The DNA-binding properties of two heat shock factors, HSF1 and HSF3, are induced in the avian … - Full text - MIT Libraries
A Nakai, Y Kawazoe, M Tanabe, K Nagata, RI … - Mol. Cell. Biol, 1995 - mcb.asm.org
... Whereas HSF1 was rapidly translocated to the nu- cleus, the fraction of
nucleus-localized HSF3 was delayed rel- ative to HSF1, a result which is consistent ...
Cited by 43 - Web Search - biochem.northwestern.edu - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

HSF1 granules: a novel stress-induced nuclear compartment of human cells - Full text - MIT Libraries
JJ Cotto, SG Fox, RI Morimoto - J. Cell Sci, 1997 - jcs.biologists.org
... However, given the rel- atively large size of the HSF1 granules, it is also possible
that their location within the nucleus may be unaffected even if nucleic ...
Cited by 44 - Web Search - jcs.biologists.org - biochem.northwestern.edu - ncbi.nlm.nih.gov - all 5 versions »

Evolutionary relationships among Rel domains indicate functional diversification by recombination - Full text - MIT Libraries
IA Graef, JM Gastier, U Francke, GR Crabtree - Proceedings of the National Academy of Sciences, 2001 - pnas.org
... it appears that recombination between the translocation exon and the rel
domain-coding ... is present twice in the heat-shock factor 1 (HSF1) transcription factor ...
Cited by 19 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Induction of HSF1 expression is associated with sporadic colorectal cancer - Full text - MIT Libraries
H Cen, S Zheng, YM Fang, XP Tang, Q Dong - World J Gastroenterol, 2004 - wjgnet.com
... be- tween the human heat shock transcription factor 1 (HSF1) and prostate ... Heat shock
protein expression and immunity: rel- evance to gynecologic oncology. ...
View as HTML - Web Search - wjgnet.com - wjgnet.com - ncbi.nlm.nih.gov - all 5 versions »

Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans - Full text - MIT Libraries
TJ Schuetz, GJ Gallo, L Sheldon, P Tempst, RE … - Proc Natl Acad Sci US A, 1991 - pubmedcentral.nih.gov
... G, Clos J, Wu C. Molecular cloning and expression of a human heat shock factor,
HSF1. ... of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal. ...
Cited by 81 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Pervanadate induces the hyperphosphorylation but not the activation of human heat shock factor 1 - Full text - MIT Libraries
J Park, AYC Liu - Journal of Cellular Physiology, 2000 - doi.wiley.com
... The specificity of this effect of pervanadate is suggested by its efficacy in promoting
the hyperphosphorylation of HSF1 at a rel- atively low concentration ...
Cited by 7 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

GEArray Q Series Mouse Signal Transduction in Cancer Gene Array: AR-SAMM-044
FG Grouping, A Pathway, C Cdk, E Pathway, B Bcl, H … - eurogentec.be
... transcription factor 1 (HSF1). J Biol Chem. 2000 Aug 11; 275 (32): 24970-6.
Survival/NF-kappa B Pathway: 1. Chen C, Edelstein LC, Gelinas C. The Rel/NF-kappaB ...
View as HTML - Web Search - eurogentec.com

GEArray Q Series Human Signal Transduction in Cancer Gene Array: AR-SAHS-044
FG Grouping, A Pathway, C CDK, E Pathway, B BCL, H … - eurogentec.com
... transcription factor 1 (HSF1). J Biol Chem. 2000 Aug 11; 275 (32): 24970-6.
Survival/NF-kappa B Pathway: 1. Chen C, Edelstein LC, Gelinas C. The Rel/NF-kappaB ...
View as HTML - Web Search - eurogentec.be

Cyclopentenone Prostaglandins as Anti-Inflammatory Agents: A Novel Therapeutic Strategy?
A Ianaro, P Maffia, M Di Rosa, A Ialenti - ingentaconnect.com
... of resting cells as an inactive complex, whose predominant form is a heterodimer
composed of p50 and p65 (Rel A) subunits ... (2). Time-course of HSF1/DNA binding ...
Web Search

Modulation of thermal induction of hsp70 expression by Ku autoantigen or its individual subunits - Full text - MIT Libraries
SH Yang, A Nussenzweig, L Li, D Kim, H Ouyang, P … - Mol. Cell. Biol, 1996 - mcb.asm.org
... induced HSF1-HSE binding ability and hyperphosphory- lation of HSF1 in the ... The relative
(rel.) increases in luciferase activity normalized to that in unheated ...
Cited by 21 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov

Glutathione depletion impairs transcriptional activation of heat shock genes in primary cultures of … - Full text - MIT Libraries
K Rokutan, T Hirakawa, S Teshima, S Honda, K Kishi - J Clin Invest, 1996 - jci.org
... by oligomerization, modification, and rapid translocation of heat shock transcription
factor HSF1. ... 1992) The RxxRxRxxC motif conserved in all Rel/ B proteins ...
Cited by 19 - Web Search - pubmedcentral.nih.gov - jci.org - ncbi.nlm.nih.gov - all 5 versions »

The heat shock response and cytoprotection of the intestinal epithelium - Full text - MIT Libraries
JJ Malago, J Koninkx, JE van Dijk - Cell Stress Chaperones, 2002 - cest.allenpress.com
... The second group consists of p65 (Rel A), Rel (c-Rel), and Rel B. In addition to ...
of the genes by a family of DNA-binding proteins called the HSFs (HSF1–4, of ...
Cited by 7 - Web Search - bioone.org - pubmedcentral.nih.gov - apt.allenpress.com - all 7 versions »

Anti-inflammatory activity of 15-deoxydelta12, 14-PGJ2 and 2-cyclopenten-1-one: role of the heat … - Full text - MIT Libraries
A Ianaro, A Ialenti, P Maffia, P Di Meglio, M Di … - Mol Pharmacol, 2003 - intl-molpharm.aspetjournals.org
... able to switch on endogenous anti-inflammatory systems, such as the HSF1/hsp72 pathway ...
S, May MJ, and Kopp EB (1998) NF-kappa B and Rel proteins: evolutionary ...
Cited by 9 - Web Search - intl-molpharm.aspetjournals.org - ncbi.nlm.nih.gov

Experimental demonstration of plasticity in the heat shock response of the intertidal mussel Mytilus … - Full text - MIT Libraries
PM Halpin, BA Menge, GE Hofmann - Mar. Ecol. Prog. Ser, 2004 - int-res.com
... Rel. Amt. ... However, the plasticity is most likely related to the behavior of a key
transcriptional factor, heat shock factor 1 (HSF1) and its interaction with ...
Cited by 1 - View as HTML - Web Search - int-res.com - csa.com

Resolution, Detection, and Characterization of Redox Conformers of Human HSF 1 - Full text - MIT Libraries
DJ Manalo, AYC Liu - J Biol Chem, 2001 - jbc.org
... cysteine-containing motif RXXRXRXXC has been identified in all Rel/ B proteins ... by
blocking the activation, trimerization, and nuclear translocation of HSF1 (21 ...
Cited by 3 - Web Search - jbc.org - ncbi.nlm.nih.gov

Tissue-dependent expression of heat shock factor 2 isoforms with distinct transcriptional activities - Full text - MIT Libraries
ML Goodson, OK Park-Sarge, KD Sarge - Mol. Cell. Biol, 1995 - mcb.asm.org
... Isolation and cloning of HSF1 and HSF2 cDNAs and genomic DNA sequences. ... plasmid
exhibited a mean 3.6 ( 0.5)-fold-higher luciferase activity rel- ative to cells ...
Cited by 42 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Response to acetaldehyde stress in the yeastSaccharomyces cerevisiae involves a strain-dependent … - Full text - MIT Libraries
A Aranda, M del Olmo - Yeast, 2003 - doi.wiley.com
... msn4 ::URA3 tetO::HSF1::kanMX4 (Amoros and Estruch, 2001) MCY1389 MATa ura3-52,
leu2 ... Panel C indicates the basal mRNA levels of this gene (rel- ative to those ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

Full Text View - Full text - MIT Libraries
JJ Malago, JFJG Koninkx, JE van Dijk - Cell Stress & Chaperones - bioone.org
... The second group consists of p65 (Rel A), Rel (c-Rel), and Rel B. In addition to ...
of the genes by a family of DNA-binding proteins called the HSFs (HSF1–4, of ...
Web Search - bioone.org

Predicting Genetic Regulatory Response Using Classification
M Middendorf, A Kundaje, C Wiggins, Y Freund, C … - Arxiv preprint q-bio.QM/0411028, 2004 - arxiv.org
... our gene expression dataset, we have two sources of feature information rel- ative
to ... target genes [4]. The other high scoring motifs include HSF1 (heat-shock ...
Cited by 10 - View as HTML - Web Search - cs.princeton.edu - math.biu.ac.il - cs.utsa.edu - all 14 versions »

HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional … - Full text - MIT Libraries
A Nakai, M Tanabe, Y Kawazoe, J Inazawa, RI … - Mol. Cell. Biol, 1997 - mcb.asm.org
... chaperones. In vertebrates, three related HSF genes (HSF1 to -3) and the
respective gene products (HSFs) have been characterized. ...
Cited by 97 - Web Search - biochem.northwestern.edu - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Evidence for a role of heat shock factor 1 in inhibition of NF-{kappa} B pathway during heat shock … - Full text - MIT Libraries
D Wirth, F Bureau, D Melotte, E Christians, P … - Am J Physiol Lung Cell Mol Physiol, 2004 - ajplung.physiology.org
... NF- B and Rel proteins: evolutionarily conserved mediators of immune responses ...
Christians ES, Li X, Benjamin IJ, and Gustin P. Use of Hsf1 –/– mice reveals ...
Web Search - ajplung.physiology.org - ncbi.nlm.nih.gov

DNA SEQUENCE COMPLEXITY AND STRUCTURAL CLASSIFICATION OF TRANSCRIPTION FACTOR BINDING SITES
YL Orlov, AS Poplavsky, AL Proscura, P Arrigo - biocomp.ge.ismac.cnr.it
... beta- Scaffold Factors with Minor Groove Contacts), (class 4.1, RHR - Rel homology
region). ... HSF1 related to Superclass 3 (Helix-turn-helix) and 3.4 class: Heat ...
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Relationship between intracellular ionic strength and expression of tonicity-responsive genes in rat … - Full text - MIT Libraries
W Neuhofer, H Bartels, ML Fraek, FX Beck - The Journal of Physiology, 2002 - jp.physoc.org
... The heat-shock transcription factor HSF1 is rapidly activated by either hyper ...
Tonicity-responsive enhancer binding protein, a Rel-like protein that stimulates ...
Cited by 7 - Cached - Web Search - blackwell-synergy.com - dx.doi.org - jphysiol.org - all 7 versions »

Glutathione depletion inhibits oxidant-induced activation of nuclear factor-kappa B, AP-1, and c-Jun … - Full text - MIT Libraries
K Rokutan, S Teshima, M Miyoshi, T Kawai, T Nikawa … - Journal of Gastroenterology, 1998 - springerlink.com
... and posttranscrip- tional factors, as well as heat shock transcription factor 1
(HSF1). ... of redox-sensitive transcription factors, including NF-κB/Rel, 19 c-Fos ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov

Untersuchungen zum Einfluss des Strahlenprotektors Bowman-Birk-Proteinase-Inhibitor auf die …
A Radioonkologie, A Direktor, PDM Bamberg, S fuer … - w210.ub.uni-tuebingen.de
... Sie entstammen dem Hautfibroblastenstamm HSF1 aus der Leistengegend eines Kleinkindes
und ... Die Kultur der Hautfibroblasten (HSF1) wurde bei 37°C und 6,8% CO ...
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Nuclear localization signals overlap DNA-or RNA-binding domains in nucleic acid-binding proteins - Full text - MIT Libraries
EC LaCasse, YA Lefebvre - Nucleic Acids Res, 1995 - pubmedcentral.nih.gov
... controlling the nuclear uptake of NF-kappa B, Rel and dorsal ... by oligomerization,
modification, and rapid translocation of heat shock transcription factor HSF1. ...
Cited by 89 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Inducible heat shock protein 70 kD and inducible nitric oxide synthase in hemorrhage/resuscitation- … - Full text - MIT Libraries
JG KIANG, JG Kiang - Cell Research, 2004 - cell-research.com
... Heat shock transcriptional factors Four different HSFs have been identified
in vertebrate: HSF1, HSF2, HSF3, and HSF4 [24, 25]. ...
View as HTML - Web Search - cell-research.com - ncbi.nlm.nih.gov

Differential activation of heat shock and nuclear factor B transcription factors in postischemic … - Full text - MIT Libraries
L Tacchini, L Radice, G Pogliaghi, A Bernelli- … - Hepatology, 1997 - doi.wiley.com
... has revealed a family of HSFs, but it is essentially HSF1, ... of super-gel shift, with
antibodies spe- cific for the subunits, p50 (NF- k B1), p65 (Rel A), and c ...
Cited by 25 - Web Search - ncbi.nlm.nih.gov

Adverse drug reactions, transcription factors and transcriptomics - Full text - MIT Libraries
DP Williams, C O'Donnell - Comparative Clinical Pathology, 2003 - springerlink.com
... Five genes of the mammalian NF-jB familyhave been cloned: c-Rel, NF-jB1 (p50 ... At least
three HSF (HSF1-3) have been isolated from human, mouse and chicken ...
Web Search

Hsp90 isoforms: functions, expression and clinical importance
PR China - chaperone.sote.hu
... HSF1 binds to a heat shock- speci¢c enhancer composed of two typical ... a GAS (Q-interferon-
activated sequence) element to nucleotides 31612/31604 rel- ative to ...
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Intranuclear targeted delivery of functional NF-kappa B by 70 kDa heatshock protein - Full text - MIT Libraries
SM Fujihara, SG Nadler - The EMBO Journal, 1999 - embojournal.npgjournals.com
... were performed with NF- B p50, p65 and c-Rel polyclonal antibodies ... Mosser, DD and
Morimoto, RI (1998) Molecular chaperones as HSF1-specific transcriptional ...
Cited by 32 - Web Search - emboj.org - nature.com - ncbi.nlm.nih.gov - all 7 versions »

Statistical Analysis of Array Expression Data as Applied to the Problem of Tamoxifen Resistance - Full text - MIT Libraries
SG Hilsenbeck, WE Friedrichs, R Schiff, P O’ … - Journal of the National Cancer Institute, 1999 - jncicancerspectrum.oupjournals.org
... alteration and, based on a small simulation study, will likely pro- vide reasonable
power to detect moder- ate-sized alterations in clinically rel- evant genes ...
Cited by 93 - Web Search - science.gmu.edu - ingentaconnect.com - ncbi.nlm.nih.gov - all 7 versions »

Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the … - Full text - MIT Libraries
S Maheswaran, C Englert, G Zheng, SB Lee, J Wong, … - Genes Dev, 1998 - genesdev.org
... antibody C19 or a nonspecific control antibody (against c-rel), followed by ... is thought
to involve the trimerization and phosphorylation of HSF1, which binds ...
Cited by 39 - Web Search - genesdev.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Uwe Senftleben NF-κB in critical diseases: a bad guy? - Full text - MIT Libraries
U Senftleben - Intensive Care Med, 2003 - springerlink.com
... such as activator protein-1 (AP-1) or heat shock transcription factor 1 (HSF1)
[8, 9 ... 80:573–582 5. Pahl HL (1999) Activators and target genes of rel/NF-kappaB ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Cellular response to oxidative stress: Signaling for suicide and survival - Full text - MIT Libraries
JL Martindale, NJ Holbrook - Journal of Cellular Physiology, 2002 - doi.wiley.com
... The induction of Hsp in response to stress is mediat- ed largely through
transcriptional activation via heat shock transcription factor 1 (HSF1) (reviewed ...
Cited by 159 - Web Search - ncbi.nlm.nih.gov

Ub on the move - Full text - MIT Libraries
N Shcherbik, DS Haines - Journal of Cellular Biochemistry, 2004 - doi.wiley.com
... their IPT domains (this domain is also present within the Rel homology region of ...
Interestingly, there are also examples (ie, HSF1 and HSF2) where SUMO mediated ...
Web Search - ncbi.nlm.nih.gov

HLA-G unique promoter region: functional implications - Full text - MIT Libraries
C Solier, VE Mallet, FE Lenfant, A Bertrand, A … - Immunogenetics, 2001 - springerlink.com
... the other NF-κB subunits displaying transactivating properties (p65, c-Rel) are
able ... gamma-activated sequence, HSE heat shock element, bound by HSF1 (in yellow ...
Cited by 12 - Web Search - ncbi.nlm.nih.gov

Physiologically-Based Pharmacokinetics and Molecular Pharmacodynamics of 17-(allylamino)-17- …
L Xu, JL Eiseman, MJ Egorin, DZ D'Argenio - Journal of Pharmacokinetics and Pharmacodynamics, 2003 - springerlink.com
... This transcrip- tional enhancement is due to the activation of heat shock transcription
factor 1 (HSF1), which is capable of specifically binding to the HSP ...
Cited by 4 - Web Search - kluweronline.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Maintenance of genomic integrity in mammalian kidney cells exposed to hyperosmotic stress
D Kultz, D Chakravarty - Comp Biochem Physiol A Mol Integr Physiol, 2001 - kueltzlab.ucdavis.edu
... Rapid activation of the heat shock transcription fac- tor, HSF1, by hypo ...
Tonicity-responsive enhancer binding protein, a novel Rel-like protein that stimu ...
Cited by 5 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

Sustained hyposmotic stress induces cell death: apoptosis by defeat - Full text - MIT Libraries
T Jackle, C Hasel, I Melzner, S Bruderlein, PM … - Am J Physiol Cell Physiol, 2001 - ajpcell.physiology.org
... Control of apoptosis by Rel/NF- B transcription factors ... The heat-shock transcription
factor HSF1 is rapidly activated by either hyper- or hypo-osmotic stress in ...
Cited by 3 - Web Search - ajpcell.physiology.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

SUMO wrestling with type 1 diabetes - Full text - MIT Libraries
CY Wang - J Mol Med, 2005 - springerlink.com
... members: NFκB1 (p105/p50), NFκB2 (p100/ p52), RelA (P65), RelB and c-Rel. ... tran-
scriptional level by stress-inducible heat shock factors (ie, HSF1 and HSF2 ...
Web Search

A feel for the template: zinc finger protein transcription factors and chromatin - Full text - MIT Libraries
FD Urnov - Biochem Cell Biol, 2002 - article.pubs.nrc-cnrc.gc.ca
... It is possible that the known rel- ative instability of histone–DNA contacts at
the the very edges of the nucleosome (McGhee and Felsenfeld 1980) contributes ...
Cited by 7 - Web Search - ingentaconnect.com - pubs.nrc-cnrc.gc.ca - ncbi.nlm.nih.gov - all 7 versions »

Nuclear factor-kB activation in permanent intraluminal focal cerebral ischemia in the rat - Full text - MIT Libraries
HAA Seegers, E Grillon, YE Trioullier, A VaEth, JM … - Neuroscience Letters, 2000 - homepages.ulb.ac.be
... inhibitors was shown to be closely associated with activation of HSF1, a transcription ...
[1] Barkett, M. and Gilmore, TD, Control of apoptosis by Rel/ NF-kappaB ...
Cited by 8 - View as HTML - Web Search - abm.fr - ingentaconnect.com - all 5 versions »

Regulation of gene expression of the Stress Response Gene, Osp94-Identification of Tonicity Response …
R Kojima, JD Randall, E Ito, H Manshio, Y Suzuki, … - bj.portlandpress.co.uk
... Alfieri and co-workers (45) found that the hypertonicity activates binding of HSF1
to HSE, but this does not enhance HSP70 expression in 3T3 cells. ...
View as HTML - Web Search - biochemj.org

Statistical methods for joint data mining of gene expression and DNA sequence database
MD Curran, H Liu, F Long, N Ge - SIGKDD Explorations Special Issue on Microarray Data Mining, 2003 - portal.acm.org
... OCT-x OCT1 -- OCT_C 42.1% STAT1 STAT3 -- STAT_C 71.8% NF-kappaB NF-kappaB (p65)
c-Rel NFkcR_C 77.9% ... MEIS1 TGIF -- MsTGIF_C 5.6% HSF1 HSF2 -- HSF_C 71.4% ...
Cited by 3 - Web Search - acm.org - portal.acm.org

Interactions between the heat shock response and the nuclear factor-kappaB signaling pathway
V Malhotra, HR Wong - Crit. Care Med, 2002 - ccmjournal.com
... The NF-κB family of proteins consists of five known members: NF-κB1
(p50/p105), NF-κB2 (p52/p100), RelA (p65), Rel B, and c-Rel. ...
Cited by 25 - Web Search - ccmjournal.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Mood stabilizers, glycogen synthase kinase-3b and cell survival
RS Jope, GN Bijur - Mol Psychiatry, 2002 - nature.com
... NFAT family of transcription factors, which includes NFATc, NFATp, and NFAT4, contain
a DNA binding domain that is homologous to the Rel family of pro- teins. ...
Cited by 27 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Hsp70 promotes TNF-mediated apoptosis by binding IKK {gamma} and impairing NF-{kappa} B survival … - Full text - MIT Libraries
R Ran, A Lu, L Zhang, Y Tang, H Zhu, H Xu, Y Feng, … - Genes Dev, 2004 - genesdev.org
... For instance, overexpression of HSF1 (heat shock transcription factor 1, one
transcription factor that controls the heat shock response) enhances Fas-induced ...
Cited by 4 - Web Search - genesdev.org - pubmedcentral.nih.gov - dx.doi.org - all 7 versions »

The balance of nuclear import and export determines the intracellular distribution and function of … - Full text - MIT Libraries
D Heerklotz, P Doering, F Bonzelius, S Winkelhaus, … - Mol Cell Biol, 2001 - mcb.asm.org
... Heat stress transcription factors from tomato can functionally replace HSF1 in the ...
Cytoplasmic sequestration of Rel proteins by I B requires CRM1-dependent ...
Cited by 14 - Web Search - pubmedcentral.nih.gov - uni-frankfurt.de - bio.uni-frankfurt.de - all 11 versions »

Chronic COX-2 inhibition reduces medullary HSP 70 expression and induces papillary apoptosis in … - Full text - MIT Libraries
W Neuhofer, K Holzapfel, ML Fraek, N Ouyang, J … - Kidney International, 2004 - ingentaconnect.com
... potent inducer of HSP70 expression by direct activation of heat shock transcription
factor 1 (HSF1) rather than classic signaling through cell surface ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov