Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice - Full text - MIT Libraries
JJ Moskow, F Bullrich, K Huebner, IO Daar, AM … - Mol. Cell. Biol, 1995 - mcb.asm.org
... Meis1, a PBX1-Related Homeobox Gene Involved in Myeloid ... digests were analyzed by
Southern blot hy- bridization using probes for Meis1, Egfr, Rel, and Spnb2 ...
Cited by 96 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic … - Full text - MIT Libraries
BJ Feldman, T Hampton, ML Cleary… - Blood, 2000 - bloodjournal.org
... advantage to E2A-PBX1-expressing cells leading to accelerated development of lymphomas
in Notch1 C /E2A-PBX1 mice. Recent studies have shown that Rel/NF- B ...
Cited by 23 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Frequencies of the major subgroups of precursor B-cell acute lymphoblastic leukemia in Indian …
TM Med - Trends Mol Med, 2002 - nature.com
... of cell survival in CD95-induced T cell apoptosis: role of NF-kB/Rel factors ... patients
carrying BCR-ABL or E2A-PBX1 are older than patients carrying TEL-AML1 and ...
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Interaction of DNA with clusters of amino acids in proteins - Full text - MIT Libraries
S Material, R Sathyapriya, S Vishveshwara - Nucleic Acids Res, 2004 - pubmedcentral.nih.gov
... It is seen that the size of the Type II clusters from yeast mating protein alpha
(1akhA) and PBX1 homeodomain (1b72B), REL homology proteins, zinc fingers from ...
Web Search

RAS mutations in pediatric leukemias with MLL gene rearrangements
N Mahgoub, RI Parker, MR Hosler, P Close, NJ … - Genes Chromosomes and Cancer, 1998 - doi.wiley.com
... Dx diagnosis, Rel relapse, IF induction failure; ALL acute lymphoblastic leukemia ...
patho- genesis of ALLs with chromosomal translocations disrupting PBX1 or MLL. ...
Cited by 9 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Interaction of DNA with clusters of amino acids in proteins - Full text - MIT Libraries
R Sathyapriya, S Vishveshwara - Nucleic Acids Research, 2004 - nar.oupjournals.org
... It is seen that the size of the Type II clusters from yeast mating protein alpha
(1akhA) and PBX1 homeodomain (1b72B), REL homology proteins, zinc fingers from ...
Web Search - nar.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Homology between human chromosome 2p13. 3 and the wobbler critical region on mouse chromosome 11: … - Full text - MIT Libraries
K Resch, D Korthaus, N Wedemeyer, A Lengeling, M … - Mamm Genome, 1998 - springerlink.com
... SJ, Nash WG, Rice N (1985) Genetic characterization of human c-rel sequences. ... Bullrich
F, Huebner K, Daar IO, Buchberg AM (1995) Meis1, a PBX1-related homeobox ...
Cited by 10 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Notch signaling in leukemia
JC Aster, WS Pear - Curr. Opin. Hematol, 2001 - co-hematology.com
... altered by pre-existent expression of other oncoproteins (for example, E2A-PBX1
or c ... Rel-type transcription factors represent a second potential target for the ...
Cited by 27 - Web Search - co-hematology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Fine mapping of the 1 q 21 breakpoint of the papillary renal cell carcinoma-associated(X; 1) … - Full text - MIT Libraries
MAJ Weterman, M Wilbrink, T Dijkhuizen, E van den … - Human Genetics, 1996 - springerlink.com
... s) involved, we have mapped a panel of markers of the proximal 1q region rel- ative
to ... 1994); and probes corresponding to exon 1 and 9 of pbx1 by Dr. M. Cleary ...
Cited by 15 - Web Search

Frequency and Clinical Relevance of TEL-AML1 Fusion Gene in Childhood Acute Lymphoblastic Leukemia …
HM SHAKER, IA SIDHOM, IA EL-ATTAR - nci.edu.eg
... Most common of such molecular abnormalities are the E2A-PBX1, BCR-ABL and MLL-AF4
fu- sion genes which are presently used as ... L2 L2 L2 L1 L2 L2 L2 Rel Rel Rel ...
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1 The Use of Emerging Patterns in the Analysis of Gene Expression Profiles for the Diagnosis and …
G DONG, J LI, L WONG - sdmc.i2r.a-star.edu.sg
... Nevertheless, empirical evidence [68] suggests that so long as A and B are rel- ...
including T-ALL, E2A-PBX1, TEL-AML1, BCR-ABL, MLL, Hyperdiploid>50,
Cited by 1 - View as HTML - Web Search - comp.nus.edu.sg - research.i2r.a-star.edu.sg - sdmc.lit.org.sg - all 7 versions »

Table 3. Verification of SAGE tags matching to multiple UniGene clusters by GLGI
ID UniGene - pnas.org
... GTGACCACGG. GLUR. 2. Hs. 44313. 0. 7. GTGGTACGTG. REL. 2. Hs. 44865. 0. 83. GAAGAGTTCC.
LEF1. 2. ... RAD30. 3. Hs. 155691. 0. 68. TTATCAGCCA. PBX1. 2. Hs. 156114. 1. ...
Web Search

Repression by HoxA7 is mediated by the homeodomain and the modulatory action of its N-terminal-arm … - Full text - MIT Libraries
CA Schnabel, C Abate-Shen - Mol. Cell. Biol, 1996 - mcb.asm.org
... plasmid and the pCG147-c-rel CCRxC construct containing the Rel DNA binding ... the
transcriptional prop- erties of HoxA7 in the presence of the Hox cofactor Pbx1. ...
Cited by 24 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Control of the nuclear localization of Extradenticle by competing nuclear import and export signals - Full text - MIT Libraries
M Abu-Shaar, HD Ryoo, RS Mann - Genes Dev, 1999 - genesdev.org
... Dorsal, a Drosophila Rel-like protein, is phosphorylated upon activation of the ... Meis1
and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction ...
Cited by 75 - Web Search - genesdev.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

A multiplex reverse transcription-polymerase chain reaction strategy for the diagnostic molecular … - Full text - MIT Libraries
L Elia, M Mancini, L Moleti, G Meloni, S Buffolino … - Haematologica-, 2003 - haematologica.org
... 67 E2A-PBX1 7 4 − − − − − 3 ... What is already known on this topic Molecular
characterization of leukemic cells is rel- evant to clinical decision ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov - haematologica.it - haematologica.it - all 7 versions »

BMC Bioinformatics - Full text - MIT Libraries
LR Grate - BMC Bioinformatics, 2005 - biomedcentral.com
... free parameters in this method is m + 1, hence is very small rel- ative to ... 12,625
Affymetrix HG_U95Av2 probes) [26] 43 T-lineage ALL (T) 27 E2A-PBX1 (E2A) 15 ...
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Mutator phenotype in human hematopoietic neoplasms and its association with deletions disabling DNA … - Full text - MIT Libraries
S Indraccolo, S Minuzzo, L Nicoletti, E Cretella, … - Blood, 1999 - bloodjournal.org
... R, remission; Rel, relapse ... While specific genetic changes are very sensitive tumor
markers, including the BCR-ABL, MLL-AF4, E2A-PBX1, and TEL-AML1 fusion genes ...
Cited by 17 - Web Search - bloodjournal.org - bloodjournal.org - ncbi.nlm.nih.gov - all 6 versions »

CANCER ET GENETIQUE: DETERMINATION DES SUJETS A RISQUE
IAT RISK - adfcongres.com
... L. aiguë lymphoblastique t(1;19)(q23;p13.3) E2A-PBX1 F. de transcription ...
(L. : leucémie) • myc • rel • jun • ski • fos • mtb (4) ...
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Comparative genomics provides evidence for an ancient genome duplication event in sh
JS Taylor, Y Van de Peer, I Braasch, A Meyer - Phil. Trans. R. Soc. Lond. B, 2001 - journals.royalsoc.ac.uk
Page 1. Comparative genomics provides evidence for an ancient genome duplication
event in sh John S. Taylor, Yves Van de Peer, Ingo Braasch and Axel Meyer * ...
Cited by 102 - Web Search - evolutionsbiologie.uni-konstanz.de - mit.edu - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute …
JJ van Dongen, EA Macintyre, JA Gabert, E … - Leukemia, 1999 - nature.com
... A total of nine well-defined chromosome aberrations with fusion gene transcripts
were selected: t(1;19) with E2A-PBX1 , t(4;11) with MLL-AF4 , t(8;21) with AML1 ...
Cited by 213 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Ho me o box genes: a mole cu lar link betwe en deve lop ment and cancer Ge nes home o box: uma rela …
IDUCTI ON - Pesqui Odontol Bras, 2003 - scielo.br
... Other fusions, as PBX1 to E2A and HRX to nuclear proteins, alter the se-
quence-specific ... Vita G, Barba P, Odartchen ko N, Givel JC, Freschi G, Buc ci a rel ...
View as HTML - Web Search - scielo.br

Molecular diagnosis and monitoring of acute lymphoblastic leukaemia: applications and limitations
A Biondi, G Cazzaniga - haematologica.it
... data have not confirmed the predictive value of MRD detection of E2A-PBX1 chimeric
mRNA ... oc- curring in leukaemia has emerged as one the most rel- evant issue ...
View as HTML - Web Search - haematologica.org

Drosophila in cancer research
CJ Potter, GS Turenchalk, T Xu - Trends Genet, 2000 - botany.utoronto.ca
... dorsal NF- B/Rel family D.NF1 NF1 lats Lats1, Lats2 D.E2F (D.E2F DP) E2F patched
ptch l(1)malignant ? extradenticle Pbx1 PP2A-29B PPP2RIB l(2)k07918 ? ...
Cited by 33 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Chromosomal abnormalities and tumor development: from genes to therapeutic mechanisms - Full text - MIT Libraries
C Cobaleda, J Perez-Losada, I Sanchez-Garcia - BioEssays, 1998 - doi.wiley.com
... 16)(q26;p13) T lymphoma IL-2, BCM inv(2;2)(p13;p11–14) NHL REL/NGR inv ... products include
homeodomain proteins, such as HOX11 in T-ALL (10–12) and PBX1 in pre ...
Cited by 13 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Heterozygous HESX 1 mutations associated with isolated congenital pituitary hypoplasia and septo- … - Full text - MIT Libraries
PQ Thomas, MT Dattani, JM Brickman, D McNay, G … - Human Molecular Genetics, 2001 - hmg.oupjournals.org
... with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1–Hox–DNA ...
1999) Interactions between an HMG-1 protein and members of the Rel family ...
Cited by 64 - Web Search - hmg.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Improved bubble velocity equation for bubbling fluidized beds
AW Weimer, DE Clough - AIChE Journal, 1983 - doi.wiley.com
... It has the form &'Jb(pD - pBX1 - (SB)) 1/2 [ PD ... The bubble-phase drift velocity,
VBj, is related to the local rel- ative velocity between phases by (5 1 ...
Cited by 1 - Web Search - Get it from MIT Libraries

Genomic approaches to hematologic malignancies - Full text - MIT Libraries
BL Ebert, TR Golub - Blood, 2004 - bloodjournal.org
... the top panel, the 3 component dimensions separate cases of T-ALL, E2A-PBX1,
TEL-AML1 ... 2 gene, was present in 26 cases, and amplification of the c-rel gene was ...
Cited by 8 - Web Search - broad.mit.edu - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Evi9 encodes a novel zinc finger protein that physically interacts with BCL6, a known human B-cell … - Full text - MIT Libraries
T Nakamura, Y Yamazaki, Y Saiki, M Moriyama, DA … - Mol. Cell. Biol, 2000 - mcb.asm.org
... REL proto-oncogene is frequently amplified in extranodal diffuse large cell lymphoma. ...
The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within ...
Cited by 15 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Abnormalities of the ETV 6 gene occur in the majority of patients with aberrations of the short arm …
HE O’Connor, TA Butler, R Clark, S Swanton, CJ … - Leukemia, 1998 - nature.com
... 1 F/9 c-ALL Rel del(12)(p11)[18]/[2] t(12;21) Exon 5-6 + NA NA ?G/R 2 F/8 c-ALL
Rel del(12)(p13)[17]/[1] NA Exon 5-6 + G/R 6.5kb+6.5kb ?G/R ...
Cited by 16 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Original Contributions
TN Ferraro, GT Golden, GG Smith, JF Martin, FW … - springerlink.com
... We now confirm this seizure-related QTL (Szs1) using reciprocal, interval-specific
con- genic strains and map it to a 6.6-Mb segment be- tween Pbx1 and D1Mit150 ...
Web Search - med.uc.edu

Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function - Full text - MIT Libraries
CM McKinnon, K Docherty - Diabetologia, 2001 - springerlink.com
... This redundancy could also explain the rel- atively high amounts of insulin in ... is
in part stabilised through interactions between PDX-1 and PBX1 that involve a ...
Cited by 44 - Web Search - uni-greifswald.de - biochemie.uni-greifswald.de - ncbi.nlm.nih.gov - all 5 versions »

CONSEQUENCES OF CHROMOSOMAL ABNORMALITIES IN TUMOR DEVELOPMENT - Full text - MIT Libraries
I Sanchez-Garcia - Annual Review of Genetics, 1997 - dx.doi.org
... Also present are homeodomain proteins such as HOX11 in T-ALL (54, 64, 79) or PBX1,
which can be fused to E2A in preB-cell leukemias (61, 93); paired box ...
Cited by 25 - Web Search - wwwlib.bionet.nsc.ru - genet.annualreviews.org - ncbi.nlm.nih.gov - all 6 versions »

Molecular effects of novel mutations in Hesx1/HESX1 associated with human pituitary disorders - Full text - MIT Libraries
JM Brickman, M Clements, R Tyrell, D McNay, K … - Development, 2001 - dev.biologists.org
... et al., 1998) via its conserved DNA binding motif, the Rel domain. ... Recent structural
studies of Pbx1 class homeodomains highlight the importance of homeodomain ...
Cited by 32 - Web Search - www-unix.oit.umass.edu - dev.biologists.org - ncbi.nlm.nih.gov

New Molecular Methods for Classification, Diagnosis and Therapy Prediction of Hematological … - Full text - MIT Libraries
A Zvara, L Hackler Jr, BZ Nagy, T Micsik, LG … - Pathol. Oncol. Res, 2002 - webio.hu
... with t(12;21)/TEl-AML1 and t(1;19)/E2A-PBX1 translocations is ... be recognized with
fluorescent antibodies, the direct visualization of the rel- ative position of ...
Cited by 1 - View as HTML - Web Search - ncbi.nlm.nih.gov - webio.hu

Genomic and Proteomic Profiling of Responses to Toxic Metals in Human Lung Cells - Full text - MIT Libraries
AS Andrew, AJ Warren, A Barchowsky, KA Temple, L … - Environmental Health Perspectives, 2003 - ehpnet1.niehs.nih.gov
... RPL6 BTF2p44 H2TF1 hSMN NF-X1 GRRF1 PBX1 ROBO1 HIF1-α HOX-A5 GABP-a
PN-II JUN Synapsin SAP2 AREB6 ADA2 BRCA1 bcl-6 IL2RA CREB2 ...
Cited by 12 - View as HTML - Web Search - earthscape.org - dx.doi.org - csa.com - all 9 versions »

Human t (1; 19)(q23; p13) pre-B acute lymphoblastic leukemia in mice with severe combined … - Full text - MIT Libraries
FM Uckun, JR Downing, R Gunther, LM Chelstrom, D … - Blood, 1993 - bloodjournal.org
... SCID) mice were in- jected intravenously with 5 X 1 OB primary bone marrow (BM)
blasts from newly diagnosed patients with E2A-PBX1 fusion transcript positive t ...
Cited by 14 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Transcript profiling of human dendritic cells maturation-induced under defined culture conditions: … - Full text - MIT Libraries
F Moschella, A Maffei, RP Catanzaro, KP … - British Journal of Haematology, 2001 - ingentaconnect.com
... 8 IL-8, T-cell chemotactic factor; (LYNAP), Y00787 8 c-rel,X75042 4 IL ... X69292 32
CD30 ligand (CD30L); CD153 antigen, L09753 16 homeobox protein pbx1/prl, M86546 ...
Cited by 11 - Web Search - ncbi.nlm.nih.gov

Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators
M Wilson, P Koopman - Curr Opin Genet Dev, 2002 - imb.uq.edu.au
... complex was able to increase the transcriptional activity of the Hox/Pbx1 complex. ...
M, Locker D: HMG boxes of DSP1 protein interact with the rel homology domain ...
Cited by 41 - View as HTML - Web Search - imb.uq.edu.au - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

TranSignal TM GR-TF Interaction Arrays
PU Manual - panomics.com
... 11. REFERENCES 1. Rayet, B. and Gelinas, C. (1999) Aberrant rel/NFkB genes and activity
in human cancer. Oncogene 18: 6938-6947. 2. Gugasyan, R. et al. ...
View as HTML - Web Search - biocat.de

Compilation of vertebrate-encoded transcription factors - Full text - MIT Libraries
S Faisst, S Meyer - Nucleic Acids Res, 1992 - pubmedcentral.nih.gov
... t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins ...
B is identical to factor KBF1 and homologous to the rel oncogene product. ...
Cited by 344 - Web Search - ncbi.nlm.nih.gov

Identification of a novel mouse Iroquois homeobox gene, Irx 5, and chromosomal localisation of all … - Full text - MIT Libraries
A Bosse, A Stoykova, K Nieselt-Struwe, K Chowdhury … - Developmental Dynamics, 2000 - doi.wiley.com
... The next rel- atives are the homeodomain protein of the mouse TGIF gene (40%), the ...
gene (40%) as well as the mouse homeodo- main protein of the PBX1 gene (38 ...
Cited by 14 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

4 ONCOGENES
MA Pierotti, SA Schichman, G Sozzi, CM Croce - cancer.org
... Deregulated activity Transcription factor v-rel 2p12–14 Viral homologue
Lymphatic leukemia Deregulated activity Mutant NFKB v-ets-1 ...
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Gene Expression Profiling of Adult Acute Myeloid Leukemia Identifies Novel Biologic Clusters for …
CS Wilson, GS Davidson, SB Martin, E Andries, Y Xu … - hsc.unm.edu
... STK17A plays a role in the regulation of apoptosis; PBX1 is a cofactor in genetic
mechanisms that ... (IRF4), a gene regulated by NF-kappa β member c-rel; 68 IL ...
View as HTML - Web Search - hsc.unm.edu

Signal transduction by activated mNotch: Importance of proteolytic processing and its regulation by … - Full text - MIT Libraries
R Kopan, EH Schroeter, H Weintraub, JS Nye - Developmental Biology, 1996 - dx.doi.org
PDF Version of this Article. Similar articles found in: PNAS Online PubMed. PubMed
Citation. This Article has been cited by: other online articles. ...
Cited by 178 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Follow-up of residual disease using metaphase-FISH in patients with acute lymphoblastic leukemia in …
W El-Rifai, T Ruutu, K Vettenranta, E Elonen, UM … - Leukemia, 1997 - nature.com
... or t(11;14) provide specific fusion genes BCR/ABL, E2A/PBX1, ... important, 11,16,29
this finding seems to have less clinical rel- evance early after BMT (3–6 ...
Cited by 9 - Web Search - nature.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Genetics of Diabetes
RB Horenstein, AR Shuldiner - Reviews in Endocrine and Metabolic Disorders, 2004 - springerlink.com
... member 9 (KCNJ9), pre-B-cell leukemia transcrip- tion factor 1 (PBX1), solute carrier ...
the T2DM susceptibility gene in this region will likely be rel- evant to ...
Cited by 1 - Web Search - kluweronline.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

The last common bilaterian ancestor - Full text - MIT Libraries
DH Erwin, EH Davidson - Development, 2002 - dev.biologists.org
... The Wnt/TCF, Dpp or TGFß/MADS, TollR/Rel Factor, Hedgehog/Ci, Nuclear ... transcription
factors to specify proximal regions (meis1/2 and pbx1 in vertebrates, and ...
Cited by 37 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

[PS] CITATIONS FOR PROTEIN/DNA (REGULATORY) - Full text - MIT Libraries
PDA White, X Ding, JC Vanderspek, JR Murphy, D … - J. Biol. Chem, 2004 - aist.go.jp
... C.-P.Chang, ML.Cleary, C.Wolberger Structure of a Hoxb1-Pbx1 Heterodimer Bound ... Phelps,
G.Ghosh X-ray Crystal Structure of Proto-Oncogene Product c-Rel Bound to ...
Cited by 10 - View as HTML - Web Search - ndbserver.rutgers.edu - ndbserver.rutgers.edu

The use of genetic microarray analysis to classify and predict prognosis in haematological … - Full text - MIT Libraries
AP Levene, GJ Morgan, FE Davies - Clinical and Laboratory Haematology, 2003 - blackwell-synergy.com
... the known prognostically important leukaemic cell types (T-ALL, E2A-PBX1, BCR-ABL ...
the BCL-2 gene, and chromosome 2p amplifications involving the c-REL gene only ...
Cited by 2 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH …
WS Pear, JC Aster - Curr Opin Hematol, 2004 - co-hematology.com
... NOTCH signaling, this work shows that CSL has two rel homology domains ... deletion mutant
of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice. ...
Cited by 3 - Web Search - co-hematology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries