A Cross-Talk Between Hypoxia and TGF-b Orchestrates Erythropoietin Gene Regulation Through SP1 and … - Full text - MIT Libraries
T Sanchez-Elsner, JR Ramır, F Rodriguez-Sanz, E … - J. Mol. Biol, 2004 - utminers.utep.edu
... SP1 and Smads ... More- over, Sp1 has been identified as the factor binding the promoter
necessary for the full hypoxia inducibility of the EPO gene. ...
Cited by 7 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The Role of HNF4A Variants in the Risk of Type 2 Diabetes
KL Mohlke, M Boehnke - Current Diabetes Reports, 2005 - f-www.sph.umich.edu
... mutation screens of coding and proximal pro- moter regions of HNF4A have identified ...
one T2DM family, include V393I [57], a deletion of an Sp1 tran- scription ...
View as HTML - Web Search - fusion.sph.umich.edu - ncbi.nlm.nih.gov - Get it from MIT Libraries

Analysis of the HNF4 a gene in Caucasian Type II diabetic nephropathic patients - Full text - MIT Libraries
JA Price, SC Fossey, MM Sale, CS Brewer, BI … - Diabetologia, 2000 - springerlink.com
... sequence suggesting the mutation could have a pronounced effect on HNF4a gene
expression. TheD7promotermutationdeletesoneoftwoputative Sp1 transcription factor ...
Cited by 24 - Web Search - ncbi.nlm.nih.gov

Role of hepatocyte nuclear factors in growth hormone-regulated, sexually dimorphic expression of …
CA WIWI, DJ WAXMAN - Growth Factors, 2004 - dx.doi.org
... with Sp1 to activate the rat CYP2D5 gene (Lee et al., 1994). In the case of CYP3A4,
the major catalyst of drug metabolism in human liver, HNF4a binding to ...
Web Search - taylorandfrancis.metapress.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

The orphan nuclear receptor HNF4alpha determines PXR-and CAR-mediated xenobiotic induction of CYP3A4 - Full text - MIT Libraries
RG Tirona, W Lee, BF Leake, LB Lan, CB Cline, V … - Nat Med, 2003 - nature.com
... Here we show that the orphan nuclear receptor hepatocyte nuclear fac- tor-4α (HNF4α;
HNF4A) is critically involved in the PXR- and CAR-mediated ...
Cited by 55 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

TRANSFAC (R): transcriptional regulation, from patterns to profiles - Full text - MIT Libraries
V Matys, E Fricke, R Geffers, E Gossling, M … - Nucleic Acids Research, 2003 - nar.oupjournals.org
... due to the differences in particular protein domains (gene id HS$HNF4A, factors
ids ... both inducible (GR, NF- B, STAT, AP-1, CREB) and constitutive (Sp1, TBP, NF ...
Cited by 201 - Web Search - pubmedcentral.nih.gov - informatik.uni-leipzig.de - csb.yale.edu - all 13 versions »

Functional characterization of transcription factor binding sites for HNF 1-alpha, HNF 3-beta(FOXA 2 … - Full text - MIT Libraries
H Ceelie, CC Spaargaren-van Riel, M de Jong, RM … - Journal of Thrombosis and Haemostasis, 2003 - ingentaconnect.com
... alpha (HNF4a); À888 to À877, hepatocyte nuclear factor 1 alpha (HNF1a); À886 to
À875, hepatocyte nuclear factor 3 beta (HNF3b); and À854 to À842, Sp1 and ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Dietary polyunsaturated fatty acid regulation of hepatic gene transcription
DB Jump - Scandinavian Journal of Nutrition, 2002 - taylorandfrancis.metapress.com
... CoA, 20:5,n3-CoA or 22:6,n3-CoA inhib- ited HNF4a effects on ... 1c functionally interacts
with ancillary transcription factors, like NF-Y and:or Sp1, which bind ...
Web Search

Dietary polyunsaturated fatty acid regulation of hepatic gene transcription
DB Jump - Scandinavian Journal of Nutrition, 2002 - dx.doi.org
... CoA, 20:5,n3-CoA or 22:6,n3-CoA inhib- ited HNF4a effects on ... 1c functionally interacts
with ancillary transcription factors, like NF-Y and:or Sp1, which bind ...
Web Search - ingentaconnect.com

ORIGINAL ARTICLE ARP1 interacts with the 5'flanking region of the coagulation factor VII gene - Full text - MIT Libraries
JA Carew, AA Jackson, KA Bauer - Journal of Thrombosis and Haemostasis, 2003 - blackwell-synergy.com
... the HNF4 binding site [5,6] and the third within the Sp1 binding site [7 ... In
cotransfections, expression vectors pCDNAI-HNF4A [24] encoding the rat 2 isoform ...
Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

6. Control genico de la expresion del citocromo P-450 en el higado
RJ ATIENZA - ranf.com
... Por ejemplo, hay un sitio de respuesta a HNF4a en el promotor del gen HNF1a [6].
Esto implica me- canismos de regulación ... CYP2D5 C/EBPb & Sp1 Lee-YH, et al. ...
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Insulin Action: Molecular Basis of Diabetes
S Najjar - biochem.wisc.edu
... include hepatic nuclear factor (HNF) 1a (which is upregulated by HNF4a) and the ... sites
in the insulin promoter and the basal elements include Sp1, a negative ...
View as HTML - Web Search - biochem.wisc.edu

Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and … - Full text - MIT Libraries
K Shakib, JT Norman, LG Fine, LR Brown, J Godovac- … - Proteomics, 2005 - doi.wiley.com
... Changes in nuclear receptor transcription factors (THRa1, RORa4, HNF4a, NUR77),
other transcription factors (GATA1, AP-2a, OCT1, ATF6a, ZFP161, ZNF354A, PDCD2 ...
Web Search - ncbi.nlm.nih.gov

The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of … - Full text - MIT Libraries
J Corchero, CP Granvil, TE Akiyama, GP Hayhurst, S … - Mol Pharmacol, 2001 - intl-molpharm.aspetjournals.org
... Moreover, we show in vivo regulation of CYP2D6 by HNF4a. ... controlling the rat CYP2D5
gene and requiring cooperativity between C/EBP beta and an Sp1 factor. ...
Cited by 19 - Web Search - intl-molpharm.aspetjournals.org - ncbi.nlm.nih.gov

Cross-talk between xenobiotic detoxication and other signalling pathways: clinical and toxicological …
JM Pascussi, S Gerbal-Chaloin, L Drocourt, E Ass& … - Xenobiotica, 2004 - dx.doi.org
... These notably include the CCAAT box-binding proteins, SP1, members of hepatocyte
nuclear factor (HNF) family (liver-enriched transcription factors that play ...
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Defining the CREB Regulon: A Genome-Wide Analysis of Transcription Factor Regulatory Regions - Full text - MIT Libraries
S Impey, SR McCorkle, H Cha-Molstad, JM Dwyer, GS … - Cell, 2004 - ohsu.edu
... suggested that these concerns are more than theoretical (Cawley et al., 2004). These
workers examined the binding of Sp1, c-myc, Results ... neuron Hnf4a p75 NGF R ...
Cited by 6 - View as HTML - Web Search - cmu.edu - neuro.med.harvard.edu - ncbi.nlm.nih.gov

Genomic studies of transcription factor–DNA interactions - Full text - MIT Libraries
D Sikder, T Kodadek - Current Opinion in Chemical Biology, 2005 - kodadeklab.swmed.edu
... combined tiled arrays across non-repeat genomic sequences of chromosomes 21 and
22 with chromatin immunoprecipitation to map occupancy sites for Sp1, cMyc and ...
View as HTML - Web Search - ncbi.nlm.nih.gov

The HNF1/HNF4-dependent We2 element of woodchuck hepatitis virus controls viral replication and can … - Full text - MIT Libraries
G Fourel, F Ringeisen, M Flajolet, F Tronche, M … - J. Virol, 1996 - jvi.asm.org
... Sequences of putative binding sites for Sp1 and Oct family pro- teins, based on
perfect ... 5; and B, lanes 4 and 9). Although combined mutations of HNF4a and -b ...
Cited by 17 - Web Search - pubmedcentral.nih.gov - intl-jvi.asm.org - ncbi.nlm.nih.gov

BMC Cancer - Full text - MIT Libraries
M Raponi, RT Belly, JE Karp, JE Lancet, D Atkins, … - BMC Cancer, 2004 - biomedcentral.com
Page 1. ...
View as HTML - Web Search - biomedcentral.com - bmc.ub.uni-potsdam.de

Lipids in Health and Disease - Full text - MIT Libraries
A Berger, DM Mutch, JB German, MA Roberts - Lipids in Health and Disease, 2002 - gdrs-intranet.ath.cx
Page 1. ...
View as HTML - Web Search - bmc.ub.uni-potsdam.de - bmc.ub.uni-potsdam.de - lipidworld.com

ARTICLE IN PRESS
JE Lindsley, J Rutter - biochem.utah.edu
... HNF4a, a member of the steroid hormone receptor super- family that regulates expression
of several key genes in both liver and pancreatic h-cells, is also a ...
View as HTML - Web Search - ttuhsc.edu

Computer-assisted generation of a protein-interaction database for nuclear receptors - Full text - MIT Libraries
S Albert, S Gaudan, H Knigge, A Raetsch, A Delgado … - Mol Endocrinol, 2003 - mend.endojournals.org
Page 1. Computer-assisted generation of a protein- interaction database for nuclear
receptors Abbreviated title: text mining for nuclear receptor interactors ...
Cited by 11 - Web Search - lionbioscience.com - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides
G Lemaire, G de Sousa, R Rahmani - Biochemical Pharmacology, 2004 - antibes.inra.fr
Page 1. A PXR reporter gene assay in a stable cell culture system: CYP3A4 and
CYP2B6 induction by pesticides Géraldine Lemaire * , Georges ...
Cited by 1 - View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries