Transcriptional mechanisms of chondrocyte differentiation - Full text - MIT Libraries
B de Crombrugghe, V Lefebvre, RR Behringer, W Bi, … - Matrix Biol, 2000 - ingentaconnect.com
... Sox9. Our experiments suggest the hypothesis that, like Sox9, Sox5 and
Sox6 might also be needed for chondrocyte differentiation. ...
Cited by 72 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

The transcription factor Sox 9 has essential roles in successive steps of the chondrocyte … - Full text - MIT Libraries
H Akiyama, MC Chaboissier, JF Martin, A Schedl, B … - Genes & Development, 2002 - dx.doi.org
... [Key Words: Sox9; Sox5/Sox6; chondrocyte differentiation; osteochondroprogenitors;
apoptosis] 4 These authors contributed equally to this work. ...
Cited by 78 - Web Search - genesdev.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Accelerated up-regulation of L-Sox5, Sox6, and Sox9 by BMP-2 gene transfer during murine fracture …
H Uusitalo, A Hiltunen, M Ahonen, TJ Gao, V … - J Bone Miner Res, 2001 - ncbi.nlm.nih.gov
... Marked up-regulation of L-Sox5 and Sox9 messenger RNA (mRNA) and smaller changes
in Sox6 mRNA levels were observed in RNAse protection assays during early ...
Cited by 19 - Web Search - Get it from MIT Libraries

L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway
V Lefebvre, RR Behringer, B de Crombrugghe - Osteoarthritis Cartilage, 2001 - ncbi.nlm.nih.gov
... Collagen Type II; DNA-Binding Proteins; High Mobility Group Proteins; Nuclear Proteins;
SOX9 protein; Sox5 protein; Sox6 protein, mouse; Transcription Factors. ...
Cited by 14 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

SOX9 is a potent activator of the chondrocyte-specific enhancer of the proa1 (II) collagen gene - Full text - MIT Libraries
V Lefebvre, W Huang, VR Harley, PN Goodfellow, B … - Mol. Cell. Biol, 1997 - mcb.asm.org
... proteins in binding to their cognate motifs have also been observed (5); the homologies
between Sox4 and Sox9 HMG domains and between Sox5 and Sox9 HMG domains ...
Cited by 189 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

A new long form of Sox 5(L-Sox 5), Sox 6 and Sox 9 are coexpressed in chondrogenesis and … - Full text - MIT Libraries
V Lefebvre, P Li, B de Crombrugghe - The EMBO Journal, 1998 - embojournal.npgjournals.com
... Keywords: chondrogenesis/collagen2/Sox5/Sox6/Sox9, ... 10T1/2 fibroblasts were transfected
with expression plasmids for no protein (-), L-Sox5, Sox6, SOX9 or Sox5. ...
Cited by 144 - Web Search - nature.com - emboj.org - ncbi.nlm.nih.gov - all 7 versions »

The novel zinc finger-containing transcription factor osterix is required for osteoblast … - Full text - MIT Libraries
K Nakashima, X Zhou, G Kunkel, Z Zhang, JM Deng, … - Cell, 2002 - faculty.evansville.edu
... Three members of the Sox family of transcription factors, Sox9, L-Sox5, and Sox6,
which are needed for ... ments expressed Sox9, Sox5, Col2a1, and Ihh tran- ...
Cited by 136 - View as HTML - Web Search - faculty.evansville.edu - ncbi.nlm.nih.gov

[CITATION] deCrombrugghe B. 1998. A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in … - Full text - MIT Libraries
V Lefebvre, P Li - EMBO J
Cited by 3 - Web Search

Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal … - Full text - MIT Libraries
W Bi, W Huang, DJ Whitworth, JM Deng, Z Zhang, RR … - J. Biol. Chem, 2005 - dx.doi.org
... transcription factor Sox9 has essential roles in successive steps of the chondrocyte
differentiation pathway and is required for expression of Sox5 and Sox6 ...
Cited by 65 - Web Search - pnas.org - pubmedcentral.nih.gov - arthritis-research.com - all 9 versions »

Toward understanding the functions of the two highly related Sox 5 and Sox 6 genes - Full text - MIT Libraries
V Lefebvre - Journal of Bone and Mineral Metabolism, 2002 - springerlink.com
... 1. Comparison of Sox9, Sox5, L- Sox5, Sox6, and Sox13 proteins. A Schematic of Sox9. ...
C Percentage of identity between L-Sox5 and Sox6, Sox13, and Sox9 Page 3. ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov

[CITATION] deBrombrugghe B (2002) Transcription factor Sox9 has essential roles in successive steps of the … - Full text - MIT Libraries
H Akiyama, MC Chaboissier, JF Martin, A Schedl - Genes Dev
Cited by 1 - Web Search

Extracellular Matrix Gene Regulation.
K Okazaki, LJ Sandell - Clinical Orthopaedics and Related Research, 2004 - corronline.com
... Furthermore, the expression of Sox9, Sox5, and Col2a1 were observed in endochondral
and membranous skeletal elements, suggesting that Osterix has a potential ...
Cited by 1 - Web Search - corronline.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

The combination of SOX 5, SOX 6, and SOX 9(the SOX trio) provides signals sufficient for induction … - Full text - MIT Libraries
T Ikeda, S Kamekura, A Mabuchi, I Kou, S Seki, T … - Arthritis & Rheumatism, 2004 - doi.wiley.com
... These factors included SOX5, SOX6, SOX9, IGF-1, FGF-2, IHH, BMP-2, TGF , and Wnt
proteins. ... This is the first direct proof that SOX9 induces SOX5 and SOX6. ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

SOX 9-dependent and-independent Transcriptional Regulation of Human Cartilage Link Protein - Full text - MIT Libraries
I Kou, S Ikegawa - J Biol Chem, 2004 - jbc.org
... transfection of green fluorescent protein (open circles), SOX5 (closed circles),
SOX6 (open diamonds), SOX9 (closed squares), and SOX9 with SOX5 and SOX6 (open ...
Web Search - jbc.org - ncbi.nlm.nih.gov

Childhood’s End: Growth Plate Senescence and Epiphyseal Fusion
G Plate - content.karger.com
... We will discuss our results providing evidence that three members of the Sox family
of transcription factors Sox9, L-Sox5 and Sox6 control the differentiation ...
Web Search - content.karger.com

Conserved molecular program regulating cranial and appendicular skeletogenesis - Full text - MIT Libraries
BF Eames, JA Helms - Developmental Dynamics, 2004 - doi.wiley.com
... Molecular mark- ers of cartilage include genes en- coding the transcription factors
Sox9, Sox5, Sox6, and Runx2; compo- nents of the extracellular matrix ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

Regulatory mechanisms in the pathways of cartilage and bone formation
B de Crombrugghe, V Lefebvre, K Nakashima - Curr Opin Cell Biol, 2001 - cb207.med.harvard.edu
... 723 Figure 2 Sox9 L-Sox5 Sox6 L-Sox5 Sox6 Sox9? Sox9? Sox9 Cbfa1 ... 724 Cell
differentiation Figure 3 Sox9 L-Sox5 Sox6 L-Sox5 Sox6 Sox9? Sox9? Sox9 Cbfa1 ...
Cited by 62 - View as HTML - Web Search - cbi.pku.edu.cn - ingentaconnect.com - all 7 versions »

Regulation of skeletal development by the Runx family of transcription factors - Full text - MIT Libraries
T Komori - Journal of Cellular Biochemistry, 2005 - doi.wiley.com
... À/À embryos, the expression of Sox9, Sox5, Coll2a1, Indian hedgehog (Ihh), and Col10a1,
which are markers of chondrocytes, is observed in the mesenchymal ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

From the editor's desk. - Full text - MIT Libraries
C Differentiation, VEG Factors, DNAB Proteins, EG … - Matrix Biol, 2002 - ncbi.nlm.nih.gov
... Peptides and Proteins; Lymphokines; Nuclear Proteins; Receptors, LDL; SOX9 protein;
Sox5 protein; Sox6 protein, mouse; Transcription Factors; ...
Web Search

Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in … - Full text - MIT Libraries
P Smits, P Dy, S Mitra, V Lefebvre - The Journal of Cell Biology - jcb.org
... Because Sox5, Sox6 and Sox9 are no longer expressed in hypertrophic
chondrocytes, their actions on these cells must be indirect. ...
Cited by 2 - Web Search - idp.med.ufl.edu - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Mechanism of regulatory target selection by the SOX high-mobility-group domain proteins as revealed … - Full text - MIT Libraries
Y Kamachi, KS Cheah, H Kondoh - Mol. Cell. Biol, 1999 - mcb.asm.org
... In addition, Lefebvre et al. (31) showed that the mouse 48-bp Col2a1 enhancer
containing the COL2C2 sequence is activated by SOX9 but not by SOX4 or SOX5. ...
Cited by 45 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

SOX 9 interacts with a component of the human thyroid hormone receptor-associated protein complex - Full text - MIT Libraries
R Zhou, N Bonneaud, CX Yuan, P de Santa Barbara, B … - Nucleic Acids Research, 2002 - nar.oupjournals.org
... Cooperative interactions of SOX9 with SOX5 or SOX6 have been implicated in type
II collagen gene activation during chondrogenesis (15), whereas activation of ...
Cited by 7 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - all 7 versions »

Sry and Sox9: mammalian testis-determining genes - Full text - MIT Libraries
P Koopman - Cell Mol Life Sci, 1999 - springerlink.com
... 1999 Sry and Sox9: mammalian testis-determining genes P. Koopman ... sequences.
One of these, SOX9, will be discussed in some detail below. ...
Cited by 66 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa - Full text - MIT Libraries
H Akiyama, MC Chaboissier, RR Behringer, DH … - Proc Natl Acad Sci US A, 2004 - pubmedcentral.nih.gov
... As in the chondrogenic differentiation pathway, Sox9 is needed for expression
of Sox5 and Sox6 in endocardial cushion cells. It ...
Cited by 3 - Web Search - uphs.upenn.edu - dx.doi.org - pnas.org - all 6 versions »

The Sox10 (Dom) mouse: modeling the genetic variation of Waardenburg-Shah (WS4) syndrome - Full text - MIT Libraries
EM Southard-Smith, M Angrist, JS Ellison, R … - Genome Res, 1999 - genome.org
... Although the majority of Sox genes exhibit a monoexonic structure, Sox10 is analogous
to Sox9, SOX5, Sox17, and SOX20, which possess multiple exons that ...
Cited by 44 - Web Search - genome.org - ncbi.nlm.nih.gov

Interactions between Sox9 and beta-catenin control chondrocyte differentiation - Full text - MIT Libraries
H Akiyama, JP Lyons, Y Mori-Akiyama, X Yang, R … - Genes Dev, 2004 - genesdev.org
... 2001 ). Indeed, Sox9 is required for expression of Sox5 and Sox6 in all
endochondral skeletal elements (Akiyama et al. 2002 ). Moreover ...
Cited by 16 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages … - Full text - MIT Libraries
AE Brent, T Braun, CJ Tabin - Development, 2005 - genetics.med.harvard.edu
... Within the Sox family of transcription factors, characterized by a high-mobility-
group (HMG)-box DNA binding domain, three members, Sox9, Sox5 and Sox6, are ...
View as HTML - Web Search - dev.biologists.org - dev.biologists.org - ncbi.nlm.nih.gov

Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of … - Full text - MIT Libraries
P De Santa Barbara, N Bonneaud, B Boizet, M … - Mol Cell Biol, 1998 - mcb.asm.org
... HMG domain transcription factors such as Sox2 (1, 52), Sox5 (7), and ... the COS-7 cell
line, transient-cotransfection experiments with the SOX9 expression plasmid ...
Cited by 142 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic … - Full text - MIT Libraries
H Chikuda, F Kugimiya, K Hoshi, T Ikeda, T … - Genes & Development, 2004 - genesdev.org
... (A) Fluorescent images of HeLa cells cotransfected with cGKII and Sox9, Sox5,
or Sox6. Cells were transfected with plasmids encoding ...
Cited by 2 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Highly conserved proximal promoter element harboring paired Sox9-binding sites contributes to the … - Full text - MIT Libraries
O Rentsendorj, A Nagy, I Sinko, A Daraba, E Barta, … - Biochem J, 2005 - biochemj.org
... interacted with chondrogenic transcription factors Sox9, L-Sox5 and Sox6 in
vitro and another factor ... Although Pe1 can bind to Sox9, L-Sox5 ...
View as HTML - Web Search - biochemj.org - ncbi.nlm.nih.gov

