Translocation breakpoints in three patients with campomelic dysplasia and autosomal sex reversal map … - Full text - MIT Libraries
J Wirth, T Wagner, J Meyer, RA Pfeiffer, HU Tietze … - Hum. Genet, 1996 - springerlink.com
... The breakpoints would then be in the first intron and would thus interrupt the SOX9
transcription unit. A detailed analysis of the rel- evant fetal transcripts ...
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Potent Inhibition of the Master Chondrogenic Factor Sox 9 Gene by Interleukin-1 and Tumor Necrosis … - Full text - MIT Libraries
S Murakami, V Lefebvre, B de Crombrugghe - J Biol Chem, 2000 - jbc.org
... phenotype (62-66), the NF B pathway may play an important role in the physiological
regulation of Sox9. Recent reports demonstrated a role for c-rel in chick ...
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The phenotype of survivors of campomelic dysplasia - Full text - MIT Libraries
S Mansour, AC Offiah, S McDowall, P Sim, J Tolmie, … - Journal of Medical Genetics, 2002 - dx.doi.org
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[CITATION] NF- B mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene … - Full text - MIT Libraries
R Sitcheran, PC Cogswell, AS Baldwin Jr - Genes & Development, 2003
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transcription factor Sox9 is required for cartilage devel- opment (Bi et al. ...
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Stuve-Wiedemann Syndrome: Update and Historical
HR Wiedemann - American Journal of Medical Genetics, 1996 - doi.wiley.com
... to a SOX9 mutation [Foster et al., 1994; Wagner et al., 1994; Kwok et al ... The ilia
were rel- atively small, and the pubic and ischial bones were rel- atively ...
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Protein Kinases in Chondrocyte Signaling and Osteoarthritis.
CJ Malemud - Clinical Orthopaedics and Related Research, 2004 - corronline.com
... was also shown to be dependent on ERK-1 and -2, but Sox9 gene expression ... Nuclear
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Web Search - corronline.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Skeletal development and regeneration.
ZPD Ali, FPD Beier, TBS Leask, PPD LuValle - Current Opinion in Orthopedics, 1999 - co-orthopedics.com
... K, Tanaka O, Semba I, Dashner R, et al.: Compressive force promotes sox9, type II ...
Ghosh S, May MJ, Kopp EB: NF-κB and Rel proteins: evolutionarily conserved ...
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Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators
M Wilson, P Koopman - Curr Opin Genet Dev, 2002 - imb.uq.edu.au
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are present in the DNA-binding high mobility group domains of SRY and SOX9. ...
Cited by 41 - View as HTML - Web Search - imb.uq.edu.au - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

Supplementary data Table I.
T NP, SV VP, SV VP - emboreports.npgjournals.com
... (1987). KAKRQR. v-Rel. Gilmore and Temin (1988). RGRRRRQR. Amida. Irie et al. ... Sudbeck
and Scherer (1997). KRPMNAFMVWAQAARRK. SOX9. Sudbeck and Scherer (1997). PRRRK ...
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Cloning and characterization of the proximal murine Phex promoter - Full text - MIT Libraries
S Liu, R Guo, LD Quarles - Endocrinology, 2001 - endo.endojournals.org
... Mertin S, McDowall SG, Harley VR 1999 The DNA-binding specificity of SOX9 and other ...
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A nuclear export signal in the N-terminal regulatory domain of I kappa B alpha controls cytoplasmic … - Full text - MIT Libraries
TT Huang, N Kudo, M Yoshida, S Miyamoto - Biochemistry, 2000 - dx.doi.org
... S. Edin, and T. Grundstrom Regulation of c-Rel Nuclear Localization ... mobility group
domain regulates the nucleocytoplasmic translocation of SOX9 during sexual ...
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Tumor Necrosis Factor alpha Induces Proteins that Bind Specifically to kappa B-Like Enhancer … - Full text - MIT Libraries
JW Lowenthal, DW Ballard, E Bohnlein, WC Greene - Hypertension, 2004 - pnas.org
... of lymphocyte subsets exhibiting transcriptionally active NF-{kappa}B/Rel complexes
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Cited by 18 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Appendix: Finding nuclear localization signals
M Cokol, R Nair, B Rost - cubic.bioc.columbia.edu
... GKKRSKA H2B Moreland et al., 1987. KAKRQR v-Rel Gilmore and Temin, 1988. ... PRRRK SRY
Sudbeck and Scherer, 1997. KRPMNAFMVWAQAARRK SOX9 Sudbeck and Scherer, 1997. ...
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77030, USA
G Karsenty - doi.wiley.com
... Verma IM, Stevenson JK, SchwarzEM, Van Antwerp D, Miyamoto S 1995 Rel/NF- ... campomelic
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Sex Determination in Primates: the SRY Locus.
SM Thompson - bio.fsu.edu
... WT1+KTS, GATA4, and FOG2 are all implicated in the regulation of Sry, that Sox9 ...
rel.44.2 entries that are 1) eukaryotic, but are not plants, animals, or fungi ...
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The molecular genetics of human sex determination
U Wolf - Journal of Molecular Medicine, 1995 - springerlink.com
... To the Y chromosome only a rel- ative role can be ascribed, and it has not yet
been estab- lished which gene is on top of the cascade. ... SOX9 ...
Cited by 10 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Assessment of the gene expression profile of differentiated and dedifferentiated human fetal … - Full text - MIT Libraries
DG Stokes, G Liu, IB Coimbra, S Piera-Velazquez, … - Arthritis & Rheumatism, 2002 - doi.wiley.com
... 407 Page 5. Table 3. List of 283 genes most frequently expressed by human fetal
epiphyseal chondrocytes in poly-HEMA culture* Gene ID C DE REL Gene ID C DE REL ...
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Effects of Curcumin (Diferuloylmethane) on Nuclear Factor {kappa} B Signaling in Interleukin-1ss- … - Full text - MIT Libraries
G SCHULZE-TANZIL, ALI MOBASHERI, J SENDZIK, T JOHN … - Ann. NY Acad. Sci, 2004 - annalsnyas.org
... Five different subunits are known to exist: c-Rel, RelA (also called p65 ... seems to
be mediated by downregulation of the transcription factor sox9, probably by ...
Web Search - dx.doi.org - annalsnyas.org - ncbi.nlm.nih.gov

Sex determination: where environment and genetics meet
SEXV SEXUALITY - EVOLUTION & DEVELOPMENT, 2003 - ingentaconnect.com
... substance; SF-1, steroidogenic factor one; SOX9, SRY-related HMG box nine ... temperature
also influences metabolic capacity in other behaviorally rel- evant nuclei ...
Web Search - npb.ucdavis.edu - cluster3.biosci.utexas.edu

Induction of chondrogenesis in neural crest cells by mutant fibroblast growth factor receptors - Full text - MIT Libraries
A Petiot, P Ferretti, AJ Copp, CTJ Chan - Developmental Dynamics, 2002 - doi.wiley.com
... Despite this rel- atively high transfection rate, chondrogenesis was in- duced in
only 2 ... Ex- pression of Sox9 and Col2a1 in secondary colonies of this culture ...
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Nuclear Factor-{kappa} B is an Important Modulator of the Altered Gene Expression Profile and … - Full text - MIT Libraries
R Articles - Cancer Research, 2004 - cancerres.aacrjournals.org
... in the NF- B-dependent down-regulation of mRNA expression of MyoD and Sox9 was detected ...
in an inactive form in most cells, composed of NF- B p50 and Rel A p65 ...
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Characterization of Pisrt1/Foxl2 in Ellobius lutescens and exclusion as sex-determining genes. - Full text - MIT Libraries
A Baumstark, H Hameister, M Hakhverdyan, I … - Mamm Genome, 2005 - springerlink.com
... as candidate male-determining genes in this species, namely, the SRY-related gene
Sox9 (Baumstark et al. ... With Dan PrestridgeÕs online tool Promoter Scan (rel. ...
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DNA sequence variations of the entire anti-Mullerian hormone(AMH) gene promoter and AMH protein … - Full text - MIT Libraries
P Oppelt, PL Strissel, A Kellermann, S Seeber, A … - Human Reproduction, 2004 - humrep.oupjournals.org
... Interestingly, human XY male patients with SOX9 gene mutations develop campomelic
dysplasia where ... The MALDI-TOF-MS spectra showing the relative intensity (rel. ...
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The 22 q 11 deletion syndromes - Full text - MIT Libraries
PJ Scambler - Human Molecular Genetics, 2000 - hmg.oupjournals.org
... have been observed at distances of up to 800 kb from the SOX9 gene in ... deletion
breakpoints extend over 200 kb and include GGT, BCRL, V7-rel, POM121-like and GGT ...
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Genetically Controlled Hormonal Regulation of Human Sexual Differentiation and Reproductive System …
VB Chernykh, LF Kurilo - RUSSIAN JOURNAL OF GENETICS, 2001 - springerlink.com
... Note that the Sox9 gene is to a larger extent a qualitative activator ... In
patient’s rel- atives, nondifferentiated clinical variants can be diag- nosed [51]. ...
Web Search - kluweronline.com

Sp 1 and Sp 3 Transcription Factors Mediate Interleukin-1 {beta} Down-regulation of Human Type II … - Full text - MIT Libraries
C Chadjichristos, C Ghayor, M Kypriotou, G Martin, … - J Biol Chem, 2003 - jbc.org
... with transcription factors that form chondrocyte-specific complexes, such as SOX9,
L-SOX5 ... heterodimeric complex composed of p50, p52, p65 (RelA), c-Rel, or RelB ...
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Defective calmodulin-mediated nuclear transport of SRY in XY sex reversal - Full text - MIT Libraries
H Sim, K Rimmer, S Kelly, LM Ludbrook, AH Clayton, … - Mol. Endocrinol, 2005 - mend.endojournals.org
... HMG box) family and has been shown to bind CaM also in SOX9 (Fig. 1) (26). ... also
inhibited SRY interaction with CaM (data not shown), as for SOX9 (26), ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

Syndecan-3 in limb skeletal development - Full text - MIT Libraries
RA Kosher - Microscopy Research and Technique, 1998 - doi.wiley.com
... The onset of cartilage-specific gene expression is accompanied by initiation of
the expres- sion of Sox9, a transcription factor that is a key regulator of ...
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Chondrosarcoma Cell Differentiation
GS Joseph - PATHOLOGY & ONCOLOGY RESEARCH, 2004 - webio.hu
... the anti-apoptotic nuclear factor κB (NFκB), suppresses Sox9 and antagonizes ... RevT
reticuloendotheliosis retrovirus of turkeys carries the v-rel gene, which ...
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Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice - Full text - MIT Libraries
M Moser, AK Bosserhoff, EB Hunziker, L Sandell, R … - Mol Cell Biol, 2002 - mcb.asm.org
... trancriptional regulatory elements, including melanoma-associated transcription
factor (10), AP-2, and Sox9 binding sites (19 ... neg., negative; rel., relative. ...
Cited by 7 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov

Disrupted expression of matrix genes in the growth plate of the mouse cartilage matrix deficiency( …
AWK Wai, LJ Ng, H Watanabe, Y Yamada, PPL Tam, KSE … - Developmental Genetics, 1998 - doi.wiley.com
... Regulatory molecules expressed by these cells include Sox9 [Ng et al., 1997] and
the receptor for parathyroid hormone related protein (PTHrPR; data not shown ...
Cited by 9 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Sox regulates transcription of the sea urchin arylsulfatase gene - Full text - MIT Libraries
M Ogawa, K Akasaka, K Mitsunaga-Nakatsubo, H … - Development Growth and Differentiation, 2000 - blackwell-synergy.com
... 133 bp to + 142 bp), which is homologous to binding sites of Rel family transcription ...
group domain proteins as revealed by comparison of SOX1/2/3 and SOX9. ...
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Regulation of Nuclear Transport: Central Role in Development and Transformation? - Full text - MIT Libraries
IKH Poon, DA Jans - Traffic, 2005 - blackwell-synergy.com
... after 4 days in culture (78), concomitant with increased nuclear localization of
the male sex-determining chromatin-remodeling factor SOX9; whether these ...
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Human Y Chromosome, Sex Determination, and Spermatogenesis—A Feminist View - Full text - MIT Libraries
JAM Graves - Biol. Reprod, 2000 - biolreprod.org
... the genes that determine sex and control spermatogenesis—are rel- ics of ... Another
related gene, SOX9, was found to be involved in testis determination in ...
Cited by 13 - Web Search - bioone.org - biolreprod.org - ncbi.nlm.nih.gov - all 5 versions »

Human Muellerian inhibiting substance promoter contains a functional TFII-I-binding initiator - Full text - MIT Libraries
N Morikawa, TR Clarke, CD Novina, K Watanabe, C … - Biol Reprod, 2000 - bioone.org
... be Sertoli derivatives, because they express MIS (unpublished results) and Sox9
(unpublished results ... The HIV-1 initiator appears to require Rel p50, which may ...
Cited by 8 - Web Search - biolreprod.org - mgh.harvard.edu - ncbi.nlm.nih.gov - all 6 versions »

Molecular control of vertebrate limb development, evolution and congenital malformations - Full text - MIT Libraries
MJ Cohn, PE Bright - Cell & Tissue Research, 1999 - springerlink.com
... The Rel/NFkappaB gene, a vertebrate homolog of the Dorsal gene in Droso- phila,
regulates expression of ... SOX9 Campomelic dysplasia Bowed long bones Foster et al ...
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Cytokines and fracture healing
TJ Cho, LC Gerstenfeld, GL Barnes, TA Einhorn - Current Opinion in Orthopaedics, 2001 - co-orthopedics.com
... Clin Orthop Rel Res 1998 , 355S: S283 -293. [Context Link]. 15. ... Bell BM , Leung KK ,
Wheatley SC , et al.: SOX9 directly regulates the type-II collagen gene . ...
Web Search - co-orthopedics.com

Constructive antagonism in limb development
AT Dudley, CJ Tabin - Curr. Opin. Genet. Dev, 2000 - genetics.med.harvard.edu
... years ago, two laboratories [22,23] demonstrated that c-rel, a homologue ... The appearance
of truncations is preceded by downregulation of sox9 and bmpr1b, genes ...
Cited by 13 - View as HTML - Web Search - lifesci.sussex.ac.uk - ingentaconnect.com - all 4 versions »

Fertility, sex determination, and the X chromosome - Full text - MIT Libraries
D Vaiman, F Alert - Cytogenetic and Genome Research, 2002 - content.karger.com
... The common feature of these four recent studies is their rel- ative inconclusiveness. ...
Clarkson MJ, Harley VR: Sex with two SOX on: SRY and SOX9 in testis ...
Cited by 2 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions »

Detection of Preferentially Co-occurring Transcription Factor Binding Sites
H Klein, M Vingron - cmb.molgen.mpg.de
... 3.3 Dataset We extract 1796 non-redundant human promoter sequences from the Eukaryotic
Promoter Database (EPD, rel. ... 48 ROX1 Q6 64 SOX9 B1 1.3070 1.4060 1.6421 ...
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Microarray analysis of gene expression in human donor sclera - Full text - MIT Libraries
TL Young, GS Scavello, PC Paluru, JD Choi, EF … - Mol Vis, 2004 - molvis.org
Page 1. Molecular Vision 2004; 10:163-76 <http://www.molvis.org/molvis/v10/a22>
Received 3 October 2003 | Accepted 16 March 2004 | Published 22 March 2004 ...
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Cellular Physiology and Biochemistry
V Dossinger, T Kayademir, N Blin, P Goett - Cell Physiol Biochem, 2002 - content.karger.com
... 32 Schmid RM, Adler G: NF-kappaB/rel/ IkappaB: implications in gastrointestinal
diseases. ... B: Potent inhibition of the master chondro- genic factor Sox9 gene by ...
Web Search - content.karger.com

Sry and the testis: Molecular pathways of organogenesis - Full text - MIT Libraries
J Brennan, J Karl, J Martineau, K Nordqvist, J … - The Journal of Experimental Zoology, 1998 - doi.wiley.com
... These cells lay adjacent to Sertoli cells expressing Sox9, in positions nor- mally ...
This work has broad rel- evance to our understanding of how the formation of ...
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Transcriptional Profiling of Bone Regeneration - Full text - MIT Libraries
M Hadjiargyrou, F Lombardo, S Zhao, W Ahrens, J … - J. Biol. Chem, 2002 - jbc.org
... 1, TGF, FGF, PDGF-R, NGF-R (32, 37-40), cytokines, IL-1, IL-6, G-MCF, neuroleukin
(17, 42), transcription factors, Fos (35), c-myc (43), and Sox9 (15-16 ... Rel. ...
Cited by 28 - Web Search - jbc.org - bme.sunysb.edu - ncbi.nlm.nih.gov - all 5 versions »

ZAS: C2H2 zinc finger proteins involved in growth and development
LC Wu - Gene Expr, 2002 - ingentaconnect.com
... tous proteins that bind to the κB motif with the Rel homology domain (57 ... activator
Sox9 to a nearby target site, and thereby represses Col2α1 gene expression ...
Cited by 8 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Identical mutations and phenotypic variation - Full text - MIT Libraries
U Wolf - Human Genetics, 1997 - springerlink.com
... and III 4 families SOX9 17q24.3- Frameshift after SRY-related Campomelic
dysplasia Two unrelated Kwok et al. 1995 q25.1 codon 368 ...
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Relief of gene repression by torso RTK signaling: Role of capicua in Drosophila terminal and … - Full text - MIT Libraries
G Jimenez, A Guichet, A Ephrussi, J Casanova - Genes Dev, 2000 - genesdev.org
... Such patterning depends on the Dorsal morphogen, a rel domain factor that accumulates
in ... Group domain proteins as revealed by comparison of Sox1/2/3 and Sox9. ...
Cited by 21 - Web Search - genesdev.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 7 versions »

Regulation of I kappa B beta Expression in Testis - Full text - MIT Libraries
LM Budde, C Wu, C Tilman, I Douglas, S Ghosh - Regulation, 2002 - molbiolcell.org
... These include I B , I B , and I B ; the precursor proteins of the p50 and p52 Rel
protein family members, known as p105 and p100; and the C-terminal portion of ...
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Signaling transduction: target in osteoarthritis.
F Berenbaum - Current Opinion in Rheumatology, 2004 - co-rheumatology.com
... adhesion molecules, acute phase reactants, I-κB, p50, c-rel, cyclooxygenase-2 ...
Crombrugghe B: Potent inhibition of the master chondrogenic factor Sox9 gene by ...
Cited by 1 - Web Search - co-rheumatology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Characterization of the human synaptogyrin gene family - Full text - MIT Libraries
D Kedra, HQ Pan, E Seroussi, I Fransson, C … - Human Genetics, 1998 - springerlink.com
... Uni- versal AB, Sweden) were sacrificed with carbon dioxide, and the rel- evant
tissues ... 1 and 2; MYH8 and MYH9, myosin heavy polypeptide 8 and 9; SOX9 and SOX10 ...
Cited by 19 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov