Cooperative interaction between AhR. Arnt and Sp1 for the drug-inducible expression of CYP1A1 gene - Full text - MIT Libraries
A Kobayashi, K Sogawa, Y Fujii-Kuriyama - J. Biol. Chem, 1996 - jbc.org
... Both in vivo transfection assays using Drosophila Schneider line 2 (SL2) cells,
which is devoid of endogenous Sp1, AhR, and Arnt, and in vitro transcription ...
Cited by 53 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Regulation of constitutive gene expression through interactions of Sp1 protein with the nuclear aryl … - Full text - MIT Libraries
F Wang, W Wang, S Safe - Biochemistry, 1999 - ncbi.nlm.nih.gov
... The functional interactions of Sp1 with AhR-Arnt were paralleled by physical
interactions showing that AhR-Arnt and Sp1 proteins were co-immunoprecipitated and ...
Cited by 10 - Web Search

Functional and physical interactions between the estrogen receptor Sp 1 and nuclear aryl hydrocarbon … - Full text - MIT Libraries
F Wang, D Hoivik, R Pollenz, S Safe - Nucleic Acids Research, 1998 - nar.oupjournals.org
... Interaction of ER/Sp1 and AhR/ARNT complexes. ... Previous studies have reported direct
interactions between Sp1 with ER (35) and Sp1 with AhR/ARNT proteins (42). ...
Cited by 43 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Regulation of mouse Ah receptor (Ahr) gene basal expression by members of the Sp family of …
CT Fitzgerald, DW Nebert, A Puga - DNA Cell Biol, 1998 - ncbi.nlm.nih.gov
... this construct with expression plasmids for each of the Sp factors revealed that
Sp3 was approximately 1.6-fold more efficient than Sp1 in Ahr transactivation. ...
Cited by 4 - Web Search - Get it from MIT Libraries

Transcriptional activation of c-fos protooncogene by 17ss-estradiol: Mechanism of aryl hydrocarbon … - Full text - MIT Libraries
R Duan, W Porter, I Samudio, C Vyhlidal, M Kladde, … - Mol. Endocrinol, 1999 - mend.endojournals.org
... The cooperative ER/Sp1-AhR/Arnt interactions also decreased with increasing
distance between the GC-rich and core DRE-binding sites (45). ...
Cited by 34 - Web Search - mend.endojournals.org - ncbi.nlm.nih.gov

Differential Recruitment of Coactivator RIP140 by Ah and Estrogen Receptors - Full text - MIT Libraries
MB Kumar, RW Tarpey, GH Perdew - J Biol Chem, 1999 - jbc.org
... Sp1, AhR, and ARNT were found to synergistically enhance both transcription in in
vitro transcription assays and reporter gene activity in transient ...
Cited by 62 - Web Search - jbc.org - cas.psu.edu - ncbi.nlm.nih.gov

Critical Enhancer Region to Which AhR/ARNT and Sp 1 Bind in the Human CYP 1 B 1 Gene - Full text - MIT Libraries
Y Tsuchiya, M Nakajima, T Yokoi - Journal of Biochemistry, 2003 - jb.oupjournals.org
... These results were similar to those of previous studies showing that transcription
of the CYP1A1 gene is cooperatively regulated by Sp1 and AhR (30, 31). ...
Cited by 4 - Web Search - p.kanazawa-u.ac.jp - ingentaconnect.com - ncbi.nlm.nih.gov - all 7 versions »

Proteasome inhibition induces nuclear translocation of the dioxin receptor through an Sp1 and … - Full text - MIT Libraries
B Santiago-Josefat, PM Fernandez-Salguero - J Mol Biol, 2003 - ncbi.nlm.nih.gov
... These data suggest that cellular control of protein kinase C activity, through Sp1
and ARNT, could regulate AhR transcriptional activity in the absence of ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

… nucleotide polymorphism analysis and functional characterization of the human Ah receptor (AhR) … - Full text - MIT Libraries
J Racky, HJ Schmitz, HM Kauffmann, D Schrenk - Arch Biochem Biophys, 2004 - ingentaconnect.com
... by cotransfection experiments in Drosophila SL2 cells. The obtained results
prove an involvement of Sp1 in AhR gene regulation. ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of … - Full text - MIT Libraries
M Wormke, M Stoner, B Saville, K Walker, M … - Mol Cell Biol, 2003 - mcb.asm.org
... in mammalian cells (10, 16, 17), and studies in this laboratory have applied this
technique for study of ER /Sp1 and AhR action in breast cancer cells (1; M ...
Cited by 32 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

The binding of transformed aromatic hydrocarbon (Ah) receptor to its DNA recognition site is not …
MS Denison, RM Deal - Mol Cell Endocrinol, 1990 - ncbi.nlm.nih.gov
... a metal ion chelating agent, inhibited the DNA binding of SP1 and transformed
glucocorticoid receptor, no inhibition of transformed AhR was observed. ...
Cited by 5 - Web Search - Get it from MIT Libraries

A novel positive regulatory element that enhances hamster CYP2A8 gene expression mediated by … - Full text - MIT Libraries
K Kurose, M Tohkin, M Fukuhara - Mol Pharmacol, 1999 - molpharm.org
... Cooperative Transcriptional Enhancement of AhR-Arnt with Sp1. ... This means that
AhR-Arnt activates the gene expression by 3-MC in cooperation with Sp1. ...
Cited by 4 - Cached - Web Search - molpharm.aspetjournals.org - molpharm.org - ncbi.nlm.nih.gov - all 5 versions »

Aryl hydrocarbon receptor/dioxin receptor in human monocytes and macrophages
K Komura, S Hayashi, I Makino, L Poellinger, H … - Mol. Cell. Biochem, 2001 - springerlink.com
... a GC-rich motif that binds Sp1 protein and core sequence of a XRE element, and physical
and functional interactions between the Sp1 and AhR/Arnt complex were ...
Cited by 6 - Web Search - kluweronline.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Analysis of the Murine AhR Gene Promoter
PM Garrison, MS Denison - J Biochem Toxicol, 2000 - doi.wiley.com
... 23]. Recently, Fitzgerald et al. [24] demonstrated the functionality of
the Sp1 elements contained within the AhR promoter region. ...
Cited by 5 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

[CITATION] Cooperative Interaction between AhR bullet Arnt and Sp1 for the Drug-inducible Expression...
S In, PST Access, S Up
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Topic 1.13 Transcriptional roles of AhR in expression of biological effects induced by endocrine …
Y Fujii-Kuriyama, J Mimura - iupac.org
... Synergistic transactivation by SP1 and AhR/Arnt heterodimer is con- sidered to be
a common mechanism for inducible expression of the drug-metabolizing enzymes ...
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Symposium: _Other (free) topic_
GG Tolna, A Stephenson, P Rehling, P Kovermann, R … - wissenschaft-online.de
... Gel mobility shift assays with various DNA fragments indicated that the GC-Box,
SP1, Ahr/Arnt binding sites interact specifically with nuclear protein (s) of ...
View as HTML - Web Search - wissenschaft-online.de

3-Methylcholanthrene Activates Human Immunodeficiency Virus Type 1 Replication via Aryl Hydrocarbon … - Full text - MIT Libraries
H Ohata, T Tetsuka, H Hayashi, K Onozaki, T … - Microbiol. Immunol, 2003 - sanbi.co.jp
... Additionally, it remains to be clarified whether AhR interacts with Sp1 in cells
treated with 3-MC since the binding between Sp1 and AhR were reported (16). ...
View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - sanbi.co.jp

Structure and Expression of the Mouse AhR Nuclear Translocator(mArnt) Gene - Full text - MIT Libraries
F Wang, J Gao, J Mimura, A Kobayashi, K Sogawa, Y … - J Biol Chem, 1998 - intl.jbc.org
... Aryl hydrocarbon receptor (AhR) nuclear translocator (Arnt) gene has been isolated
and ... Among them, Sp1 and Sp3, and CAAT-box binding factor-A were identified ...
Cited by 12 - Web Search - jbc.org - jbc.org - ncbi.nlm.nih.gov

Histone deacetylase 1 can repress transcription by binding to Sp1 - Full text - MIT Libraries
A Doetzlhofer, H Rotheneder, G Lagger, M Koranda, … - Mol. Cell. Biol, 1999 - mcb.asm.org
... Kuriyama. 1996. Cooperative interaction between AhR.Arnt and Sp1 for the
drug-inducible expression of CYP1A1 gene. J. Biol. Chem. ...
Cited by 95 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor … - Full text - MIT Libraries
R Muangmoonchai, D Smirlis, SC Wong, M Edwards, IR … - Biochem J, 2001 - biochemj.org
... requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1 ... 2001
Biochemical Society Page 3. 73 CYP2B1 gene regulation by CAR, SRC-1 and Sp1 ...
Cited by 22 - View as HTML - Web Search - biochemj.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

A novel computational approach for the prediction of networked transcription factors of Ah-receptor … - Full text - MIT Libraries
A Kel, S Reymann, V Matys, P Nettesheim, E … - Molecular Pharmacology, 2004 - molpharm.aspetjournals.org
... are: HNF1/Sp1 and AP-1/NF-1 for the max. distance R=100bp; E2F/NF-1,
AhR/Myb, HNF3/NFY, HNF6/NF-kappaB, and Sp1/Myb for the max. ...
Cited by 3 - Web Search - molpharm.org - molpharm.aspetjournals.org - ncbi.nlm.nih.gov - all 5 versions »

Characterization of the survival motor neuron (SMN) promoter provides evidence for complex … - Full text - MIT Libraries
R Rouget, F Vigneault, C Codio, C Rochette, I … - Biochem. J, 2005 - biochemj.org
... annotated in Figure 2. The potential Sp1, Ets, AhR and IL-6 cis-elements were
explored further. Electrophoretic mobility shift assays To ...
Cited by 1 - View as HTML - Web Search - biochemj.org - ncbi.nlm.nih.gov

[CITATION] Assessment of metabolites and AhR and CYP1A1 mRNA expression subsequent to prenatal exposure to …
J Wu, A Ramesh, T Nayyar, DB Hood
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… -mediated disruption of vitellogenin synthesis in the fish liver: Cross-talk between AHR- and ERα- … - Full text - MIT Libraries
V Bemanian, R Male, A Goksoeyr - Comparative Hepatology, 2004 - dx.doi.org
... been described [34]; in addition, it has been shown that both AHR/ARNT complex
[35] and ERα are able to interact with general transcription factor Sp1 [36,37 ...
Cited by 1 - Web Search - pubmedcentral.nih.gov - comparative-hepatology.com - citebase.eprints.org - all 9 versions »

… polkappa: testis-specific developmental regulation and AhR-dependent inducible transcription - Full text - MIT Libraries
T Ogi, J Mimura, M Hikida, H Fujimoto, Y Fujii- … - Genes to Cells, 2001 - blackwell-synergy.com
... putative Sp1 binding sequence are located upstream of P1a, but P1a lacks a TATA
box (Fig. 1). In addition, two sequences similar to the consensus AhR binding ...
Cited by 15 - Web Search - ingentaconnect.com - genestocellsonline.org - ncbi.nlm.nih.gov - all 5 versions »

Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel … - Full text - MIT Libraries
R URRUTIA - Biochem. J, 2002 - biochemj.org
... with Sp1, both BTEB3 and BTEB4 can repress the TCDD- and 3-MC-induced CYP1A1 promoter
activity via the BTE site. We also show that, as opposed to AhR, BTEB4 is ...
Cited by 5 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

… Fluorescent Protein (GFP) as a Marker of Aryl Hydrocarbon Receptor (AhR) Function in Developing … - Full text - MIT Libraries
GFP AhR-regulated, D Homogenizer, F Scientific - Environmental Health Perspectives, 2001 - ehp.niehs.nih.gov
... AhR- regulated gene CYP1A1 to the cDNA sequences of firefly luciferase and jellyfish
GFP, respectively. The 5 CYP1A1 promoter region includes a TATA box, Sp1, ...
Cited by 10 - View as HTML - Web Search - ehpnet1.niehs.nih.gov - ehis.niehs.nih.gov - csa.com - all 5 versions »

Polymorphism of tandem repeat in promoter of 5-lipoxygenase in ASA-intolerant asthma: a positive … - Full text - MIT Libraries
SH Kim, JS Bae, CH Suh, DH Nahm, JW Holloway, HS … - Allergy, 2005 - ncbi.nlm.nih.gov
... However, there was a strong association of the ALOX5 Sp1 repeat polymorphism with
airway hyperresponsiveness (AHR; PC20 methacholine); AIA patients carrying a ...
Web Search

Transactivation Domains Facilitate Promoter Occupancy for the Dioxin-Inducible CYP1A1 Gene In Vivo
HP KO, ST OKINO, Q MA, JP WHITLOCK JR - Plasmid - mcb.asm.org
... C-terminal half of AhR during the induction of CYP1A1 transcription by TCDD; in
contrast, the transactivation domain of Sp1 cannot substitute for AhR in this ...
Cited by 25 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

… the transactivation domain of the aryl hydrocarbon receptor (AhR) inhibit AhR and estrogen receptor … - Full text - MIT Libraries
RK Reen, A Cadwallader, GH Perdew - Arch. Biochem. Biophys, 2002 - cas.psu.edu
... number of the amino acid residues in the Q-rich subdomains of the AhR TAD from ...
Q-rich TADs of several transcription factors such as Sp1, TF(II)130, GAGA, and NF ...
Cited by 9 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Functional Analysis of BTEB3 and BTEB4, a novel Sp1-like protein, Reveal a Subfamily of …
JA Kaczynski, AA Conley, MF Zapico, SM Delgado - biochemj.org
... characterization of the AhR and Arnt transcriptional activators [6]. In addition,
deletion of the BTE site in the CYP1A1 promoter, a target of Sp1 and Sp1-like ...
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ERalpha-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin … - Full text - MIT Libraries
TV Beischlag, GH Perdew - Journal of Biological Chemistry, 2005 - jbc.org
... that the ER interaction domain within AHR resides within the P/S/T region of the
transactivation domain of AHR (Fig. 1A). GST fusion chimeras of Sp1 and VP16 ...
Web Search - jbc.org - ncbi.nlm.nih.gov

Ceramide Reduction and Transcriptional Up-Regulation of Glucosylceramide Synthase through … - Full text - MIT Libraries
Y Uchida, M Itoh, Y Taguchi, S Yamaoka, H Umehara, … - Cancer Research, 2004 - cancerres.aacrjournals.org
... putative regulatory elements were evident, including five GC-rich Sp1 sites. Among
the recognized transcription factor-binding sites, which include AhR, NF- B ...
Cited by 2 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

Modulation of AhR-Mediated CYP1A1 mRNA and EROD Activities by 17ss-Estradiol and Dexamethasone in … - Full text - MIT Libraries
KP Lai, MH Wong, CKC Wong - Toxicological Sciences, 2004 - toxsci.oupjournals.org
... Role of the transcription activaton and DNA binding of AhR. J. Biol. ... in muscle cells
is increased by glucocorticoids through a mechanism involving Sp1 and MEK1 ...
Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - csa.com - all 8 versions »

Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast …
S Safe, M Wormke, I Samudio - J. Mammary Gland Biol. Neoplasia, 2000 - kluweronline.com
... This novel mecha- nism of repression involves at least four different transcription
factors (Sp1, ER , AhR and Arnt) and Page 8. 302 Safe, Wormke, and Samudio ...
Cited by 17 - Web Search - springerlink.com - microvet.arizona.edu - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Chapter 2.8 Modulation of Soluble Receptor Signaling by Coregulators
M KUMAR, GH PERDEW - cas.psu.edu
... Ah receptor (AhR) 41 and NF-κB 42 . ... translocator (ARNT)/single-minded (PAS) domain
43 (Figure 2.8.1), which are found in the AhR, ARNT, and ...
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Dioxin induces localized, graded changes in chromatin structure: implications for Cyp1A1 gene … - Full text - MIT Libraries
ST Okino, JP Whitlock Jr - Mol. Cell. Biol, 1995 - mcb.asm.org
... DNA interactions on the Cyp1A1 enhancer; LMPCR analysis with primer set B. Binding
sites for AhR/Arnt, Sp1, and the G-box- binding protein (GBP) are indicated. ...
Cited by 40 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov - all 5 versions »

AhR and PPAR a: antagonistic effects on CYP 2 B and CYP 3 A, and additive inhibitory effects on CYP …
Z Shaban, M Soliman, S El-Shazly, K El-Bohi, A … - Xenobiotica, 2005 - taylorandfrancis.metapress.com
... AhR and PPARa: antagonistic effects on CYP2B and CYP3A, and additive inhibitory
effects on CYP2C11 ... Keywords: AhR, PPAR , CYP2B, CYP 2C11, CYP3A Introduction ...
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Aryl Hydrocarbon Receptor Gene Silencing with Small Inhibitory RNA Differentially Modulates Ah- … - Full text - MIT Libraries
M Pharmacol - Mol Pharmacol, 2003 - molpharm.aspetjournals.org
... Cells were transfected with siRNA for lamin A (iLMN) and iAhR, and whole-cell extracts
were analyzed for AhR and Sp1 proteins by Western blot analysis as ...
Cited by 10 - Web Search - dx.doi.org - molpharm.aspetjournals.org - ncbi.nlm.nih.gov

Differential regulation of mouse Ah receptor gene expression in cell lines of different tissue … - Full text - MIT Libraries
CT FitzGerald, P Fernandez-Salguero, FJ Gonzalez, … - Arch Biochem Biophys, 1996 - ingentaconnect.com
... to another, this finding was also confirmed by measurements of AHR mRNA steady ... which
include several putative binding sites for the transcription factor Sp1. ...
Cited by 14 - Web Search - ncbi.nlm.nih.gov

Mechanisms of estrogen action - Full text - MIT Libraries
S Nilsson, S Makela, E Treuter, M Tujague, J … - Physiol Rev, 2001 - intl-physrev.physiology.org
... 292). Another example of indirect action on DNA is the physical interaction
of ER with the Sp1 transcription factor (25, 277, 289). ...
Cited by 213 - Web Search - physrev.physiology.org - physrev.physiology.org - ncbi.nlm.nih.gov

Original article Polymorphism of tandem repeat in promoter of 5-lipoxygenase in ASA-intolerant … - Full text - MIT Libraries
SH Kim, JS Bae, CH Suh, DH Nahm, JW Holloway, HS … - Allergy, 2005 - blackwell-synergy.com
... However, there was a strong association of the ALOX5 Sp1 repeat polymorphism with
airway hyperresponsiveness (AHR; PC 20 methacholine); AIA patients carrying a ...
Web Search

Mechanism of action and development of selective aryl hydrocarbon receptor modulators for treatment … - Full text - MIT Libraries
S Safe, A McDougal - Int. J. Oncol, 2002 - 147.52.72.117
... For example, binding of the AhR complex to the upstream iDRE in the cathepsin D
gene promoter (-175 to -181) disrupts formation of the ER/Sp1 complex which is ...
Cited by 9 - View as HTML - Web Search - virology.med.uoc.gr - ncbi.nlm.nih.gov

Interaction between Dioxin Signaling and Sex Steroid Hormones - Full text - MIT Libraries
H Sone, J Yonemoto - Journal of Health Science, 2002 - jhs.pharm.or.jp
... 28) Kobayashi, A., Sogawa, K. and Fujii-Kuriyama, Y. (1996) Cooperative interaction
between AhR.Arnt and Sp1 for the drug-inducible expression of CYP1A1 gene. ...
Cited by 1 - Web Search - jhs.pharm.or.jp - csa.com

Transcriptional activation of cathepsin D gene expression by 17beta-estradiol: mechanism of aryl …
F Wang, I Samudio, S Safe - Mol. Cell. Endocrinol, 2001 - ingentaconnect.com
... formation of a transcriptionally active estrogen receptor (ER)-Sp1 complex. ... and
inhibition of E2-induced transactivation involves inhibitory AhR crosstalk with ...
Cited by 16 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

Biotin Supplementation Increases Expression of the Cytochrome P 450 1B1 Gene in Jurkat Cells, … - Full text - MIT Libraries
R Rodriguez-Melendez, JB Griffin, J Zempleni - J. Nutr, 2004 - nutrition.org
... Collectively, these data are consistent with the hypothesis that Sp1/Sp3 (rather
than AhR/ARNT) mediate effects of biotin on the transcriptional activity of ...
Cited by 2 - Web Search - nutrition.org - ncbi.nlm.nih.gov

The aryl hydrocarbon receptor interacts with transcription factor IIB - Full text - MIT Libraries
HI Swanson, JH Yang - Mol. Pharmacol, 1998 - molpharm.aspetjournals.org
... Kobayashi A, Sogawa K and Fujii-Kuriyama Y (1996) Cooperative interaction between
AhR-Arnt and Sp1 for the drug-inducible expression of CYP1A1 gene. ...
Cited by 19 - Web Search - molpharm.org - molpharm.org - ncbi.nlm.nih.gov - all 5 versions »

Gene Expression Assay for Hazard Assessment of Chemicals
F Otsuka - Industrial Health, 2002 - niih.go.jp
... protease, one of the ER responsive sequence comprises the ERE half site, the Sp1
site and XRE (xenobiotic responsive element), the target site of AhR. ...
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Transcriptional Activation by the Mouse Ah Receptor - Full text - MIT Libraries
IBM STIMULATORY, I FUNCTIONS - J. Biol. Chem, 2002 - jbc.org
... Similarly, by analogy with findings for Sp1, the AhR's glutamine/proline-rich
transactivating domains may interact with TATA-binding protein (Emili et al., 1994 ...
Web Search - jbc.org