2 - Web Search - content.karger.com

CANCER ET GENETIQUE: DETERMINATION DES SUJETS A RISQUE
IAT RISK - adfcongres.com
... Rhabdomyosarcome alvéolaire t(2;13)(q35;q14) PAX3-FKHR F. de transcription ... L. aiguë
lymphoblastique t(1;19)(q23;p13.3) E2A-PBX1 F. de transcription ...
View as HTML - Web Search

Hop is an unusual homeobox gene that modulates cardiac development - Full text - MIT Libraries
F Chen, H Kook, R Milewski, AD Gitler, MM Lu, J Li … - Cell, 2002 - imbt.ntou.edu.tw
... paired and engrailed, and human PBX1 and HOX-B1, ... teins. While the isolated Pax3
homeodomain bound to all of these sequences (with varying affinities), Hop did ...
Cited by 39 - View as HTML - Web Search - uphs.upenn.edu - ingentaconnect.com - all 6 versions »

4 ONCOGENES
MA Pierotti, SA Schichman, G Sozzi, CM Croce - cancer.org
Page 1. Since the early proposals of Boveri more than a century ago, multi-
ple experimental evidences have confirmed that at the ...
View as HTML - Web Search

Homeobox genes in normal and malignant cells - Full text - MIT Libraries
C Cillo, M Cantile, A Faiella, E Boncinelli - Journal of Cellular Physiology, 2001 - doi.wiley.com
... Homeoproteins of paralogy groups 1 to 10 are stabilised in their binding by the
PBX1 protein (Knoep¯er and Kamps, 1997), whereas AbdB-like Hox proteins ...
Cited by 30 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Molecular Characterisation of Three Murine HOXI I-Related Homeobox Genes, Tlx-I,-2, and-3, and …
SH Cheng, TW Mak - blackwell-synergy.com
... Similarly, Pax3 and Pax-6 were also shown to possess an oncogenic potential ... appears
that the translocation results in the deregulation of PBX1, which normally ...
Web Search

HESX1 and Septo-Optic Dysplasia
MT Dattani, IC Robinson - Reviews in Endocrine & Metabolic Disorders, 2002 - springerlink.com
... by Cohen and Radovick), PAX2 (renal- coloboma syndrome), PAX3 (Waardenberg syndrome ...
Recent structural studies of the Pbx1 class homeodomains [82,83] highlight ...
Cited by 3 - Web Search - kluweronline.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Cellular transformation of NIH 3 T 3 fibroblasts by CIZ/NMP 4 fusions - Full text - MIT Libraries
A Corveleyn, H Janssen, A Martini, R Somers, J … - Journal of Cellular Biochemistry, 2005 - doi.wiley.com
... 2A). A similar transformed phenotype has been observed in 3T3 fibroblasts
overexpressing E2A-HLF or E2A-PBX1 [Yoshihara et al., 1995; Kamps et al., 1996]. ...
Web Search - ncbi.nlm.nih.gov

Prevalence estimates of recurrent balanced cytogenetic aberrations and gene fusions in unselected …
F Mitelman, F Mertens, B Johansson - GENES, CHROMOSOMES & CANCER, 2005 - doi.wiley.com
Page 1. Prevalence Estimates of Recurrent Balanced Cytogenetic Aberrations and
Gene Fusions in Unselected Patients with Neoplastic Disorders ...
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TranSignal TM GR-TF Interaction Arrays
PU Manual - panomics.com
Page 1. TranSignal TM GR-TF Interaction Arrays GR-TFCat. # MA5061, MA5062 &
MA5063 Product User Manual Released 07/29/04 Panomics, Inc. ...
View as HTML - Web Search - biocat.de

Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the … - Full text - MIT Libraries
PL Pfeffer, M Bouchard, M Busslinger - Development, 2000 - dev.biologists.org
... EMSA analysis The mouse Pax2b, Pax3, Pax5, Pax6, Oct1, Otx2, Gbx2, En2 and Xenopus
HoxD1 cDNAs were cloned into the expression vector pKW2T, and proteins were ...
Cited by 21 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

TranSignal TM Protein/DNA Arrays
PU Manual, MA MA1014 - panomics.com
Page 1. TranSignal TM Protein/DNA Arrays Cat. # MA1010, MA1011, MA1012 Product User
Manual, MA1013 & MA1014, MA1015 Released 09/28/04 Panomics, Inc. ...
View as HTML - Web Search - biocat.de

chromosomal abnormalities - Full text - MIT Libraries
I SANCHEZ-GARCfA, TH RABBITTS - Biochemistry, 1994 - pnas.org
... activated in Burkitt lymphoma (5); homeodomain proteins such as HOX11 in
T-cell acute leukemia (6-9) or PBX1, which can be fused to E2A ...
Web Search

TranSignal TM Protein/DNA Arrays
CS Version - panomics.com
Page 1. TranSignal TM Protein/DNA Arrays (Column Separation Version) Cat. #
MA1210, MA1211, MA1212l, MA1213 & MA1214, MA1215 Product ...
View as HTML - Web Search

Evidence for a direct functional antagonism of the selector genes proboscipedia and eyeless in … - Full text - MIT Libraries
C Benassayag, S Plaza, P Callaerts, J Clements, Y … - Development, 2003 - dev.biologists.org
... eye development in quail (Plaza et al., 1997 ), and between Pax3 and Msx1 for ... of
a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes ...
Cited by 4 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

