… NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated … - Full text - MIT Libraries
SC Sun, J Elwood, C Beraud, WC Greene - Mol Cell Biol, 1994 - mcb.asm.org
... We further demonstrate that Tax induction of nuclear c-Rel expression is activated
by the RelA (p65) subunit of NF-kappa B, which activates transcription of ...
Cited by 81 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the … - Full text - MIT Libraries
M Grossmann, LA O’Reilly, R Gugasyan, A Strasser … - The EMBO Journal, 2000 - embojournal.npgjournals.com
... The anti-apoptotic activities of Rel and RelA required during B-cell maturation
involve the regulation of Bcl-2 expression. Mathis ...
Cited by 79 - Web Search - emboj.org - nature.com - ncbi.nlm.nih.gov - all 7 versions »

Activators and target genes of Rel/NF-kappa B transcription factors - Full text - MIT Libraries
HL Pahl - Oncogene, 1999 - nature.com
... (1992) selected optimal DNA-binding sites for p50, RelA and c-Rel, as homodimers.
The preferred binding site differs for each homodimer. ...
Cited by 563 - Web Search - nature.com - ncbi.nlm.nih.gov

Corepression of RelA and c-Rel inhibits immunoglobulin kappa gene transcription and rearrangement in … - Full text - MIT Libraries
DC Scherer, JA Brockman, HH Bendall, GM Zhang, DW … - Immunity, 1996 - ncbi.nlm.nih.gov
Click here to read Corepression of RelA and c-rel inhibits immunoglobulin kappa
gene transcription and rearrangement in precursor B lymphocytes. ...
Cited by 38 - Web Search

The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell … - Full text - MIT Libraries
M Grossmann, D Metcalf, J Merryfull, A Beg, D … - Cell, 1999 - dx.doi.org
... 1999. Cell Biology The combined absence of the transcription factors Rel
and RelA leads to multiple hemopoietic cell defects. Mathis ...
Cited by 38 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

… IB is responsible for inhibition of DNA binding but not for cytoplasmic retention of c-Rel or RelA … - Full text - MIT Libraries
MK Ernst, LL Dunn, NR Rice - Mol. Cell. Biol, 1995 - mcb.asm.org
... of DNA Binding but Not for Cytoplasmic Retention of c-Rel or RelA Homodimers
MARY K. ERNST, LINDA L. DUNN, AND NANCY R. RICE* Laboratory ...
Cited by 47 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

NF-kappa B subunit-specific regulation of the interleukin-8 promoter - Full text - MIT Libraries
C Kunsch, CA Rosen - Mol Cell Biol, 1993 - mcb.asm.org
... Cotransfection with various NF-kappa B subunits indicated that RelA and c-Rel, but
neither NFKB1 nor heterodimeric NFKB1-RelA, was able to activate ...
Cited by 145 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Constitutive and inducible Rel/NF-kappa B activities in mouse thymus and spleen
F Weih, D Carrasco, R Bravo - Oncogene, 1994 - ncbi.nlm.nih.gov
... of thymus and spleen extracts with deoxycholate (DOC), however, results in a strong
increase in binding to kappa B sites of both RelA and c-Rel complexes. ...
Cited by 70 - Web Search - Get it from MIT Libraries

Oncogenic Ha-Ras-induced Signaling Activates NF-kappa B Transcriptional Activity, Which Is Required … - Full text - MIT Libraries
MMT Virus c-rel, TMDM Tumors - Am J Physiol Lung Cell Mol Physiol, 2005 - dx.doi.org
... and AS Baldwin The Nuclear Factor {kappa}B Subunits RelA/p65 and c-Rel Potentiate
but Are Not Required for Ras-Induced Cellular Transformation Cancer Res ...
Cited by 180 - Web Search - ncbi.nlm.nih.gov

[CITATION] … -B/Rel involves phosphorylation and degradation of IB and RelA (p65)-mediated induction of the c-rel … - Full text - MIT Libraries
SC Sun, J Elwood, C Beraud, WC Greene - Mol. Cell. Biol, 1994
Cited by 28 - Web Search

… I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B … - Full text - MIT Libraries
O Le Bail, R Schmidt-Ullrich, A Israel - Circulation, 2004 - embojournal.npgjournals.com
... TNF. This kappa B motif binds NF-kappa B (p50/relA), p50/c-rel and
relA/c-rel heterodimers as well as KBF1 (p50 homodimer). These ...
Cited by 126 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Differential roles of RelA (p65) and c-Rel subunits of nuclear factor kappa B in tumor necrosis … - Full text - MIT Libraries
X Chen, K Kandasamy, RK Srivastava - Cancer Res, 2003 - cancerres.aacrjournals.org
... The dual function of NF- B, as an inhibitor or activator of apoptosis,
depends on the relative levels of RelA and c-Rel subunits. ...
Cited by 24 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong … - Full text - MIT Libraries
SK Hansen, PA Baeuerle, F Blasi - Mol Cell Biol, 1994 - pubmedcentral.nih.gov
... We have purified this activity from the HeLa cell cytosol and have shown that it
represents a performed heteromeric complex between p65 (RelA) and c-Rel. ...
Cited by 18 - Web Search - mcb.asm.org - ncbi.nlm.nih.gov

High mobility group protein I (Y) is required for function and for c-Rel binding to CD28 response … - Full text - MIT Libraries
SR Himes, LS Coles, R Reeves, MF Shannon - Immunity, 1996 - ncbi.nlm.nih.gov
... We show that the CK-1 element (CD28RE) within the GM-CSF promoter binds the RelA
and c-Rel transcription factors in response to CD28 activation. ...
Cited by 56 - Web Search

Control of apoptosis by Rel/NF-κB transcription factors - Full text - MIT Libraries
M Barkett, TD Gilmore - Oncogene, 1999 - nature.com
... insects to humans. The vertebrate family includes five cellular proteins:
c-Rel, RelA, RelB, p50/p105, and p52/p100. As homodimers or ...
Cited by 350 - Web Search - nature.com - ncbi.nlm.nih.gov

Regulation of DNA binding by Rel/NF-κB transcription factors: structural views - Full text - MIT Libraries
FE Chen, G Ghosh - Oncogene, 1999 - nature.com
... Rel/NF- B protein family members, which include p50, p52, c-Rel, RelA (p65), and
RelB, share an N-terminal domain called the Rel homology (RH) domain. ...
Cited by 92 - Web Search - nature.com - ncbi.nlm.nih.gov

… of Genes Encoding Bacterial(p) ppGpp Synthetases/Hydrolases(the Rel, RelA and SpoT Proteins)
G Mittenhuber - Journal of Molecular Microbiology and Biotechnology, 2001 - ncbi.nlm.nih.gov
Comparative genomics and evolution of genes encoding bacterial (p)ppGpp
synthetases/hydrolases (the Rel, RelA and SpoT proteins). ...
Cited by 13 - Web Search - horizonpress.com - csa.com - Get it from MIT Libraries

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of … - Full text - MIT Libraries
RC Bargou, F Emmerich, D Krappmann, K Bommert, MY … - J Clin Invest, 1997 - jci.org
... Since I B N binds efficiently to both RelA and c-Rel, possible differences in these
factors for antiapoptotic or cell growth functions have to be considered. ...
Cited by 210 - Web Search - jci.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Distinct Domains of the RelA NF-kappa B Subunit Are Required for Negative Cross-talk and Direct … - Full text - MIT Libraries
S Wissink, EC van Heerde, ML Schmitz, E Kalkhoven, … - Am J Physiol Lung Cell Mol Physiol, 2004 - dx.doi.org
... in intact cells. However, only the Rel homology domain of RelA was found
to associate with the glucocorticoid receptor in vitro. ...
Cited by 44 - Web Search - jbc.org - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality - Full text - MIT Libraries
TS Doi, MW Marino, T Takahashi, T Yoshida, T … - Immunology, 1999 - dx.doi.org
... and S. Gerondakis The Transcription Factors c-rel and RelA Control Epidermal
Development and Homeostasis in Embryonic and Adult Skin via Distinct Mechanisms ...
Cited by 98 - Web Search - pnas.org - pubmedcentral.nih.gov - jrheum.com - all 8 versions »

Effects on NF-κB 1/p 105 processing of the interaction between the HTLV-1 transactivator Tax and … - Full text - MIT Libraries
R Rousset, C Desbois, F Bantignies, P Jalinot - Nature, 1996 - nature.com
... nuclear translocation of the NF- B/Rel transcription factors and relieves cytoplasmic
sequestration of RelA and Rel by heterodimerization with NF- B1/p105 ...
Cited by 60 - Web Search - ncbi.nlm.nih.gov

… HBx protein activates transcription factor NF-B by acting on multiple cytoplasmic inhibitors of rel … - Full text - MIT Libraries
F Su, RJ Schneider - J Virol, 1996 - jvi.asm.org
... Both p105 and p100, as well as IB , bind RelA and rel-related proteins, mediating
their cytoplasmic retention through a com- mon C-terminal ankyrin motif (3, 14 ...
Cited by 38 - Web Search

The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x (L) - Full text - MIT Libraries
C Chen, LC Edelstein, C Gelinas - Mol. Cell. Biol, 2000 - dx.doi.org
... death inhibitors and that it directly activates the expression of Bcl-x L . While
Bcl-x L was significantly upregulated by c-Rel and RelA, Bcl-2 was not. ...
Cited by 282 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

The relA/spoT-homologous gene in Streptomyces coelicolor encodes both ribosome-dependent(p) ppGpp- … - Full text - MIT Libraries
OH Martinez-Costa, MA Fernandez-Moreno, F … - Journal of Bacteriology, 1998 - jb.asm.org
... The recombinant plasmids used and their construction are summarized in Table 2.
Hybrid plasmids containing the relA and rel genes, including their promoter ...
Cited by 20 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - csa.com - all 5 versions »

Role of Rel/NF-B Transcription Factors in Apoptosis of Human Hepatocellular Carcinoma Cells
PJ Chiao, R Na, J Niu, GM Sclabas, Q Dong, SA … - Cancer, 2002 - doi.wiley.com
... 1–3 The Rel/NF- B family consists of RelA, Rel (v- rel), RelB, p50 (p105), and p52
(p100), which can form heterodimers and homodimers among themselves. ...
Cited by 21 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Genetic approaches in mice to understand Rel/NF-κB and IκB function: transgenics and knockouts - Full text - MIT Libraries
S Gerondakis, M Grossmann, Y Nakamura, T Pohl, R … - Oncogene, 1999 - nature.com
... In mammals, there are five distinct Rel/NF- B transcription factor subunits -
p50/p105, p52/p100, c-Rel, RelA and RelB - each encoded by a unique gene. ...
Cited by 112 - Web Search - nature.com - ncbi.nlm.nih.gov

NF-kappa B/Rel family members regulating the ICAM-1 promoter in monocytic THP-1 cells
S Wissink, A van de Stolpe, E Caldenhoven, L … - Immunobiology, 1997 - ncbi.nlm.nih.gov
... In vitro, the ICAM-1 kappa B site appeared to bind RelA and c-Rel homodimers as
well as heterodimers with NF-kappa B1, but weakly NF-kappa B1 homodimers. ...
Cited by 16 - Web Search - Get it from MIT Libraries

Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the … - Full text - MIT Libraries
E Caldenhoven, J Liden, S Wissink, A Van de Stolpe … - Mol Endocrinol, 1995 - dx.doi.org
... transcriptional activation by GR via a glucocorticoid response element is specifically
repressed by RelA, but not by other NF-kappa B/Rel family members. ...
Cited by 141 - Web Search - mend.endojournals.org - ncbi.nlm.nih.gov

… protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of rel … - Full text - MIT Libraries
F Su, RJ Schneider - J Virol, 1996 - jvi.asm.org
... dependent manner, of transcriptionally active NF- kappaB DNA-binding complexes,
which make up the family of Rel-related proteins, p50, p52, RelA, and c-Rel. ...
Cited by 47 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Inhibition of Interleukin-1-stimulated NF-kappa B RelA/p 65 Phosphorylation by Mesalamine Is … - Full text - MIT Libraries
LJ Egan, DC Mays, CJ Huntoon, MP Bell, MG Pike, WJ … - J Biol Chem, 1999 - jbc.org
... transcription without preventing I B degradation or nuclear translocation and DNA
binding of the transcriptionally active NF- B proteins, RelA, c-Rel, or RelB. ...
Cited by 52 - Web Search - jbc.org - ncbi.nlm.nih.gov

A similar DNA-binding motif in NFAT family proteins and the Rel homology region. - Full text - MIT Libraries
J Jain, E Burgeon, TM Badalian, PG Hogan, A Rao - J Biol Chem, 1995 - jbc.org
... B1, RelA, and Rel, can be accommodated in the context of Rel proteins, since the
conserved motif in murine Rel B, human Rel B, and dorsal is RFRYECEG (34-36; ...
Cited by 66 - Web Search - jbc.org - ncbi.nlm.nih.gov

The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic … - Full text - MIT Libraries
W Wang, JL Abbruzzese, DB Evans, L Larry, KR … - Clin Cancer Res, 1999 - intl-clincancerres.aacrjournals.org
... B binding activity was shifted by anti-RelA antibody, pointing out that the
constitutive B DNA binding activity contained RelA protein, not c-Rel or RelB (Fig. ...
Cited by 140 - Web Search - intl-clincancerres.aacrjournals.org - ncbi.nlm.nih.gov

REL proto-oncogene is frequently amplified in extranodal diffuse large cell lymphoma - Full text - MIT Libraries
J Houldsworth, S Mathew, PH Rao, K Dyomina, DC … - Blood, 1996 - bloodjournal.org
... oxidative stress, and other pathogenic products.26 To date, five members of the
ReVNF- KB gene family have been identified which include REL, RELA, RELB, NFKBI ...
Cited by 92 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF- … - Full text - MIT Libraries
Z Li, GJ Nabel - Mol. Cell. Biol, 1997 - mcb.asm.org
... I kappaB epsilon interacts with different NF-kappaB proteins, including p65 (RelA),
c-Rel, p50, and p52, in vitro and in vivo and inhibits the DNA-binding ...
Cited by 37 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

… of I kappa B beta which is associated with accelerated activation of various NF-kappa B/Rel … - Full text - MIT Libraries
EW Harhaj, SB Maggirwar, L Good, SC Sun - Mol. Cell. Biol, 1996 - mcb.asm.org
... we show that CD28 costimulation leads to biphasic induction of NF-kappaB/Rel
heterodimers, including early-phase induction of p50/RelA and c- Rel/RelA and late ...
Cited by 26 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor … - Full text - MIT Libraries
RJ Grumont, IJ Rourke, S Gerondakis - Genes Dev, 1999 - genesdev.org
... NF- B1(p50) and NF- B2(p52) only consist of the Rel homology domain and lack intrinsic
transcriptional transactivating properties, whereas Rel, RelA (p65), and ...
Cited by 201 - Web Search - genesdev.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 7 versions »

Constitutive nuclear factor-B-RelA activation is required for proliferation and survival of Hodgkin … - Full text - MIT Libraries
RC Bargou, F Emmerich, D Krappmann, K Bommert, MY … - J Clin Invest, 1997 - 141.80.156.97
... Other studies with knockout mice have shown that not only RelA, but also RelB,
c-Rel, and p105 at some point play a role in B cell proliferation (45, and ...
Cited by 70 - View as HTML - Web Search - fg-doerken.mdh2.mdc-berlin.de

Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase - Full text - MIT Libraries
QW Xie, Y Kashiwabara, C Nathan - J Biol Chem, 1994 - jbc.org
... The proteins binding both probes reacted with antibodies against p50 and c-rel but
not RelB; those binding the shorter probe also reacted with anti-RelA (p65). ...
Cited by 582 - Web Search - ncbi.nlm.nih.gov

Activators and target genes of Rel/NF-B transcription factors - Full text - MIT Libraries
HL Pahl - Oncogene, 1999 - nature.com
... Ghosh, 1999, this issue). In vertebrates, this family includes p50/p105,
p52/p100, RelA (p65), c- Rel and RelB. These dimers bind to ...
Cited by 113 - Web Search

RelA is a potent transcriptional activator of the CD28 response element within the interleukin 2 … - Full text - MIT Libraries
JH Lai, G Horvath, J Subleski, J Bruder, P Ghosh, … - Mol. Cell. Biol, 1995 - mcb.asm.org
... Our previous work demon- strates that the Rel/NF- B family proteins c-Rel, RelA
(p65), and NFKB1 (p50) are involved in the complex that binds to the CD28RE. ...
Cited by 77 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

NF-kappa B RelA (p65) is essential for TNF-alpha-induced fas expression but dispensable for both TCR … - Full text - MIT Libraries
Y Zheng, F Ouaaz, P Bruzzo, V Singh, S Gerondakis, … - J. Immunol, 2001 - jimmunol.org
... show that unlike fibroblasts, which consist primarily of RelA-containing NF- B
complexes, T cells have high levels of both RelA and c-Rel complexes, suggesting ...
Cited by 39 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Involvement of Jun and Rel Proteins in Up-regulation of Interleukin-4 Gene Activity by the T Cell … - Full text - MIT Libraries
M Li-Weber, M Giasi, PH Krammer - J Biol Chem, 1998 - jbc.org
... In correlation with CD28-induced tran- scriptional activation, AP-1 (c-Jun, JunD)
and NF- B/ Rel (c-Rel, RelA) family members are found to bind to the two ...
Cited by 34 - Web Search - jbc.org - ncbi.nlm.nih.gov

Tumor Necrosis Factor alpha-induced Phosphorylation of RelA/p 65 on Ser 529 Is Controlled by Casein … - Full text - MIT Libraries
D Wang, SD Westerheide, JL Hanson, AS Baldwin Jr - J Biol Chem, 2000 - dx.doi.org
... In unstimulated cells, NF- B/Rel proteins are sequestered in the cytoplasm by ... Previously,
we have shown that TNF induces RelA/p65 phosphorylation at serine 529 ...
Cited by 79 - Web Search - jbc.org - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

The N-terminal domain of IkappaB alpha masks the nuclear localization signal (s) of p50 and c-Rel … - Full text - MIT Libraries
M Latimer, MK Ernst, LL Dunn, M Drutskaya, NR Rice - Mol. Cell. Biol, 1998 - mcb.asm.org
... i) the dimerization regions of p50, RelA, and c-Rel are sufficient for binding to
I B , (ii) the NLSs of RelA and c-Rel are not required for binding to I B but ...
Cited by 25 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Genetics and physiology of the rel system of Bacillus subtilis
I Smith, P Paress, K Cabane, E Dubnau - MGG Molecular & General Genetics, 1980 - springerlink.com
... IS56 relA 5 b 2.7 IS58 rel + 223 94.1 IS169 reIC 562 314 IS1 rel + 530 217 ... The
rel + label points to a Rel + Leu + transductant, while the relA ...
Cited by 29 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

RelA/p65 is a molecular target for the immunosuppressive action of protein kinase A - Full text - MIT Libraries
M Neumann, T Grieshammer, S Chuvpilo, B Kneitz, M … - J. Immunol, 2005 - embojournal.npgjournals.com
... in Jurkat T cells with the PKA activator forskolin leads to an increase in synthesis
of c-Rel and p105/p50, while synthesis of p65/RelA remains unchanged. ...
Cited by 70 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Tumor Necrosis Factor--dependent Activation of a RelA Homodimer in Astrocytes - Full text - MIT Libraries
JA Diehl, W Tong, G Sun, M Hannink - J. Biol. Chem, 1995 - jbc.org
... To confirm that RelA is the only activatable Rel protein in astrocytes, nuclear
extracts from the LPS-treated cells were subjected to solution UV-cross-linking ...
Cited by 18 - Web Search - jbc.org - ncbi.nlm.nih.gov

Transcription factor NF-kappaB and inhibitor I kappaBalpha are localized in macrophages in active …
D Gveric, C Kaltschmidt, ML Cuzner, J Newcombe - J Neuropathol Exp Neurol, 1998 - apt.allenpress.com
... In contrast, in actively demyelinating plaques, the RelA, c-Rel, and p50 subunits
of NF-κB and IκBα were all present in macrophage nuclei in both ...
Cited by 25 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

… Transcription by the NF-{kappa} B Transcription Factor by Binding to the Rel Domain of the p 65/RelA … - Full text - MIT Libraries
M Benezra, N Chevallier, DJ Morrison, TK … - J Biol Chem, 2003 - jbc.org
... p65/RelA is a member of the NF- B family of transcription factors, which consists
of five members: p65/RelA, c-Rel, RelB, p50/p105, and p52/p100. ...
Cited by 6 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

… in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA … - Full text - MIT Libraries
N Sizemore, S Leung, GR Stark - Mol. Cell. Biol, 1999 - mcb.asm.org
... heterodimer (46). p65/RelA, RelB, and c-Rel stimulate transcription, whereas
p50 and p52 serve primarily to bind to DNA (25). Activation ...
Cited by 219 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »