PBX1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in … - Full text - MIT Libraries
MA van Duk, PM Voorhoeve, C Murre - Proc. Natl. Acad. Sci. USA, 1993 - pnas.org
... Using a fixed amount (50 ng) ofGST-Pbxl fusion protein and increasing amounts
(0.1-2 pg) of the nonspecific competitor poly(dI-dC) we determined the rela- ...
Cited by 51 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

… genes: a mole cu lar link betwe en deve lop ment and cancer Ge nes home o box: uma rela cao mole cu …
IDUCTI ON - Pesqui Odontol Bras, 2003 - scielo.br
... ra tem mostra do um núme ro cada vez mai or de traba lhos rela- ci o ... Other fusions,
as PBX1 to E2A and HRX to nuclear proteins, alter the se- quence-specific ...
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Cross-talk between glucocorticoid and retinoic acid signals involving glucocorticoid receptor … - Full text - MIT Libraries
N Subramaniam, J Campion, I Rafter, S Okret - Biochem J, 2003 - biochemj.org
... Repression of RelA transactivation. J. Biol. ... required for cooperative DNA binding
with Pbx1, physically contacts Pbx1, and enhances DNA binding by Pbx1. Mol. ...
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Receptor Interacting Protein RIP 140 Inhibits Both Positive and Negative Gene Regulation by … - Full text - MIT Libraries
N Subramaniam, E Treuter, S Okret - J Biol Chem, 1999 - dx.doi.org
... in as much as it slightly increased signaling through the RelA and the Pit-1/Pbx
proteins and only slightly repressed signaling through the Pbx1/HOXB1 and AP-1 ...
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Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute …
JJ van Dongen, EA Macintyre, JA Gabert, E … - Leukemia, 1999 - nature.com
... A total of nine well-defined chromosome aberrations with fusion gene transcripts
were selected: t(1;19) with E2A-PBX1 , t(4;11) with MLL-AF4 , t(8;21) with AML1 ...
Cited by 213 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Expression of stem cell markers and transcription factors during the remodeling of the rat pancreas … - Full text - MIT Libraries
K Peters, R Panienka, J Li, G Kloeppel, R Wang - Virchows Archiv, 2005 - springerlink.com
... by findings in the literature report- ing a complex of Pdx1:Pbx1 in acinar ... and a
few ductal cells [18, 31] and the close developmental rela- tionship between ...
Web Search - ncbi.nlm.nih.gov

Homeobox genes: a molecular link between development and cancer
I PhD, II Dentist, TIIID Student - scielo.br
... Genes homeobox: uma rela molecular entre o desenvolvimento eo c er. ... Other fusions,
as PBX1 to E2A and HRX to nuclear proteins, alter the sequence-specific ...
Cached - Web Search - scielo.br

Outcomes of patients with acute leukaemia who relapsed after reduced-intensity stem cell …
K Kobayashi, M Kami, N Murashige, E Kusumi, Y … - ingentaconnect.com
... MRD was monitored by RT-PCR in two patients (AML1-MTG8 and E2A/PBX1 in cases 6 and
18 respectively). ... First Second 1 5 5 F AML Rela pse Absent 100 Not perform ...
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Rapid Generation of de novo Biological Pathways from Large-Scale Gene Expression Data Using the …
DC Siu - ingenuity.com
... PBX1, SPP1, MEIS1, MADH1, MADH4, MLL, CHD4, SMARCA2, TAF6, SIN3A, TBP, Histone H3 ...
GRB2, LCK, VIL2, ERBB2, FYN, CD3Z, FGF2, FGFR1, NUDT6, RELA, HMGA1, EZRIN, MSN ...
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[BOOK] Music and Women: The Story of Women in Their Relation to Music
S Drinker - 1995 - print.google.com
... MUSIC AND WOMEN Thi 6 One IIIIIIIIIIIIIIIIIIIIIIIIIHIIIIU PBX1 -N17-EW4D Page 3.
F ft ... MUSIC AND WOMEN THE S TOR Y OF WOMEX IX THEIR RELA TIOX TO M USIC BY ...
Cited by 4 - Web Search - Get it from MIT Libraries - Library Search

Results of therapy for acute lymphoblastic leukemia in black and white children - Full text - MIT Libraries
CH Pui, JT Sandlund, D Pei, GK Rivera, SC Howard, … - JAMA, 2003 - jama.ama-assn.org
... t(1;19)/E2A-PBX1 Present 10 (3.0) 8 (11.8) .005 ... 11)/MLL-AF4 or a CNS3 status attained
statistical signifi- cance, most likely because of the rela- tively small ...
Cited by 20 - Web Search - dx.doi.org - jama.ama-assn.org - ncbi.nlm.nih.gov

Global Gene Expression as a Function of Germline Genetic Variation - Full text - MIT Libraries
D French, MR Wilkinson, W Yang, L de Chaisemartin, … - Human Molecular Genetics, 2005 - hmg.oxfordjournals.org
... These include RELA, a component of the NF B transcription factor complex that regulates
many ... this set, including t(9 ;22 )[BCR-ABL], t(1 ;19 )[E2A-PBX1], t(12 ...
Web Search - hmg.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Patterning defects in the primary axonal scaffolds caused by the mutations of the extradenticle and … - Full text - MIT Libraries
T Nagao, K Endo, H Kawauchi, U Walldorf, K … - Development Genes and Evolution, 2000 - springerlink.com
... of adult animals these embryo- logical studies suggest that the underlying molecular
mechanisms of brain patterning can be reduced to rela- tively simple ...
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MOLECULAR TARGETS FOR THERAPY (MTT)
J Roche, C Zeng, A Baron, S Gadgil, RM Gemmill, I … - Leukemia, 2004 - nature.com
... 1,2 Other than chromosomal rearrangements, rela- tively little is known of ... Cooperative
activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias. ...
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From Informatics to Bioinformatics
VB Bajic, V Brusic, J Li, SK Ng, L Wong - APBC, 2003 - portal.acm.org
... Cur- rently, Kleisli supports a “comprehension syntax”-based language called CPL
(Wong 2000a) and a “nested rela- tionalized” version of SQL ... E2A-PBX1? ...
Cited by 1 - Web Search - crpit.com - comp.nus.edu.sg - sdmc.lit.org.sg - all 12 versions »

Original Contributions
DJ Symula, Y Zhu, JC Schimenti, EM Rubin - springerlink.com
... 1.24 0.04 differentiation 94804_at 18514 Pbx1: pre B-cell leukemia transcription
factor 1 1.18 0.01 96075_at 22388 Wdr1: WD repeat domain 1 1.19 0.05 ...
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Repression by HoxA7 is mediated by the homeodomain and the modulatory action of its N-terminal-arm … - Full text - MIT Libraries
CA Schnabel, C Abate-Shen - Mol. Cell. Biol, 1996 - mcb.asm.org
... or absence ( ) of an expression plasmid encoding HoxA7 (500 ng), Pbx1 (500 ng ... which
is likely to contribute to its enhanced repressor potency rela- tive to ...
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The roles of an ephrin and a semaphorin in patterning cell–cell contacts in C. elegans sensory … - Full text - MIT Libraries
AC Hahn, SW Emmons - Dev. Biol, 2002 - worms.aecom.yu.edu
... digested N2-genomic DNA and 2 ng/ l XhoI-digested pBX1, which carries ... However, rela-
tive expression strength appeared to be preserved, since the frequency at ...
Cited by 4 - View as HTML - Web Search - worms.aecom.yu.edu - ncbi.nlm.nih.gov

Chromosomal Translocations Involving the E2A Gene in Acute Lymphoblastic Leukemia: Clinical Features …
P Stephen - bloodjournal.org
... I will also discuss, in detail, the structural features and functional properties
of E2A-PBX1 and E2A-HLF, the fusion proteins created by the t(1; 19) and t(17 ...
Web Search

Nucleocytoplasmic localisation of extradenticle protein is spatially regulated throughout … - Full text - MIT Libraries
SE Aspland, RAH White - Development, 1997 - dev.biologists.org
... This has formed the prevailing view of the rela- tionship between exd and the ... Dpbx,
a new homeobox gene closely related to the human proto-oncogene pbx1. ...
Cited by 46 - Web Search - dev.biologists.org - wwwlib.bionet.nsc.ru - ncbi.nlm.nih.gov

EUROGLYCANET: a European network focused on congenital disorders of glycosylation - Full text - MIT Libraries
MC Biol, C Biol - Mol Cell Biol, 2004 - nature.com
... deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic
mice ... C ascade screening, that is, sys- tematically approaching rela- tives of ...
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Minimal Residual Disease Studies by Flow Cytometry in Acute Leukemia
D Campana, E Coustan-Smith - Acta Haematologica, 2004 - content.karger.com
... for the produc- tive detection of MRD by flow cytometry, and the rela- tion between ...
fusions, such as BCR-ABL, AML1-ETO, or PBX-1 in E2A-PBX1 should contribute ...
Cited by 5 - Web Search - content.karger.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Genomic and Proteomic Profiling of Responses to Toxic Metals in Human Lung Cells - Full text - MIT Libraries
AS Andrew, AJ Warren, A Barchowsky, KA Temple, L … - Environmental Health Perspectives, 2003 - ehpnet1.niehs.nih.gov
... RPL6 BTF2p44 H2TF1 hSMN NF-X1 GRRF1 PBX1 ROBO1 HIF1-α HOX-A5 GABP-a
PN-II JUN Synapsin SAP2 AREB6 ADA2 BRCA1 bcl-6 IL2RA CREB2 ...
Cited by 12 - View as HTML - Web Search - earthscape.org - dx.doi.org - csa.com - all 9 versions »

Chapter 2.8 Modulation of Soluble Receptor Signaling by Coregulators
M KUMAR, GH PERDEW - cas.psu.edu
... p65 (RelA) and the pituitary-specific factor Pit-1/homeodomain transcription factor
Pbx complex and only slightly repressed signaling through the Pbx1/HOXB1 ...
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Effects of HOX homeobox genes in blood cell differentiation - Full text - MIT Libraries
MC Magli, C Largman, HJ Lawrence - J Cell Physiol, 1997 - doi.wiley.com
... HOX gene knockouts reported in the literature, rela- tively little has been ... Given
that the various translocations main’’ in Pbx1 and demonstrated that this ...
Cited by 57 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The World Health Organization Classification of Lymphomas
J Jakiae-Razumoviae, I Aurer - cmj.hr
... important prognostic factors within precursor B lymphoblastic neoplasms t(9;22),
q(34;q11), BCR/ ABL, 11q23, MLL, t(1;19)(q23;p13), E2A/PBX1, t(12 ... Indeed, rela- ...
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MCN - Full text - MIT Libraries
YA Zhang, A Okada, CH Lew, SK McConnell - Molecular and Cellular Neuroscience, 2002 - stanford.edu
... A well-characterized example of intermolecular tar- get sequence masking is represented
by the p65 subunit of the DNA-binding protein NF- B (RelA), which con ...
Cited by 5 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

O Hrusak and A Porwit-MacDonald 2
S Stockholm - Leukemia, 2002 - nature.com
... We describe immunophenotype of: B-lineage ALL with MLL rearrangements, TEL/AML1,
BCR/ABL, E2A/PBX1 translocations, hyperdiploidy, and myc fusion genes; T-ALL ...
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BRIEF COMMUNICATION Occurrence of TEL-AML1 fusion resulting from (12; 21) translocation in human …
CC Uphoff, RAF MacLeod, SA Denkmann, TR Golub, A … - Leukemia, 1997 - nature.com
... the residual TEL allele. The low rate of early B-lineage ALL cell lines carrying
this translocation contrasts clearly with the rela- ... PBX1-E2A ; ...
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WA2-1O: 40
F STABILIZATIONS - ieeexplore.ieee.org
Page 1 JC Geromel CC de Souza* LAC-DT/FEE - UNICAMP CP 6101, 13081 - 970, Campinas,
SP, Brazil e-mail: geromeldt.jee.’urzicarnp.br RE Skelton Space Systems ...
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Synergistic Cooperation between Sp 1 and Smad 3/Smad 4 Mediates Transforming Growth Factor beta 1 … - Full text - MIT Libraries
W Zhang, J Ou, Y Inagaki, P Greenwel, F Ramirez - J Biol Chem, 2000 - jbc.org
... Incubation with an anti-PBX1 antibody was used as a negative control ... these lines,
a recent report has implicated activation of the NF B/RelA-dependent pathways ...
Cited by 37 - Web Search - jbc.org - ncbi.nlm.nih.gov

Synergistic cooperation between Sp1 and Smad3/Smad4 mediates TGFβ1 stimulation of α2 (I) collagen … - Full text - MIT Libraries
W Zhang, J Ou, Y Inagaki, P Greenwel, F Ramirez - J Biol Chem, 2000 - jbc.org
Page 1. Synergistic cooperation between Sp1 and Smad3/Smad4 mediates TGFβ1
stimulation of α2(I) collagen (COL1A2) transcription*. ...
Cited by 4 - Web Search

Luciferase Reporters: Less is More
A Paguio, B Almond, F Fan, P Stecha, D Garvin, M … - promega.com
... HLF NUDR NUDR NUDR NUDR AC-t Pbx1 TCF11 BACH1 GBF1 AD-b FLI Hox1.3 CREB CREB ... 1,000
10,000 100,000 1,000,000 10,000,000 Luminescence (Rela t ive Ligh t Uni t s) ...
Web Search

The Role of Prognostic Features in the Treatment of Childhood Acute Lymphoblastic Leukemia - Full text - MIT Libraries
AM Friedmann, HJ Weinstein - The Oncologist, 2000 - theoncologist.alphamedpress.org
... of the E2A gene on chromosome 19 with part of PBX1 on chromosome 1 to ... defined subclasses
of acute lymphoblastic leukemia in children: their rela- tionship to ...
Cited by 11 - Web Search - theoncologist.alphamedpress.org - dx.doi.org - ncbi.nlm.nih.gov

The World Health Organization Classification of Hematological Malignancies Report of the Clinical …
O Columbus - Mod Pathol, 2000 - nature.com
... are important prognostic factors within precursor B lymphoblas- tic neoplasms
(t[9;22][q34;q11], BCR/ABL; 11q23, MLL; t[1;19][q23;p13], E2A/PBX1; t[12;21][p12 ...
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Progress in Hematology
A Iwama, H Oguro, M Negishi, Y Kato, H Nakauchi - Int J Hematol, 2005 - cardenjennings.metapress.com
... due to a decreased number of B-cells that results in the rela- tive enrichment ... 1
has been revealed as a critical downstream target for the E2a-Pbx1 oncogene to ...
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Over-expression of tobacco knotted1-type class1 homeobox genes alters various leaf morphology
A Nishimura, M Tamaoki, T Sakamoto, M Matsuoka - Plant Cell Physiol, 2000 - nacos.com
... Because of the di‚culty in estimating rela- tive levels of the di˙erent NTH ... domain,
Pbx1, and this interaction is essential for binding to their target DNA ...
Cited by 11 - View as HTML - Web Search - plantsci.cam.ac.uk - ncbi.nlm.nih.gov - Get it from MIT Libraries

Construction and analysis of a subtracted library and microarray of cDNAs expressed specifically in … - Full text - MIT Libraries
M Afrakhte, TM Schultheiss - Developmental Dynamics, 2004 - doi.wiley.com
... Therefore, an unmodified library constructed from cDNA from any tissue would pri-
marily contain many copies of rela- tively few, commonly expressed genes. ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

Identification of Endogenous Glucocorticoid Repressed Genes Differentially Regulated by a … - Full text - MIT Libraries
LG Bladh, J Liden, K Dahlman-Wright, M Reimers, S … - Mol Pharmacol, 2005 - molpharm.org
... 2001 ). NF- B consists of a dimer of proteins belonging to the Rel family,
typically a heterodimer of RelA (p65) and NF- B1 (p50). ...
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Regulation of Cell Division Cycle Progression by bcl-2 Expression: A Potential Mechanism for …
S Maze, D Burtrum, HT Petrie - jem.org
... Expression of the homeobox fusion gene E2A-PBX1 (resulting from at(1;19) chromosomal ...
population of cells can thus provide an estimate of the rela- tive cell ...
Web Search

Chromosome Committee Reports: enome
M Chromosome - springerlink.com
Page 1. Chromosome Committee Reports : enome Mammalian Genome 4, S10-$30 (1993).
9 Springer-Veriag New York Inc. 1993 Mouse Chromosome 1 ...
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Gene regulatory factors in pancreatic development - Full text - MIT Libraries
J Jensen - Developmental Dynamics, 2004 - doi.wiley.com
... Such experi- ments, as well as dedicated clono- genic assays should be capable of
revealing the level of lineage rela- tionships, lineage restrictions, and ...
Cited by 14 - Web Search - pi.be - ncbi.nlm.nih.gov

ENL, the Gene Fused With HRX in t (l1; 19) Leukemias, Encodes Protein With Transcriptional …
JE Rubnitz, J Morrissey, PA Savage, L Cleary - bloodjournal.org
... Such factors that are components of, or interact with, the basal transcription com-
plex have been decribed.’ÃEn1 may be a rela- tively weak activator that ...
Web Search

Xenopus hoxc8 during early development - Full text - MIT Libraries
C Ko, HM Chung - Biochemical and Biophysical Research Communications, 2003 - plaza1.snu.ac.kr
... Compared to the rela- tively strong expression in the anterior boundary and tail
end of ... in Hoxb-8 is required for cooperative DNA binding with Pbx1 and Pbx2 ...
View as HTML - Web Search - ncbi.nlm.nih.gov

Comparison of the immunoglobulin gene transcripts between immature B lineage acute lymphoblastic …
H Mori, H Kiyoi, K Horibe, R Ohno, T Naoe - Leukemia, 1997 - nature.com
Page 1. Leukemia (1997) 11, 1274–1280 © 1997 Stockton Press All rights reserved
0887-6924/97 $12.00 Comparison of the immunoglobulin ...
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Identification of a purine-rich intronic enhancer element in the mouse eosinophil-associated … - Full text - MIT Libraries
KD Dyer, T Nitto, JM Moreau, AL McDevitt, HF … - Mammalian Genome, 2004 - springerlink.com
... (A) The neighbor-joining phylogenetic tree demarcates distance rela- tionships among
the ... Fu X, Kamps MP (1997) E2a-Pbx1 induces aberrant expression of tissue ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

New methodologic approaches for immunophenotyping acute leukemias - Full text - MIT Libraries
G Basso, B Buldini, L De Zen, A Orfao - Haematologica, 2001 - haematologica.it
... antibody combinations (5/6 color analy- sis) but only APC/Cy5, PerCP/Cy5, APC/Cy7
and Per- CP/Cy7 conjugates have been produced on a rela- tively large scale. ...
Cited by 16 - View as HTML - Web Search - haematologica.org - ncbi.nlm.nih.gov - haematologica.org - all 7 versions »

CLUB ESPANOL DE CITOLOGIA HEMATOLOGICA: EL LINFOBLASTO EN EL CONTEXTO
A DE LA LEUCEMIA LINFOBLASTICA - db2.doyma.es
Page 1. CLUB ESPAÑOL DE CITOLOGÍA HEMATOLÓGICA: EL LINFOBLASTO EN EL CONTEXTO DE
LA LEUCEMIA LINFOBLÁSTICA AGUDA C OORDINADORAS : M.ªC. J IMÉNEZ . ...
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Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with … - Full text - MIT Libraries
E Hedlund, SL Karsten, L Kudo, DH Geschwind, EM … - Journal of Neuroscience Research, 2004 - doi.wiley.com
... These observations suggest that the expression of most RNA species will be conserved
between mutant and wild-type samples; therefore rela- tively few genes ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Meningioma Expression Analysis
G Wrobel - dkfz-heidelberg.de
Page 1. Meningioma Expression Analysis Gunnar Wrobel February 26, 2004 Page
2. Contents 1 Preprocessing 3 1.1 Introduction . . . . . ...
View as HTML - Web Search - dkfz.de