Gene Expression Profiling and Microarrays Gene expression profiling of leukemic cell lines reveals …
A Andersson, P Eden, D Lindgren, J Nilsson, C … - Leukemia, 2005 - nature.com
... We obtained further support for this by analyzing primary ALL and AML samples with
11q23/MLL rearrangements, TCF3/PBX1, RUNX1/CBFA2T1, P190 BCR/ABL1, or ETV6 ...
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Research Paper Prospective gene expression analysis accurately subtypes acute leukaemia in children …
FW van Delft, T Bellotti, Z Luo, LK Jones, N Patel … - blackwell-synergy.com
... five categories in those with ALL (hyperdiploid; ETV6 RUNX1; E2A PBX1; RUNX1
amplification; T-ALL) and three categories in those with AML (MLL; RUNX1 ETO; M7). ...
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The E2A-HLF oncoprotein activates Groucho-related genes and suppresses Runx1 - Full text - MIT Libraries
J Dang, T Inukai, H Kurosawa, K Goi, T Inaba, NT … - Mol Cell Biol, 2001 - mcb.asm.org
... are activated by E2A-HLF, and they suggest that downregulation of RUNX1 may contribute
to ... The t(1;19) generates the E2A-PBX1 chimera, consisting of the AD1 and ...
Cited by 7 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov

Children and adults with acute lymphoblastic leukaemia have similar gene expression profiles. - Full text - MIT Libraries
E Kuchinskaya, M Heyman, D Grander, M Linderholm, … - European Journal Of Haematology, 2005 - blackwell-synergy.com
... included into the study: 7 with MLL rearrangement, 8 with ETV6/RUNX1, 5 with
BCR/ABL, 3 with high hyperdiploidy and 1 with PBX1/TCF3. Microarray analysis ...
Web Search - blackwell-synergy.com - ejh.dk - ncbi.nlm.nih.gov

Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among …
A Andersson, P Eden, D Lindgren, J Nilsson, C … - Leukemia, 2005 - ncbi.nlm.nih.gov
... the gene expression profiles of 40 cell lines as well as of primary leukemias harboring
11q23/MLL rearrangements, t(1;19)[TCF3/PBX1], t(12;21)[ETV6/RUNX1], t(8 ...
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Pattern robustness of diagnostic gene expression signatures in leukemia
A Kohlmann, C Schoch, M Dugas, S Rauhut, F … - Genes Chromosomes and Cancer, 2005 - doi.wiley.com
... nostically relevant subclasses (Pui et al., 2004): pre- cursor T-cell ALL;
t(1;19)(q23;p13.3) (E2A/PBX1); t(12;21)(p13;q22) (ETV6/RUNX1); rearrangements of ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Prevalence estimates of recurrent balanced cytogenetic aberrations and gene fusions in unselected …
F Mitelman, F Mertens, B Johansson - GENES, CHROMOSOMES & CANCER, 2005 - doi.wiley.com
Page 1. Prevalence Estimates of Recurrent Balanced Cytogenetic Aberrations and
Gene Fusions in Unselected Patients with Neoplastic Disorders ...
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Update on human systemic lupus erythematosus genetics
BP Tsao - Curr Opin Rheumatol, 2004 - co-rheumatology.com
... and the SLE-associated haplotypes were replicated in 149 white families, implicating
PBX1 as a ... SNP affects a binding site of a transcription factor RUNX1 in an ...
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Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia - Full text - MIT Libraries
R Strick, PL Strissel, S Borgers, SL Smith, JD … - Cancer Res, 2004 - dx.doi.org
... translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in ...
Beau, RA Larson, and JD Rowley Genomic DNA breakpoints in AML1/RUNX1 and ETO ...
Cited by 82 - Web Search - pnas.org - pubmedcentral.nih.gov - soyonlineservice.co.nz - all 8 versions »

Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dcl3 by ear … - Full text - MIT Libraries
MY Ahn, G Huang, SC Bae, HJ Wee, WY Kim, Y Ito - Mol. Cell. Biol, 2005 - dx.doi.org
... the Cytoplasm and Prevented from Functioning as a Partner of the Runx1 Transcription
Factor ... page DB Sykes and MP Kamps Estrogen-dependent E2a/Pbx1 myeloid cell ...
Cited by 4 - Web Search - pnas.org - pnas.org - pubmedcentral.nih.gov

Current Advances in the Human Lupus Genetics - Full text - MIT Libraries
N Shen, BP Tsao - Current Science, 2004 - current-reports.com
Cited by 1 - Web Search - current-reports.com - biomedcentral.com - ncbi.nlm.nih.gov

Clinical and biological importance of cytogenetic abnormalities in childhood and adult acute …
B Johansson, F Mertens, F Mitelman - Annals of Medicine, 2004 - dx.doi.org
Page 1. Clinical and biological importance of cytogenetic abnormalities
in childhood and adult acute lymphoblastic leukemia Bertil ...
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Leukaemia- a developmental perspective - Full text - MIT Libraries
S Izraeli - British Journal of Haematology, 2004 - blackwell-synergy.com
... This review describes three examples of this general paradigm of leukaemogenesis:
RUNX1 abnormalities in acute leukaemias, GATA1 mutations in the leukaemias of ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

Hematopoietic, angiogenic and eye defects in Meis 1 mutant animals - Full text - MIT Libraries
T Hisa, SE Spence, RA Rachel, M Fujita, T Nakamura … - The EMBO Journal, 2004 - embojournal.npgjournals.com
... transcription factors such as GATA3 (Pandolfi et al, 1995), RUNX1 (Okuda et ... Pbx1
and Meis1 mutant animals share several phenotypes in common, including defects ...
Cited by 9 - Web Search - nature.com - embojournal.npgjournals.com - ncbi.nlm.nih.gov

Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia - Full text - MIT Libraries
LH Castilla, P Perrat, NJ Martinez, SF Landrette, … - Proc Natl Acad Sci US A, 2004 - pubmedcentral.nih.gov
... to that resulting from homozygous disruption of either the a (Runx1 -/- )- or b ...
associated with lymphomagenesis, including CD2-myc (14), E2A-PBX1 (15), Pim1 ...
Cited by 8 - Web Search - dx.doi.org - pnas.org - ncbi.nlm.nih.gov - all 5 versions »

Transcriptional Profiling During the Early Differentiation of Granulocyte and Monocyte Progenitors …
DB Sykes, J Scheele, M Pasillas, MP Kamps - Leukemia & Lymphoma, 2003 - dx.doi.org
... Conditional Versions of the E2a–Pbx1 Oncoprotein ... E2a–Pbx1 Enforces the Transcription
of Genes Required for RNA Processing, DNA Synthesis and the Cell Cycle ...
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acquises de la cellule souche hematopoietique ou d’un precurseur deja commis vers les lignees …
S YNTHESE - MEDECINE/SCIENCES, 2003 - ist.inserm.fr
... core binding factor) qui comporte deux sous-unités CBFA2 (ou AML1, RUNX1) et CBFβ ...
19p13) Facteur de transcription de type bHLH LAL pré-B PBX1 (1q23) Facteur ...
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Origins of chromosome translocations in childhood leukaemia - Full text - MIT Libraries
MF Greaves, J Wiemel - Nature Reviews Cancer, 2003 - nature.com
... Site-specific translocation and evidence of post-natal origin of the t(1;19)
E2A-PBX1 translocation in childhood acute lymphoblastic leukemia. Proc. Natl Acad. ...
Cited by 47 - Web Search - nature.com - ncbi.nlm.nih.gov

Both 5' and 3' flanks regulate Zebrafish brain-derived neurotrophic factor gene expression - Full text - MIT Libraries
G Heinrich, C Pagtakhan - BMC Neuroscience, 2004 - biomedcentral.com
... sites in HCS1 (table 5). Potential binding sites for Pbx1, Cdx, CHOP, Gata, HSF
and AML-1a were found. AML-1, also known as Runx1, contains a runt type of DNA ...
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Redundant function of Runt Domain binding partners, Big brother and Brother, during Drosophila … - Full text - MIT Libraries
JS Kaminker, R Singh, T Lebestky, H Yan, U … - Development, 2001 - dev.biologists.org
... to our results, in mammalian systems it is the -subunit, Runx1, that is ... The subcellular
localization of PBX1 and EXD proteins depends on nuclear import and ...
Cited by 7 - Web Search - mcdb.ucla.edu - dev.biologists.org - ncbi.nlm.nih.gov

Pediatric Acute Lymphoblastic Leukemia - Full text - MIT Libraries
WL Carroll, D Bhojwani, DJ Min, E Raetz, M Relling … - Hematology, 2003 - asheducationbook.org
... were identified representing known leukemia subtypes including: BCR-ABL, E2A-PBX1,
TEL-AML1 ... also called ETV6) with the AML1 gene (also called CBFA2 or RUNX1). ...
Cited by 8 - Web Search - asheducationbook.org - ncbi.nlm.nih.gov

Gene Expression Profiling of Leiomyoma and Myometrial Smooth Muscle Cells In Response to TGF-β
X Luo, L Ding, J Xu, N Chegini - Endocrinology (submitted), 2004 - endo.endojournals.org
... dependent regulation of IL-11, TGIF, TIEG, EGR3, CITED2, Nur77, RUNX1, RUNX2,
p27, p57, Gas-1 ... in LSMC and MSMC are Runx1 and Runx2. ...
Cited by 1 - Web Search - endo.endojournals.org

SUPPLEMENTARY DATA FOR CLASSIFICATION, SUBTYPE DISCOVERY, AND PREDICTION OF OUTCOME IN PEDIATRIC …
I Section, E Methods, II Section, P Dataset - stjuderesearch.org
... The average percent present calls for our overall dataset was 29.7%, and for each
of the genetic subgroups was BCR-ABL (31.1%), E2A-PBX1 (28.9%), Hyper >50 (31 ...
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Oncogenes et leucemies: historique et perspectives
S Gisselbrecht, BG Roussy - M e decine et Science, 2003 - erudit.org
... CBF (core binding factor) qui comporte deux sous-unités CBFA2 (ou AML1, RUNX1) et
CBFβ ... de fixation à l’ADN de la protéine à homéodomaine PBX1 alors que ...
Cited by 2 - Cached - Web Search

Gene Expression Profile in AML Gene expression profile reveals deregulation of genes with relevant …
NC Gutierrez, R Lopez-Perez, JM Hernandez, I … - Leukemia, 2005 - nature.com
... AML samples with an intensity level similar to controls while PBX1 expression was ...
However, RUNX1 (at 21q22) expression levels had similar intensity in all AML ...
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Hematopoietic perturbation in zebrafish expressing a tel-jak2a fusion.
SM Onnebo, MM Condron, DO McPhee, GJ Lieschke, AC … - Experimental Hematology, 2005 - eanimal.snu.ac.kr
... myeloid leukemia, reproduced the hematological consequences observed in RUNX1-CBF2T1
knock ... Estrogen-dependent E2a/Pbx1 myeloid cell lines exhibit conditional ...
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[PS] CITATIONS FOR PROTEIN/DNA (REGULATORY) - Full text - MIT Libraries
PDA White, X Ding, JC Vanderspek, JR Murphy, D … - J. Biol. Chem, 2004 - aist.go.jp
... C.-P.Chang, ML.Cleary, C.Wolberger Structure of a Hoxb1-Pbx1 Heterodimer Bound ...
Z.Li, NA.Speck, AJ.Warren The Leukemia-Associated Aml1 (Runx1)-Cbfbeta Complex ...
Cited by 10 - View as HTML - Web Search - ndbserver.rutgers.edu - ndbserver.rutgers.edu

Molecular signatures of self-renewal, differentiation, and lineage choice in multipotential … - Full text - MIT Libraries
L Bruno, R Hoffmann, F McBlane, J Brown, R Gupta, … - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... in this pan-downregulated cluster encode proteins such as SPARC, calcyclin, and
Pbx1 that have been ... Like Runx1, PU.1 and the C/EBPs have been implicated in the ...
Cited by 4 - Web Search - mcb.asm.org - ncbi.nlm.nih.gov

Gene expression profile reveals deregulation of genes with relevant functions in the different …
S Salamanca-CSIC - Leukemia, 2005 - nature.com
... AML samples with an intensity level similar to controls while PBX1 expression was ...
However, RUNX1 (at 21q22) expression levels had similar intensity in all AML ...
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Prenatal origin of separate evolution of leukemia in identical twins
O Teuffel, DR Betts, M Dettling, R Schaub, BW … - Leukemia, 2004 - nature.com
... T-cell leukemia) and cytogenetic abnormalities such as TEL-AML1, E2A-PBX1, BCR-ABL ...
Clonal variation of the immunogenotype in relapsed ETV6/RUNX1-positive acute ...
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Cell intrinsic alterations underlie hematopoietic stem cell aging - Full text - MIT Libraries
DJ Rossi, D Bryder, JM Zahn, H Ahlenius, R Sonu, … - Proc Natl Acad Sci US A, 2005 - pnas.org
... Of these, Runx1/AML1, Cbfa2t1h/ETO, Pml, Nckipsd, Arhgef12, Trim24, Erg, Fgfr1,
Whsc1/1 ... in the majority of human myeloid leukemias, whereas Bcl3, Pbx1, and Maf ...
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Animal models of acute myelogenous leukaemia– development, application and future perspectives
E Mc Cormack, O Bruserud, BT Gjertsen - Leukemia, 2005 - nature.com
... Firstly, the AML1(Cbfa2, Runx1, Pebp2 B) 84 oncogene targeted by chromosomal
translocation t(8 ... MDS1/EVI1, 446 Hoxa9-Meis1 447 and Hoxa9-E2A/Pbx1 448 transfected ...
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BIO-TECHNICAL METHODS (BTS)
J Qiu, P Gunaratne, LE Peterson, D Khurana, N … - Leukemia, 2003 - nature.com
... o45) chromosomal status, or one of the following chromosomal translocations:
TEL-AML t(12;21), E2A-PBX1 ... 12 21–30 AML1, RUNX1 Acute myeloid leukemia 1 gene 21 ...
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Genome-based identification of cancer genes by proviral tagging in mouse retrovirus-induced T-cell … - Full text - MIT Libraries
R Kim, A Trubetskoy, T Suzuki, NA Jenkins, NG … - J Virol, 2003 - jvi.asm.org
... One of its paralogs, Runx1/AML1, is important in human leukemias and was also ...
Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias ...
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Hematopoietic stem cells
D Bonnet - Birth Defects Research Part C Embryo Today Reviews, 2003 - doi.wiley.com
... Using Runx1 LacZ knock-in embryos, HSC activity could be found in AGM cells express ...
expansion could be achieved by knocking down the ex- pression of PBX1 in HOX ...
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Recognition of 5 0-YpG-3 0 Sequences by Coupled Stacking/Hydrogen Bonding Interactions with Amino … - Full text - MIT Libraries
JS Lamoureux, JT Maynes, JNM Glover - J. Mol. Biol, 2004 - gloverlab.biochem.ualberta.ca
... 1B72 Pbx1- Hox1 2.35 R55 (B290) RTGATT 2.02 20.83 0.42 3.34 23.75 9.01 33.9 4.5
1B8I Ubx-Exd 2.40 R55 (B258) RTGATT 1.58 20.66 0.36 3.45 21.96 10.77 35.1 3.6 ...
Cited by 4 - View as HTML - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov

Appearance of leukemia in peripheral blood
A Neutropenia, B Anemia, C Thrombocytopenia, C Mac - bloodjournal.org
... Non-lymphoid Hematopoietic Sarcomas. Granulocytic sarcoma. ENU treated Runx1-ETO
knock-in mice. Histiocytic sarcoma. Retroviral transduction with BCR-ABL Fusion ...
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Production of high-titer helper-free retroviruses by transient transfection - Full text - MIT Libraries
WS PEAR, GP NOLAN, ML SCOTT, D BALTIMORE - Proc. Nat. Acad. Sci, 1993 - pnas.org
... Home page BA Hug, N. Ahmed, JA Robbins, and MA Lazar A Chromatin Immunoprecipitation
Screen Reveals Protein Kinase C{beta} as a Direct RUNX1 Target Gene J. Biol ...
Cited by 1223 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - adsabs.harvard.edu - all 5 versions »

Progress in Hematology
M Eguchi, M Eguchi-Ishimae, M Greaves - Int J Hematol, 2005 - cardenjennings.metapress.com
... Multistep leukemogenesis appears to be the rule, as, for example, in childhood ALL
with TEL-AML1 (ETV6- RUNX1) fusion or in AML with AML1-ETO and Cbfb- MYH11 ...
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CHROMATIN MODIFICATION, LEUKAEMIA AND IMPLICATIONS FOR THERAPY - Full text - MIT Libraries
EIINP MODIFICATION - British Journal of Haematology, 2002 - ingentaconnect.com
... EVI-1 ZF Vinatzer et al (2001) E2A E12, E47, LH Dang et al (2001) PBX1 HD
de La Fuente et al (2000) HLF bZIP, LZ Dang et al (2001) ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov

Animal Models for the Study of Childhood Leukemia: Considerations for Model Identification and …
DL McCormick, R Kavet - International Journal of Toxicology, 2004 - dx.doi.org
... such as AML1 (RUNX1), or the presence of translocation-associated chimeric fusion
genes such as TEL-AML1, AML1-ETO, BCR-ABL, MLL-AF4, or E2A-PBX1 have been ...
Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Expression Profiling of Genes and Proteins in HaCaT Keratinocytes: Proliferating Versus … - Full text - MIT Libraries
G Lemaıt, J Lamartine, A Pitaval, P Vaigot, J … - Journal of Cellular Biochemistry, 2004 - doi.wiley.com
Page 1. Journal of Cellular Biochemistry 93:1048–1062 (2004) Expression Profiling
of Genes and Proteins in HaCaT Keratinocytes: Proliferating ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

[BOOK] Cytogenetic and molecular genetic changes in childhood acute leukaemias
T Niini - 2002 - ethesis.helsinki.fi
... factor receptor HLH helix-loop-helix LOH loss of heterozygosity MLL mixed lineage
leukaemia MYC v-myc avian myelocytomatosis viral oncogene homologue PBX1 pre-B ...
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Bibliography Current World Literature
L Benboubker, H Watier, A Carion, MT Georget, I … - Current Opinion in Hematology, 2002 - co-hematology.com
May 2002, 9:3 > Bibliography Current World Literature. < Previous | Next >.
ARTICLE LINKS: Permissions | View full size inline images. ...
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Bibliography Current World Literature
JY Bertrand, S Giroux, R Golub… - Current Opinion in Hematology, 2005 - co-hematology.com
... [44]. •• Maier H, Ostraat R, Gao H, et al.: Early B cell factor cooperates with
Runx1 and mediates epigenetic changes associated with mb-1 transcription. ...
Web Search - co-gastroenterology.com - co-ophthalmology.com - coronary-artery.com