De la cytogenetique a la cytogenomique des tumeurs: le point en 2004
A Bernheim, JL Huret, M Guillaud-Bataille, O … - Bull Cancer, 2004 - john-libbey-eurotext.fr
... Leucémies aiguës lymphoblastiques LAL L1/L2 Pre-B t(1;19)(q23;p13) PBX1-TCF3 ...
Rhabdomysarcomes (alvéolaires) t(2;13)(q37;q14) PAX3-FKHR t(1;13)(p36;q14) PAX7 ...
View as HTML - Web Search - john-libbey-eurotext.fr

1.1 Mechanismen der Steuerung der Embryonalentwicklung
B Christ, B Brand-Saberi - springeronline.com
... Die teilungsfähigen Zellen des Dermomyotoms, die zB das pax3-Gen exprimieren, das
für einen Transkriptionsfaktor kodiert, haben die Option, sich zu Muskel ...
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Expression of Meis2, a Knotted-related murine homeobox gene, indicates a role in the differentiation … - Full text - MIT Libraries
F Cecconi, G Proetzel, G Alvarez-Bolado, D Jay, P … - Dev. Dyn, 1997 - doi.wiley.com
... The expression of Pax3 spatially and temporally precedes expression of myogenic ... new
homeobox genes with extensive homology to the human proto- oncogene PBX1. ...
Cited by 20 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

The third helix of the homeodomain of paired class homeodomain proteins acts as a recognition helix … - Full text - MIT Libraries
JA Bruun, EIS Thomassen, K Kristiansen, G Tylden, … - Nucleic Acids Research, 2005 - nar.oxfordjournals.org
... R57 and R58 in helix 3 of the homeodomain We have previously shown that Pax6 PD
as well as other homeodomain proteins, such as Rax, Chx10, HoxB1, Pbx1 and Lhx2 ...
Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Eye development: a view from the retina pigmented epithelium - Full text - MIT Libraries
JR MartınMorales, I Rodrigo, P Bovolenta - BioEssays, 2004 - doi.wiley.com
Page 1. Eye development: a view from the retina pigmented epithelium Juan
Ramón MartınMorales, Isabel Rodrigo, and Paola Bovolenta* ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

6 RECURRING CHROMOSOME REARRANGEMENTS IN HUMAN CANCER
OI Olopade, OM Sobulo, JD Rowley - cancer.org
Page 1. Acquired clonal chromosomal abnormalities are found in the malignant cells
of most patients with leukemia, lymphoma, and solid tumors. ...
View as HTML - Web Search

DNA Microarray Analysis of Region-Specific Gene Expression in the Mouse Epididymis - Full text - MIT Libraries
N Hsia, GA Cornwall - Biol Reprod, 2004 - biolreprod.org
... X-binding 1 (Nfx1), pre-ß cell leukemia transcription factor 1 (pbx1), pou domain ...
A. FGF signaling regulates expression of Tbx2, Erm, Pea3, and Pax3 in the ...
Cited by 6 - Web Search - bioone.org - dx.doi.org - ncbi.nlm.nih.gov - all 10 versions »

Molecular basis for the inhibition of Drosophila eye development by Antennapedia - Full text - MIT Libraries
S Plaza, F Prince, J Jaeger, U Kloter, S Flister, … - The EMBO Journal, 2001 - embojournal.npgjournals.com
... of a novel nonhomeodomain protein that inhibits the binding of PBX1–HOX complexes ...
Shen,C. (1999) Msx1 antagonizes the myogenic activity of Pax3 in migrating ...
Cited by 15 - Web Search - nature.com - emboj.org - pubmedcentral.nih.gov - all 7 versions »

Full Text View - Full text - MIT Libraries
N Hsia, GA Cornwall - Biology of Reproduction - bioone.org
... X-binding 1 (Nfx1), pre-β cell leukemia transcription factor 1 (pbx1), pou domain ...
FGF signaling regulates expression of Tbx2, Erm, Pea3, and Pax3 in the early ...
Web Search

DNA Microarray Analysis of Region-Specific Gene Expression 14 In the Mouse Epididymis 15 16 17
N Hsia, GA Cornwall - DNA - biolreprod.org
... Nfx1), pre β 385 cell leukemia transcription factor 1 (pbx1), pou domain
class 5 transcription factor 386 1 (pou5f1), prostate ...
Web Search

Hox Genes and Their Candidate Downstream Targets in the Developing Central Nervous System
ZN Akin, AJ Nazarali - springerlink.com
... These residues also function in the binding of DNA by HoxB1 within the
HoxB1-Pbx1-DNA complex as determined by X-ray Page 6. 702 Akin and Nazarali ...
Web Search

Turning heads: Development of vertebrate branchiomotor neurons - Full text - MIT Libraries
A Chandrasekhar - Developmental Dynamics, 2004 - doi.wiley.com
Page 1. REVIEWS–A PEER REVIEWED FORUM Turning Heads: Development of Vertebrate
Branchiomotor Neurons Anand Chandrasekhar* The cranial ...
Cited by 4 - Web Search - missouri.edu - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger …
J Lin, MT Friesen, P Bocangel, D Cheung, K Rawszer … - Key words, 2005 - springerlink.com
... been shown for the control of nuclear localiza- tion of PBX1 in developing ... Homeodomain
proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors ...
Web Search - ingentaconnect.com