Enlarged and Prominent Nucleoli May Be Indicative of MYCN Amplification
C Kobayashi, HL Monforte-Munoz, RB Gerbing, DO … - Cancer, 2005 - doi.wiley.com
... NBL, U/PD-H, without MYCN amplification was rela- tively rare, accounting for 5.3%
of all pNTs in the CCG-3881 and CCG-3891 studies (33 of 628). ...
Web Search - nant.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

Chromosome bands 1 p 35–36 contain two distinct neuroblastoma tumor suppressor loci, one of which …
H Caron, N Spieker, M Godfried, M Veenstra, P van … - Genes Chromosomes and Cancer, 2001 - doi.wiley.com
... Appar- ently, amplification of MYCN strongly correlates with deletion of 1p, suggesting
a functional rela- tionship between MYCN and a 1p suppressor locus. ...
Cited by 24 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Constitutively Active NFkappa B Is Required for the Survival of S-type Neuroblastoma - Full text - MIT Libraries
X Bian, AW Opipari Jr, AB Ratanaproeksa, AE … - J Biol Chem, 2002 - jbc.org
... Malignant S-type cells express neither high levels of MYCN nor Bcl-2, suggesting
that ... family of related proteins including NF B1/p50, NF B2/p52, RelA/p65, RelB ...
Cited by 11 - Web Search - dx.doi.org - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

Multidrug resistance‐associated protein 1(MRP 1) expression in neuroblastoma cell lines and …
H Goto, N Keshelava, KK Matthay, JN Lukens, RB … - Medical and Pediatric Oncology, 2000 - doi.wiley.com
... expression level of MRP1 RNA tended to be higher in cell lines established after
chemotherapy rela- tive to ... MYCN RNA expression was found in 18 of 21 cell lines ...
Cited by 4 - Web Search - nant.org - reprints.nant.org - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

N 7: A novel multi‐modality therapy of high risk neuroblastoma(NB) in children diagnosed over 1 …
NKV Cheung, BH Kushner, M LaQuaglia, K Kramer, S … - Medical and Pediatric Oncology, 2001 - doi.wiley.com
... a phase I study of 131 I-3F8, efficacy findings and the rela- tive absence ... immunotherapy
have the potential of curing high-risk NB (stage 4 or MYCN am- plified ...
Cited by 26 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

17q Gain in Neuroblastoma Predicts Adverse Clinical Outcome
S O’Neill, C Ellershaw, P Roberts, I Lewis, ADJ … - Medical and Pediatric Oncology, 2001 - doi.wiley.com
... The distribution of 17q gain was determined in rela- tion to established ... test the
predictive significance of age, stage, 1p deletion, MYCN amplification, and ...
Web Search - doi.wiley.com

Neuroblastoma: a clinical challenge and biologic puzzle - Full text - MIT Libraries
KK Matthay - CA Cancer J Clin, 1995 - caonline.amcancersoc.org
... CT or MRI scan; MIBG scan; surgery with histologic grading, MYCN analysis Metastases ...
multivariate analysis is still required to define the rela- tive importance ...
Cited by 18 - Web Search - caonline.amcancersoc.org - ncbi.nlm.nih.gov

Evolving significance of prognostic markers associated with treatment improvement in patients with …
J Mora, WL Gerald, J Qin, NKV Cheung - Cancer, 2002 - doi.wiley.com
... dehydrogenase [LDH] levels), histopathology (International Neuroblastoma Pathology
Classification [INPC]), and tumor biologic markers (MYCN; ploidy; loss of ...
Cited by 11 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Opsoclonus-Myoclonus-Ataxia Syndrome in Neuroblastoma: Clinical Outcome and Antineuronal Antibodies …
E Rudnick, Y Khakoo, NL Antunes, RC Seeger, GM … - Medical and Pediatric Oncology, 2001 - doi.wiley.com
... report that not all these tumors have favorable characteristics, and that MYCN
ampli®cation ... Similarly, no apparent rela- tionship was found in this study. ...
Cited by 9 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Detailed molecular analysis of 1 p 36 in neuroblastoma
PS White, PM Thompson, BA Seifried, EP Sulman, SJ … - Medical and Pediatric Oncology, 2001 - doi.wiley.com
... No MYCN amplification was detected in the tumor. ... has been diagnosed in only two of
these cases, both patients with neuroblastoma had rela- tively large ...
Cited by 18 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

[CITATION] Journal of Medicine
R CHEMOTHERAPY, AB MARROW
... diagnosis the defining char- acteristics of high-risk neuroblastoma include an age
of more than one year, metastases, amplification of the MYCN oncogene, and ...
Web Search - purging.nant.org - purging.nant.org

Localization of a hereditary neuroblastoma predisposition gene to 16 p 12-p 13
MJ Weiss, C Guo, S Shusterman, G Hii, TL Mirensky, … - Medical and Pediatric Oncology, 2000 - doi.wiley.com
... patient age at diagnosis (P 0.37), disease stage (P 0.25), MYCN amplification status ...
alternatively due to coincident occurrence of this rela- tively rare cancer ...
Cited by 12 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Hypermethylation-mediated regulation of CD44 gene expression in human neuroblastoma
P Yan, A Muhlethaler, KB Bourloud, MN Beck, N … - Genes Chromosomes Cancer, 2003 - doi.wiley.com
... CD44 expression was restricted to tumor tissues, whereas a MYCN-related loss ... The
suggested rela- tionship between CD44 gene hypermethylation and loss of CD44 ...
Cited by 7 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Childhood Cancer: Past Successes, Future Directions
A Leukemia - rimed.org
... for relapsed ALL, par- ticularly in patients who relapse rela- tively late ... strong
predictors of outcome, espe- cially amplification of the mycN oncogene (which ...
View as HTML - Web Search - rimed.org

Identification of a novel zinc finger gene, zf 5-3, as a potential mediator of neuroblastoma … - Full text - MIT Libraries
J Dimitroulakos, M Pienkowska, P Sun, S Farooq, M … - International Journal of Cancer, 1999 - doi.wiley.com
... Similarly, neuroblastoma cells that represent rela- tively undifferentiated neural
crest ... parallels the expression pattern observed for mycN (Mugrauer et al ...
Cited by 3 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

ECop (EGFR-Coamplified and overexpressed protein), a novel protein, regulates NF-jB transcriptional … - Full text - MIT Libraries
S Park, CD James - Oncogene, 2005 - nature.com
... frequently involved in promoting cell prolif- eration, as exemplified by MYCN (2p24)
in ... group of inducible transcription factors that consist of p65/RelA, c-Rel ...
Web Search - nature.com - ncbi.nlm.nih.gov

Histopathology defines prognostic subsets of ganglioneuroblastoma, nodular
S Umehara, A Nakagawa, KK Matthay, JN Lukens, RC … - Cancer, 2000 - doi.wiley.com
... of 552 patients (19.2%) with tumors of the non-GNBn subtypes had amplified MYCN
(P 0.005). ... 1, 2), it was rela- tively easy to distinguish the stroma-rich/stroma ...
Cited by 6 - Web Search - reprints.nant.org - nant.org - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

Natural antibody against neuroblastoma among Japanese children with or without neuroblastoma
M Fukuda, C Nozaki, Y Ishiguro, K Horibe - Cancer, 1999 - doi.wiley.com
... studies in large cohorts should be performed to clarify the rela- tion among ... However,
the unusual fact that our study included only one MYCN-amplified tumor of ...
Cited by 2 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

The Journal of Experimental Medicine
LS Metelitsa, HW Wu, H Wang, Y Yang, Z Warsi, S … - nant.org
... in rela- tionship to iNKT infiltration showed that survival was 64 and 35% at 5
yr for iNKT and iNKT tumors (P 0.007; Fig. 5 A). Genomic amplification of MYCN ...
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The proteasome in cancer biology and treatment - Full text - MIT Libraries
F Pajonk, WH McBride - Radiat. Res, 2001 - bioone.org
... a very short half-life of 30 min (105) , and MYC and MYCN are both ... different NFKB
subunits: p50 (TNFRSF5)/p105 (NFKB1), p52/p100 (NFKB2), REL, p65/RELA and RELB ...
Cited by 13 - Web Search - strahlenbiologie.bei.t-online.de - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Development of resistance to vincristine and doxorubicin in neuroblastoma alters malignant … - Full text - MIT Libraries
R Kotchetkov, J Cinatl, R Blaheta, JU Vogel, J … - International Journal of Cancer, 2003 - doi.wiley.com
... METHODS Cell culture and induction of drug resistance The human MYCN-amplified NB ...
Comparison of rela- tive fluorescence intensities (RFU) for P-gp showed that ...
Web Search - ncbi.nlm.nih.gov

Sphingolipids in Neuroblastoma: Their Role in Drug Resistance Mechanisms
H Sietsma, AJ Dijkhuis, W Kamps, JW Kok - Neurochemical Research, 2002 - springerlink.com
... silencing of the gene provides a permis- sive environment for MYCN gene amplification
(27 ... They are rela- tively abundant in cells of neuronal tissue but usually ...
Cited by 2 - Web Search - kluweronline.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

University of California Postprints
S Gebauer, AL Lu, M Omura-Minamisawa, A Batova, MB … - repositories.cdlib.org
... As we observed in neuroblastoma cell lines, no rela- tionship between CDKN2A and ...
Cell line Type MYCN amplification ID2 mRNA ID2 protein CDKN2A protein a CDKN1B ...
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TOPICAL TOPICS Recent Advances in the Diagnosis of Pediatric Soft-Tissue Tumors
SE Kilpatrick, AJ Garvin - Medical and Pediatric Oncology, 1999 - doi.wiley.com
... and molecular ab- errations have involved many established as well as rela- tively
new ... EMA CD99 Neuroblastoma SYN 1p36 deletion or MYCN amplification 70%–80% ...
Cited by 4 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Prognostic significance of DNA di-tetraploidy in neuroblastoma
R Ladenstein, IM Ambros, U Poetschger, G Amann, C … - Medical and Pediatric Oncology, 2001 - doi.wiley.com
... we describe combined studies of DNA ploidy, MYCN amplification (NMA), 1p deletion,
and serological factors (NSE, LDH, ferritin) and their rela- tionship to ...
Cited by 11 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Neuron-Specific Enolase Evaluation in Patients with Neuroblastoma - Full text - MIT Libraries
M Casanova, C Botti, L Ferrari, A Martinetti, SN … - Tumor Biol, 1998 - content.karger.com
... age and advanced stage, pseudodiploid karyotypes, 1p deletions, MYCN oncogene
amplification ... is shown in figure 1. We found a statistical rela- tionship between ...
Cited by 3 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 6 versions »

Neuroblastoma and parental occupation
AF Olshan, AJ De Roos, K Teschke, JP Neglia, DO … - Cancer Causes & Control, 1999 - springerlink.com
... 4]. Nonethe- less, few studies have speci®cally evaluated the rela- tionship between ...
The relatively small number of cases with MYCN oncogene ampli®ed tumors ...
Cited by 14 - Web Search - kluweronline.com - ncbi.nlm.nih.gov - csa.com - Get it from MIT Libraries

Genomic DNA-chip hybridization in t (11; 14)-positive mantle cell lymphomas shows a high frequency … - Full text - MIT Libraries
H Kohlhammer, C Schwaenen, S Wessendorf, K … - Blood, 2004 - bloodjournal.org
... TNFRSF10C, TNFRSF10D); 10p13 (2.7 Mbp; BMI1); 11q13 (1.4 Mbp; RELA); 11q13 (5.2
Mbp ... so-called secondary genetic aberrations, as, for example, Mycn or Mycl ...
Cited by 10 - Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov - all 6 versions »

Neuroblastoma tumour genetics: clinical and biological aspects - Full text - MIT Libraries
N Bown - J Clin Pathol, 2001 - jcp.bmjjournals.com
... plex combinations of acquired genetic aberrations, including ploidy changes, deletions
of chromosome arms 1p and 11q, amplification of the MYCN oncogene, and ...
Cited by 25 - Web Search - doccancers.info - doccancers.info - ncbi.nlm.nih.gov - all 6 versions »

Monitoritzacio de malaltia residual minima en el neuroblastoma mitjancant dilucions seriades amb RT- …
A Parareda, A Llort, J Reventos, JS de Toledo, S … - acmcb.es
... In four out of five patient studied, we found a rela- tive increase in ... els pacients
amb tumors avançats amb amplificació de l’oncogen MYCN, delecció de l ...
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Microarray transcript profiling distinguishes the transient from the acute type of megakaryoblastic … - Full text - MIT Libraries
S McElwaine, C Mulligan, J Groet, M Spinelli, A … - British Journal of Haematology, 2004 - ingentaconnect.com
... In contrast, MYCN (neuroblastoma-derived oncogene) was expressed in TMD
at a significantly greater level than in AMKL. MYCN has ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

Shedding Light on the Dark Side of the Genome: Overlapping Genes in Higher Eukaryotes
S Boi, G Solda, ML Tenchini - Current Genomics, 2004 - dx.doi.org
... Multiple antisense transcripts, originated by a divergent gene (MYCNOS), which starts
within the first intron of the human MYCN, have been reported. ...
Cited by 3 - Web Search - ingentaconnect.com

Antioncogenes and human cancer - Full text - MIT Libraries
AG Knudson - Proc Natl Acad Sci USA, 1993 - pnas.org
Page 1. Proc. Natl. Acad. Sci. USA Vol. 90, pp. 10914-10921, December 1993
Review Antioncogenes and human cancer Alfred G. Knudson ...
Cited by 232 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Evolving Therapies for a Disease with Many Faces
RE Goldsby, KK Matthay - ingentaconnect.com
... Hirschsprung disease, central hy- the presence or absence of MYCN (the gene encoding
the n-myc ... independent of other variables such as stage and MYCN gene ...
Web Search

Cytogenetic Abnormalities and Clinical Outcome in Wilms Tumor: A Study by the UK Cancer Cytogenetics …
S Hibbert, H Middleton, A Kelsey, D Tritton, C … - Med Pediatr Oncol, 2002 - doi.wiley.com
... ndings (particularly ploidy changes, chromosome arm 1p deletion or MYCN gene ampli ...
We investigated outcome in rela- tion to the complexity of tumor karyotype ...
Cited by 6 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Transcriptional Control of Hepatocanalicular Transporter Gene Expression - Full text - MIT Libraries
M MUeLLER - Seminars in Liver Disease, 2000 - humanabc.4t.com
... NF- B consists of homo- or heterodimers of Rel (c-Rel), p65 (RelA), RelB, p50, and
p52, all of which have a conserved N-terminal Rel homology do- main that has ...
Cited by 31 - View as HTML - Web Search - ncbi.nlm.nih.gov

Frequent aberrant promoter hypermethylation of O 6-methylguanine-DNA methyltransferase and death- … - Full text - MIT Libraries
D Rossi, G Gaidano, A Gloghini, C Deambrogi, S … - British Journal of Haematology, 2003 - ingentaconnect.com
... the frequency of MGMT aberrant hypermethylation among immunodeficiency-rela- ted
NHL ... preferentially in childhood neu- roblastomas with amplification of MYCN. ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Detection of chromosomal imbalances in retinoblastoma by matrix-based comparative genomic …
B Zielinski, S Gratias, G Toedt, F Mendrzyk, DE … - Genes Chromosomes and Cancer, 2005 - doi.wiley.com
... are listed in Table 1, and the imbalanced chromosomal regions in the cell lines
are listed in Table 2 in rela- tion to ... 2p24.1–2p24.1 [Mb 21.20–21.49] MYCN ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

HISTONE-DEACETYLASE INHIBITORS: NOVEL DRUGS FOR THE TREATMENT OF CANCER - Full text - MIT Libraries
RW Johnstone - Nature Reviews Drug Discovery, 2002 - nature.com
... 35. Teitz, T. et al. Caspase -8 is deleted or silenced preferentially in childhood
neuroblastomas with amplification of MYCN. Nature Med. 6, 529-535 (2000). ...
Cited by 137 - Web Search - nature.com - ncbi.nlm.nih.gov

Transcriptional Control of Hepatocanalicular Transporter Gene Expression - Full text - MIT Libraries
G TRANSCRIPTION, T FACTORS - Semin Liver Dis, 2000 - thieme-connect.com
... κB consists of homo- or heterodimers of Rel (c-Rel), p65 (RelA), RelB, p50 ... A close
correlation between the expression of MRP1 and the MYCN oncoprotein has been ...
Web Search

TUMOeRER DIAGNOSTISERAS MED CYTOGENETIK
F MITELMAN, B JOHANSSON, N MANDAHL, F MERTENS - ltarkiv.lakartidningen.se
... Rela- tion of cytogenetic abnormalities and clini- cal outcome in metastatic ... Comparison
of DNA aneuploidy, chromosome 1 abnor- malities, MYCN amplification and ...
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Molecular modes of action of cephalotaxine and homoharringtonine from the coniferous tree …
T Efferth, A Sauerbrey, ME Halatsch, DD Ross, E … - Naunyn-Schmiedeberg’s Arch Pharmacol, 2003 - springerlink.com
... features leads to the formation of a cluster, where the length of the branch indicates
the degree of rela- tion. ... MYCN v-myc-related oncogene, neuroblastoma ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Expression of MHC class I, MHC class II, and cancer germline antigens in neuroblastoma - Full text - MIT Libraries
M Woelfl, AA Jungbluth, F Garrido, T Cabrera, S … - Cancer Immunology Immunotherapy, 2005 - springerlink.com
... class I antigens in human neuroblastoma cells: analysis of its rela- tionship to ...
Sarkar AK, Nuchtern JG (2000) Lysis of MYCN-amplified neuroblastoma cells by ...
Web Search - ncbi.nlm.nih.gov

Metaiodobenzylguanidine assessment of metastatic neuroblastoma: Observer dependency and …
D Frappaz, A Bonneu, P Chauvot, V Edeline, F … - Medical and Pediatric Oncology, 2000 - doi.wiley.com
... The rela- tive score also failed to predict outcome; only six of ten patients with ...
of subjects with a good prognosis [9]. Biologic factors such as MYCN or CD44 ...
Cited by 8 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Semantic Relations Asserting the Etiology of Genetic Diseases
TC Rindflesch, B Libbus, D Hristovski, AR Aronson, … - Proc AMIA Symp, 2003 - lhncbc.nlm.nih.gov
... An overview of the distribution of the rela- tionships is given in (5), where the
relative frequency of the three positive relationships reflects the ... myc mycn ...
Cited by 6 - View as HTML - Web Search - 0-lhncbc.nlm.nih.gov.csulib.ctstateu.edu - skr.nlm.nih.gov - nls5.nlm.nih.gov - all 6 versions »

AF64A-Induced Changes in N-myc Expression in the LA-N-2 Human Neuroblastoma Cell Line are Modulated …
LR Santiago, LC Erickson, I Hanin - Neurochemical Research, 1998 - springerlink.com
... In other studies, a causal rela- tionship between a reduction in N-myc ... Decrease of
proliferation rate and induction of differentiation by a MYCN antisense DNA ...
Cited by 1 - Web Search - kluweronline.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Neoplasias pulmonares broncogenicas
FC Millan, JC Bayona - scielo-co.bvs.br
... a revisar de mane- ra superficial los diferentes eventos que se han rela- cionado
con ... siendo los dos miembros más importantes de esta familia los MYCN y MYCL ...
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[BOOK] Neuroblastoma
GM Brodeur, T Sawada, Y Tsuchida - 2000 - print.google.com
... 22 3. MYCN amplification and chromosome lp deletion: initial events or acquired
during tumor evolution 9 23 ... Non-syntenic amplification of MYCN and MDM2 ...
Cited by 175 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries - Library Search

Use of whole genome amplification and comparative genomic hybridisation to detect chromosomal copy … - Full text - MIT Libraries
S Hughes, G Lim, B Beheshti, J Bayani, P Marrano, … - Cytogenetic and Genome Research, 2004 - content.karger.com
... the utility of a microscope-guided hollow bore to obtain a rela- tively pure cell ...
was demonstrated by the failure to detect the amplification of MYCN at 2p24 ...
Cited by 2 - Web Search - utoronto.ca - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Selective Reporting Biases in Cancer Prognostic Factor Studies - Full text - MIT Libraries
PA Kyzas, KT Loizou, JPA Ioannidis - Journal of the National Cancer Institute, 2005 - jncicancerspectrum.oxfordjournals.org
... The strength of the rela- tionship between TP53 status and mortality decreased when
we used standardized, prespecified definitions of TP53 status and used 2 ...
Cited by 1 - Web Search