… of the testis-determining factors, SRY (sex-determining region on the Y chromosome) and SOX9 [SRY- … - Full text - MIT Libraries
VR Harley, MJ Clarkson, A Argentaro - Endocr. Rev, 2003 - edrv.endojournals.org
... The Molecular Action and Regulation of the Testis-Determining Factors, SRY
(Sex-Determining Region on the Y Chromosome) and SOX9 [SRY-Related High-Mobility ...
Cited by 19 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

… sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX …
T Wagner, J Wirth, J Meyer, B Zabel, M Held, J … - Cell, 1994 - ncbi.nlm.nih.gov
... Transcription Factors/genetics*; Transcription, Genetic; Translocation, Genetic.
Gene Symbols: SOX9; SRY. Substances: DNA-Binding Proteins; ...
Cited by 367 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

The DNA-binding specificity of SOX 9 and other SOX proteins - Full text - MIT Libraries
S Mertin, SG McDowall, VR Harley - Nucleic Acids Research, 1999 - nar.oupjournals.org
... MATERIALS AND METHODS. Production of recombinant SOX9 and SRY proteins. ... RESULTS.
Production of full-length SOX9 and HMG domains of SOX9 and SRY. ...
Cited by 50 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 7 versions »

Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of … - Full text - MIT Libraries
P De Santa Barbara, N Bonneaud, B Boizet, M … - Mol Cell Biol, 1998 - mcb.asm.org
... Furthermore, unlike human SRY, SOX9 was shown to act as a transcriptional activator
during chondrocyte differentiation (2, 30) and to display a high level of ...
Cited by 142 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

SRY, SOX9, and DAX1 expression patterns during human sex determination and gonadal development - Full text - MIT Libraries
NA Hanley, DM Hagan, M Clement-Jones, SG Ball, T … - Mech Dev, 2000 - ncl.ac.uk
... Mutation of the human genes which encode SRY (Sex- determining Region of the Y
chromosome) and SOX9 (SRY- related HMG BOX gene 9) results in 46,XY pure gonadal ...
Cited by 48 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

The Sry-related gene Sox 9 is expressed during chondrogenesis in mouse embryos
E Wright, MR Hargrave, J Christiansen, L Cooper, J … - Nature Genetics, 1995 - nature.com
... Article. Nature Genetics 9, 15 - 20 (1995) doi:10.1038/ng0195-15 The Sry-related
gene Sox9 is expressed during chondrogenesis in mouse embryos. ...
Cited by 186 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

… Localization Signals Are Present in the DNA-binding High-mobility Group Domains of SRY and SOX9
P Suedbeck, G Scherer - dx.doi.org
... A. Argentaro The Molecular Action and Regulation of the Testis-Determining Factors,
SRY (Sex-Determining Region on the Y Chromosome) and SOX9 [SRY-Related High ...
Cited by 55 - Web Search - jbc.org - jbc.org - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

Sox9 induces testis development in XX transgenic mice - Full text - MIT Libraries
VP Vidal, MC Chaboissier, DG de Rooij, A Schedl - Nat Genet, 2001 - nature.com
... gene Sry (ref. 3). One of the first genes induced in male gonads after Sry
expression is the Sry homolog Sox9 (refs. 4,5). The DNA ...
Cited by 109 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Sry and Sox9: mammalian testis-determining genes - Full text - MIT Libraries
P Koopman - Cell Mol Life Sci, 1999 - springerlink.com
... Basel, 1999 Sry and Sox9: mammalian testis-determining genes P. Koopman Centre ...
mo- Page 2. P. Koopman Sry and Sox9 genes 840 bility-group ...
Cited by 66 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Deletion of long-range regulatory elements upstream of SOX9 causes campomelic dysplasia - Full text - MIT Libraries
VM Wunderle, R Critcher, N Hastie, PN Goodfellow, … - Developmental Biology, 1998 - dx.doi.org
... A. Argentaro The Molecular Action and Regulation of the Testis-Determining Factors,
SRY (Sex-Determining Region on the Y Chromosome) and SOX9 [SRY-Related High ...
Cited by 46 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Sox9 is required for cartilage formation - Full text - MIT Libraries
W Bi, JM Deng, Z Zhang, RR Behringer, B de … - Nat Genet, 1999 - nature.com
... Autosomal sex reversal and campomelic dysplasia are caused by mutations in and
around the SRY-related gene SOX9. Cell 79, 1111-1120 (1994). ...
Cited by 215 - Web Search - nature.com - ncbi.nlm.nih.gov

A regulatory cascade hypothesis for mammalian sex determination: SRY represses a negative regulator … - Full text - MIT Libraries
K McElreavey, E Vilain, N Abbas, I Herskowitz, M … - Proceedings of the National Academy of Sciences, 1993 - pnas.org
... A. Argentaro The Molecular Action and Regulation of the Testis-Determining Factors,
SRY (Sex-Determining Region on the Y Chromosome) and SOX9 [SRY-Related High ...
Cited by 96 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

… binding properties of the high mobility group domain of murine and human SRY sex-determining factors - Full text - MIT Libraries
K Giese, J Pagel, R Grosschedl - Proc Nat Acad Sci, 1994 - pnas.org
... A. Argentaro The Molecular Action and Regulation of the Testis-Determining Factors,
SRY (Sex-Determining Region on the Y Chromosome) and SOX9 [SRY-Related High ...
Cited by 38 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

A transgenic insertion upstream of Sox9 is associated with dominant XX sex reversal in the mouse - Full text - MIT Libraries
CE Bishop, DJ Whitworth, Y Qin, AI Agoulnik, IU … - Nat Genet, 2000 - nature.com
... Autosomal sex reversal and campomelic dysplasia are caused by mutations in and
around the SRY-related gene SOX9. Cell 79, 1111-1120 (1994). ...
Cited by 82 - Web Search - devcell.bio.uci.edu - tu-cottbus.de - med.umich.edu - all 8 versions »

Interactions between SRY and SOX genes in mammalian sex determination - Full text - MIT Libraries
JAM Graves - Bioessays, 1998 - doi.wiley.com
... THE ROLES OF SRY AND SOX9 IN SEX DETERMINATION SRY is a small intronless gene that
contains a DNA-binding HMG box, named for its homology with similar domains ...
Cited by 44 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Dax1 antagonizes Sry action in mammalian sex determination - Full text - MIT Libraries
A Swain, V Narvaez, P Burgoyne, G Camerino, R … - Nature, 1998 - nature.com
... 42. Wagner, T. et al. Autosomal sex reversal campomelic dysplasia are caused by
mutations in and around the SRY related gene SOX9. Cell 79, 1111-1120 (1994). ...
Cited by 190 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene - Full text - MIT Libraries
JW Foster, MA Dominguez-Steglich, S Guioli, C Kwok … - Nature, 1994 - nature.com
... breakpoint from a sex-reversed patient with campomelic dysplasia, followed by mutation
analysis of an adjacent gene, indicates that SOX9, an SRY-related gene ...
Cited by 381 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Sex with two SOX on: SRY and SOX9 in testis development
MJ Clarkson, VR Harley - Trends Endocrinol Metab, 2002 - courses.bio.psu.edu
... Transcription cofactors that interact with SRY and SOX9 SRY-interacting protein
1 (SIP-1) was isolated in a yeast two-hybrid screen for proteins that interact ...
Cited by 20 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

Autosomal XX sex reversal caused by duplication of SOX9 - Full text - MIT Libraries
B Huang, S Wang, Y Ning, AN Lamb, J Bartley - Am J Med Genet, 1999 - doi.wiley.com
... This finding warrants study of other cell types besides peripheral blood lymphocyte
in search for SOX9 duplication in SRY negative XX sex reversal cases. ...
Cited by 60 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Primate DAX1, SRY, and SOX9: evolutionary stratification of sex-determination pathway - Full text - MIT Libraries
M Patel, KS Dorman, YH Zhang, BL Huang, AP Arnold, … - American Journal of Human Genetics, 2001 - journals.uchicago.edu
... each other. These results were consistent with a discontinuity in the pressures
driving the evolution of SOX9 versus SRY and DAX1. ...
Cited by 12 - Web Search - journals.uchicago.edu - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Sry, Sox9 and mammalian sex determination
P Koopman - EXS, 2001 - ncbi.nlm.nih.gov
Sry, Sox9 and mammalian sex determination. ... Like Sry, mutations in Sox9 disrupt male
development, but unlike Sry, the role of Sox9 is not limited to mammals. ...
Cited by 14 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Calmodulin activates nuclear protein import: a link between signal transduction and nuclear … - Full text - MIT Libraries
TD Sweitzer, JA Hanover - Proc Natl Acad Sci USA, 1996 - dx.doi.org
... A. Argentaro The Molecular Action and Regulation of the Testis-Determining Factors,
SRY (Sex-Determining Region on the Y Chromosome) and SOX9 [SRY-Related High ...
Cited by 29 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

