The leukemia-associated AML1 (Runx1)–CBF beta complex functions as a DNA-induced molecular clamp - Full text - MIT Libraries
J Bravo, Z Li, NA Speck, AJ Warren - Nat. Struct. Biol, 2001 - nature.com
... sugar phosphate The leukemia-associated AML1 (Runx1)–CBFβ complex functions
as a DNA-induced molecular clamp Jerónimo Bravo ...
Cited by 39 - Web Search - nature.com - cs.dartmouth.edu - ncbi.nlm.nih.gov

Point mutations of the RUNx1/AML1 gene in sporadic and familial myeloid leukemias
M Osato, M Yanagida, K Shigesada, Y Ito - Int J Hematol, 2001 - cardenjennings.metapress.com
... conditions, low frequencies of concurrent genetic alterations, and tight rela-
tionships to disease phenotypes.A heterozygous point muta- tion of RUNX1 may not ...
Cited by 10 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

AT Lymphocyte-Specific Transcription Complex Containing RUNX1 Activates MHC Class I Expression - Full text - MIT Libraries
TK Howcroft, JD Weissman, A Gegonne, DS Singer - The Journal of Immunology, 2005 - jimmunol.org
... of MHC class I, these observations raise the possibility that the RUNX1 variants
associated ... Synergistic induction of HLA class I expression by RelA and CIITA. ...
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GEArray S Series Mouse Autoimmune and Inflammatory Response Gene Array: AR-SAMM-602.3
FG Grouping, A Proteins, CS Receptors, ST Proteins … - eurogentec.com
... Mef2d, Myc, Nfat5, Nfatc1, Nfatc2, Nfatc2ip, Nfatc3, Nfatc4, Nfkb1, Nfkb2, Nfkbia,
Nfkbib, Nfkbie, Nfkbil1, P300-ESTs, Raf1, Rel, Rela, Relb, Runx1, Runx2, Sp1 ...
View as HTML - Web Search - eurogentec.be

GEArray S Series Human Autoimmune and Inflammatory Response Gene Array: AR-SAHS-602
FG Grouping, A Proteins, CS Receptors, ST Proteins … - eurogentec.be
... MEF2D, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB,
NFKBIE, NFKBIL1, NFKBIL2, NFRKB, RAF1, REL, RELA, RELB, RUNX1, RUNX2, SP1, SP3 ...
View as HTML - Web Search - eurogentec.com

[CITATION] Disruption of C/EBPa Function in Acute Myeloid Leukemia
S Froehling, H Doehner
Web Search

The Apparent Uptake of Fluorescently Labeled siRNAs by Electroporated Cells Depends on the …
J Dunne, B Drescher, H Riehle, P Hadwiger, BD … - Oligonucleotides, 2003 - dx.doi.org
... luciferase-specific siRNAs, Fl-siGL2 or Cy3-siGL2, affected RUNX1-CBFA2T1 ex ... In
electroporated cells, rela- tively homogeneous staining of the cytoplasm is ob ...
Cited by 2 - Web Search - liebertonline.com - liebertonline.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Protracted postnatal natural histories in childhood leukemia
AT Maia, J Koechling, R Corbett, M Metzler, JL … - Genes Chromosomes and Cancer, 2004 - doi.wiley.com
... AML RUNX1-CBFA2T1 (AML1-ETO) 12 years, 2 months (Wiemels et al., 2002) ... International
workshop on the rela- tionship of prior therapy to balanced chromosome ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: Amplification discloses … - Full text - MIT Libraries
CD Baldus, S Liyanarachchi, K Mrozek, H Auer, SM … - Proceedings of the National Academy of Sciences, 2004 - pnas.org
... events in acute myeloid leukemia (AML) and usually occur in rela- tively simple ... already
been shown that RUNX1 (AML1, CBFA2) was not the likely target (8). Our ...
Cited by 5 - Web Search - pubmedcentral.nih.gov - knm1.ibe.med.uni-muenchen.de - dx.doi.org - all 9 versions »

Tumor suppressor gene Runx 3 sensitizes gastric cancer cells to chemotherapeutic drugs by … - Full text - MIT Libraries
C Guo, J Ding, L Yao, L Sun, T Lin, Y Song, L Sun, … - International Journal of Cancer, 2005 - doi.wiley.com
... CBFb does not bind to DNA on itself but enhances binding of the Runt domain with
DNA. Mammals have 3 kinds of RUNX proteins: Runx1, Runx2 and Runx3. ...
Web Search - ncbi.nlm.nih.gov

BMC Genomics - Full text - MIT Libraries
SH Dairkee, Y Ji, Y Ben, DH Moore, Z Meng, SS … - BMC Genomics, 2004 - bmc.ub.uni-potsdam.de
... Immortal cell lines Tumor tissue Tumor cell cultures RUNX1 MYLK AKT3 HSPG2 LOXL1 ...
The primary tumor culture with the highest rela- tive expression of hTERT (257T ...
View as HTML - Web Search - stanford.edu

Progress in Hematology
R Ono, T Nosaka, Y Hayashi - Int J Hematol, 2005 - cardenjennings.metapress.com
... which regulate both primitive and definitive hematopoiesis, and AML1/RUNX1/CBF and
CBF ... homology among the various MLL fusion partners, the rela- tionships of ...
Web Search

Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profiling
BJ Quade, TY Wang, K Sornberger, PD Cin, GL Mutter … - Genes Chromosomes and Cancer, 2004 - doi.wiley.com
... of Dysregulation in the Selected Genes In the selected set of 153 oligonucleotides,
the expression ratios of uterine leiomyosarcoma rela- tive to myometrium ...
Cited by 7 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

[CITATION] Resynchronizing Ventricular Contraction in Heart Failure - Full text - MIT Libraries
J Pedersen-Bjergaard, L Specht, SO Larsen… - Proc Natl Acad Sci USA, 2002
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Production of high-titer helper-free retroviruses by transient transfection - Full text - MIT Libraries
WS PEAR, GP NOLAN, ML SCOTT, D BALTIMORE - Proc. Nat. Acad. Sci, 1993 - pnas.org
... Home page BA Hug, N. Ahmed, JA Robbins, and MA Lazar A Chromatin Immunoprecipitation
Screen Reveals Protein Kinase C{beta} as a Direct RUNX1 Target Gene J. Biol ...
Cited by 1223 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - adsabs.harvard.edu - all 5 versions »

Emergence of translocation t (9; 11)-positive leukemia during treatment of childhood acute …
M Metzler, PL Strissel, R Strick, C Niemeyer, S … - Genes Chromosomes and Cancer, 2004 - doi.wiley.com
... ETV6–RUNX1 negative ETV6–RUNX1 negative ETV6–RUNX1 negative ... 2002. International workshop
on the rela- tionship of prior therapy to balanced chromosome ...
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Frequent Loss of RUNX 3 Expression by Promoter Hypermethylation in Gastric Carcinoma
Y Oshimo, N Oue, Y Mitani, H Nakayama, Y Kitadai, … - Pathobiology, 2004 - content.karger.com
... There are three mammalian Runt-related genes, RUNX1/AML1, RUNX2/CBFA1, and RUNX3/
PEBP2 ... We next performed RT-PCR analysis to investigate the rela- tion between ...
Cited by 4 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 7 versions » - Get it from MIT Libraries

The role of the AML1 transcription factor in leukemogenesis
RB Lorsbach, JR Downing - Int J Hematol, 2001 - cardenjennings.metapress.com
... Key words: AML1; Runx1;Acute leukemia; ETO;AML1-ETO ... overexpressing AML1-ETO has
identified several genes whose level of expression was increased rela- tive to ...
Cited by 7 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related … - Full text - MIT Libraries
H Harada, Y Harada, H Tanaka, A Kimura, T Inaba - Blood, 2003 - bloodjournal.org
... Somatically acquired point mutations of AML1/RUNX1 gene have been recently identified
in rare cases of acute myeloid leukemia (AML) and myelodysplastic syn ...
Cited by 15 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Focus on myeloproliferative diseases and myelodysplastic syndromes - Full text - MIT Libraries
RA Van Etten, KM Shannon - Cancer Cell, 2004 - tufts-mori.org
... dysplasia usually accompanied by cytopenias, while in MPD there is rela- tively
normal ... also con- tribute to MDS, as germline haploinsufficiency of RUNX1 is the ...
Cited by 1 - View as HTML - Web Search - ncbi.nlm.nih.gov

Respiratory Research - Full text - MIT Libraries
EA Renzoni, DJ Abraham, S Howat, X Shi-Wen, P … - Respiratory Research, 2004 - eprints.kcl.ac.uk
... Other TGFβ targets in lung fibroblasts identified by this study included Smad
co-activators RUNX1 and CBFB, recently implicated in the targeted subnuclear ...
View as HTML - Web Search - bmc.ub.uni-potsdam.de

Gene Expression Profiles of BRCA1-Linked, BRCA2-Linked, and Sporadic Ovarian Cancers - Full text - MIT Libraries
AA Jazaeri, CJ Yee, C Sotiriou, KR Brantley, J … - Journal of the National Cancer Institute, 2002 - jncicancerspectrum.oupjournals.org
... medium, and stored at –80°C. The rationale for and rela- tive merits ... BRCA1 tumors
expressed higher levels of RUNX1/ AML1, whereas BRCA2-associated samples ...
Cited by 44 - Web Search - math.wm.edu - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Leucemia mieloide aguda t (8; 21): frequeencia em pacientes brasileiros
C ScienTI - scielo.br
... At(8;21) envolve os genes AML1, também conhecido como RUNX1 que codifica o ... em rearranjos
cromossômicos tipicamente encontrados em SMD e LMA rela­cionadas à ...
Cached - Web Search - scielo.br

Using a Customized DNA Microarray for Expression Profiling of the Estrogen-Responsive Genes to … - Full text - MIT Libraries
S Terasaka, Y Aita, A Inoue, S Hayashi, M … - Environmental Health Perspectives, 2004 - earthscape.org
... 17 oncogene homolog (JUN) 7.5 c-fos (FOS) 14.4 AML1b (RUNX1) Tumor-associated ... The
response to the other chemicals with rela- tively high estrogen activity ...
Cited by 3 - View as HTML - Web Search - ehis.niehs.nih.gov - dx.doi.org - csa.com - all 7 versions »

BMC Genomics - Full text - MIT Libraries
PB Dallas, NG Gottardo, MJ Firth, AH Beesley, K … - BMC Genomics, 2005 - biomedcentral.com
... tested on the same numbers of samples as those genes that did correlate, and there
was no rela- tionship between ... RUNX1 210365_at 13 6.95 9.24 1.47 0.29 0.28 ...
View as HTML - Web Search - bmc.ub.uni-potsdam.de

and CD7
P Kusumakumary, P Kumari, GJ Morgan - Leuk Res, 1998 - haematologica.org
... in the fusion of the oncogene TEL1(ETV6) from 12p13 with AML1 (RUNX1) at 21q22 ... The
site of cancer age at diagnosis, and status of any affected rela- tives with ...
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Finding fusion genes resulting from chromosome rearrangement by analyzing the expressed sequence …
Y Hahn, TK Bera, K Gehlhaus, IR Kirsch, IH Pastan, … - Proceedings of the National Academy of Sciences - pnas.org
... 3 RUNX1 Known 4 4 0 21q22.12 Runt-related transcription factor ... two BAC clones, IRA1
(3q26.32) and RGS17 (6q25.2), to determine the physical rela- tionship of ...
Cited by 2 - Web Search - pubmedcentral.nih.gov - imm.med.ncku.edu.tw - dx.doi.org - all 6 versions » - Get it from MIT Libraries

Leucemia mieloide aguda t (8; 21): frequeencia em pacientes brasileiros
MLLF Chauffaille, D Borri, SLR Martins - sbhh.com.br
... 8;21) envolve os genes AML1, também conheci- do como RUNX1 que codifica ... em rearranjos
cromos- sômicos tipicamente encontrados em SMD e LMA rela- cionadas à ...
View as HTML - Web Search - scielo.br - scielo.br

Chromosome Rearrangement Breakpoint Clustering: The Role of Clonal Selection
ON Umanskaya, AA Bystritskiy, SV Razin - MOLECULAR BIOLOGY, 2005 - springerlink.com
... As in the cases of MLL and AML1, most breakpoints in the EWS gene cluster in a rela-
tively short region between ... RUNX1/AML1: A central player in hematopoiesis. ...
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Tenth International Workshop on the Identification of Transcribed Sequences 2000
G Heidelberg, B Korn, S Weissman, T Werner, K … - Cytogenet Cell Genet, 2001 - content.karger.com
... Genome organization G. Bernardi (Stazione Zoologica, Napoli) discussed the rela-
tionships among ... on the structure and regulation of expression of the RUNX1 gene ...
Web Search - content.karger.com

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in … - Full text - MIT Libraries
T Pabst, BU Mueller, P Zhang, HS Radomska, S … - Nat Genet, 2001 - nature.com
... cell death have been identified in leukemias and other cancers, but rela- tively
few ... study reported point mutations in the runt domain of RUNX1 (previously AML1 ...
Cited by 137 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Comparative expressed sequence hybridization studies of high-hyperdiploid childhood acute …
AM Gruszka-Westwood, SW Horsley, A Martinez- … - Genes Chromosomes and Cancer, 2004 - doi.wiley.com
... The ampli- fied test and reference cDNAs are tagged with different fluorochromes,
thereby allowing the rela- tive amount of hybridization from each to be as ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Novel sulfasalazine analogues with enhanced NF-kB inhibitory and apoptosis promoting activity.
F Habens, N Srinivasan, F Oakley, DA Mann, A … - Apoptosis, 2005 - springerlink.com
... modimeric complexes of Rel family proteins, c-Rel, RelA (p65), RelB, p50 (NF-kB1)
and p52 (NF-kB2). The com- monest form of NF-kB is the p65-p50 heterodimer. ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Epigenetic and Chromatin Modifiers As Targeted Therapy of Hematologic Malignancies - Full text - MIT Libraries
KN Bhalla - J Clin Oncol, 2005 - jco.org
... status of lysine residues of transcription factors (eg, p53, E2F1, GATA1, RelA,
YY1, Mad/Max ... of the core binding factor (CBF) AML1 (also known as RUNX1 or CBFA2 ...
Cited by 2 - Web Search - dx.doi.org - jco.org - ncbi.nlm.nih.gov

Centromeric breakage and highly rearranged chromosome derivatives associated with mutations of TP53 …
MK Andersen, DH Christiansen, J Pedersen-Bjergaard - GENES, CHROMOSOMES & CANCER, 2005 - doi.wiley.com
... Page 2. karyotype, methylation of the CDKN4B gene pro- moter (Christiansen et al.,
2003), and somatic mutations of the RUNX1 gene (Christiansen et al., 2004). ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Lysine acetylation and the bromodomain: a new partnership for signaling - Full text - MIT Libraries
XJ Yang - BioEssays, 2004 - doi.wiley.com
... and transcription ( 55) STAT6 CBP Augment DNA binding and transcription ( 56) Runx1 (
AML1) K24, 43 p300 Augment DNA binding (99) HMG-box HMGI(Y) K65 CBP ...
Cited by 15 - Web Search - ncbi.nlm.nih.gov

Characterization of the malignant melanoma of soft-parts cell line GG-62 by expression analysis … - Full text - MIT Libraries
KL Schaefer, D Wai, C Poremba, E Korsching, F van … - Virchows Archiv, 2002 - springerlink.com
... We employed a rela- tive quantification method in which the gene-expression ... factor
1 Nuclear EN2 Engrailed homolog 2 (transcription/DNA) RUNX1 Runt-related ...
Cited by 8 - Web Search - ncbi.nlm.nih.gov

The hare and the tortoise: an embryonic haematopoietic race - Full text - MIT Libraries
I Godin, A Cumano - Nat Rev Immunol, 2002 - nature.com
... 32. Grossmann, M. et al. The combined absence of the transcription factors Rel and
RelA leads to multiple hemopoietic cell defects. Proc. Natl Acad. Sci. ...
Cited by 26 - Web Search - nature.com - ncbi.nlm.nih.gov

Issues in Development
MAS MOORE - dx.doi.org
... The Runx1/AML1 gene plays a critical role in estab- lishment of definitive
hematopoiesis in the AGM. Runx1 expression is initiated ...
Web Search - liebertonline.com - liebertonline.com

Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone … - Full text - MIT Libraries
GL Barnes, A Javed, SM Waller, MH Kamal, KE Hebert … - Cancer Res, 2003 - csdb.nidcr.nih.gov
... 3. Transient transfection analyses of rela- tive Bsp promoter activities in ... For example,
genes encoding the Runx1/ AML1/CBF transcriptional complex are the ...
Cited by 14 - View as HTML - Web Search - csdb.nidcr.nih.gov - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - all 5 versions »

A second field metachronous Merkel cell carcinoma of the lip and the palatine tonsil confirmed by … - Full text - MIT Libraries
JNLZF Istvan, SJLBI Laszlo, G Puskas - Virchows Arch, 2005 - springerlink.com
... RNF139) 9q34 TRAF2 (ABL1) 11p11.2 (MADD) 11q13 DPF2, BAD, FADD (RELA, CCND1, RAD9A ...
MRVI1 14q31–32 SIVA 16q23–24 (LOC145908) CBFA2T3 21q22.13 RUNX1 22q11 BID ...
Web Search - ncbi.nlm.nih.gov

Molecular pathogenesis of MDS
H Hirai - Int J Hematol, 2002 - haem.nus.edu.sg
... proximately 5% of primary MDS and confers a rela- tively favorable prognosis ... The
AML1 (Runx1) gene encoding the heterodimeric transcription factor, which binds ...
Cited by 3 - View as HTML - Web Search - ishapd.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

[CITATION] Insights into Leukemogenesis from Therapy-Related Leukemia
RA Pauwels, S Pedersen, WW Busse… - Childhood
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Jun Hirose A developing picture of Taku Kouro lymphopoiesis in bone marrow - Full text - MIT Libraries
H Igarashi, T Yokota, N Sakaguchi, PW Kincade - Immunological Reviews, 2002 - ingentaconnect.com
... The rela- tively long time required for cells in this fraction to generate lymphocytes
in culture and their tendency to down-regulate c-Kit suggested a ...
Web Search

Microarray transcript profiling distinguishes the transient from the acute type of megakaryoblastic … - Full text - MIT Libraries
S McElwaine, C Mulligan, J Groet, M Spinelli, A … - British Journal of Haematology, 2004 - ingentaconnect.com
Page 1. Microarray transcript profiling distinguishes the transient from
the acute type of megakaryoblastic leukaemia (M7) in Down’s ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

Novel transcription factors in human CD34 antigen-positive hematopoietic cells - Full text - MIT Libraries
I Gomes, TT Sharma, S Edassery, N Fulton, BG Mar, … - Blood, 2002 - bloodjournal.org
... 13.7 I W Hs.129914 RUNX1 Runt-related transcription factor 1 (acute myeloid
leukemia 1; aml1 oncogene) 21q22.3 13.6 I W Hs.247433 ...
Cited by 3 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

BASL Meeting 2003
F Liver - basl.org.uk
... A SINGLE CENTRE EXPERIENCE R Srinivasan, N Hadzic, M Rela, N Heaton ... Functional
interaction between the transcription factors JunD and Runx1: Implications for ...
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Analysis of translocations that involve the NUP98 gene in patients with 11p15 chromosomal …
YN Kobzev, J Martinez-Climent, S Lee, J Chen, JD … - GENES, CHROMOSOMES & CANCER, 2004 - doi.wiley.com
... Thus, NUP98, along with MLL, ETV6 (TEL), and RUNX1 (AML1), is one of the rare genes
that have numerous genetic partners with vastly different functions. ...
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21 q 22 balanced chromosome aberrations in therapy-related hematopoietic disorders: Report from an …
ML Slovak, V Bedell, L Popplewell, DA Arber, C … - Genes Chromosomes and Cancer, 2002 - doi.wiley.com
... chromosomes were also documented with involvement of AML1(CBFA2/RUNX1),
identifying a total of 23 different 21q22/AML1 transloca- tions. ...
Cited by 10 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Inducible Transgene Expression in Mouse Stem Cells
DT Ting, M Kyba, GQ Daley - Methods Mol Med, 2005 - biomed.humanapress.com
... We determined that inverting the orientation of the inducible locus in rela- tion
to the HPRT locus and eliminating the co-inducible GFP reporter successfully ...
Web Search - journals.humanapress.com - neurosci.humanapress.com - ncbi.nlm.nih.gov - Get it from MIT Libraries