Dimerization of SOX 9 is required for chondrogenesis, but not for sex determination - Full text - MIT Libraries
P Bernard, P Tang, S Liu, P Dewing, VR Harley, E … - Human Molecular Genetics, 2003 - hmg.oupjournals.org
... binding to these multimerized sites. For example, Sox9, Sox5 and Sox6 can
bind to four consensus sites in the Col2a1 enhancer (23). ...
Cited by 13 - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

SOX9 Exerts a Bifunctional Effect on Type II Collagen Gene (COL2A1) Expression in Chondrocytes …
M KYPRIOTOU, M FOSSARD-DEMOOR, C CHADJICHRISTOS, C … - DNA AND CELL BIOLOGY, 2003 - dx.doi.org
... A new long form of SOX5 (L-SOX5), SOX6 and SOX9 are coexpressed in chondogenesis
and cooperatively activate the type II collagen gene. EMBO J. 17, 5718–5733. ...
Cited by 5 - Web Search - liebertonline.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Chromosome assignment of eight SOX family genes in chicken - Full text - MIT Libraries
A Kuroiwa, M Uchikawa, Y Kamachi, H Kondoh, C … - Cytogenetic and Genome Research, 2002 - content.karger.com
... Chromosome locations of the eight SOX family genes, SOX1, SOX2, SOX3, SOX5, SOX9,
SOX10, SOX14 and SOX21, were determined in the chicken by fluorescence in ...
Cited by 7 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions »

SOX9-dependent and SOX9-independent transcriptional regulation of human cartilage link protein
I Kou, S Ikegawa - jbc.org
... Unlike other cartilage matrix genes, however, the activation of CRTL1 by SOX9 and
its known transcriptional co-activators L-SOX5 and SOX6 was cell-type ...
Web Search

The DNA-binding specificity of SOX 9 and other SOX proteins - Full text - MIT Libraries
S Mertin, SG McDowall, VR Harley - Nucleic Acids Research, 1999 - nar.oupjournals.org
... An alignment of the HMG domains of LEF-1, SOX9, Sox17, Sox5 and SRY reveal the
corresponding residues in the SOX9 and Sox17 HMG domains to be Leu, His, Gln and ...
Cited by 50 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 7 versions »

Potential use of Sox9 gene therapy for intervertebral degenerative disc disease
R Paul, RC Haydon, H Cheng, A Ishikawa, N … - Spine, 2003 - spinejournal.com
... Li P, de Crombrugghe B. A new long form of Sox5 (L-Sox5), Sox6, and Sox9 are
coexpressed in chondrogenesis and cooperatively activate the Type 2 collagen gene. ...
Cited by 5 - Web Search - spinejournal.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Many scattered bones do not a skeleton make - Full text - MIT Libraries
BR Olsen - Development, 2004 - dev.biologists.org
... Given what we now know about the essential roles of the transcription factors Sox9,
Sox5 and Sox6 in chondrocyte differentiation, it is remarkable that the ...
Web Search

Mutagenesis study on the zebra fish SOX9 high-mobility group: comparison of sequence and non- … - Full text - MIT Libraries
NW Hsiao, D Samuel, YN Liu, LC Chen, TY Yang, G … - Biochemistry, 2003 - tts.idv.tw
... The three-dimensional structure of the zebra fish SOX9 HMG domain was modeled using
the mouse SOX5 HMG domain as a template structure (PDB entry 1I11) (28). ...
Cited by 1 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Serum-Free Growth Medium Sustains Commitment of Human Articular Chondrocyte through Maintenance of … - Full text - MIT Libraries
B DOZIN - TISSUE ENGINEERING, 2004 - dx.doi.org
... Besides Sox9, the three-dimensional conformation of the cell is thus fundamental
as well and the presence of ad- ditional cooperative effectors, such as Sox5, ...
Cited by 2 - Web Search - liebertonline.com - liebertonline.com - ncbi.nlm.nih.gov - all 5 versions »

[CITATION] A new long form of SOX5 (L-SOX5)
V Lefebvre, P Li, B de Crombrugghe - SOX6 and SOX9 are coexpressed in chondrogenesis and …, 1998
Cited by 2 - Web Search

A zebrafish sox9 gene required for cartilage morphogenesis - Full text - MIT Libraries
YL Yan, CT Miller, RM Nissen, A Singer, D Liu, A … - Development, 2002 - dev.biologists.org
... DEVELOPMENT AND DISEASE. A zebrafish sox9 gene required for cartilage morphogenesis. ...
Sox9 may also participate in transcript splicing (Ohe et al., 2002 ). ...
Cited by 25 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

The genetic basis for skeletal diseases - Full text - MIT Libraries
E Zelzer, BR Olsen - Nature, 2003 - nature.com
... The transcription factor Sox9 has essential roles in successive steps of the
chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6 ...
Cited by 21 - Web Search - nature.com - weizmann.ac.il - ncbi.nlm.nih.gov

Reaching a genetic and molecular understanding of skeletal development - Full text - MIT Libraries
G Karsenty, EF Wagner - Dev. Cell, 2002 - oeh.univie.ac.at
... However, unlike Sox9, Sox5 and ... experiments, Sox5 and Sox6 increase Sox9 transactiva-
tion function (Lefebvre et al., 1998). This evidence sug- ...
Cited by 98 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

The SOX9 Transcription Factor in the Human Disc: Decreased Immunolocalization With Age and Disc …
HE Gruber, H Norton, JA Ingram, EN Hanley Jr - Spine, 2005 - spinejournal.com
... 332-6. [Context Link]. 6. Lefebvre V, Behringer RR, De Crombrugghe B. L-Sox5, Sox6
and Sox9 control essential steps of the chondrocyte differentiation pathway. ...
Web Search - spinejournal.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

The Transcription Factor SOX 9 Regulates Cell Cycle and Differentiation Genes in Chondrocytic CFK 2 … - Full text - MIT Libraries
DK Panda, D Miao, V Lefebvre, GN Hendy, D Goltzman - J Biol Chem, 2001 - intl.jbc.org
... development, we overexpressed this transcription factor in a rat chondrocytic cell
line (CFK2) that normally expresses low levels of SOX9 as well as SOX5. ...
Cited by 17 - Web Search - jbc.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Thyroxine downregulates Sox9 and promotes chondrocyte hypertrophy q, qq - Full text - MIT Libraries
Y Okubo, AH Reddi - Biochemical and Biophysical Research Communications, 2003 - ucdmc.ucdavis.edu
... The transcription factor Sox9 has essential roles in successive steps of the
chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6 ...
Cited by 2 - View as HTML - Web Search - ncbi.nlm.nih.gov

A New Long Form of c-Maf Cooperates with Sox 9 to Activate the Type II Collagen Gene - Full text - MIT Libraries
W Huang, N Lu, H Eberspaecher, B de Crombrugghe - J Biol Chem, 2002 - jbc.org
... After condensation, when cells overtly differentiate into chondrocytes, Lc-Maf
expression was shut off, whereas the levels of Sox9, L-Sox5, and Sox6 remained ...
Cited by 5 - Web Search - dx.doi.org - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

NiceProt View of Swiss-Prot: P35710
S None - expasy.cbr.nrc.ca
... Crombrugghe B.; "A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed
in chondrogenesis and cooperatively activate the type II collagen gene."; EMBO ...
Cached - Web Search

Expression of Sox transcription factors in the developing mouse pancreas - Full text - MIT Libraries
O Lioubinski, M Muller, M Wegner, M Sander - Dev. Dyn, 2003 - doi.wiley.com
... We detected transcripts for Sox11, Sox4, Sox13, Sox5, Sox9, Sox8, Sox10, Sox7, Sox17,
Sox18, Sox15, and Sox30 in embryonic pancreas and found Sox4, Sox9, and ...
Cited by 6 - Web Search - devcell.bio.uci.edu - ncbi.nlm.nih.gov

Induction of chondro-, osteo- and adipogenesis in embryonic stem cells by bone morphogenetic protein … - Full text - MIT Libraries
N zur Nieden, G Kempka, D Rancourt, HJ Ahr - BMC Developmental Biology, 2005 - biomedcentral.com
... During the revision of this paper, a study was published describing that the
overexpression of the sox triad, namely Sox9, Sox5 and Sox6, markedly increased ...
Cached - Web Search - dx.doi.org - pubmedcentral.nih.gov - citebase.eprints.org - all 6 versions »