SOX 9 Enhances Aggrecan Gene Promoter/Enhancer Activity and Is Up-regulated by Retinoic Acid in a … - Full text - MIT Libraries
I Sekiya, K Tsuji, P Koopman, H Watanabe, Y Yamada … - J Biol Chem, 2000 - dx.doi.org
... A. Argentaro The Molecular Action and Regulation of the Testis-Determining Factors,
SRY (Sex-Determining Region on the Y Chromosome) and SOX9 [SRY-Related High ...
Cited by 64 - Web Search - jbc.org - jbc.org - ncbi.nlm.nih.gov

SEX IN THE 90 s: SRY and the Switch to the Male Pathway - Full text - MIT Libraries
B Capel - Annual Review of Physiology, 1998 - arjournals.annualreviews.org
... At least three genes, SRY itself, SOX9, and DAX1, are dosage sensitive, providing
molecular evidence that the sex determination step operates at a critical ...
Cited by 56 - Web Search - mcb.berkeley.edu - cellbio.duke.edu - ncbi.nlm.nih.gov - all 5 versions »

… importin {beta} recognition and nuclear import of the sex-determining factor SRY are associated with … - Full text - MIT Libraries
VR Harley, S Layfield, CL Mitchell, JK Forwood, AP … - Mol. Endocrinol, 2005 - dx.doi.org
... A. Argentaro The Molecular Action and Regulation of the Testis-Determining Factors,
SRY (Sex-Determining Region on the Y Chromosome) and SOX9 [SRY-Related High ...
Cited by 15 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Sex reversal by loss of the C–terminal transactivation domain of human SOX 9
P Suedbeck, ML Schmitz, PA Baeuerle, G Scherer - Nature Genetics, 1996 - nature.com
... Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around
the SRY-related gene SOX9. Cell 79, 1111–1120 (1994). Foster, JW et al. ...
Cited by 87 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

A male-specific role for SOX9 in vertebrate sex determination - Full text - MIT Libraries
J Kent, SC Wheatley, JE Andrews, AH Sinclair, P … - Development, 1996 - dev.biologists.org
... determining pathway. Second, SOX9 protein might interact with SRY to form
a complex that initiates testis development. In this model ...
Cited by 199 - Web Search - dev.biologists.org - wwwlib.bionet.nsc.ru - ncbi.nlm.nih.gov - all 5 versions »

Expression and subcellular localization of SF-1, SOX 9, WT 1, and AMH proteins during early human … - Full text - MIT Libraries
P De Santa Barbara, B Moniot, F Poulat, P Berta - Developmental Dynamics, 2000 - doi.wiley.com
... differentiation and subsequent anti-Müllerian hormone (AMH) secretion in eu- therian
mammals, they include steroidogenic factor-1 (SF-1), SOX9 (SRY HMG box ...
Cited by 38 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

A direct role of SRY and SOX proteins in pre-mRNA splicing - Full text - MIT Libraries
K Ohe, E Lalli, P Sassone-Corsi - Proceedings of the National Academy of Sciences, 2002 - pnas.org
... A. Argentaro The Molecular Action and Regulation of the Testis-Determining Factors,
SRY (Sex-Determining Region on the Y Chromosome) and SOX9 [SRY-Related High ...
Cited by 20 - Web Search - pubmedcentral.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

The rise and fall of SRY
JAM Graves - Trends Genet, 2002 - anu.edu.au
... the basis of its functional homology and interactions, it has been proposed that
SOX3 is involved in testis determination by interacting with SOX9 and SRY [36 ...
Cited by 22 - View as HTML - Web Search

Regulation of male sexual development by Sry and Sox9 - Full text - MIT Libraries
P Koopman, M Bullejos, J Bowles - J exp Zool, 2001 - doi.wiley.com
... Regulation of Male Sexual Development by Sry and Sox9 PETER KOOPMAN,* MONICA BULLEJOS, ...
Two genes, Sry and Sox9, have assumed a primacy in this pathway. ...
Cited by 12 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

[CITATION] Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of … - Full text - MIT Libraries
BP De Santa, N Bonneaud, B Boizet, M Desclozeaux, … - Mol. Cell. Biol, 1998
Cited by 12 - Web Search

The genetic basis of murine and human sex determination: a review
K McElreavey, S Barbaux, A Ion, M Fellous - Heredity, 1995 - ncbi.nlm.nih.gov
... In addition, mutations in the SRY-related gene SOX9 (SRY-related box) are
associated with a failure of human testicular determination. ...
Cited by 19 - Web Search - Get it from MIT Libraries

Sry requires a CAG repeat domain for male sex determination in Mus musculus - Full text - MIT Libraries
J Bowles, L Cooper, J Berkman, P Koopman - Nat Genet, 1999 - nature.com
... ChemPort |; Südbeck, P. & Scherer, G. Two independent nuclear localization signals
are present in the DNA-binding high-mobility group domains of SRY and SOX9. ...
Cited by 50 - Web Search - nature.com - ncbi.nlm.nih.gov

Correlation of germ-line mutations and two-hit inactivation of the WT1 gene with Wilms tumors of … - Full text - MIT Libraries
V Schumacher, S Schneider, A Figge, G Wildhardt, D … - Proc Natl Acad Sci USA, 1997 - dx.doi.org
... A. Argentaro The Molecular Action and Regulation of the Testis-Determining Factors,
SRY (Sex-Determining Region on the Y Chromosome) and SOX9 [SRY-Related High ...
Cited by 36 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Mutations in SRY and SOX 9: Testis‐determining genes - Full text - MIT Libraries
FJ Cameron, AH Sinclair - Human Mutation, 1997 - doi.wiley.com
... HUMU 764 MUTATION UPDATE Mutations in SRY and SOX9: Testis-Determining Genes ...
Correspondence to Andrew H. Sinclair. Page 2. MUTATIONS IN SRY AND SOX9 389 ...
Cited by 52 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

SOX 9 directly regulates the type-ll collagen gene
DM Bell, KKH Leung, SC Wheatley, LJ Ng, S Zhou, K … - Nature Genetics, 1997 - nature.com
... Autosomal sex reversal and campomelic dysplasia are caused by mutations in and
around the SRY-related gene SOX9. Cell 79, 1111–1120 (1994). ...
Cited by 184 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Mapping in pig of genes involved in sexual differentiation: AMH, WT1, FTZF1, SOX2, SOX9, AHC, and …
Y Lahbib-Mansais, A Barbosa, M Yerle, P Parma, D … - Cytogenet Cell Genet, 1997 - ncbi.nlm.nih.gov
... expressed in embryo) was mapped to porcine 1q12-->q17, AHC (alias DAX1, adrenal
hypoplasia congenital) to porcine Xp24, SOX2 and SOX9 (SRY sex determining ...
Cited by 12 - Web Search - Get it from MIT Libraries

… factor in Ellobius lutescens: evidence for another testis determining gene besides SRY and SOX9 - Full text - MIT Libraries
A Baumstark, M Akhverdyan, A Schulze, I Reisert, W … - Mol Genet Metab, 2001 - ingentaconnect.com
... Exclusion of SOX9 as the Testis Determining Factor in Ellobius lutescens: Evidence
for Another Testis Determining Gene Besides SRY and SOX9. ...
Cited by 7 - Web Search - ncbi.nlm.nih.gov

A nuclear export signal within the high mobility group domain regulates the nucleocytoplasmic … - Full text - MIT Libraries
S Gasca, J Canizares, P de Santa Barbara, C Mejean … - Hum. Mol. Genet, 2005 - dx.doi.org
... SOX9, like SRY, contains a high mobility group domain and is sufficient
to induce testis differentiation in transgenic XX mice. ...
Cited by 20 - Web Search - pnas.org - pubmedcentral.gov - ncbi.nlm.nih.gov - all 6 versions »

A Gene Involved in XY Sex Reversal Is Located on Chromosome 9, Distal to Marker D 9 S 1779 - Full text - MIT Libraries
WL Flejter, J Fergestad, J Gorski, T Varvill, S … - The American Journal of Human Genetics, 1998 - journals.uchicago.edu
... 1990) and SOX9 (SRY-related box gene 9) (Foster et al. 1994; Wagner et al. 1994),
both shown to be involved in the sex-determining pathway. ...
Cited by 34 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Expression of AMH, SF1, and SOX9 in gonads of genetic female chickens during sex reversal induced by … - Full text - MIT Libraries
S Vaillant, S Magre, M Dorizzi, C Pieau, N Richard … - Dev Dyn, 2001 - doi.wiley.com
... A more specific marker of Sertoli cells during normal gonadal differen- tiation
in the chicken is SOX9 (SRY HMG box related gene 9), a transcription factor ...
Cited by 15 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

SOX9 is a potent activator of the chondrocyte-specific enhancer of the proa1 (II) collagen gene - Full text - MIT Libraries
V Lefebvre, W Huang, VR Harley, PN Goodfellow, B … - Mol. Cell. Biol, 1997 - mcb.asm.org
... The identification of mutations in the SRY-related SOX9 gene in patients with
campomelic dysplasia, a severe skeletal malformation syndrome, and the abundant ...
Cited by 189 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

SRY Recognizes Conserved DNA Sites in Sex-Specific Promoters - Full text - MIT Libraries
CM Haqq, C King, PK Donahoe, MA Weiss - Proceedings of the National Academy of Sciences - pnas.org
... and P. Berta Direct Interaction of SRY-Related Protein SOX9 and Steroidogenic Factor
1 Regulates Transcription of the Human Anti-Mullerian Hormone Gene Mol. ...
Cited by 43 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - adsabs.harvard.edu

Localisation of the SRY-related HMG box protein, SOX9, in rodent brain - Full text - MIT Libraries
S Pompolo, VR Harley - Brain Res, 2001 - ingentaconnect.com
... Localisation of the SRY-related HMG box protein, SOX9, in rodent brain. Authors:
Pompolo S. 1 ; Harley VR. Source: Brain Research, 6 July 2001, vol. 906, no. ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov

Related function of mouse SOX 3, SOX 9, and SRY HMG domains assayed by male sex determination - Full text - MIT Libraries
DE Bergstrom, M Young, KH Albrecht, EM Eicher - genesis, 2000 - doi.wiley.com
ARTICLE Related Function of Mouse SOX3, SOX9, and SRY HMG ... Key words: Sry; Sox3; Sox9;
sex determination; testis de- termination; transgenic mice INTRODUCTION ...
Cited by 21 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Early expression of AMH in chicken embryonic gonads precedes testicular SOX9 expression - Full text - MIT Libraries
E Oreal, C Pieau, MG Mattei, N Josso, JY Picard, D … - Dev Dyn, 1998 - doi.wiley.com
... developing, mostly neural, tissues but one, SOX9, closely related to SRY, in addition
to its role in chondro- genesis, is expressed in the developing testis of ...
Cited by 44 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Intersex disorders: shedding light on male sexual differentiation beyond SRY - Full text - MIT Libraries
HE MacLean, GL Warne, JD Zajac - Clinical Endocrinology, 1997 - ingentaconnect.com
... SOX9 is thought to be required very early on in gonadal development; however, the
precise interaction between SOX9 and SRY is not yet known. ... SOX9 SRY ...
Cited by 8 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

SOX 9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors - Full text - MIT Libraries
R SEKIDO, I BAR, V NARVAEZ, G PENNY, R LOVELLBADGE - Developmental Biology, 2004 - ncbi.nlm.nih.gov
Click here to read SOX9 is up-regulated by the transient expression of
SRY specifically in Sertoli cell precursors. Sekido R, Bar ...
Cited by 7 - Web Search

Sex differentiation and mRNA expression of p 450 c 17, p 450 arom and AMH in gonads of the chicken
H Nishikimi, N Kansaku, N Saito, M Usami, Y Ohno, … - Molecular Reproduction and Development, 2000 - doi.wiley.com
... In mammals, AMH gene expression occurs after the expression of Sox9 and Sry genes. ...
In females, AMH is not expressed because Sox9 and Sry are not expressed. ...
Cited by 16 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries