Cooperative interaction between AhR. Arnt and Sp1 for the drug-inducible expression of CYP1A1 gene - Full text - MIT Libraries
A Kobayashi, K Sogawa, Y Fujii-Kuriyama - J. Biol. Chem, 1996 - jbc.org
... Biochemistry and Molecular Biology, Inc. Cooperative Interaction between AhR
Arnt and Sp1 for the Drug-inducible Expression of CYP1A1 Gene. ...
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Regulation of constitutive gene expression through interactions of Sp1 protein with the nuclear aryl … - Full text - MIT Libraries
F Wang, W Wang, S Safe - Biochemistry, 1999 - ncbi.nlm.nih.gov
... The functional interactions of Sp1 with AhR-Arnt were paralleled by physical
interactions showing that AhR-Arnt and Sp1 proteins were co-immunoprecipitated and ...
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Proteasome inhibition induces nuclear translocation of the dioxin receptor through an Sp1 and … - Full text - MIT Libraries
B Santiago-Josefat, PM Fernandez-Salguero - J Mol Biol, 2003 - ncbi.nlm.nih.gov
... These data suggest that cellular control of protein kinase C activity, through Sp1
and ARNT, could regulate AhR transcriptional activity in the absence of ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

Critical Enhancer Region to Which AhR/ARNT and Sp 1 Bind in the Human CYP 1 B 1 Gene - Full text - MIT Libraries
Y Tsuchiya, M Nakajima, T Yokoi - Journal of Biochemistry, 2003 - jb.oupjournals.org
... MOLECULAR BIOLOGY. Critical Enhancer Region to Which AhR/ARNT and Sp1 Bind in the
Human CYP1B1 Gene. Yuki Tsuchiya , Miki Nakajima and Tsuyoshi Yokoi + ...
Cited by 4 - Web Search - p.kanazawa-u.ac.jp - ingentaconnect.com - ncbi.nlm.nih.gov - all 7 versions »

Histone deacetylase 1 can repress transcription by binding to Sp1 - Full text - MIT Libraries
A Doetzlhofer, H Rotheneder, G Lagger, M Koranda, … - Mol. Cell. Biol, 1999 - mcb.asm.org
... Kuriyama. 1996. Cooperative interaction between AhR.Arnt and Sp1 for the
drug-inducible expression of CYP1A1 gene. J. Biol. Chem. ...
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[CITATION] Cooperative Interaction between AhR bullet Arnt and Sp1 for the Drug-inducible Expression...
S In, PST Access, S Up
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Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel … - Full text - MIT Libraries
R URRUTIA - Biochem. J, 2002 - biochemj.org
... nuclear translocator (Arnt) transcriptional acti- vators [6]. In addition, deletion
of the BTE site in the CYP1A1 promoter, a target of Sp1 and Sp1-like ...
Cited by 5 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor … - Full text - MIT Libraries
R Muangmoonchai, D Smirlis, SC Wong, M Edwards, IR … - Biochem J, 2001 - biochemj.org
... requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1 ... 2001
Biochemical Society Page 3. 73 CYP2B1 gene regulation by CAR, SRC-1 and Sp1 ...
Cited by 22 - View as HTML - Web Search - biochemj.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Toxicite de la dioxine: role des proteines" PAS
P Lesca, T Pineau - Med Sci, 1999 - ist.inserm.fr
... complexe, sui- vant la reconnaissance spécifique d’un motif XRE, exerce une transac-
tivation génique durant laquelle AHR coopère avec Sp1 et Arnt avec CBP ...
Cited by 2 - View as HTML - Web Search

… translocation of hypoxia-inducible factor-1 (HIF-1): heterodimerization with ARNT is not necessary … - Full text - MIT Libraries
D Chilov, G Camenisch, I Kvietikova, U Ziegler, M … - J. Cell Sci, 1999 - jcs.biologists.org
... ARNT polyclonal IgG antibodies and the mouse anti-ARNT monoclonal antibody ...
Rabbit-anti Sp1 polyclonal IgG antibodies were purchased from SantaCruz Biotechnology ...
Cited by 40 - Web Search - jcs.biologists.org - elib.tiho-hannover.de - ncbi.nlm.nih.gov

Functional Analysis of BTEB3 and BTEB4, a novel Sp1-like protein, Reveal a Subfamily of …
JA Kaczynski, AA Conley, MF Zapico, SM Delgado - biochemj.org
... Interaction between ArH-Arnt and Sp1 for the Drug-inducible Expresion of
CYP1A1 genes. J. Biol. Chem. 271, 12310-12316 16. Song, A ...
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Symposium: _Other (free) topic_
GG Tolna, A Stephenson, P Rehling, P Kovermann, R … - wissenschaft-online.de
... Gel mobility shift assays with various DNA fragments indicated that the GC-Box,
SP1, Ahr/Arnt binding sites interact specifically with nuclear protein (s) of ...
View as HTML - Web Search - wissenschaft-online.de

Topic 1.13 Transcriptional roles of AhR in expression of biological effects induced by endocrine …
Y Fujii-Kuriyama, J Mimura - iupac.org
... Synergistic transactivation by SP1 and AhR/Arnt heterodimer is con- sidered to be
a common mechanism for inducible expression of the drug-metabolizing enzymes ...
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Induction of VEGF gene expression by retinoic acid through Sp1-binding sites in retinoblastoma Y79 … - Full text - MIT Libraries
H Akiyama, T Tanaka, T Maeno, H Kanai, Y Kimura, S … - Invest Ophthalmol Vis Sci, 2002 - iovs.org
... hypoxia-inducible factor-1 /aryl hydrocarbon receptor translocator (HIF-1 /ARNT)
heterodimer and ... in response to IL-1ß and TNF- is mediated by Sp1-binding sites ...
Cited by 5 - Web Search - iovs.org - ncbi.nlm.nih.gov

Functional and physical interactions between the estrogen receptor Sp 1 and nuclear aryl hydrocarbon … - Full text - MIT Libraries
F Wang, D Hoivik, R Pollenz, S Safe - Nucleic Acids Research, 1998 - nar.oupjournals.org
... Interaction of ER/Sp1 and AhR/ARNT complexes. ... Figure 7. Co-immunoprecipitation
of in vitro translated 35 S-labeled ER with AhR, ARNT and Sp1. ...
Cited by 43 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Cyclin dependent kinase inhibitor p 27 Kip 1 is upregulated by hypoxia via an ARNT dependent pathway - Full text - MIT Libraries
G Wang, R Reisdorph, RE Clark, R Miskimins, R … - Journal of Cellular Biochemistry, 2003 - doi.wiley.com
... Kip1 Is Upregulated by Hypoxia Via an ARNT Dependent Pathway ... Hepa-1 produces
functional aryl hydrocarbon receptor nuclear translocator (ARNT). ...
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ERalpha-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin … - Full text - MIT Libraries
TV Beischlag, GH Perdew - Journal of Biological Chemistry, 2005 - jbc.org
... 1, 2) we were able to demonstrate an interaction between ER and AHR or ARNT. ... GST
fusion chimeras of Sp1 and VP16 failed to precipitate in vitro translated ER . ...
Web Search - jbc.org - ncbi.nlm.nih.gov

A novel positive regulatory element that enhances hamster CYP2A8 gene expression mediated by … - Full text - MIT Libraries
K Kurose, M Tohkin, M Fukuhara - Mol Pharmacol, 1999 - molpharm.org
... Cooperative Transcriptional Enhancement of AhR-Arnt with Sp1. We ... Arnt and
Sp1 for the drug-inducible expression of CYP1A1 gene. J ...
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Transcriptional activation of c-fos protooncogene by 17ss-estradiol: Mechanism of aryl hydrocarbon … - Full text - MIT Libraries
R Duan, W Porter, I Samudio, C Vyhlidal, M Kladde, … - Mol. Endocrinol, 1999 - mend.endojournals.org
... 2 ). ER but not AhR/Arnt enhanced Sp1-DNA binding (lanes 3 and 4), and in unlabeled
oligonucleotide competition studies (lanes 6–8), Sp1 but not mutant Sp1 ...
Cited by 34 - Web Search - mend.endojournals.org - ncbi.nlm.nih.gov

Cellular and molecular biology of aryl hydrocarbon (Ah) receptor-mediated gene expression
S Safe, V Krishnan - Arch Toxicol Suppl, 1995 - ncbi.nlm.nih.gov
... the nucleus as an Ah-receptor:aryl hydrocarbon nuclear translocator (Arnt) protein
heterodimeric ... and this is associated with formation of an ER/Sp1 complex at ...
Cited by 35 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Aryl hydrocarbon receptor/dioxin receptor in human monocytes and macrophages
K Komura, S Hayashi, I Makino, L Poellinger, H … - Mol. Cell. Biochem, 2001 - springerlink.com
... a GC-rich motif that binds Sp1 protein and core sequence of a XRE element, and physical
and functional interactions between the Sp1 and AhR/Arnt complex were ...
Cited by 6 - Web Search - kluweronline.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Differential Recruitment of Coactivator RIP140 by Ah and Estrogen Receptors - Full text - MIT Libraries
MB Kumar, RW Tarpey, GH Perdew - J Biol Chem, 1999 - jbc.org
... Sp1, AhR, and ARNT were found to synergistically enhance both transcription in in
vitro transcription assays and reporter gene activity in transient ...
Cited by 62 - Web Search - jbc.org - cas.psu.edu - ncbi.nlm.nih.gov

Computational analysis of composite regulatory elements - Full text - MIT Libraries
P Qiu, W Ding, Y Jiang, JR Greene, L Wang - Mammalian Genome, 2002 - springerlink.com
... FREAC3 FREAC7 220.8 PBX1 TATA 66.3 SP1 USF 33.0 ARNT GRE 220.0 ATF P53 63.4 MZF1
SP1 32.8 E4BP4 Oct-1 209.3 MYCMAX SP1 63.1 FREAC4 ISRE 32.8 ...
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Dioxin induces localized, graded changes in chromatin structure: implications for Cyp1A1 gene … - Full text - MIT Libraries
ST Okino, JP Whitlock Jr - Mol. Cell. Biol, 1995 - mcb.asm.org
... DNA interactions on the Cyp1A1 enhancer; LMPCR analysis with primer set B. Binding
sites for AhR/Arnt, Sp1, and the G-box- binding protein (GBP) are indicated. ...
Cited by 40 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov - all 5 versions »

Interaction between Dioxin Signaling and Sex Steroid Hormones - Full text - MIT Libraries
H Sone, J Yonemoto - Journal of Health Science, 2002 - jhs.pharm.or.jp
... 28) Kobayashi, A., Sogawa, K. and Fujii-Kuriyama, Y. (1996) Cooperative interaction
between AhR.Arnt and Sp1 for the drug-inducible expression of CYP1A1 gene. ...
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The aryl hydrocarbon receptor interacts with transcription factor IIB - Full text - MIT Libraries
HI Swanson, JH Yang - Mol. Pharmacol, 1998 - molpharm.aspetjournals.org
... Kobayashi A, Sogawa K and Fujii-Kuriyama Y (1996) Cooperative interaction between
AhR-Arnt and Sp1 for the drug-inducible expression of CYP1A1 gene. ...
Cited by 19 - Web Search - molpharm.org - molpharm.org - ncbi.nlm.nih.gov - all 5 versions »

Aryl Hydrocarbon Receptor Gene Silencing with Small Inhibitory RNA Differentially Modulates Ah- … - Full text - MIT Libraries
M Pharmacol - Mol Pharmacol, 2003 - molpharm.aspetjournals.org
... HepG2 cells were transfected with iAhR, iLMN, or iARNT, and AhR, ARNT, or Sp1 proteins
were determined in the various treatment groups by Western blot analysis ...
Cited by 10 - Web Search - dx.doi.org - molpharm.aspetjournals.org - ncbi.nlm.nih.gov

3-Methylcholanthrene Activates Human Immunodeficiency Virus Type 1 Replication via Aryl Hydrocarbon … - Full text - MIT Libraries
H Ohata, T Tetsuka, H Hayashi, K Onozaki, T … - Microbiol. Immunol, 2003 - sanbi.co.jp
... Cooperative interaction between AhR.Arnt and Sp1 for the drug-inducible
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Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast …
S Safe, M Wormke, I Samudio - J. Mammary Gland Biol. Neoplasia, 2000 - kluweronline.com
... This novel mecha- nism of repression involves at least four different transcription
factors (Sp1, ER , AhR and Arnt) and Page 8. 302 Safe, Wormke, and Samudio ...
Cited by 17 - Web Search - springerlink.com - microvet.arizona.edu - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2, 3, 7, 8- … - Full text - MIT Libraries
V Krishnan, W Porter, M Santostefano, X Wang, S … - Molecular and Cellular Biology, 1995 - mcb.asm.org
... complex to the ER/Sp1 oligonucleotide was further investigated with an Ah receptor
complex formed by reconstituting the Ah receptor and Arnt proteins expressed ...
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Epigenetic regulation of 11ss-hydroxysteroid dehydrogenase type 2 expression - Full text - MIT Libraries
R Alikhani-Koopaei, F Fouladkou, FJ Frey, BM Frey - J. Clin. Invest, 2004 - jci.org
... Methylation of recognition sequences of transcription factors, including those for
Sp1/Sp3, Arnt, and nuclear factor 1 (NF1) diminished their DNA-binding ...
Cited by 1 - Web Search - pubmedcentral.nih.gov - jci.org - ncbi.nlm.nih.gov

Biotin Supplementation Increases Expression of the Cytochrome P 450 1B1 Gene in Jurkat Cells, … - Full text - MIT Libraries
R Rodriguez-Melendez, JB Griffin, J Zempleni - J. Nutr, 2004 - nutrition.org
... 23. Tsuchiya, Y., Nakajima, M. & Yokoi, Y. (2003) Critical enhancer region to which
AhR/ARNT and Sp1 bind in the human CYP1B1 gene. J. Biochem. 133:583-592. ...
Cited by 2 - Web Search - nutrition.org - ncbi.nlm.nih.gov

Structure and Expression of the Mouse AhR Nuclear Translocator(mArnt) Gene - Full text - MIT Libraries
F Wang, J Gao, J Mimura, A Kobayashi, K Sogawa, Y … - J Biol Chem, 1998 - intl.jbc.org
... Among them, Sp1 and Sp3, and CAAT-box binding factor-A were identified to ... Expression
of MyoD in HeLa cells stimulated the Arnt promoter activity by binding to ...
Cited by 12 - Web Search - jbc.org - jbc.org - ncbi.nlm.nih.gov

Transactivation Domains Facilitate Promoter Occupancy for the Dioxin-Inducible CYP1A1 Gene In Vivo
HP KO, ST OKINO, Q MA, JP WHITLOCK JR - Plasmid - mcb.asm.org
... Arnt (744-776) , and pG-Sp1 B were cotransfected with 5 g of the reporter plasmid
pGECAT into wild-type hepatoma cells by using a Polybrene method (15). ...
Cited by 25 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

Exposure of Mouse Preimplantation Embryos to 2, 3, 7, 8-Tetrachlorodibenzo-P-dioxin(TCDD) Alters the … - Full text - MIT Libraries
Q Wu, S Ohsako, R Ishimura, JS Suzuki, C Tohyama - Biology of Reproduction, 2004 - bioone.org
... preimplantation development [28] , and an in vitro transcription study using CYP1A1
promoter showed synergistic enhancing effects between AhR/Arnt and Sp1 [29 ...
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Isolation and characterization of the human cytochrome P 450 CYP 1 B 1 gene. - Full text - MIT Libraries
YM Tang, YY Wo, J Stewart, AL Hawkins, CA Griffin, … - J Biol Chem, 1996 - jbc.org
... Home page Y. Tsuchiya, M. Nakajima, and T. Yokoi Critical Enhancer Region to Which
AhR/ARNT and Sp1 Bind in the Human CYP1B1 Gene J. Biochem. ...
Cited by 117 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

An autoregulatory loop controlling CYP1A1 gene expression: role of H 2 O 2 and NFI - Full text - MIT Libraries
Y Morel, N Mermod, R Barouki - Mol Cell Biol, 1999 - mcb.asm.org
... Kuriyama. 1996. Cooperative interaction between AhR.Arnt and Sp1 for the
drug-inducible expression of CYP1A1 gene. J. Biol. Chem. ...
Cited by 31 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov - all 5 versions »

Characterization of the rat Class 3 aldehyde dehydrogenase gene promoter - Full text - MIT Libraries
Y Xie, K Takimoto, HC Pitot, WK Miskimins, R … - Mol. Pharmacol, 1999 - nar.oupjournals.org
... with the large size (>300 kDa) and complexity of an Ah/Arnt-DNA interaction ... with
the probe from -67 to -24 (11/12), which contains the putative Sp1 site (lanes ...
Cited by 4 - Web Search - nar.oupjournals.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

17 beta-Estradiol hydroxylation catalyzed by human cytochrome P450 1B1 - Full text - MIT Libraries
CL Hayes, DC Spink, BC Spink, JQ Cao, NJ Walker, … - Carcinogenesis, 2004 - dx.doi.org
... Home page Y. Tsuchiya, M. Nakajima, and T. Yokoi Critical Enhancer Region to Which
AhR/ARNT and Sp1 Bind in the Human CYP1B1 Gene J. Biochem. ...
Cited by 160 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

BOR Papers in Press. Published on February 11, 2004 as DOI: 10.1095/biolreprod. 103.025387
I Genes - biolreprod.org
... 9 an in vitro transcription study using CYP1A1 promoter showed synergistic
enhancing effects between AhR/Arnt and Sp1 [29]. ... Arnt and Sp1 ...
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The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of … - Full text - MIT Libraries
M Wormke, M Stoner, B Saville, K Walker, M … - Mol Cell Biol, 2003 - mcb.asm.org
... (C) The same membrane reprobed with Sp1 antibody (PEP2 ... TCDD alone (DMSO) and in
combination with proteasome inhibitors (MG132 and PSI) on ER , AhR, Arnt, and ß ...
Cited by 32 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Localization of Xenobiotic-responsive Element Binding Protein in Rat Hepatocyte Nuclei After … - Full text - MIT Libraries
Y Asaka, J Watanabe, S Kanamura - J Histochem Cytochem, 1998 - jhc.org
... Kobayashi A, Sogawa K, Fujii–Kuriyama Y (1996) Cooperative interaction between AhR ·
Arnt and Sp1 for the drug-inducible expression of CYP1A1 gene. ...
Cited by 3 - Web Search - jhc.org - ncbi.nlm.nih.gov

MAP kinases and hypoxia in the control of VEGF expression
E Berra, G Pages, J Pouyssegur - Cancer Metastasis Rev, 2000 - kluweronline.com
... remains to be resolved, our investiga- tion has revealed that Sp1 is a ... HIF-1β is
the already characterized ARNT previously shown to heterodimerize with the AHR ...
Cited by 46 - Web Search - springerlink.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Pancreatic cancer research: challenges, opportunities, and recent developments.
ME Fernandez-Zapico, JA Kaczynski, R Urrutia - Current Opinion in Gastroenterology, 2002 - co-gastroenterology.com
... In addition, the binding of Sp1 to the BTE site is facilitated by interaction
with the AhR/Arnt heterodimer and vice versa. BTEB1 ...
Web Search - co-gastroenterology.com

Hypoxia-inducible Factor 1 alpha (HIF-1 alpha) Protein Is Rapidly Degraded by the Ubiquitin- … - Full text - MIT Libraries
ITSSBYHD ON, RI CHANGES - Pediatr. Res, 2004 - jbc.org
... accumulation of the complex. No effects were observed on SP1 binding activity.
Supershift assays against HIF-1 and ARNT (Fig. 5B) confirmed ...
Web Search - jbc.org

Dioxin-responsive AHRE-II gene battery: identification by phylogenetic footprinting - Full text - MIT Libraries
PC Boutros, ID Moffat, MA Franc, N Tijet, J … - Biochem Biophys Res Commun, 2004 - okeylabimac.med.utoronto.ca
... between the AHR complex and the ubiqui- tous Sp1 regulatory protein ... First, the AHRÕs
heterodimerization partner protein, ARNT, was shown to directly interact ...
Cited by 5 - View as HTML - Web Search - ncbi.nlm.nih.gov

Green Fluorescent Protein (GFP) as a Marker of Aryl Hydrocarbon Receptor (AhR) Function in … - Full text - MIT Libraries
GFP AhR-regulated, D Homogenizer, F Scientific - Environmental Health Perspectives, 2001 - ehp.niehs.nih.gov
... It was first important to determine whether AhR and Arnt were expressed during ... The
5 CYP1A1 promoter region includes a TATA box, Sp1, NF1 binding sites, and ...
Cited by 10 - View as HTML - Web Search - ehpnet1.niehs.nih.gov - ehis.niehs.nih.gov - csa.com - all 5 versions »

Discrimination Between Related DNA Sites by a Single Amino Acid Residue of Myc-Related Basic-Helix- … - Full text - MIT Libraries
CV Dang, C Dolde, ML Gillison, GJ Kato - Proceedings of the National Academy of Sciences - pnas.org
... IDENTIFICATION OF AN UPSTREAM ACTIVATOR SEQUENCE, ACTIVATION BY Sp1 AND Sp3, AND
CELL CYCLE ... Function of the Basic Helix-Loop-Helix/PAS Factor Arnt J. Biol. ...
Cited by 56 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Molecular interactions of the aryl hydrocarbon receptor and its biological and toxicological … - Full text - MIT Libraries
P Pocar, B Fischer, T Klonisch, S Hombach-Klonisch - Reproduction, 2005 - reproduction-online.org
... Kobayashi A, Sogawa K & Fujii-Kuriyama Y 1996 Cooperative interaction between
AhR.Arnt and Sp1 for the drug-inducible expression of CYP1A1 gene. ...
Cited by 1 - Web Search - reproduction-online.org - ncbi.nlm.nih.gov

A Pathway Leading to Hypoxia-Induced Vascular Fibrin Deposition - Full text - MIT Libraries
MD Shi-Fang Yan, DJ Pinsky, DM Stern - Semin Thromb Hemost, 2000 - thieme-connect.com
... of the tissue factor gene in human epithelial cells is mediated by Sp1 and Egr ... Wood
SM, Gleadle J, Pugh C, Hankinson O, Ratcliffe P. The role of ARNT in hypoxic ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov