Genetic Alterations in Primary Cutaneous CD30 Anaplastic Large Cell Lymphoma
X Mao, G Orchard, DM Lillington, R Russell-Jones, … - GENES, CHROMOSOMES & CANCER, 2003 - doi.wiley.com
... REL, MYCN, and YES1 are human homologs of viral oncogenes, and play im- portant
roles in cell proliferation, differentiation, and transformation (NCBI LocusLink ...
Cited by 8 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

… chromosomal imbalances in gastric adenocarcinoma revealed amplified protooncogenes MYCN, MET, WNT2, …
M Nessling, S Solinas-Toldo, KK Wilgenbus, F … - Genes Chromosomes Cancer, 1998 - doi.wiley.com
... Protooncogenes MYCN, MET, WNT2, and ERBB2 ... noma. One of the novel amplified
protooncogenes iden- tified by this approach was MYCN (tumor 19). ...
Cited by 33 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Relationship between histopathological features, MYCN amplification, and prognosis: A UKCCSG study
RE George, S Variend, C Cullinane, SJ Cotterill, … - Medical and Pediatric Oncology, 2001 - doi.wiley.com
... This study suggested that the prognostic rel- evance of MYCN amplification
may vary according to the histologic features of the tumour. ...
Cited by 4 - Web Search - doi.wiley.com

Intratumoural heterogeneity of 1 p deletions and MYCN amplification in neuroblastomas
PF Ambros, IM Ambros, R Kerbl, A Luegmayr, S … - Medical and Pediatric Oncology, 2001 - doi.wiley.com
... hetero- geneity in Wilms’ tumor: incidence and potential clinical rel- evance. ...
Heterogeneity of MYCN amplification in a child with stroma-rich neuroblastoma ...
Cited by 14 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Spontaneously immortalized human T lymphocytes develop gain of chromosomal region 2 p 13-24 as an …
JK Siwicki, M Berglund, J Rygier, B Pienkowska- … - Genes Chromosomes and Cancer, 2004 - doi.wiley.com
... We showed that immortalized S4 and S7 cells had in- creased copy numbers of
the REL, MYCN, and ALK genes corresponding to the CGH data. ...
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Amplification of Mycn, Ddx1, Rrm2, and Odc1 in rat uterine endometrial carcinomas
A Karlsson, K Helou, A Walentinsson, HJ Hedrich, C … - Genes Chromosomes Cancer, 2001 - doi.wiley.com
... Mycn, Ddx1, and Rrm2 were each co-amplified with -actin (primers 5 ... were situated
in RNO6q14– q16 (Table 2). Subsequently, their orientation rel- ative to one ...
Cited by 5 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Genomic Alterations in Blastic Natural Killer/Extranodal Natural Killer-Like T Cell Lymphoma with … - Full text - MIT Libraries
X Mao, Z Onadim, EA Price, F Child, DM Lillington, … - Journal of Investigative Dermatology, 2003 - ingentaconnect.com
... by CGH. Case 4 had real-time PCR and genomic microarray evidence of MYCN,
REL, RAF1, CTSB, and JUNB ampli¢cation. Case 6 showed ...
Cited by 6 - Web Search - jidonline.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

C6. Genetic Analyses of Murine Neuroblastoma: Implications for Human Disease
B INJURY - doi.wiley.com
... tumors, and compared these results with array-CGH data from 40 MYCN-amplified human ...
The results of this study demonstrate a rel- atively high rate of response ...
Web Search

Telomerase activity by TRAP assay and telomerase RNA(hTR) expression are predictive of outcome in …
LMR Choi, NW Kim, JJ Zuo, R Gerbing, D Stram, JN … - Medical and Pediatric Oncology, 2000 - doi.wiley.com
... Key words: neuroblastoma; telomerase; hTR; hTERT; TRAP; ALT; MYCN; prognostic marker ...
de- termine therapy) and can also identify biologically rel- evant targets ...
Cited by 9 - Web Search - nant.org - reprints.nant.org - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

Genetic heterogeneity and clonal evolution in neuroblastoma - Full text - MIT Libraries
J Mora, NKV Cheung, WL Gerald - British Journal of Cancer, 2001 - nature.com
... in sporadic NB cases using different biological markers including 1p LOH, MYCN and
ploidy (Ambros ... 1252-rel retroperitoneum 80% 1.76 H 0.9 H 1.2 – H + 1.6 + H ...
Cited by 6 - Web Search - dx.doi.org - nature.com - ncbi.nlm.nih.gov - all 5 versions »

The role of complete surgical resection in stage IV neuroblastoma - Full text - MIT Libraries
PJ Bastian, G Fleischhack, M Zimmermann, C Hasan, … - World Journal of Urology, 2004 - springerlink.com
... However, there seems to be no rel- evant difference for the final outcome whether ...
to 16% [7]. In our small series, all relapses were MYCN negative; this is ...
Web Search - ncbi.nlm.nih.gov

ECop (EGFR-Coamplified and overexpressed protein), a novel protein, regulates NF-jB transcriptional … - Full text - MIT Libraries
S Park, CD James - Oncogene, 2005 - nature.com
... frequently involved in promoting cell prolif- eration, as exemplified by MYCN (2p24)
in ... The NF-kB/Rel family is a group of inducible transcription factors that ...
Web Search - nature.com - ncbi.nlm.nih.gov

Fluorescence in situ hybridization analyses of chromosome band 1 p 36 in neuroblastoma detect two …
R Spitz, B Hero, F Westermann, K Ernestus, M … - Genes Chromosomes and Cancer, 2002 - doi.wiley.com
... Few investigations described imprinting in 1p in MYCN single-copy tumors but not
in ... Contrary to the rel- atively large number of LOH studies, only very few ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Correspondence re: J. Mora et al., Neuroblastic and Schwannian Stromal Cells of Neuroblastoma Are … - Full text - MIT Libraries
IM Ambros, G Amann, PF Ambros - Cancer Research, 2002 - cancerres.aacrjournals.org
... cell stroma-poor tumors, among them, untreated stage 4 tumors, MYCN-amplified tumors ...
One tumor (case 2052-rel) is mentioned with a triploid DNA content in Table ...
Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Examination of oncogene amplification by genomic DNA microarray in hepatocellular carcinomas: … - Full text - MIT Libraries
S Takeo, H Arai, N Kusano, T Harada, T Furuya, S … - Cancer Genet Cytogenet, 2001 - cs.toronto.edu
... 2 MYCL1; LMYC 1p34.3 P1 3 NRAS 1p13.2 BAC 4 LAMC2 1q25 q31 BAC 5 MYCN, N-myc
2p24.1 PAC 6 REL 2p13 p12 BAC 7 RAF1 3p25 BAC 8 TERC, hTR 3q26 BAC ...
Cited by 21 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Comparative genomic hybridization analysis of primary cutaneous B-cell lymphomas: Identification of …
X Mao, D Lillington, F Child, R Russell-Jones, B … - Genes Chromosomes and Cancer, 2002 - doi.wiley.com
... chromosomal loci. In case 5, gains of 2p13p21 and 2p25 were seen with metaphase
CGH, but no gains of REL (2p13) or MYCN (2p24) were seen. ...
Cited by 20 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Survival analysis of clinical, pathologic, and genetic features in neuroblastoma presenting as …
J Mora, NKV Cheung, L Chen, J Qin, W Gerald - Cancer, 2001 - doi.wiley.com
... Stage Specimen Age Gender Histology Ploidy a MYCN 1p36 1p22 11q 14q Treatment Disease
status Progress ... Dx Spinal T. 14 mos F U 1.54 NA MM MM MM MM SX REL — A ...
Cited by 11 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Immunolocalization of Pit-1 in gonadotroph nuclei is indicative of the transdifferentiation of … - Full text - MIT Libraries
JH Mukdsi, AL Paul, S Munoz, A Aoki, AI Torres - Histochemistry and Cell Biology, 2004 - springerlink.com
... time as a factor and Pit-1N, Pit-1C, c-MycN, c-MycC, PRLs, and PRLp as co- variates.
A stepwise procedure was performed to evaluate the rel- ative importance ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Constitutively Active NFkappa B Is Required for the Survival of S-type Neuroblastoma - Full text - MIT Libraries
X Bian, AW Opipari Jr, AB Ratanaproeksa, AE … - J Biol Chem, 2002 - jbc.org
... Malignant S-type cells express neither high levels of MYCN nor Bcl-2, suggesting
that other ... including NF B1/p50, NF B2/p52, RelA/p65, RelB, and c-Rel (1, 2 ...
Cited by 11 - Web Search - dx.doi.org - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

High level amplification of N-MYC is not associated with adverse histology or outcome in primary … - Full text - MIT Libraries
DM Lillington, LK Goff, JE Kingston, Z Onadim, E … - British Journal of Cancer, 2002 - nature.com
... Relationship between histopathological features, MYCN amplification and prognosis:
a UKCCSG ... genomic hybridization to identify amplification of the REL gene in ...
Cited by 1 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Characterization of karyotypic events and evolution in neuroblastoma
DR Betts, N Cohen, KE Leibundgut, T Kuehne, U … - Pediatric Blood & Cancer, 2005 - doi.wiley.com
... PT, presentation but therapy received; PC, post chemotherapy resection; rel, relapse. ...
defined and only a negative association of 1p and MYCN amplification in ...
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B7. Clinical and Metabolic Investigations Offer New Insights into Pathophysiology of Succinic …
PL Pearl, MT Acosta, EJ Novotny, C Jakobs, KM … - doi.wiley.com
... tumors, and compared these results with array-CGH data from 40 MYCN-amplified human ...
The results of this study demonstrate a rel- atively high rate of response ...
Web Search

Neuroblastoma metastatic to the central nervous system
K Kramer, B Kushner, G Heller, NKV Cheung - Cancer, 2001 - doi.wiley.com
Page 1. Neuroblastoma Metastatic to the Central Nervous System The Memorial
Sloan-Kettering Cancer Center Experience and A Literature Review ...
Cited by 15 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Role of the Aspartyl-Asparaginyl-beta-Hydroxylase Gene in Neuroblastoma Cell Motility - Full text - MIT Libraries
PS Sepe, SA Lahousse, B Gemelli, H Chang, T Maeda, … - Lab Invest, 2002 - nature.com
... MYCN expression is mediated by HuD stabilization of MYCN mRNA transcripts ... of AAH
antisense, AAH sense, or nonrelevant (Non-Rel) oligodeoxynucleotides (ODNs). ...
Cached - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

[CITATION] Journal of Medicine
R CHEMOTHERAPY, AB MARROW
... diagnosis the defining char- acteristics of high-risk neuroblastoma include an age
of more than one year, metastases, amplification of the MYCN oncogene, and ...
Web Search - purging.nant.org - purging.nant.org

Einfuehrung in die Real-Time TaqMan™ PCR-Technologie
TA Schild, AB GmbH - Handbuch Applied Biosystems, Version, 1996 - ukl.uni-freiburg.de
Page 1. ´´7 Einführung in die Real-Time TaqMan™ PCR-Technologie Vers. 2.1 Dr.
Thomas A. Schild Applied Biosystems GmbH Weiterstadt Page 2. 2 ...
Cited by 1 - View as HTML - Web Search

Cloning and mapping of cat( Felis catus) immunoglobulin and T-cell receptor genes - Full text - MIT Libraries
KW Cho, HY Youn, H Satoh, S Cevario, SJ O'Brien, T … - Immunogenetics, 1998 - springerlink.com
... Since the IGKC gene is syntenic with genes for N-myc (MYCN), v-rel (REL), CD8 antigen
(CD8A), and interleukin 1 A (IL1A) spanning on HSA 2p24-q21 and is also ...
Cited by 1 - Web Search - ncifcrf.gov - ncbi.nlm.nih.gov

Combined comparative genomic hybridization and genomic microarray for detection of gene …
J Zhao, J Roth, B Bode-Lesniewska, M Pfaltz, PU … - Genes Chromosomes and Cancer, 2002 - doi.wiley.com
... 4 LAMC2 1q25–q31 34 MDM2 12q14.3–q15 5 MYCN 2p24.1 35 AKT1 14q32.3 6 REL
2p13–p12 36 IGFR1 15q25–q26 7 RAF1 3p25 37 FES 15q26.1 ...
Cited by 15 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Shedding Light on the Dark Side of the Genome: Overlapping Genes in Higher Eukaryotes
S Boi, G Solda, ML Tenchini - Current Genomics, 2004 - dx.doi.org
... in regulating responses to cytokines by members of the Rel/NF-kappaB ... MYCN v-myc
myelocytomatosis viral related oncogene MYCNOS DNA-binding transcriptional ...
Cited by 3 - Web Search - ingentaconnect.com

Alterations of chromosomal copy number during progression of diffuse-type gastric carcinomas: … - Full text - MIT Libraries
DF Peng, H Sugihara, K Mukaisho, Y Tsubosa, T … - The Journal of Pathology, 2003 - doi.wiley.com
Page 1. Journal of Pathology J Pathol 2003; 201: 439–450. Published online 18
August 2003 in Wiley InterScience (www.interscience.wiley.com). ...
Cited by 8 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Transcriptional Control of Hepatocanalicular Transporter Gene Expression - Full text - MIT Libraries
M MUeLLER - Seminars in Liver Disease, 2000 - humanabc.4t.com
... Members of the Rel/NF- B family of transcription factors play a central role in
the regulation of inflamma- tory and immune responses (for recent reviews, see ...
Cited by 31 - View as HTML - Web Search - ncbi.nlm.nih.gov

Neuroblastomas of infancy exhibit a characteristic ganglioside pattern
K Kaucic, N Etue, B LaFleur, W Woods, S Ladisch - Cancer, 2001 - doi.wiley.com
... favorable prognosis (ie, hyperdiploid or trip- loid DNA and lack of MYCN amplification
or ... Similarly, the rel- ative number of patients in each of the 3 groups ...
Cited by 2 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

A novel and consistent amplicon at 13 q 31 associated with alveolar rhabdomyosarcoma
AT Gordon, C Brinkschmidt, J Anderson, N Coleman, … - Genes Chromosomes and Cancer, 2000 - doi.wiley.com
... Also, a number of oncogenes, primarily MYCN at 2p24 and GLI1/SAS/MDM2/ CDK4 in the
12q13–15 region, have been found to be ... 110 dia and rel, indicate diagnosis ...
Cited by 16 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Antioncogenes and human cancer - Full text - MIT Libraries
AG Knudson - Proc Natl Acad Sci USA, 1993 - pnas.org
Page 1. Proc. Natl. Acad. Sci. USA Vol. 90, pp. 10914-10921, December 1993
Review Antioncogenes and human cancer Alfred G. Knudson ...
Cited by 232 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Genetic lineage of poorly differentiated gastric carcinoma with a tubular component analysed by … - Full text - MIT Libraries
DF Peng, H Sugihara, K Mukaisho, ZQ Ling, T … - The Journal of Pathology, 2004 - doi.wiley.com
Page 1. Journal of Pathology J Pathol 2004; 203: 884–895 Published online 18
June 2004 in Wiley InterScience (www.interscience.wiley.com). ...
Cited by 1 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

De la cytogenetique a la cytogenomique des tumeurs: le point en 2004
A Bernheim, JL Huret, M Guillaud-Bataille, O … - Bull Cancer, 2004 - john-libbey-eurotext.fr
... 31 Page 4. A B C D MYCN MYCN ... L’amplification de MYCN est indiquée sur le chromosome
2. D) Micro-matrice CGH de 1 re génération (six répliques). ...
View as HTML - Web Search - john-libbey-eurotext.fr

A model for the outer rings of SN 1987A - Full text - MIT Libraries
N Soker - Monthly Notices of the Royal Astronomical Society, 1999 - blackwell-synergy.com
... The closest structure is that of the Hourglass nebula (also named MyCn 18 and PN
G 307.5 04.9 ... A H. The accretion radius is given by R A 2GM s /v 2 rel , where v ...
Web Search - ingentaconnect.com - arxiv.org - adsabs.harvard.edu - all 5 versions »

Distinct cytogenetic pathways of advanced-stage neuroblastoma tumors, detected by spectral …
B Stark, M Jeison, I Bar-Am, L Glaser-Gabay, J … - Genes Chromosomes and Cancer, 2002 - doi.wiley.com
... Hayashi et al., 1989), which were found to represent amplification of the MYCN gene
(Brodeur ... Stage Primary site a Metastases b HVA/VMA c LDH d 1st rel e (months ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

4 ONCOGENES
MA Pierotti, SA Schichman, G Sozzi, CM Croce - cancer.org
... Deregulated activity Transcription factor v-rel 2p12–14 Viral homologue
Lymphatic leukemia Deregulated activity Mutant NFKB v-ets-1 ...
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Transcriptional Control of Hepatocanalicular Transporter Gene Expression - Full text - MIT Libraries
G TRANSCRIPTION, T FACTORS - Semin Liver Dis, 2000 - thieme-connect.com
... Activators and target genes of Rel/NF-kappaB transcription factors. ... 231-238 91 Haber
M, Bordow SB, Gilbert J. Altered expression of the MYCN oncogene modulates ...
Web Search

Establishment and characterization of unique human gallbladder cancer cell lines - Full text - MIT Libraries
M Ghosh, N Koike, G Yanagimoto, S TSUNODA, S KAUL, … - Int. J. Oncol, 2004 - 147.52.72.117
... 1q41-qter G NC NC G G TGFß2(1q41) 2p G G G G G MYCN (2p24), REL (2p13-12)
2q12-q21 G NC G G G 3p12-p13 L L L NC NC 3q13 G G G NC NC ...
Cited by 3 - View as HTML - Web Search - ncbi.nlm.nih.gov

The Novel ETS Factor TEL2 Cooperates with Myc in B Lymphomagenesis {dagger}
M Cardone, A Kandilci, C Carella, JA Nilsson, JA … - mcb.asm.org
... one-third of B-ALL samples displayed coordinated elevated expression of MYC/MYCN
and TEL2 ... bcl-x gene encoding the anti-apoptotic Bcl-xL protein by Ets, Rel/NF- B ...
Web Search - mcb.asm.org

Gene amplifications associated with the development of hormone resistant prostate cancer - Full text - MIT Libraries
J Edwards, NS Krishna, CJ Witton, JMS Bartlett - Clin Cancer Res, 2003 - eprints.gla.ac.uk
... LAMC2 1q25-q31 0.89 0.12 MDM2 12q14.3-q15 0.81 0.22 MYCN 2p24.1 0.80 0.10 Akt1
14q32.3 0.75 0.23 REL 2p13-p12 0.76 0.13 IGFR1 15q25-q26 0.87 0.26 ...
Cited by 8 - View as HTML - Web Search - clincancerres.aacrjournals.org - eprints.gla.ac.uk - ncbi.nlm.nih.gov

Segregation of partly melted molecules: isolation of CpG islands by polyacrylamide gel …
M Shiraishi, AJ Oates, X Li, YH Chuu, T Sekiya - Biol. Chem, 2004 - degruyter.com
... This restriction digests leaves the CpG island rel- atively intact, while the majority ...
the entire portion of human ECGF, FOS, HRAS1, MYC, and MYCN genes were ...
Web Search - extenza-eps.com - degruyter.de - dx.doi.org - all 8 versions »

The proteasome in cancer biology and treatment - Full text - MIT Libraries
F Pajonk, WH McBride - Radiat. Res, 2001 - bioone.org
... has a very short half-life of 30 min (105) , and MYC and MYCN are both ... The members
of the REL/NFKB family of transcription factors share a highly conserved DNA ...
Cited by 13 - Web Search - strahlenbiologie.bei.t-online.de - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Peter Greenwald, MD, DrPH Gary Kelloff, MD Cynthia Burch-Whitman
BS Kramer - caonline.amcancersoc.org
... Vitamin D MYC BALB-3T3 No change Vitamin D MYC NIH-3T3 No change Retinoic acid MYCN
Human neuroblastoma Decreases Fucoxanthin MYCN Neuroblastoma Decreases ...
Web Search

Comparative Genomic Hybridization: A Valuable Tool for Genome-Scale Analysis of Rodent Cancer Models
R Kappler, H Scherthan - Current Genomics, 2001 - ingentaconnect.com
... Weiss and colleagues [42] introduced a mouse model for neuroblastoma by using the
tyrosine hydroxylase promotor to overexpress Mycn in the neural crest of ...
Web Search

Expression of tumor necrosis factor alpha, TNF-related apoptosis-inducing ligand, and their … - Full text - MIT Libraries
H Kumamoto, K Ooya - Journal of Oral Pathology and Medicine, 2005 - blackwell-synergy.com
... Control of apoptosis by Rel/NF- B transcription factors ... Caspase 8 is deleted or silenced
preferentially in childhood neuroblastomas with amplification of MYCN. ...
Web Search - ncbi.nlm.nih.gov

Expression profiling targeting chromosomes for tumor classification and prediction of clinical …
YJ Lu, D Williamson, R Wang, B Summersgill, S … - Genes Chromosomes and Cancer, 2003 - doi.wiley.com
... cancers) identified tumor- specific regions differentially expressing genes rel-
ative to ... a 66% 94% 42% POML, RHOE, DDEF2, LOC165323, PIG3, MYCN, DDX1, SRC-1 ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Response of malignant B lymphocytes to ionizing radiation: Gene expression and genotype - Full text - MIT Libraries
H Lyng, KS Landsverk, E Kristiansen, PM DeAngelis, … - International Journal of Cancer, 2005 - doi.wiley.com
... The table also contains data for the rel- ative expression of unirradiated (control)
Reh vs. ... HCK HMOX1 IL2RA IRF4 MAN2A1 MYCN NAGLU NFE2L1 NFKB1 NFKB2 NFKBIA ...
Web Search - ncbi.nlm.nih.gov