A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream … - Full text - MIT Libraries
JR McWhirter, M Goulding, JA Weiner, J Chun, C … - Development, 1997 - dev.biologists.org
... Pbx1 is a homeodomain transcription factor that has the ability to form heterodimers
with homeodomain proteins encoded by the homeotic selector (Hox) gene ...
Cited by 87 - Web Search - www-biology.ucsd.edu - wwwlib.bionet.nsc.ru - ncbi.nlm.nih.gov - all 6 versions »

The pentapeptide motif of Hox proteins is required for cooperative DNA binding with Pbx1, physically … - Full text - MIT Libraries
PS Knoepfler, MP Kamps - Mol. Cell. Biol, 1995 - mcb.asm.org
... Lane 1 contains reticulocyte lysate alone, and lane 2 contains E2A-Pbx1 alone ... 2,
for the Hox-B8 P134L mutant one-third as much protein was used as for the rest. ...
Cited by 65 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when … - Full text - MIT Libraries
X Fu, MP Kamps - Mol. Cell. Biol, 1997 - mcb.asm.org
... JBgl 12), were ligated to the amplified fragments from the E2a-Pbx1-transformed
NIH ... The rest of the procedures are approximately the same as in the first-round ...
Cited by 44 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

One price to run, swim or fly? - Full text - MIT Libraries
RMN Alexander - EMBO J, 1998 - nature.com
... terminal side, and which is essential for the cooperative binding of Pbx1 and
HoxB-1 ... seems to be that mammals and birds have much higher rest- ing metabolic ...
Cited by 3 - Web Search - nature.com - dx.doi.org - ncbi.nlm.nih.gov

Many accurate small-discriminatory feature subsets exist in microarray transcript data: biomarker … - Full text - MIT Libraries
LR Grate - BMC Bioinformatics, 2005 - biomedcentral.com
... Figure 7 From the YeohALL data, E2A vs the rest, the best single gene PBX1. Figure
8 From the YeohALL data, E2A vs the rest, the best gene pair RPS6 and LRMP. ...
Cited by 1 - Cached - Web Search - dx.doi.org - pubmedcentral.nih.gov - citebase.eprints.org - all 6 versions »

BMC Bioinformatics - Full text - MIT Libraries
LR Grate - BMC Bioinformatics, 2005 - biomedcentral.com
... (note that there are two probes for PBX1 both giving the same result, so there are
really only 3 genes) All of these are high in E2A and lower in the rest. ...
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Antagonism between - Full text - MIT Libraries
M Torres, C MartınA, RS Mann, G Morata - NATURE, 1998 - nature.com
... of the limb into two antagonistic domains, as defined by exd (Pbx1) function and ...
This subdivision into Exd-nuc and Exd-cyt domains persists for the rest of leg ...
Web Search - nature.com

The HoxB 1 hexapeptide is a prefolded domain: Implications for the Pbx 1/Hox interaction - Full text - MIT Libraries
CM Slupsky, DB Sykes, GL Gay, BD Sykes - Protein Science, 2001 - proteinscience.org
... Similar , , and 1 angles are found between the X-ray structure bound to Pbx1 and
DNA and the ... are close to 1 Å), this is to be expected because the rest of the ...
Cited by 7 - Web Search - protsci.highwire.org - dx.doi.org - ncbi.nlm.nih.gov - all 8 versions »

Formation of der (19) t (1; 19)(q 23; p 13) in acute lymphoblastic leukemia
K Paulsson, A Horvat, T Fioretos, F Mitelman, B … - Genes Chromosomes and Cancer, 2005 - doi.wiley.com
... all loci telomeric to PBX1, only A and B would—in all instances and in one-third
of the cases, respectively—give rise to LOH for the rest of chromosome 1 ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - lu-research.lub.lu.se - Get it from MIT Libraries

HOXA10, Pbx2, and Meis1 protein expression in the human endometrium: formation of multimeric … - Full text - MIT Libraries
JL Sarno, HJ Kliman, HS Taylor, HS Taylor, A … - J Clin Endocrinol Metab, 2005 - jcem.endojournals.org
... Meis2, Pbx1, and Pbx3 were not identified in the endometrium and so are ... in early
proliferative glandular epithelium and was absent throughout the rest of the ...
Cited by 2 - Web Search - jcem.endojournals.org - ncbi.nlm.nih.gov

Children and adults with acute lymphoblastic leukaemia have similar gene expression profiles. - Full text - MIT Libraries
E Kuchinskaya, M Heyman, D Grander, M Linderholm, … - European Journal Of Haematology, 2005 - blackwell-synergy.com
... compared to the rest of the samples. Thus, in case No. 16, that was previously found
to have a normal karyotype, a high expression of the PBX1 gene was observed ...
Web Search - blackwell-synergy.com - ejh.dk - ncbi.nlm.nih.gov

Gene mining: a novel and powerful ensemble decision approach to hunting for disease genes using … - Full text - MIT Libraries
X Li, S Rao, Y Wang, B Gong - Nucleic Acids Research, 2004 - nar.oupjournals.org
... of D i and N i constitutes a test set and the rest of the ... expression of this gene
as highly associated with a leukemia subtype, E2A-PBX1 (24), suggesting that ...
Cited by 7 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Apoptosis: death as a“vital” biological function
HW Schnaper - Pediatric Nephrology, 1994 - springerlink.com
... The proto-oncogene c-myc, the homeobox gene E2A-PBX1 or the cytokine transforming ...
involution, whereas in others the structure fails to grow as the rest of the ...
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Using Rules to Analyse Bio-medical Data: A Comparison between C4. 5 and PCL
J Li, L Wong - Proc. of Advances in Web-Age Information Management, 2003 - springerlink.com
... The rest of the paper is organized as follows. ... BCR-ABL 12558 BCR-ABL, others 9 +
206 6 + 106 E2A-PBX1 12558 E2A-PBX1, others 18 + 197 9 + 103 ...
Cited by 1 - Web Search - research.i2r.a-star.edu.sg - sdmc.lit.org.sg - sdmc.i2r.a-star.edu.sg - all 7 versions »

Control of Drosophila adult pattern by extradenticle - Full text - MIT Libraries
S Gonzalez-Crespo, G Morata - Development, 1995 - dev.biologists.org
... Similarly, the ectopic expression of each of these homeotic genes in the absence
of the rest of BX-C products results in gene-specific segment patterns ...
Cited by 57 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Gene Expression Profile in AML Gene expression profile reveals deregulation of genes with relevant …
NC Gutierrez, R Lopez-Perez, JM Hernandez, I … - Leukemia, 2005 - nature.com
... Genes distinguishing the APL from the rest of AML (non-APL) were identified ... AML samples
with an intensity level similar to controls while PBX1 expression was ...
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The Smad transcriptional corepressor TGIF recruits mSin3 - Full text - MIT Libraries
D Wotton, PS Knoepfler, CD Laherty, RN Eisenman, J … - Cell Growth Differ, 2001 - cgd.aacrjournals.org
... solution and bound to DNA: proposal for a mechanism of HoxB1-Pbx1-DNA complex ... T.
The co-repressor mSin3A is a functional component of the REST-CoREST repressor ...
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1 The Use of Emerging Patterns in the Analysis of Gene Expression Profiles for the Diagnosis and …
G DONG, J LI, L WONG - sdmc.i2r.a-star.edu.sg
... Childhood leukaemia is a heterogeneous disease comprising more than 10 subtypes,
including T-ALL, E2A-PBX1, TEL-AML1, BCR-ABL, MLL, Hyperdiploid>50,
Cited by 1 - View as HTML - Web Search - comp.nus.edu.sg - research.i2r.a-star.edu.sg - sdmc.lit.org.sg - all 7 versions »

Gene expression profile reveals deregulation of genes with relevant functions in the different …
S Salamanca-CSIC - Leukemia, 2005 - nature.com
... Genes distinguishing the APL from the rest of AML (non-APL) were identified ... AML samples
with an intensity level similar to controls while PBX1 expression was ...
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Discovery of significant rules for classifying cancer diagnosis data - Full text - MIT Libraries
J Li, H Liu, SK Ng, L Wong - Bioinformatics, 2003 - sdmc.i2r.a-star.edu.sg
... other than E2A-PBX1, while 100% of the samples in the E2A-PBX1 class each ... The rest
of the paper is organized as follows: Section 2 provides more background ...
Cited by 10 - View as HTML - Web Search - sdmc.lit.org.sg - bioinformatics.oupjournals.org - ncbi.nlm.nih.gov - all 9 versions »

Using the Human Genome - Full text - MIT Libraries
JA Boyle - Biochemistry and Molecular Biology Education, 2002 - intl.bambed.org
... was ideal for this purpose and provided the core for the rest of the course ... CP Chang,
ML Cleary, C. Wolberger (1999) Structure of a HoxB1-Pbx1 heterodimer bound ...
Web Search - intl.bambed.org

Assessing the impact of alternative splicing on domain interactions in the human proteome - Full text - MIT Libraries
A Resch, Y Xing, B Modrek, M Gorlick, R Riley, C … - J. Proteome Res, 2004 - pubs.acs.org
... Two functionally distinct protein isoforms of Pbx1 (Pbx1a and Pbx1b) have been identi ...
BTB/POZ dimerization domain (Figure 4B) while leaving the rest of the ...
Cited by 17 - Web Search - pubs.acs.org - ncbi.nlm.nih.gov

Comparison of Machine Learning Algorithms on Different Microarray Data Sets
B Brors, P Warnat, R Eils - dkfz.de
... Classes consisted of cytogenetically defined groups, namely BCR-ABL, E2A-PBX1 and
TEL-AML1 fusion genes by ... compared the largest class (HD) versus the rest: ...
View as HTML - Web Search - dkfz-heidelberg.de - dkfz.de - dkfz-heidelberg.de

The Arabidopsis BELL1 and KNOX TALE homeodomain proteins interact through a domain conserved between … - Full text - MIT Libraries
M Bellaoui, MS Pidkowich, A Samach, K Kushalappa, … - Plant Cell, 2001 - intl.plantcell.org
... proteins includes the vertebrate pre–B cell leukemia homeodomain proteins (PBX1,
PBX2, and PBX3 ... The function of this sequence, and the rest of the BELL domain ...
Cited by 26 - Web Search - pubmedcentral.nih.gov - bioinfo.pbi.nrc.ca - plantcell.org - all 6 versions »

Multiplex Real-time RT-PCR for Prospective Evaluation of WT 1 and Fusion Gene Transcripts in Newly …
M Yanada, S Terakura, T Yokozawa, K Yamamoto, H … - Leukemia & Lymphoma, 2004 - dx.doi.org
... and micro BCR-ABL, AML1-MTG8, CBFb-MYH11, PML-RARa, TEL-AML1, E2A-PBX1, MLL-AF4 ... Patients
with PML-RARa showed signifi- cantly higher levels than the rest of the ...
Cited by 2 - Web Search - taylorandfrancis.metapress.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

From Informatics to Bioinformatics
VB Bajic, V Brusic, J Li, SK Ng, L Wong - APBC, 2003 - portal.acm.org
... No Y Y Y Y Y Y T-ALL MLL T-ALL? E2A-PBX1? TEL-AML1? BCR-ABL? Hyperdip z 50?
BCR-ABL TEL-AML1 E2A-PBX1 No No OTHERS Hyperdip 50 Figure 9: The classification
Cited by 1 - Web Search - crpit.com - comp.nus.edu.sg - sdmc.lit.org.sg - all 12 versions »

High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice - Full text - MIT Libraries
W Yan, AZ Young, VC Soares, R Kelley, R Benezra, Y … - Mol. Cell. Biol, 1997 - mcb.asm.org
... link the E2A gene to one of two novel genes, one (pbx1) encoding a ... tumors, three
were sick due to incidental bacterial infections, and the rest were normal at ...
Cited by 84 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Interaction of DNA with clusters of amino acids in proteins - Full text - MIT Libraries
S Material, R Sathyapriya, S Vishveshwara - Nucleic Acids Res, 2004 - pubmedcentral.nih.gov
... of the proteins in the dataset and through individual residues in the rest. ... same
cluster as in the ETS domain proteins (1bc8C, 1pueE), PBX1 homeodomain (1b72B ...
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Multiple levels of transcriptional and post-transcriptional regulation are required to define the … - Full text - MIT Libraries
T Brend, J Gilthorpe, D Summerbell, PW Rigby - Development, 2003 - dev.biologists.org
... and cross-regulation by Hoxa1, in association with the cofactor Pbx1 (Pöpperl et
al ... continued to shift posteriorly until 9.5 dpc, coming to rest alongside so6 ...
Cited by 9 - Web Search - dx.doi.org - dev.biologists.org - ncbi.nlm.nih.gov - all 5 versions »

Severe digital abnormalities in a patient heterozygous for both a novel missense mutation in HOXD 13 … - Full text - MIT Libraries
P Debeer, C Bacchelli, PJ Scambler, L De Smet, JP … - Journal of Medical Genetics, 2002 - dx.doi.org
... proteins, have an arginine at this position, while most of the rest have lysine. ...
Chang CP, Cleary ML, Wolberger C. Structure of a HoxB1-Pbx1 heterodimer bound ...
Cited by 9 - Web Search - jmg.bmjjournals.com - jmg.bmjjournals.com - ncbi.nlm.nih.gov - all 5 versions »

Regulation of a decapentaplegic midgut enhancer by homeotic proteins - Full text - MIT Libraries
JR Manak, LD Mathies, MP Scott - Development, 1994 - dev.biologists.org
... exd encodes a homeodomain protein closely related to the mammalian proto-oncogene
Pbx1 (Rauskolb et al., 1993) and its family members. ...
Cited by 36 - Web Search - scottlab.stanford.edu - med.stanford.edu - ncbi.nlm.nih.gov - all 6 versions »

Bachelor’s Thesis
M Held, R Spang, PDM Vingron - molgen.mpg.de
... each combination can be assessed. For the rest of this section, we will
make use of the following notation: X is a p×n matrix of ...
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FGF signaling through FGFR 1 is required for olfactory bulb morphogenesis - Full text - MIT Libraries
JM Hebert, M Lin, J Partanen, J Rossant, SK … - Development, 2003 - dev.biologists.org
... in initial OB formation. Compared with the rest of the telencephalon, the
OB undergoes unique morphological changes. In mice, OB ...
Cited by 17 - Web Search - stanford.edu - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Interaction of DNA with clusters of amino acids in proteins - Full text - MIT Libraries
R Sathyapriya, S Vishveshwara - Nucleic Acids Research, 2004 - nar.oupjournals.org
... of the proteins in the dataset and through individual residues in the rest. ... same
cluster as in the ETS domain proteins (1bc8C, 1pueE), PBX1 homeodomain (1b72B ...
Web Search - nar.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation - Full text - MIT Libraries
GW Klappacher, VV Lunyak, DB Sykes, D Sawka- … - Cell, 2002 - rosenfeldlab.ucsd.edu
... E2A-Pbx1-immortalized bone marrow progenitor cells using a DP103-specific antibody ...
To investigate whether METS can induce cell cycle ar- rest independently of ...
Cited by 17 - View as HTML - Web Search - rosenfeldlab.ucsd.edu - ncbi.nlm.nih.gov

Molecular effects of novel mutations in Hesx1/HESX1 associated with human pituitary disorders - Full text - MIT Libraries
JM Brickman, M Clements, R Tyrell, D McNay, K … - Development, 2001 - dev.biologists.org
... of the corpus callosum is more hypoplastic than the rest of the ... Recent structural
studies of Pbx1 class homeodomains highlight the importance of homeodomain ...
Cited by 32 - Web Search - www-unix.oit.umass.edu - dev.biologists.org - ncbi.nlm.nih.gov

On the role of structural information in remote homology detection and sequence alignment: new … - Full text - MIT Libraries
CL Tang, L Xie, IY Koh, S Posy, E Alexov, B Honig - J. Mol. Biol, 2003 - perun.bioc.columbia.edu
... they were considered to be structurally similar by our structural distance criterion,
namely PSD ,1. As an example, the Homeodomain protein, Pbx1 (SCOP domain ...
Cited by 13 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

PATTERNING MECHANISMS CONTROLLING VERTEBRATE LIMB DEVELOPMENT - Full text - MIT Libraries
J Capdevila, JCI Belmonte - Annual Review of Cell and Developmental Biology, 2001 - intl-cellbio.annualreviews.org
Annual Reviews tagline graphic, ...
Cited by 99 - Web Search - astro.annualreviews.org - lifesci.sussex.ac.uk - ncbi.nlm.nih.gov - all 6 versions »

Variation in the Lamin A/C Gene - Full text - MIT Libraries
NI Steinle, R Kazlauskaite, IG Imumorin, WC Hsueh, … - Arteriosclerosis, Thrombosis, and Vascular Biology, 2004 - atvbaha.org
... Excellent positional candidate genes include APOA (apolipoprotein A2), 6 PBX1
(pre–B ... sphygmomanometer while the subject was seated after 10 minutes of rest. ...
Cited by 2 - Cached - Web Search - atvb.ahajournals.org - ahavj.ahajournals.org - ncbi.nlm.nih.gov - all 7 versions »

Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding … - Full text - MIT Libraries
A Miyamoto, X Cui, L Naumovski, ML Cleary - Mol. Cell. Biol, 1996 - mcb.asm.org
... 3). Similarly, the E2a-PBX1 fusion protein, which lacks the HLH of E2a, was not ... sion
levels of such T-cell markers could cause maturation ar- rest and lead to ...
Cited by 22 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov - all 5 versions »

Alterations in the conserved SL1 trans-spliced leader of Caenorhabditis elegans demonstrate … - Full text - MIT Libraries
KC Ferguson, JH Rothman - Mol. Cell. Biol, 1999 - mcb.asm.org
... with an 8-kb plasmid containing the wild-type pha-1 gene (pBX1 [13]; kindly ... An outline
of the rest of the structure (67 nt), generated by computer prediction (6 ...
Cited by 7 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov

Current Status of Acute Lymphoblastic Leukaemia in Children
J HK - fmshk.com.hk
... count <50×10 9 /L Must not have CNS leukaemia (CNS-3 status), overt testicular
leukaemia, t(9;22) or BCR-ABL fusion, t(1;19) or E2A-PBX1 fusion, rearranged MLL ...
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Functional and regulatory interactions between Hox and extradenticle genes - Full text - MIT Libraries
N Azpiazu, G Morata - Genes Dev, 1998 - genesdev.org
... for DNA binding have been described at the molecular level for Exd and homeotic
products in Drosophila and for the mouse Hoxb7 and Hoxb8 and Pbx1 and Pbx2 ...
Cited by 27 - Web Search - genesdev.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Dialogue
U CANCER - cancer.uchc.edu
... As you enter the Cancer Center, there is a comfortable work or rest area designed
to meet ... q11.2) BCR/ABL 11q23 rearrangement for t(4;11) MLL/AF4 E2A/PBX1[t(1;19 ...
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Leukaemia stem cells and the evolution of cancer-stem-cell research - Full text - MIT Libraries
BJP Huntly, DG Gilliland - Nature Reviews Cancer, 2005 - nature.com
... Cohnheim 150 years ago (TIMELINE) that cancer results from the activation of dormant
embryonic-tissue rem- nants 14,15 .This ‘embryonal-rest hypothesis’of ...
Cited by 3 - Web Search - biochem.northwestern.edu - ncbi.nlm.nih.gov

Immunological Detection of Minimal Residual Disease in Acute Lymphoblastic Leukemia
MN Dworzak, F fuer krebskranke Kinder, W St Anna … - Onkologie, 2001 - content.karger.com
... Chimeric proteins (eg of the E2A- PBX1 rearrangement) or antigens expressed due
to ... apy, and later on of hematopoietic regeneration after rest from chemotherapy ...
Cited by 2 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

Dorsotonals/homothorax, the Drosophila homologue of meis1, interacts with extradenticle in … - Full text - MIT Libraries
E Kurant, CY Pai, R Sharf, N Halachmi, YH Sun, A … - Development, 1998 - dev.biologists.org
Page 1. INTRODUCTION The embryonic peripheral nervous system (PNS) of Drosophila
comprises approximately 600 neurons and 1200 associated ...
Cited by 65 - Web Search - dev.biologists.org - wwwlib.bionet.nsc.ru - ncbi.nlm.nih.gov

Bachelor Thesis
J Toedling - molgen.mpg.de
... in leukemia include E2A-PBX1 and TEL-AML1, which also promote cell proliferation. ...
T-lymphocytes and six originating from B-lymphocytes (BCR-ABL, E2A-PBX1, MLL, ...
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Long-term follow-up of patients with newly diagnosed adult acute lymphoblastic leukemia: a single …
X Thomas, C Danaila, QH Le, C Sebban, J Troncy, C … - Leukemia, 2001 - nature.com
... Molecular characterization of BCR/ABL, E2A-PBX1, HRX-AF4 rearrangements at diagnosis
were ... 190 relapses occurred by year 3 and nearly all the rest occurred by ...
Cited by 14 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Differentiation of Insulin-Producing Cells from Human Neural Progenitor Cells
S Material, Y Hori, X Gu, X Xie, S Kim - pubmedcentral.nih.gov
... Nestin (NM_006617), ngn3 (AF234829), Nkx6.1 (NM_006168), NRSF/REST (U13879), Olig2 ...
Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice ...
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