Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 genes and their prognostic implications in … - Full text - MIT Libraries
T Tsuchiya, K Sekine, S Hinohara, T Namiki, T … - Cancer Genet Cytogenet, 2000 - tmd.ac.jp
... LEAD ARTICLE Analysis of the p16INK4, p14ARF, p15, TP53, and ... Alterations of TP53
were found in 15 (50%) of 30 osteosarcomas and 1 (3%) of 24 Ewing sarcomas. ...
Cited by 23 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

O 6-Methylguanine-DNA Methyltransferase methylation and TP53 mutation in malignant astrocytomas and … - Full text - MIT Libraries
T Watanabe, Y Katayama, C Komine, A Yoshino, A … - Int J Cancer, 2004 - doi.wiley.com
Page 1. O 6 -Methylguanine-DNA Methyltransferase methylation and TP53 mutation in
malignant astrocytomas and their relationships with clinical course ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

Polymorphisms of CYP1A1, CYP2E1, GSTM1, GSTT1, and TP53 genes in Amerindians
PA Gaspar, MH Hutz, FM Salzano, K Hill, AM Hurtado … - American Journal of Physical Anthropology, 2002 - doi.wiley.com
... The rela- tionships between these Amerindians and with other eth- nic groups ... In the
TP53 comparison with other eth- nic groups, Amerindians clustered together ...
Cited by 9 - Web Search - unm.edu - ncbi.nlm.nih.gov - Get it from MIT Libraries

THE TP53 GENOTYPE BUT NOT IMMUNOHISTOCHEMICAL RESULT IS PREDICTIVE OF RESPONSE TO CISPLATIN-BASED …
D Kandioler-Eckersberger, S Kappel, M Mittlboeck, … - Cardiovascular Surgery - akh-wien.ac.at
... found no rela- tionship between good response and the absence or presence of K-ras
mutations, whereas Kishimoto and associates 6 found that TP53 mutations and K ...
Cited by 13 - View as HTML - Web Search - jtcs.ctsnetjournals.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

TP53 ALTERATIONS IN RELATION TO THE CELL CYCLE-ASSOCIATED PROTEINS p21, CYCLIN D1, CDK4, RB, MDM2, … - Full text - MIT Libraries
R HOLM - J. Pathol, 1999 - doi.wiley.com
... According to our results, accumulation of p21 is rela- tively common and this may
be caused by TP53- dependent and/or -independent induction, or abnormal ...
Cited by 7 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

TP53 and p21 W AF1: CIP1 Behave Differently in Euploid versus Aneuploid Bladder Tumours Treated with …
R Roetterud, H Skomedal, A Berner, HEE Danielsen, … - Acta Oncologica, 2001 - dx.doi.org
... The p21 WAF 1:C IP 1 protein displays almost the same rela- tion to survival as
TP53, with a signi cant association in Page 8. Acta Oncologica 40 (2001) ...
Cited by 1 - Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Genetic Variants of TP53 and EPHX1 in Leber’s Hereditary Optic Neuropathy and Their Relationship … - Full text - MIT Libraries
K Ishikawa, T Funayama, H Ohde, Y Inagaki, Y … - Jpn J Ophthalmol, 2005 - springerlink.com
... 27 Polymorphisms of two apoptosis- related genes,Arg72Pro in p53 (TP53) 28 and 670A
G ... Each genetic polymorphism was analyzed in rela- tion to the age at onset ...
Web Search - ncbi.nlm.nih.gov

TP53 polymorphisms and haplotypes in South Amerindians and neo-Brazilians
PA Gaspar, MH Hutz, FM Salzano, TA Weimer - Ann Hum Biol, 2001 - dx.doi.org
Page 1. TP53 polymorphisms and haplotypes in South Amerindians and
neo-Brazilians ... TP53 polymorphisms in Brazilian populations 185 ...
Cited by 4 - Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Ovarian Carcinoma In Situ With Germline BRCA1 Mutation and Loss of Heterozygosity at BRCA1 and TP53
IOG Jones, RA DiCioccio, J Wiest, Y Tsukada, BAJ … - jncicancerspectrum.oupjournals.org
... Holm R. TP53 pro- tein accumulation and gene mutation in rela- tion to overexpression
of MDM2 protein in ovarian borderline tumours and stage I carci- nomas. ...
Web Search

IMPACT OF GSTT1, GSTM1, GSTP1 AND NAT2 GENOTYPES ON KRAS2 AND TP53 GENE MUTATIONS IN COLORECTAL … - Full text - MIT Libraries
PF Pompidou - Int. J. Cancer, 2004 - doi.wiley.com
... We conducted an exploratory study to investigate the rela- tionship between the
occurrence of KRAS2 and TP53 mutations and different functional polymorphism of ...
Web Search

Different Expression of P14ARF Defines Two Groups of Breast Carcinomas in Terms of TP73 Expression …
G Domın, J Silva, JM Silva, JM Garcıa, FJ … - GENES, CHROMOSOMES & CANCER, 2001 - doi.wiley.com
... com- mon pathway involving P14ARF, MDM2, and TP53. Other reports, one of them focusing
on the same tumor type, did not show this inverse rela- tionship between ...
Web Search - doi.wiley.com

in BRCA2, TGFb-RII, KRAS2, TP53 and/or CDNK2A - Full text - MIT Libraries
V Samouelian, CM Maugard, M Jolicoeur, R Bertrand, … - Cancer Chemother Pharmacol, 2004 - springerlink.com
... While an association between TP53 mutations and EOC sensitivity to drugs or c ... No
rela- tionship has been found between Kirsten-Ras protein levels and cisplatin ...
Web Search

Centromeric breakage and highly rearranged chromosome derivatives associated with mutations of TP53 …
MK Andersen, DH Christiansen, J Pedersen-Bjergaard - GENES, CHROMOSOMES & CANCER, 2005 - doi.wiley.com
... Chromosome Derivatives Associated with Mutations of TP53 Are Common in Therapy-Related
MDS and ... Revised karyotype a TP53 exon Normal base?Mutated base (codon) ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Isolation and mutational analysis of a novel human cDNA, DEC 1(deleted in esophageal cancer 1), …
T Nishiwaki, Y Daigo, T Kawasoe, Y Nakamura - Genes Chromosomes and Cancer, 2000 - doi.wiley.com
... However, although mutational analyses have detected rela- tively frequent somatic
mutations of TP53 and occasional mutations of CDKN2A in esophageal cancers ...
Cited by 11 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

DT-Diaphorase Expression and Tumor Cell Sensitivity to 17-Allylamino, 17-demethoxygeldanamycin, an … - Full text - MIT Libraries
LR Kelland, SY Sharp, PM Rogers, TG Myers, P … - Journal of the National Cancer Institute, 1999 - jncicancerspectrum.oupjournals.org
... tant oncogenic proteins, including Raf-1 and mutant p53 (also known as TP53). ... in
vitro human tumor cell panels, we observed a positive rela- tionship between DT ...
Cited by 67 - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov

A substantial proportion of microsatellite-unstable colon tumors carryTP 53 mutations while not …
JL Westra, LG Boven, P van der Vlies, H Faber, B … - Genes Chromosomes and Cancer, 2005 - doi.wiley.com
... The number and type of subtelomeric aberra- tions of the microsatellite-unstable
tumors in rela- tion to TP53 status are presented in Figure 1A. ...
Web Search - ijmm.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

The IARC TP 53 database: New online mutation analysis and recommendations to users - Full text - MIT Libraries
M Olivier, R Eeles, M Hollstein, MA Khan, CC … - Human Mutation, 2002 - doi.wiley.com
... Somatic Mutations The database of somatic mutations is a rela- tional database built ...
representation of the database structure can be found on the TP53 web site ...
Cited by 139 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

GEArray S Series Human Immunology Signaling Pathways Gene Array: AR-SAHS-605
FG Grouping, A Molecules, I ICAM, CS Molecules, C … - eurogentec.com
... MAPKAPK2, MAPKAPK3, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MHC2TA, MKNK1, MLLT7, MYC,
MYF5, NFKB2, NFKBIB, NFKBIE, NR4A2, PCNA, RAF1, RELA, RPS6KA5, SP1, SP3, TP53. ...
View as HTML - Web Search - eurogentec.be

lymphoproliferative disorders - Full text - MIT Libraries
G Volpe, B Gamberi, C Pastore, A Roetto, MPG … - Ann Hematol, 1996 - springerlink.com
... Chronic lymphoproliferative disorders represent a rela- tively heterogeneous group
of lymphoid maligancies of mature lymphoid cells which include chronic ... TP53 ...
Cited by 16 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Gene therapy for pancreatic cancer based on genetic characterization of the disease - Full text - MIT Libraries
M Sunamura, T Yatsuoka, F Motoi, DG Duda, M Kimura … - J Hepatobiliary Pancreat Surg, 2002 - springerlink.com
... In pancreatic cancer, KRAS, TP53, p16, and SMAD4 have been considered as ... of the genetic
alterations in pancreatic cancer and the rela- tionship between the ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

Genes implicated in hereditary breast cancer syndromes
PN Tonin, C Quebec - Seminars in Surgical Oncology, 2000 - doi.wiley.com
... pedigree; Jews; polymerase chain reaction; Li-Fraumeni syndrome; TP53; ataxia
telangiectasia ... for an individual with two first-degree rela- tives diagnosed with ...
Cited by 13 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

MDM 2 expression in areca quid chewing-associated oral squamous cell carcinomas in Taiwan - Full text - MIT Libraries
JS Huang, TJ Ho, CP Chiang, SH Kok, YS Kuo, MYP … - Journal of Oral Pathology and Medicine, 2001 - ingentaconnect.com
... pro- tein overexpression may constituent an alternative mechanism for TP53 inactivation
in ... the SCCs suggests that MDM2 alteration may be a rela- tively early ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov

Are p 53 mutations and p 53 overexpression prognostic factors for astrocytic tumors? - Full text - MIT Libraries
N Ishii, N de Tribolet - Critical Reviews in Neurosurgery, 1998 - springerlink.com
... 4. Pollack IF, Hamilton RL, Finkelstein SD, Campbell JW, Martinez AJ, Sherwin RN,
Bozik ME, Gollin SM (1997) The rela- tionship between TP53 mutations and ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Influence of apoptosis on the enhancement of radiotoxicity by ouabain - Full text - MIT Libraries
FA Verheye-Dua, L Bohm - Strahlenther Onkol, 2000 - springerlink.com
... Materials and Methods: Seven human cell lines of defined TP53 status were
irradiated with 60 Co-γ irradiation in the ... 2 delay in TP53 ...
Cited by 12 - Web Search - ncbi.nlm.nih.gov

Two Na, K-ATPase 2 Subunit Isoforms Are Differentially Expressed Within the Central Nervous System … - Full text - MIT Libraries
JR RAJARAO, VA CANFIELD, B LOPPIN, B THISSE, C … - DEVELOPMENTAL DYNAMICS, 2002 - doi.wiley.com
... Phylogenetic anal- ysis was performed to explore the evolutionary rela- tionships
between ... 2). In humans, ATP1B2 and TP53 are very tightly linked on Hsa 17p13. ...
Cited by 6 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Mutations of BRAF are associated with extensive hMLH1 promoter methylation in sporadic colorectal … - Full text - MIT Libraries
K Koinuma, K Shitoh, Y Miyakura, T Furukawa, Y … - Int J Cancer, 2004 - doi.wiley.com
... are rarely associated with KRAS mutations and loss of heterozygosity (LOH) of TP53
gene ... stable (MSI ), maintain MMR gene expression and show a rela- tively high ...
Cited by 10 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

P53 A KARCINOM PROSTATY P53 AND PROSTATE CARCINOMA
UEMAV aR PRAHA - linkos.cz
... Vût‰ina karcinomÛ prostaty roste pomalu a metastazuje rela- tivnû pozdû. ... Souhrn:
Inaktivace tumor-supresorového genu TP53 znamená ztrátu kontrolního ...
View as HTML - Web Search - linkos.cz

Challenges of genetic diversity and the use of high throughput genotyping in genetic epidemiology
VN Kristensen - Norsk Epidemiologi, 2002 - medisin.ntnu.no
... repeat in a PIG gene as the first TP53-responsive element ... low sensitivity, poor dis-
crimination of deletions, repetitive sequences, rela- tive dependence on ...
View as HTML - Web Search

Expression of p53 protein in pituitary adenomas - Full text - MIT Libraries
CB Pizarro, JF Pereira-Lima, LM Barbosa-Coutinho, … - Brazilian Journal of Medical and Biological Research, 2002 - scielo.br
... nohistochemistry (4). Inactivating mutations of TP53 are among the most frequent
alter- ations in ... subset in which it was found, was too low in rela- tion to ...
View as HTML - Web Search - scielo.br

Dominant Negative ATM Mutations in Breast Cancer Families - Full text - MIT Libraries
G Chenevix-Trench, AB Spurdle, M Gatei, H Kelly, A … - Journal of the National Cancer Institute, 2002 - jncicancerspectrum.oupjournals.org
... reported an elevated frequency of breast cancer in female rela- tives, particularly ...
A number of well-characterized tumor sup- pressor genes (TP53, BRCA1, and ...
Cited by 73 - Web Search - ingentaconnect.com - genepi.qimr.edu.au - ncbi.nlm.nih.gov - all 6 versions »

Caffeine-inhibitable control of the radiation-induced G2 arrest in L5178Y-S cells deficient in non- … - Full text - MIT Libraries
D Kowalczyk, P Janik - Radiat Environ Biophys, 2001 - springerlink.com
... Atr also modifies Tp53, so that the regulatory pathway depending on p21 (depict-
ed in ... This effect was rela- tively larger in LY-S cells, since the G2 arrest ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

The proteasome in cancer biology and treatment - Full text - MIT Libraries
F Pajonk, WH McBride - Radiat. Res, 2001 - bioone.org
... In addition, mutated TP53 can be stabilized by binding of HSP90, which could be ... subunits:
p50 (TNFRSF5)/p105 (NFKB1), p52/p100 (NFKB2), REL, p65/RELA and RELB. ...
Cited by 13 - Web Search - strahlenbiologie.bei.t-online.de - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Molecular pathogenesis of head and neck squamous cell carcinoma - Full text - MIT Libraries
D Hardisson - Eur Arch Otorhinolaryngol, 2003 - springerlink.com
... from different anatomical sites, and that the number of samples analyzed was rela-
tively small ... and already cloned TSG, such as VHL (3p), p16 (9p) and TP53 (17p ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Microsatellite instability analysis in typical and progressed mantle cell lymphoma and B-cell … - Full text - MIT Libraries
L Sanz-Vaque, D Colomer, F Bosch, A Lopez- … - Haematologica, 2001 - haematologica.it
... However, the possible rela- tionship between these clinical characteristics and
the ... in paired normal and tumoral DNAs from B-CLL-18 at locus TP53-Dint and loss ...
Cited by 6 - View as HTML - Web Search - haematologica.org - haematologica.org - ncbi.nlm.nih.gov - all 10 versions »

und immunhistochemische Untersuchung destp53-Gens in menschlichen Ameloblastomen - Full text - MIT Libraries
T Appel, R Gath, N Wernert, M Martini, S Berge - Mund Kiefer GesichtsChir, 2004 - springerlink.com
... wurden mittels PCR die Exons 5 bis 8 des tp53-Tumor- suppressorgens ... SSCP-)Analyse
ist eine Form der Gelelektrophorese,mit der sich rela- tiv schnell Mutationen ...
Web Search

Antioncogenes and human cancer - Full text - MIT Libraries
AG Knudson - Proc Natl Acad Sci USA, 1993 - pnas.org
... and endocrine Carcinoma Cloned RBI 13q14 Sarcoma Retinoblastoma WTI 11p13
Wilms tumor TP53 17pl3 Sarcoma Glioma Breast NFl 17qll ...
Cited by 232 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Altered mode of allelic replication accompanied by aneuploidy in peripheral blood lymphocytes of … - Full text - MIT Libraries
ZA Dotan, A Dotan, J Ramon, L Avivi - International Journal of Cancer, 2004 - doi.wiley.com
... hidden in nondividing cells and reveals aneuploid cells occurring in rela- tively
low ... and BPH subjects The frequencies of SD cells for AML1 and TP53 loci were ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

DETERMINATION OF STRUCTURAL FORMS OF P53 PROTEIN BY FLOW INJECTION ANALYSIS WITH ELECTROCHEMICAL …
PIASE DETEKCI - mendelu.cz
... V případě rakoviny plic, tvoří mutace proteinu p53 dokonce 70% ze všech případů
(Obrázek 1). Mimo mutace genu TP53 ... rela t i v ní kumula ...
View as HTML - Web Search

Functional and molecular analyses of 10 q deletions in human gliomas
PA Steck, H Lin, LA Langford, SA Jasser, D Koul, … - Genes Chromosomes and Cancer, 1999 - doi.wiley.com
... of genetic alterations are associated with gliomas, including mutations in TP53,
P16, DCC ... of ge- netic alterations on chromosome 10 and their rela- tionship to ...
Cited by 23 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Inhibition of NF-B, clonogenicity, and radiosensitivity of human cancer cells - Full text - MIT Libraries
F Pajonk, K Pajonk, WH McBride - J. Natl. Cancer Inst.(Bethesda), 1999 - jncicancerspectrum.oupjournals.org
... of transcription factors, such as AP-1, p53 (also known as TP53), and NF ... Homodimers
and het- erodimers of its subunits p50, p52, p65/ RelA, c-Rel, and Rel-B are ...
Cited by 41 - Web Search - strahlenbiologie.bei.t-online.de - ingentaconnect.com - ncbi.nlm.nih.gov

Selective Reporting Biases in Cancer Prognostic Factor Studies - Full text - MIT Libraries
PA Kyzas, KT Loizou, JPA Ioannidis - Journal of the National Cancer Institute, 2005 - jncicancerspectrum.oxfordjournals.org
... The strength of the rela- tionship between TP53 status and mortality decreased when
we used standardized, prespecified definitions of TP53 status and used 2 ...
Cited by 1 - Web Search

Alu-polymerase chain reaction genomic fingerprinting technique identifies multiple genetic loci …
AB McKie, T Iwamura, HY Leung, MA Hollingsworth, … - Genes Chromosomes and Cancer, 1997 - doi.wiley.com
... et al., 1995; Liu et al., 1995), and abnormalities of TP53 are found ... using one of
eight different Alu-specific primers varying in their rela- tive specificity ...
Cited by 5 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Molecular characterization of a 17 q 11. 2 translocation in a malignant schwannoma cell line
JE Reynolds, JA Fletcher, CH Lytle, L Nie, CC … - Human Genetics, 1992 - springerlink.com
... 1987), PC53-ASN/BamHI (TP53; McBride et al. ... The probes are listed in rela- tive order
from the telomere to the breakpoint except for probes AT464 and Mfdl5 ...
Cited by 8 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

p53 mutations and microsatellite instabilities in the subtype of intestinal metaplasia of the … - Full text - MIT Libraries
SS Kim, CS Bhang, KO Min, HS Chae, SW Choi, CD Lee … - J Korean Med Sci, 2002 - jkms.kams.or.kr
... implication of the subtype of intestinal metaplasia in the rela- tionship between ...
dinu- cleotide markers D2S123, D5S346, D13S170, D17S250, and TP53 were used ...
Cited by 6 - View as HTML - Web Search - ncbi.nlm.nih.gov

Genetic abnormalities involved in the pathogenesis of gallbladder carcinoma - Full text - MIT Libraries
II Wistuba, J Albores-Saavedra - J Hepatobiliary Pancreat Surg, 1999 - springerlink.com
... ences with etiological interest were seen in the muta- tional spectra of TP53 gene
mutations ... In addition, G:C to A:T transition at CpG was rela- tively frequent ...
Cited by 25 - Web Search - ncbi.nlm.nih.gov

Pancreatic Cancer Genetics
CS Genes - Pancreatology, 2001 - content.karger.com
... melanoma and the CDKN2A gene and childhood and breast cancers with TP53 gene mutations. ...
used: (1) an individual with two or more first-degree rela- tives with ...
Web Search - content.karger.com

Research Review Cancer Genetics - Full text - MIT Libraries
H PREDISPOSITION - American Journal of Medical Genetics, 2002 - doi.wiley.com
... investigation of the autosomal dominantly-inherited conditions that impose high
rela- tive risks ... Others, like RB1, TP53, NF1, and Wilms tumor 1 (WT1), may be ...
Web Search

BIOINFORMATICS - Full text - MIT Libraries
Y Lai, B Wu, L Chen, H Zhao - BIOINFORMATICS, 2004 - bioinformatics.oupjournals.org
... By using tumor suppressor genes TP53, PTEN and RB1, we identify seven genes that ...
of homo- or hetero-dimers formed from the multigene family of RelA (p65), c-Rel ...
Web Search

Acute myeloid leukemia with a complex aberrant karyotype is a distinct biological entity …
C Schoch, W Kern, A Kohlmann, W Hiddemann, S … - Genes Chromosomes and Cancer, 2005 - doi.wiley.com
... TP53 mutations also have been reported in MDS wit a complex aberrant karyotype ... with
genes/gene products as nodes and the biological rela- tionships between the ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased … - Full text - MIT Libraries
S Rocha, AM Martin, DW Meek, ND Perkins - Mol. Cell. Biol, 2003 - mcb.asm.org
... a half micrograms of cyclin E luciferase plasmid was transfected into H1299 w/tp53
cells, and ... activity has been shown to be regulated by both p50/RelA and also ...
Cited by 21 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »