… of HLA class I expression by a variant thymoma cell line involves nuclear translocation of Rel …
H Travers, J Girdlestone - doi.wiley.com
... requires all three components of ISGF3, ie STAT1, STAT2 and ISGF3 + (p48), while ...
include ISGF3 + , have been shown to interact physically with Rel proteins [29 ...
Web Search

Interferon Regulatory Factor 4 Contributes to Transformation of v-Rel-Expressing Fibroblasts - Full text - MIT Libraries
R Hrdličkova, J Nehyba, HR Bose Jr - Mol Cell Biol, 2001 - pubmedcentral.nih.gov
... Viral infection activates IRF, Rel/NF-κB, and bZIP transcription factors, leading
to IFN ... leading to DNA binding by a complex composed of STAT1, STAT2, and IRF ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Interferon Regulatory Factor 4 Contributes to Transformation of v-Rel-Expressing Fibroblasts
HR Bose Jr - mcb.asm.org
... Viral infection activates IRF, Rel/NF- B, and bZIP transcription factors, leading
to IFN ... leading to DNA binding by a complex composed of STAT1, STAT2, and IRF ...
Web Search

Interferon regulatory factor subcellular localization is determined by a bipartite nuclear … - Full text - MIT Libraries
JF Lau, JP Parisien, CM Horvath - J. Biol. Chem, 2004 - dx.doi.org
... Kraus, JF Lau, JP Parisien, and CM Horvath A Hybrid IRF9-STAT2 Protein Recapitulates ...
a Unique Role in Immune Defense and Is Induced by the v-Rel Oncoprotein Mol ...
Cited by 22 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

GEArray S Series Human Immunology Signaling Pathways Gene Array: AR-SAHS-605
FG Grouping, A Molecules, I ICAM, CS Molecules, C … - eurogentec.com
... JAK and STAT Proteins: JAK1, JAK2, JAK3, STAT1, STAT2, STAT3, STAT4, STAT5A ... Rel /
NFκB / IκB Family: NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIL1, NFKBIL2, NFRKB, REL ...
View as HTML - Web Search - eurogentec.be

Activation of the Janus kinase 3-STAT5a pathway after CD40 triggering of human monocytes but not of … - Full text - MIT Libraries
P Revy, C Hivroz, G Andreu, P Graber, C Martinache … - J Immunol, 1999 - jimmunol.org
... Rabbit polyclonal Abs against Jak3, p65 (Rel-A), c-Rel, STAT1 (p84/p91), STAT2,
STAT4, the C-terminal part of STAT5a (sc-1081 X), and STAT6 were obtained from ...
Cited by 13 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 6 versions »

Validating Real-Time Constraints in Embedded Systems
JV Aghav - ieeexplore.ieee.org
... the specified annotations and the pro gram- ming environment OfESTE REL we describe
a ... list of kernel statements is: nothing halt emit S stati; stat2 loop stat ...
Web Search

Interferon {alpha} Activates NF-{kappa} B in JAK1-deficient Cells through a TYK2-dependent Pathway - Full text - MIT Libraries
CH Yang, A Murti, WJ Valentine, Z Du, LM Pfeffer - J. Biol. Chem, 2005 - jbc.org
... proteins (1–3). Upon JAK-mediated tyrosine phosphorylation, the STATs (STAT1, STAT2,
and STAT3 ... Dimers of the various Rel proteins (p50, p52, c-Rel, v-Rel, RelA ...
Web Search - jbc.org - ncbi.nlm.nih.gov

How the sequestration of a protein interferes with its mechanism of action: example of a new family …
S Thebault, JM Mesnard - Current Protein and Peptide Science, 2001 - ingentaconnect.com
... All NF-κB proteins share a conserved region known as the Rel homology domain ... ISGF3
is comprised of three protein subunits, STAT1, STAT2 and p48/ISGF3γ [53-54 ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Interferon alpha/beta Promotes Cell Survival by Activating Nuclear Factor kappa B through … - Full text - MIT Libraries
CH Yang, A Murti, SR Pfeffer, JG Kim, DB Donner, … - J Biol Chem, 2001 - jbc.org
... phosphorylation of STAT proteins (4-6). IFN-activated STATs (STAT1, STAT2, and STAT3 ...
complexes, composed of various combinations of members of the Rel/NF- B ...
Cited by 46 - Web Search - jbc.org - ncbi.nlm.nih.gov

Meeting Report Second International Conference on Signal Transduction, Croatia May 2000 - Full text - MIT Libraries
Z Dembic - Scandinavian Journal of Immunology, 2000 - blackwell-synergy.com
... Active STAT2 recruits GCN5 factor, which in turn, recruits TAF II 130 creating the
TFTC ... of the NF B has been studied in triple KO mice with C-Rel (p75) / , p50 ...
Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

MOTIF
A MOTIF, S Books - activemotif.com
... 1: Western Blot analysis of rabbit polyclonal antibodies against STAT1, STAT2, STAT3,
STAT4 ... AP-1, C/EBP, Cell Cycle Regulators, NF k B/Rel, Myogenic Regulatory ...
View as HTML - Web Search - zlab.bu.edu - 144.16.77.27 - crsi.org.in - all 9 versions »

Activities of IRF-1
A KROeGER, M KOeSTER, K SCHROEDER, H HAUSER, PP … - J. Interferon Cytokine Res, 2002 - liebertonline.com
... Induction of iNOS is rel- evant for production of NO as defense ... bind ISGF3, a het-
erotrimerictranscriptionfactor consistingof p48 (IRF-9), Stat1, and Stat2. ...
Cited by 33 - Web Search - liebertonline.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

CpG DNA induces IgG class switch DNA recombination by activating human B cells through an innate … - Full text - MIT Libraries
B He, X Qiao, A Cerutti - J. Immunol, 2004 - jimmunol.org
... determined by incubating reaction mixtures with 1 µl of a DNA-binding inhibiting/
supershifting Ab to p65, c-Rel, Rel-B, p50, p52, STAT1, STAT2, STAT3, STAT6 ...
Cited by 5 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway - Full text - MIT Libraries
MH Heim, D Moradpour, HE Blum - J Virol, 1999 - jvi.asm.org
... Antibodies against Stat1 (sc417) and Stat2 (sc476) were from Santa Cruz Biotechnology,
Inc ... of Lienhard Schmitz (38), antibodies to RelB (sc-226), to c-Rel (sc-70 ...
Cited by 86 - Web Search - pubmedcentral.nih.gov - zeck.floop.org.uk - ncbi.nlm.nih.gov - all 5 versions »

A formal approach to reactive systems software: A telecommunications application in Esterel
LJ Jagadeesan, C Puchol, JE Olnhausen - Formal Methods in System Design, 1996 - springerlink.com
... A Formal Approach to Reactive Systems Software: A Telecommunications
Application in ESTV, REL* ... present S then statI else stat2 end ...
Cited by 42 - Web Search - doi.ieeecomputersociety.org - doi.ieeecs.org - portal.acm.org - all 7 versions »

Interferon/Promotes Cell Survival by Activating Nuclear Factor B through Phosphatidylinositol 3- … - Full text - MIT Libraries
CH Yang, A Murti, SR Pfeffer, JG Kim, DB Donner, … - J Biol Chem, 2001 - intl.jbc.org
... phorylation of STAT proteins (4–6). IFN-activated STATs (STAT1, STAT2, and STAT3 ...
complexes, composed of various combina- tions of members of the Rel/NF- B ...
Cited by 4 - Web Search - cmdr.ubc.ca - cmdr.ubc.ca

Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by … - Full text - MIT Libraries
A Pansky, P Hildebrand, E Fasler-Kan, L Baselgia, … - Int J Cancer, 2000 - doi.wiley.com
... Rel- ative protein content and IFN- -induced tyrosine phosphorylation was tested
with ... with anti- bodies to Jak1, Tyk2, ISGF3 -p48, STAT1, STAT2 and STAT3. ...
Cited by 22 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Signaling Pathways Mediated by the TNF-and Cytokine-Receptor Families Target a Common cis-Element of … - Full text - MIT Libraries
S Gupta, D Xia, M Jiang, S Lee, AB Pernis - J. Immunol, 1998 - jimmunol.org
... Polyclonal rabbit antisera against Stat1 and Stat2 were a generous gift of Dr ... Polyclonal
rabbit antisera against the Rel proteins p50, p65, c-Rel, RelB, p52 ...
Cited by 18 - Web Search - jimmunol.org - cumc.columbia.edu - ncbi.nlm.nih.gov - all 8 versions »

Interferon-· delays S-phase progression in human hepatocellular carcinoma cells via inhibition of … - Full text - MIT Libraries
D Murphy, KM Detjen, M Welzel, B Wiedenmann, S … - Hepatology, 2001 - dx.doi.org
... and immunoprecipitations were performed with antibodies to Jak1, Tyk2, Stat1, and
Stat2. ... Without the identification of rel- evant target molecules, it will be ...
Cited by 24 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Defective Induction of the Transcription Factor Interferon-StimulatedGene Factor-3 and Interferon { … - Full text - MIT Libraries
JC Cross, S Lam, S Yagel, Z Werb - Biology of Reproduction, 1999 - biolreprod.org
... Specifically, although IFN induced the transcription factors STAT1, STAT2, and IFN
regulatory ... that binds proteins of the nuclear factor (NF)- B/rel family [18 ...
Cited by 9 - Web Search - biolreprod.org - biolreprod.org - ncbi.nlm.nih.gov - all 5 versions »

Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in … - Full text - MIT Libraries
T Ouchi, SW Lee, M Ouchi, SA Aaronson, CM Horvath - Cell, 2000 - dx.doi.org
... by the NF-{kappa}B Transcription Factor by Binding to the Rel Domain of ... TA Kraus,
JF Lau, JP Parisien, and CM Horvath A Hybrid IRF9-STAT2 Protein Recapitulates ...
Cited by 87 - Web Search - pnas.org - pubmedcentral.nih.gov - medschool.mc.vanderbilt.edu - all 7 versions »

A Workbench for Program Comprehension during Software Maintenance
G Canfora, L Mancini, M Tortorella - PROGRAM COMPREHENSION WORKSHOP PROC, 1996 - doi.ieeecs.org
... write, W-Stat), rel(W-Stat, from, [Record]), rel(WJ3at, record, P ... to a variable
“Var” exists between the statements “Statl” and “Stat2” [I]. The ...
Cited by 10 - Web Search - doi.ieeecomputersociety.org - ieeexplore.ieee.org - portal.acm.org - all 6 versions »

RelA suppresses the Wnt/ß-catenin pathway without exerting trans-acting transcriptional ability - Full text - MIT Libraries
O Masui, Y Ueda, A Tsumura, M Koyanagi, M Hijikata … - Int J Mol Med, 2002 - 147.52.72.117
... In the wild-type RelA protein, the amino terminal half is termed rel homology domain
(RHD ... RelA and p53 (28-30), HTLV-1 Tax and p53 (31), RelA and STAT2 (32), AP ...
Cited by 4 - View as HTML - Web Search - virology.med.uoc.gr - ncbi.nlm.nih.gov

THE FACTS OF DEATH
CM SANFILIPPO, JA BLAHO - International Reviews Of Immunology, 2003 - dx.doi.org
... as p50, p52, Rel A(p65), Rel B, c-Rel, and v-Rel [52,53 ... the signal transducer and
activator of transcriptional (STAT) proteins, STAT1 and STAT2, are recruited ...
Cited by 1 - Web Search - taylorandfrancis.metapress.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4- … - Full text - MIT Libraries
CH Shen, J Stavnezer - Mol. Cell. Biol, 1998 - mcb.asm.org
... are interaction between the Stat1-Stat2 heterodimer and p48 (23), Stat1 or Stat2
and p300/CBP (2, 40), and Stat3 and c-Jun (26). NF- B/Rel proteins have also ...
Cited by 82 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Role of Nuclear Factor-{kappa} B in the Antiviral Action of Interferon and Interferon-regulated Gene … - Full text - MIT Libraries
LM Pfeffer, JG Kim, SR Pfeffer, DJ Carrigan, DP … - J Biol Chem, 2004 - jbc.org
... 3). Upon JAK-mediated tyrosine phosphorylation, the STAT proteins (STAT1, STAT2,
and STAT3 ... binding forms of NF- B are dimeric combinations of Rel proteins (p50 ...
Cited by 2 - Web Search - jbc.org

Requirement for STAT1 in LPS-induced gene expression in macrophages
Y Ohmori, TA Hamilton - J. Leukoc. Biol, 2001 - jleukbio.org
... These Rel family members functionally and physically interact with members of other ...
Rabbit polyclonal antibodies to mouse STAT1- (M-23), STAT2 (C-18 ...
Cited by 46 - Web Search - jleukbio.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

Dissertation Summaries
S Krishnan, EKY Lau - JOURNAL OF INTERFERON & CYTOKINE RESEARCH, 2005 - dx.doi.org
... The Role of STAT2 in Type I Interferon-induced Responses ... STAT2 plays a key
role in the type I Interferon (IFN) signaling cascade. ...
Web Search - liebertonline.com - liebertonline.com

Stat 3 Dimerization Regulated by Reversible Acetylation of a Single Lysine Residue - Full text - MIT Libraries
Z Yuan, Y Guan, D Chatterjee, YE Chin - Science, 2005 - sciencemag.org
... Stat2 and Stat6 represent the most divergent STAT members in evolution (26), and
both ... revealed that STAT (Stat1 and Stat3), nuclear factor NF- B (Rel A), and ...
Cited by 4 - Web Search - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

Kinase-deficient forms of Jakl and wk2 inhibit interferon signaling in a dominant manner
RP Kartik KRISHNAN, J KROLEWSKI - Eur. J. Biochem, 1997 - blackwell-synergy.com
... inhibited IFNa-dependent induction of ISRE-driven luciferase activity rel- ative
to the ... Kinase-deficient Jakl can block phosphorylation of Qk2 and Stat2. ...
Web Search - ingentaconnect.com - Get it from MIT Libraries

Three-dimensional structure of the Stat3 homodimer bound to DNA - Full text - MIT Libraries
S Becker, B Groner, CW Muller - Nature, 1998 - nature.com
... DNA- binding protein p48, which is bound by the Stat1/Stat2 hetero- dimer ... Comparison
with NF- B/Rel proteins Despite no obvious sequence homology, we observe a ...
Cited by 21 - Web Search

Assessment of the gene expression profile of differentiated and dedifferentiated human fetal … - Full text - MIT Libraries
DG Stokes, G Liu, IB Coimbra, S Piera-Velazquez, … - Arthritis & Rheumatism, 2002 - doi.wiley.com
... of 283 genes most frequently expressed by human fetal epiphyseal chondrocytes in
poly-HEMA culture* Gene ID C DE REL Gene ID C DE REL ... STAT2 Hs.72988 3 1.2 5398 ...
Cited by 22 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Three-dimensional structure of the Stat3 bold beta homodimer bound to DNA
S BECKER, B GRONER, CW MUeLLER - nature.com
... the DNA-binding protein p48, which is bound by the Stat1/Stat2 heterodimer ... Comparison
with NF- B/Rel proteins Despite no obvious sequence homology, we observe a ...
Web Search - nature.com

Repression of transforming-growth-factor-beta-mediated transcription by nuclear factor kappaB - Full text - MIT Libraries
RP Nagarajan, F Chen, W Li, E Vig, MA Harrington, … - Biochem J, 2000 - biochemj.org
... transactivation domain, and all five subunits have an N-terminal Rel homology domain ...
NF-κB can also repress STAT2-mediated HIV transcription through a similar ...
Cited by 38 - View as HTML - Web Search - biochemj.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Interferon-beta activates multiple signaling cascades in primary human microglia - Full text - MIT Libraries
MO Kim, Q Si, JN Zhou, RG Pestell, CF Brosnan, J … - Journal of Neurochemistry, 2002 - blackwell-synergy.com
... that the ISG-15 ISRE complex contained IRF-1, but not Stat1, Stat2, IRF3 or ... are dimeric
complexes, composed of various combinations of members of the Rel/NF- B ...
Cited by 20 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Transcription Factor Activation in Human Neutrophils
A Cloutier, PP McDonald - The Neutrophil, Basel: Karger, 2003 - content.karger.com
... conducted in other leukocytes, a role for IFN-activated STAT1 (and perhaps STAT2
as well ... as a dimer whose constituent proteins belong to the NF- B/Rel family. ...
Cited by 1 - Web Search - content.karger.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

A complex element regulates IFN-gamma-stimulated monocyte chemoattractant protein-1 gene … - Full text - MIT Libraries
AJ Valente, JF Xie, MA Abramova, UO Wenzel, HE … - J Immunol, 1998 - jimmunol.org
... bands were supershifted by anti-STAT1 Abs, but not by Abs to STAT2, p48(ISGF-3 ... sites
by cytokine-activated B-binding complexes p65/p65 and p65/c-Rel results in ...
Cited by 26 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 6 versions »

Modulation of cytokine-induced HIV gene expression by competitive binding of transcription factors … - Full text - MIT Libraries
MO Hottiger, LK Felzien, GJ Nabel - The EMBO Journal, 1998 - embojournal.npgjournals.com
... This inhibition was mediated by binding of the IFN- signal transducer and activator
of transcription 2, Stat2, to a specific domain of p300 which also binds to ...
Cited by 40 - Web Search - emboj.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Functional Interplay Between Nuclear Factor-kappaB and c-Jun Integrated by Coactivator p 300 … - Full text - MIT Libraries
SB Maggirwar, S Ramirez, N Tong, HA Gelbard, S … - Journal of Neurochemistry, 2000 - blackwell-synergy.com
... The pCMV4-based expression vectors Rel A, cRel, and I B- (wild-type and mutant ... to
the same region of p300 as the unrelated transcription factor Stat2 (the CH1 ...
Cited by 23 - Web Search - urmc.rochester.edu - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Molecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for … - Full text - MIT Libraries
H Yan, K Krishnan, JT Lim, LG Contillo, JJ … - Mol Cell Biol, 1996 - mcb.asm.org
... The position of Stat2 is indicated. ... Finally, the murine and bovine IFNaR1 proteins
both contain additional proline residues rel- ative to the human homolog in ...
Cited by 40 - Web Search - ucihs.uci.edu - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Overlapping Positive and Negative Regulatory Domains of the Human ß-Interferon Gene - Full text - MIT Libraries
S Goodbourn, T Maniatis - J. Virol, 2001 - pnas.org
... Differential Transcriptional Activation in Vitro by NF-kappaB/Rel Proteins J ... Levy
Stat2 Is a Transcriptional Activator That Requires Sequence-specific Contacts ...
Web Search

Multiparametric Flow Cytometric Analysis of Inter-Patient Variation in STAT1 Phosphorylation …
GB Lesinski, SV Kondadasula, T Crespin, L Shen, K … - Interferon - jncicancerspectrum.oupjournals.org
... facilitates the formation of interferon-stimulated gene factor 3 (ISGF3), a
DNA-binding complex that consists of STAT1 (or STAT1 ), STAT2, and interferon ...
Cited by 2 - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Interleukin-12 and the regulation of innate resistance and adaptive immunity - Full text - MIT Libraries
G Trinchieri - Nature Reviews Immunology, 2003 - nature.com
... 35. Grumont, R. et al. c-Rel regulates interleukin-12 p70 expression in CD8 + dendritic
cells by specifically inducing p35 gene transcription. J. Exp. Med. ...
Cited by 267 - Web Search - immuneweb.xxmc.edu.cn - ncbi.nlm.nih.gov - virologyj.com - all 6 versions »

Comparative genomics provides evidence for an ancient genome duplication event in sh
JS Taylor, Y Van de Peer, I Braasch, A Meyer - Phil. Trans. R. Soc. Lond. B, 2001 - journals.royalsoc.ac.uk
Page 1. Comparative genomics provides evidence for an ancient genome duplication
event in sh John S. Taylor, Yves Van de Peer, Ingo Braasch and Axel Meyer * ...
Cited by 102 - Web Search - evolutionsbiologie.uni-konstanz.de - mit.edu - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Genomic-scale gene expression profiling of normal and malignant immune cells - Full text - MIT Libraries
AA Alizadeh, LM Staudt - Curr Opin Immunol, 2000 - lymphochip.nih.gov
... this signature (ie NF-κB 1, NF-κB 2, RelB, c-Rel and IκBα ... includes genes encoding
several interferon- responsive transcription factor subunits (STAT2, IRF-2 ...
Cited by 50 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Stat1 is induced and activated by all-trans retinoic acid in acute promyelocytic leukemia cells - Full text - MIT Libraries
M Gianni, M Terao, I Fortino, M LiCalzi, V … - Blood, 1997 - bloodjournal.org
... leukemia cell lines, NB4, HL-60, and U937, with all-trans retinoic acid (ATRA) results
in a remarkable elevation in the amounts of Stat1 and Stat2 proteins. ...
Cited by 50 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Inhibition of the RelA (p 65) NF-kappa B Subunit by Egr-1 - Full text - MIT Libraries
NR Chapman, ND Perkins - J Biol Chem, 2000 - jbc.org
... Egr-1 Interacts with the Rel Homology Domain of RelA-- To ascertain whether
Egr-1 ... Egr-1 from other transcription factors, such as p53 and Stat2, that inhibit ...
Cited by 26 - Web Search - jbc.org - ncbi.nlm.nih.gov

RNA interference: A primer for the uninitiated
RNAI Silencing - imgenex.com
... Composed of homo- and het- erodimers of five members of the Rel family including
NF-κB1(p50), NF-κB2 (p52), RelA (p65), RelB, and c-Rel (Rel), activation of ...
View as HTML - Web Search

Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary … - Full text - MIT Libraries
R Moriggl, S Berchtold, K Friedrich, GJ Standke, W … - Mol Cell Biol, 1997 - mcb.asm.org
... and Stat5b and of carboxyl-terminal deletion mutants of Stat1, Stat2, Stat3, Stat5a ...
IL-4, cell extracts were prepared, and relative (rel.) luciferase activities ...
Cited by 56 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov