… genes: a mole cu lar link betwe en deve lop ment and cancer Ge nes home o box: uma rela cao mole cu …
IDUCTI ON - Pesqui Odontol Bras, 2003 - scielo.br
... ra tem mostra do um núme ro cada vez mai or de traba lhos rela- ci o ... nal hypoplasia
and renal disease 26 ; PAX3 has a role in rhabdomyosarcomas 2 and mela no ...
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Development of the limb neuromuscular system
K Sharma, JC Belmonte - Curr. Opin. Cell Biol, 2001 - cbi.pku.edu.cn
... Epaxial muscles are generated from Pax3- positive precursors located in the medial ...
example, bones and tendons) provide the static infrastructure rela- tive to ...
Cited by 4 - View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Correlation between Waardenburg syndrome phenotype and genotype in a population of individuals with … - Full text - MIT Libraries
AL DeStefano, LA Cupples, KS Arnos, JHJ Asher, CT … - Human Genetics, 1998 - springerlink.com
... were associated with both AA substitution in the paired domain (OR=5.5) and truncation
of PAX3 (OR=4.7) rela- tive to AA substitution in the homeodomain. ...
Cited by 14 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Hereditary deafness: lessons for developmental studies and genetic diagnosis - Full text - MIT Libraries
AP Read - Eur J Pediatr, 2000 - springerlink.com
... genes MITF and PAX3. Nat Genet 18: 283±286 Fig. 1 Possible role of genes described
in this paper in neural crest di€erentiation and rela- tionshipto the ...
Cited by 2 - Web Search - springerlink.com - ncbi.nlm.nih.gov

TRISOMY 2: CONFINED PLACENTAL MOSAICISM IN A FETUS WITH INTRAUTERINE GROWTH RETARDATION
I ARIEL, I LERER, S YAGEL, R COHEN, Z BEN‐NERIAH … - Prenatal Diagnosis, 1997 - doi.wiley.com
... PAX3 2q36 1/3 2/4 2/3/4 3/4 ... Confined placental mosaicism (CPM) is a rela- tively
frequent (1–2 per cent) finding in chorionic villus sampling (CVS) (Kalousek ...
Cited by 6 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Origin of the paired domain - Full text - MIT Libraries
R Breitling, JK Gerber - Development Genes and Evolution, 2000 - springerlink.com
... 3D-structure comparison, and phylogenetic reconstruction, we analyzed the rela-
tionship between ... PaxC is the sister group of Pax1–9/meso, Pax3–7/gooseberry ...
Cited by 8 - Web Search - brc.dcs.gla.ac.uk - ncbi.nlm.nih.gov

Dominance and Homozygosity - Full text - MIT Libraries
MCALOF FUNCTION - American Journal of Medical Genetics, 1997 - doi.wiley.com
... leading to the absence or to a non- functional product of PAX3 will lead to ... high
frequency among the Libyan Jews, a community that was rela- tively isolated ...
Web Search - doi.wiley.com

Muscling in on rhabdomyosarcoma - Full text - MIT Libraries
WK Cavenee - Nature Medicine, 2002 - nature.com
... Rhabdomyosarcoma is one such tumor, and is the most com- mon sarcoma of the soft
tissues in children (although still rela- tively uncommon at 5 per mil ... Pax3/7 ...
Cited by 2 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Effect of arsenite, maternal age, and embryonic sex on spina bifida, exencephaly, and resorption …
LJ Martin, AF Machado, MA Loza, GE Mao, GS Lee, DN … - Birth Defects Research Part A Clinical and Molecular …, 2003 - doi.wiley.com
... DISCUSSION The present study examines in utero arsenite exposure, maternal age,
embryonic sex, and Pax3 genotype in rela- tion to neural tube defect and ...
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Homeobox genes: a molecular link between development and cancer
I PhD, II Dentist, TIIID Student - scielo.br
... Genes homeobox: uma rela molecular entre o desenvolvimento eo c er. ... implicated
in breast cancer 34 , renal hypoplasia and renal disease 26 ; PAX3 has a ...
Cached - Web Search - scielo.br

Rhabdomyosarcoma: Value of myogenin expression analysis and molecular testing in diagnosing the …
I Hostein, M Andraud-Fregeville, L Guillou, MJ … - Cancer, 2004 - doi.wiley.com
... Thus, truly fusion transcript-negative cases of ARMS appear to be rela- tively rare. ...
(C) Detection of PAX3-FKHR transcripts using a real-time polymerase chain ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

A Cross Between Truncus Arteriosus Communis and Aortopulmonary Septal Defect: A Hitherto Undescribed … - Full text - MIT Libraries
LB Pauliks, S Bharati, MS Magid, DM Friedman - Pediatric Cardiology, 2000 - springerlink.com
... over the definition of truncus arteriosus communis and its rela- tionship to ... mice
deficient for the regulatory genes hox-1.5 or pax3 show malformations that ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

The role of bone morphogenetic proteins in vertebral development - Full text - MIT Libraries
AH Monsoro-Burq, D Duprez, Y Watanabe, M Bontoux, … - Development, 1996 - dev.biologists.org
... msx2 msx1 pax3 motoneurons floor plate ... hBMP2 in this series of experiments are
physiologically relevant owing to the close structural rela- tionships existing ...
Cited by 57 - Web Search - dev.biologists.org - wwwlib.bionet.nsc.ru - ncbi.nlm.nih.gov

Cytogenetics and Molecular Genetics of Bone and Soft-Tissue Tumors
AA SANDBERG - American Journal of Medical Genetics (Semin. Med. Genet.), 2002 - doi.wiley.com
... From a cytoge- netic viewpoint, these tumors are rela- tively easy to grow in vitro ...
Alveolar rhabdomyosarcoma t(2;13)(q35;q14) PAX3-FKHR t(1;13)(p36;q14) PAX7 ...
Cited by 2 - Web Search - med.up.pt - ncbi.nlm.nih.gov - Get it from MIT Libraries

Complementation of melanocyte development in SOX 10 mutant neural crest using lineage-directed gene … - Full text - MIT Libraries
L Hou, SK Loftus, A Incao, A Chen, WJ Pavan - Developmental Dynamics, 2004 - doi.wiley.com
... Key words: transcription factor; Pax3; neurocristopathies; Waardenburg syndrome;
RCAS ... of gene products, test transcriptional hierarchical rela- tionships, and ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

Variant EWS-WT1 chimeric product in the desmoplastic small round cell tumor - Full text - MIT Libraries
AS Chan, S MacNeill, P Thorner, J Squire, M … - Pediatr Dev Pathol, 1999 - springerlink.com
... For the detection of EWS/FLI1, PAX3/FKHR, and ... By electron microscopy, the tumor cells
showed rela- tively abundant organelles with prominent interme- diate ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Genetic Studies in Neural Tube Defects - Full text - MIT Libraries
EC Melvin, TM George, G Worley, A Franklin, J … - Pediatric Neurosurgery, 2000 - content.karger.com
... Results from specific assessments of p53, PAX3 and MTHFR failed to suggest that ...
first-degree relatives and decreases for more distantly related rela- tives. ...
Cited by 14 - Web Search - content.karger.com - ncbi.nlm.nih.gov

139E SOFT TISSUE SARCOMAS OF CHILDHOOD
LH Wexler, LJ Helman - cancer.org
... and virtually never seen in patients with orbital tumors), and rela- tively more ...
1) This translocation cre- ates a transforming, chimeric oncogene, PAX3-FKHR [t ...
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Forkhead transcription factors: new insights into protein kinase B(c-akt) signaling - Full text - MIT Libraries
GJPL Kops, BMT Burgering - Journal of Molecular Medicine, 1999 - springerlink.com
... Very recently a new target of PKB with potential rela- tions to tumorigenesis ... a
chromosomal translocation results in a fusion be- tween the PAX3 DNA-binding ...
Cited by 125 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Neurofibromin Deficiency in Mice Causes Exencephaly and Is a Modifier for Splotch Neural Tube … - Full text - MIT Libraries
M Lakkis, JA Golden, KS O’Shea, JA Epstein - Developmental Biology, 1999 - uphs.upenn.edu
... expressed in multiple embryonic tissues, including rela- tively high levels in the
developing ... we report the identification of Nf1 as a modifier of Pax3 in the ...
Cited by 13 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

TOPICAL TOPICS Recent Advances in the Diagnosis of Pediatric Soft-Tissue Tumors
SE Kilpatrick, AJ Garvin - Medical and Pediatric Oncology, 1999 - doi.wiley.com
... the chromosomal and molecular ab- errations have involved many established as well
as rela- tively new ... Alveolar Myogenin t(2;13)(q35;q14), PAX3-FKHR fusion 80% ...
Cited by 4 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Brief Clinical Report Family With Graves Disease, Multinodular Goiter, Nonmedullary Thyroid …
HA Druker, L Kasprzak, LR Begin, S Jothy, SA Narod … - J. Med. Genet, 1997 - doi.wiley.com
... These pedigrees include multiple affected rela- tives with early onset of the ... PAX3
is translocated in alveolar rhabdomyosarcomas, but PAX3 is not known to have ...
Web Search - doi.wiley.com - Get it from MIT Libraries

Identification of genes differentially expressed in melanoma sublines derived from a single surgical … - Full text - MIT Libraries
T Kocher, P Schraml, GC Spagnoli, F Harder, M … - Schweiz Med Wochenschr, 2000 - smw.ch
... 3–5) showed high homology with rela- tively longer expressed sequences encoding
gene ... the TGF- beta 3 gene and to the gene encoding PAX3 transcription factor ...
Cited by 3 - View as HTML - Web Search - ncbi.nlm.nih.gov

LETTERS TO THE EDITOR
DK Heffner - Head & Neck, 2003 - doi.wiley.com
... 2 The rela- tively small number of patients, lack of pathology re-review, and ...
PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar ...
Cited by 2 - Web Search

Spotlight on Spotted Mice: A Review of White Spotting Mouse Mutants and Associated Human … - Full text - MIT Libraries
LL Baxter, L Hou, SK Loftus, WJ Pavan - Pigment Cell Research, 2004 - ingentaconnect.com
... from mutation of the genes MITF, EDNRB, KIT, KITL, EDN3, PAX3, SOX10, all ... The
melanogenic enzymes tyrosinase (Tyr), Tyrosinase rela- ted protein 1 (Tyrp1), and ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

Retinal axon misrouting at the optic chiasm in mice with neural tube closure defects - Full text - MIT Libraries
RA Rachel, JN Murdoch, F Beermann, AJ Copp, CA … - genesis, 2000 - doi.wiley.com
... These axon path- way defects are found in two other mutants with ce- phalic neural
tube defects (NTD), loop-tail (Lp) and Pax3 (splotch; Sp 2H ). ...
Cited by 9 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Animal studies and tissue preparation - Full text - MIT Libraries
F Trust - Carcinogenesis, 2000 - nature.com
... D. Embryonic lethality and liver degeneration in mice lacking the RelA component
of NF ... We showed previously that Pax3 and Myf5 act upstream of Myod because body ...
Web Search - nature.com

Murine tongue muscle displays a distinct developmental profile of MRF and contractile gene …
KR Dalrymple, TI Prigozy, M Mayo, L Kedes, CF … - Int. J. Dev. Biol, 1999 - ijdb.ehu.es
... Both the c- met and the Pax3-Myf-5 mutants bear defects in myoblast lineages ... Our
study suggests that the rela- tively simple MRF expression profile, as well as ...
Cited by 7 - View as HTML - Web Search - ncbi.nlm.nih.gov - ijdb.ehu.es - Get it from MIT Libraries

Variability in the Phenotypic Expression of Fryns Syndrome: A Report of Two Sibships - Full text - MIT Libraries
M Ramsing, G Gillessen-Kaesbach, W Holzgreve, B … - Med. Genet, 2000 - doi.wiley.com
... However, Pax3 is prob- ably important for fine tuning of the migratory behav- ior
of the cardiac neural ... A proximally set rela- tively long thumb was noted in 30 ...
Cited by 10 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Neural crest anomaly syndromes in children with spina bifida
JS Nye, DG Mclone, J Charrow, EA Hayes - Teratology, 1999 - doi.wiley.com
... Splotch is named for its dominant pigmentary defects which arise as a consequence
of a mutation in the PAX3 gene, a paired-homeodomain transcription factor ...
Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

THE SPECIFICATION OF DORSAL CELL FATES IN THE VERTEBRATE CENTRAL NERVOUS SYSTEM - Full text - MIT Libraries
KJ Lee, TM Jessell - Annual Review of Neuroscience, 1999 - neuro.annualreviews.org
... In fact, the elimination of notochord signaling results in the ventral expansion
of the expression of certain dorsally restricted genes such as Pax3 and Pax7 ...
Cited by 155 - Web Search - invivo.caltech.edu - bioweb.usc.edu - healthsystem.virginia.edu - all 9 versions »

Multigeneration Maternal Transmission in Italian Families With Neural Tube Defects
I Genoa, MV AC - American Journal of Medical Genetics, 1996 - doi.wiley.com
... There was no difference in sex ratio in any group of rela- tives, but maternal
grandparents of children with a high spinal lesion had 14% fewer off- spring ...
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Adult Bone-Marrow-Derived Stem Cells: From Brain to Brawn - Full text - MIT Libraries
HM Blau, J Pomerantz, CJ Shatz, JB Gurdon, S … - Differentiation, 2004 - blackwell-synergy.com
Page 1. ABSTRACTS 1 Adult Bone-Marrow-Derived Stem Cells: From Brain to Brawn
Helen M. Blau, Jason Pomerantz Stanford University, CA 94305 ...
Web Search - ingentaconnect.com

Expression of sonic hedgehog downstream genes is modified in rat embryos exposed in utero to a … - Full text - MIT Libraries
F Gofflot, W Gaoua, L Bourguignon, C Roux, JJ … - Developmental Dynamics, 2001 - doi.wiley.com
... of differ- ent diet complements we bring new light on the rela- tive impact ... disrupted
after AY9944 exposure, we next examined the expression of Pax3 in early ...
Cited by 10 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Tumor de celulas pequenas redondas y azules: abordaje diagnostico
FJ Paz-Gomez - medigraphic.com
... entre EWS y un miembro de la familia ETS como ERG (ETS rela- ted gene ... La proteína
quimérica FKHR- PAX3 es un potente activador de trasnscripción (10 a 100 ...
Web Search - medigraphic.com - medigraphic.com - medigraphic.com

Local extrinsic signals determine muscle and endothelial cell fate and patterning in the vertebrate … - Full text - MIT Libraries
G Kardon, JK Campbell, CJ Tabin, RS Ahima, TS … - Dev. Cell, 2002 - genetics.med.harvard.edu
... Somites from any axial level can give defective retroviral vectors to analyze the
lineage rela- tionships of these somite-derived cells in the chick. We ...
Cited by 21 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

The MyoD family of transcription skeletal myogenesis
MA Rudnicki, R Jaenisch - BioEssays - doi.wiley.com
... is expressed@O). These experiments are consistent with the idea that Pax3 is expressed ...
Myogenin-deficient mice also display a rela- tively mild rib deformity. ...
Cited by 141 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Pathophysiology, prevention, and potential treatment of neural tube defects
SM Manning, R Jennings, JR Madsen - Mental Retardation and Developmental Disabilities Research …, 2000 - doi.wiley.com
... For example, mutations in the paired box gene Pax3 give rise to NTD in ... from decreased
cell proliferation in the notochord and hindgut endoderm rela- tive to ...
Cited by 9 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Were vertebrates octoploid - Full text - MIT Libraries
RF Furlong, PWH Holland - Philos Trans R Soc Lond B Biol Sci, 2002 - journals.royalsoc.ac.uk
... This indicates that 1 : 2, 1 : 3 and 1 : 4 ratios (fly : human or nematode : human)
are rela- tively common, although none of ... Pax3/7 1 2 1 to 2 Holland et al. ...
Cited by 42 - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov

Specification of neuronal fates in the ventral neural tube - Full text - MIT Libraries
J Briscoe, J Ericson - Curr. Opin. Neurobiol, 2001 - retinotectal.med.umn.edu
... in mutually exclusive progenitor domains and a cross-repressive rela- tionship is ...
of this, in mice lacking the dorsally expressed pro- teins Pax3 and Pax7 ...
Cited by 93 - View as HTML - Web Search - healthsystem.virginia.edu - neurobio.arizona.edu - all 5 versions »

Pax2 mutant mice display increased number and size of islets of Langerhans but no change in insulin … - Full text - MIT Libraries
M Zaiko, A Estreicher, B Ritz-Laser, P Herrera, J … - European Journal of Endocrinology, 2004 - eje.org
... Pax2 may be implicated in the prenatal determination of the rela- tive proportion ...
Group III, represented by Pax3 and Pax7, contains a second DNA-binding motif ...
View as HTML - Web Search - eje-online.org - eje.org - ncbi.nlm.nih.gov - all 5 versions »

Current perspectives on the causes of neural tube defects resulting from diabetic pregnancy - Full text - MIT Libraries
MR Loeken - American Journal of Medical Genetics Part C Seminars in …, 2005 - doi.wiley.com
... Research from the author’s laboratory has shown that expression of Pax3, a gene
required for neural tube closure, is significantly reduced by maternal ...
Web Search - ncbi.nlm.nih.gov

Signals regulating tendon formation during chick embryonic development - Full text - MIT Libraries
F Edom-Vovard, D Duprez - Developmental Dynamics, 2004 - doi.wiley.com
... to complicated phenotypes, or early death (Table 1). Regarding the rela- tionship
between all ... expression is clearly detected in E12 limbs of Pax3 / mutant mice ...
Web Search - ncbi.nlm.nih.gov

des Kindes-und Adoleszentenalters - Full text - MIT Libraries
D Harms, M Krams, I Leuschner - Der Onkologe, 2002 - springerlink.com
... oder nicht ein- deutig zu erkennen.Mit Hilfe eines rela- tiv kleinen ... 2;13)(q37;q14)-
Chromoso- mentranslokation entsteht das Fusions- produkt PAX3/FKHR,während ...
Cited by 2 - Web Search

Synteny-defined candidate genes for congenital and idiopathic scoliosis - Full text - MIT Libraries
PF Giampietro, CL Raggio, RD Blank - American Journal of Medical Genetics, 1999 - doi.wiley.com
... We report the results of this review, which yielded a rela- tively small number
of ... This locus is tightly linked to Pax3 (44 cM), for which a number of distinct ...
Cited by 9 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Characterization of the malignant melanoma of soft-parts cell line GG-62 by expression analysis … - Full text - MIT Libraries
KL Schaefer, D Wai, C Poremba, E Korsching, F van … - Virchows Archiv, 2002 - springerlink.com
... stimulates a myogenic transcription program that is not activated by normal PAX3. ...
We employed a rela- tive quantification method in which the gene-expression ...
Cited by 8 - Web Search - ncbi.nlm.nih.gov

A Screen for Mutations in Human Homologues of Mice Exencephaly Genes Tfap2 and Msx2 in Patients With …
K STEGMANN, J BOECKER, B RICHTER, V CAPRA, RH … - TERATOLOGY, 2001 - doi.wiley.com
... et al., ’99; Barber et al., ’00), PAX1 (Hol et al., ’96), PAX3 (Hol et ... patients had
a posi- tive family history with an affected first-degree rela- tive. ...
Cited by 5 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

La morphogenese du systeme nerveux chez les vertebres
A Hemmati-Brivanlou - medecine/sciences, 2000 - ist.inserm.fr
... Dans le tube neural, le signal SHH réprime aussi l’expression de Pax3 et de Pax7
(membres de la famille des protéines à homéodomaine de type paired ...
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Primary and metastatic rhabdomyosarcoma in the breast: neoplasms of adolescent females, a report …
DM Hays, SS Donaldson, H Shimada, WM Crist, WA … - Medical and Pediatric Oncology, 1997 - doi.wiley.com
... Other clinical features of interest include: (a) the rela- tively large local tumors
observed in patients with both primary and initial metastatic disease ...
Cited by 16 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Analysis of the MTHFR 1298A fi C and 677C fi T polymorphisms as risk factors for neural tube defects - Full text - MIT Libraries
A Parle-McDermott, JL Mills, PN Kirke, VB O’ … - J Hum Genet, 2003 - springerlink.com
... The rela- tionship between a second MTHFR polymorphism (1298A fi C) and NTD risk
has ... G, Murray JC (1999) Analysis of select folate pathway genes, PAX3, and hu ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov