Importance of Sp 1 consensus motifs in the MYCN promoter
T Inge, LK Casson, W Priebe, JO Trent, KE … - Surgery, 2002 - ncbi.nlm.nih.gov
Click here to read Importance of Sp1 consensus motifs in the MYCN promoter. Inge
TH, Casson LK, Priebe W, Trent JO, Georgeson KE, Miller DM, Bates PJ. ...
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[CITATION] E2F and Sp1/Sp3 Synergize but Are Not Sufficient to Activate the MYCN Gene in Neuroblastomas
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E 2 F and Sp 1/Sp 3 Synergize but Are Not Sufficient to Activate the MYCN Gene in Neuroblastomas - Full text - MIT Libraries
C Kramps, V Strieder, A Sapetschnig, G Suske, W … - J Biol Chem, 2004 - imt.uni-marburg.de
... Binding of E2F and Sp1/Sp3 to the MYCN promoter in vivo correlated with acetylation
of histones H3 and H4 and recruitment of RNA polymerase II and the protein ...
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Cytosine Methylation Does not Affect Binding of Transcription Factor Sp1 - Full text - MIT Libraries
MA Harrington, PA Jones, M Imagawa, M Karin - J. Virol, 2004 - pnas.org
... Kramps, V. Strieder, A. Sapetschnig, G. Suske, and W. Lutz E2F and Sp1/Sp3 Synergize
but Are Not Sufficient to Activate the MYCN Gene in Neuroblastomas J. Biol ...
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The p 53 regulatory gene MDM 2 is a direct transcriptional target of MYCN in neuroblastoma - Full text - MIT Libraries
A Slack, Z Chen, R Tonelli, M Pule, L Hunt, A … - Proceedings of the National Academy of Sciences, 2005 - pnas.org
... results demonstrate direct regulation of MDM2 expression by MYCN and suggest ...
oncoproteins, such as transcription (p300, NF- B, and SP1), differentiation (Numb ...
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Regulation of transcription by the retinoblastoma protein
JM Horowitz - Genes Chromosom Cancer, 1993 - ncbi.nlm.nih.gov
... Factor, Sp1/metabolism; Transcription Factors*; Transcription, Genetic*; Transforming
Growth Factor beta/genetics. Gene Symbols: DHFR; FOS; MYB; MYC; MYCN; RB1; ...
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Identification of Novel Candidate Oncogenes and Tumor Suppressors in Malignant Pleural Mesothelioma … - Full text - MIT Libraries
GJ Gordon, GN Rockwell, RV Jensen, JG Rheinwald, … - American Journal of Pathology, 2005 - ajp.amjpathol.org
Page 1. Tumorigenesis and Neoplastic Progression Identification of Novel Candidate
Oncogenes and Tumor Suppressors in Malignant Pleural ...
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CpG methylation as a mechanism for the regulation of E2F activity - Full text - MIT Libraries
MR Campanero, MI Armstrong, EK Flemington - Am J Physiol Renal Physiol, 2004 - dx.doi.org
... Kramps, V. Strieder, A. Sapetschnig, G. Suske, and W. Lutz E2F and Sp1/Sp3 Synergize
but Are Not Sufficient to Activate the MYCN Gene in Neuroblastomas J. Biol ...
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Human ribonucleotide reductase M2 subunit gene amplification and transcriptional regulation in a …
B Zhou, X Mo, X Liu, W Qiu, Y Yen, S by grant CA … - Cytogenet Cell Genet, 2001 - content.karger.com
... SP1: 5'-ATT CGA TCG GGG CGG GGC GAG C-3 ... probe (Vysis), dual-color BCR?ABI, translocation
probe (Oncor), chromosome 22 BCR probe (Oncor), and MYCN locus-specific ...
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The Ews/Fli-1 fusion gene switches the differentiation program of neuroblastomas to Ewing sarcoma/ … - Full text - MIT Libraries
CJ Rorie, VD Thomas, P Chen, HH Pierce, JP O’ … - Cancer Res, 2004 - intl-cancerres.aacrjournals.org
... C, GeneSpring 5.0 hybridization expression graph for MycN from Affymetrix GeneChip
data ... Sp1 binding sites are present in a number of genes overexpressed in NB ...
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Transcriptional Control of Hepatocanalicular Transporter Gene Expression - Full text - MIT Libraries
M MUeLLER - Seminars in Liver Disease, 2000 - humanabc.4t.com
... NR1B1 DR-1 5 -KGGGCGGRRY-3 or 5 -KRGGCGKRRY-3 MRP1 SP1 5 -CACAGGGCGGCC-3
(Mdr1b) 121 — MRP2 5 -GGGAGGCGGGGACG-3;(Mdr2) 122 Mdr1b Mdr2 ...
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Overexpression of MYC causes p53-dependent G 2 arrest of normal fibroblasts - Full text - MIT Libraries
DW Felsher, A Zetterberg, J Zhu, T Tlsty, JM … - J. Biol. Chem, 2004 - dx.doi.org
... Evidence for Defective G1 Arrest Despite WAF1 Induction in MYCN-Amplified Cells ... Tyner
Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3 PNAS ...
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p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic … - Full text - MIT Libraries
JV Thottassery, GP Zambetti, K Arimori, EG Schuetz … - Proc Natl Acad Sci USA, 1997 - dx.doi.org
... Le Roux, S. Leonce, S. Douc-Rasy, J. Benard, and G. Raguenez MYCN Enhances P ... Sun,
GP Zambetti, A. Troutman, VP Sukhatme, EG Schuetz, and JD Schuetz Sp1 and Egr ...
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Transcriptional Control of Hepatocanalicular Transporter Gene Expression - Full text - MIT Libraries
G TRANSCRIPTION, T FACTORS - Semin Liver Dis, 2000 - thieme-connect.com
... Evidence that SP1 modulates transcriptional activity of the multidrug resistance-
associated ... SB, Gilbert J. Altered expression of the MYCN oncogene modulates ...
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Methylation-associated silencing of the thrombospondin-1 gene in human neuroblastoma - Full text - MIT Libraries
QW Yang, S Liu, Y Tian, HR Salwen, A Chlenski, J … - Cancer Res, 2003 - usp.br
... Cell line Subclone N or S type MYCN amplification Tumorigenic in vivo TSP-1 ... constructs
and its activity Constructs Start End Intron1 Distal SP1 Proximal SP1 ...
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The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from … - Full text - MIT Libraries
MJ Smyth, E Krasovskis, VR Sutton, RW Johnstone - Cancer Res, 2005 - dx.doi.org
... Blanc, D. Goldschneider, E. Ferrandis, M. Barrois, G. Le Roux, S. Leonce, S.
Douc-Rasy, J. Benard, and G. Raguenez MYCN Enhances P ... ROLE OF NF-Y AND Sp1 J. Biol. ...
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Regulation of N-myc expression in development and disease - Full text - MIT Libraries
V Strieder, W Lutz - Cancer Lett, 2002 - imt.uni-marburg.de
... octamer binding site is situated between the E2F- and the Sp1-binding sites ... Bishop,
Targeted expression of MYCN causes neuroblas- toma in transgenic mice, EMBO J ...
Cited by 12 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Combined restriction landmark genomic scanning and virtual genome scans identify a novel human …
K Wimmer, X Zhu, JM Rouillard, PF Ambros, BJ Lamb, … - Genes Chromosomes and Cancer, 2002 - doi.wiley.com
... the binding affinity of sequence- specific transcription factors such as SP1 (Clark
et ... at the Children’s Cancer Research Institute for MYCN amplification (NMA ...
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The subcellular localization of E2F-4 is cell-cycle dependent - Full text - MIT Libraries
GJ Lindeman, S Gaubatz, DM Livingston, D Ginsberg - Proc. Natl. Acad. Sci. USA, 1997 - dx.doi.org
... Home page V. Strieder and W. Lutz E2F Proteins Regulate MYCN Expression in ... and C.
Seiser Histone Deacetylase 1 Can Repress Transcription by Binding to Sp1 Mol. ...
Cited by 97 - Web Search - intl.pnas.org - pnas.org - pubmedcentral.nih.gov - all 6 versions »

The identification of E 2 F 1-specific target genes - Full text - MIT Libraries
J Wells, CR Graveel, SM Bartley, SJ Madore, PJ … - Proceedings of the National Academy of Sciences, 2002 - intl.pnas.org
... target promoters are not GC rich and do not resemble typical Sp1-regulated promoters ...
Home page V. Strieder and W. Lutz E2F Proteins Regulate MYCN Expression in ...
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The effect of potent iron chelators on the regulation of p 53: examination of the expression, … - Full text - MIT Libraries
SX Liang, DR Richardson - Carcinogenesis, 2003 - carcin.oupjournals.org
... its target genes. However, WAF1 may also be transactivated by AP2, Sp1
or the p53 homologs p63 and p73 (13,14). Furthermore, the ...
Cited by 2 - Web Search - carcin.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Aberrant methylation of TMS1 in small cell, non small cell lung cancer and breast cancer - Full text - MIT Libraries
A Virmani, A Rathi, K Sugio, UG Sathyanarayana, S … - Int J Cancer, 2003 - doi.wiley.com
... The TMS1 gene promoter has several transcription factor binding sites, namely E2F
AP-2, WT1, SP1, NRSE, SP1, WT1 and NF- kappaB (p50) associated with the sense ...
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Function and dysfunction of the human oncoprotein MDM2
SP Deb - Frontiers in Bioscience, 2002 - bioscience.org
... Tumor suppressor Rb can replace sp1 from this complex restoring its DNA-binding ... M.,
Amler L., &Schwab M.: Non-syntenic amplification of MDM2 and MYCN in human ...
Cited by 10 - Cached - Web Search - xylian.igh.cnrs.fr - bioscience.org - ncbi.nlm.nih.gov - all 7 versions » - Get it from MIT Libraries

Activin A Suppresses Neuroblastoma Xenograft Tumor Growth via Antimitotic and Antiangiogenic … - Full text - MIT Libraries
E Panopoulou, C Murphy, H Rasmussen, E Bagli, EK … - Cancer Research, 2005 - cancerres.aacrjournals.org
... between SMAD2, SMAD3, and SMAD4 proteins with Sp1 transcription factor ... Amplification
of MYCN in untreated human neuroblastomas correlates with advanced disease ...
Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

Miz1 is required for early embryonic development during gastrulation - Full text - MIT Libraries
S Adhikary, K Peukert, H Karsunky, V Beuger, W … - Mol Cell Biol, 2003 - pubmedcentral.nih.gov
... The MYC (or c-MYC) gene and two of its relatives, MYCL and MYCN, are causally ... have
been identified, including TFII-I (35), YY-1 (38), Smad2 (15), Sp1 (18), and ...
Cited by 4 - Web Search - imt.uni-marburg.de - dx.doi.org - mcb.asm.org - all 5 versions »

HISTONE-DEACETYLASE INHIBITORS: NOVEL DRUGS FOR THE TREATMENT OF CANCER - Full text - MIT Libraries
RW Johnstone - Nature Reviews Drug Discovery, 2002 - nature.com
... 35. Teitz, T. et al. Caspase -8 is deleted or silenced preferentially in childhood
neuroblastomas with amplification of MYCN. Nature Med. 6, 529-535 (2000). ...
Cited by 137 - Web Search - nature.com - ncbi.nlm.nih.gov

Cell cycle regulatory functions of the human oncoprotein MDM2 - Full text - MIT Libraries
SP Deb - Mol Cancer Res, 2003 - intl-mcr.aacrjournals.org
... M., Amler, L., and Schwab, M. Non-syntenic amplification of MDM2 and MYCN in human ...
Johnson-Pais, T., Degnin, C., and Thayer, MJ pRB induces Sp1 activity by ...
Cited by 5 - Web Search - intl-mcr.aacrjournals.org - ncbi.nlm.nih.gov

Identification of Target Genes of Oncogenic Transcription Factors - Full text - MIT Libraries
KE Boyd, PJ Farnham - Proceedings of The Society for Experimental Biology and …, 1999 - ebmonline.org
... Interestingly, they also showed that a nearby Sp1 site contributed to the
repression mediated by E2F1. Others have shown a direct ...
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Neuroblastoma-specific cytotoxicity mediated by the Mash1-promoter and E. coli purine nucleoside …
Y Arvidsson, V Sumantran, F Watt, H Uramoto, K … - Pediatr Blood Cancer, 2005 - doi.wiley.com
... contain common binding sites for the transcription factors SP1 and hairy ... or silenced
preferentially in childhood neuroblastomas with amplification of MYCN. ...
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Distinct transcriptional profiles characterize oral epithelium-microbiota interactions - Full text - MIT Libraries
M Handfield, JJ Mans, G Zheng, MC Lopez, S Mao, A … - Cellular Microbiology, 2005 - blackwell-synergy.com
... multiple transcription factors among which p53, NF-kappaB/rel, Sp1 and c ... Moreover,
CDC2L2 is deleted/translocated in neuroblastomas with MYCN gene amplification ...
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Morpholino antisense oligomer targeting human midkine: Its application for cancer therapy - Full text - MIT Libraries
Y Takei, K Kadomatsu, K Yuasa, W Sato, T Muramatsu - International Journal of Cancer, 2005 - doi.wiley.com
... Examples of these sequence-independent effects include inhibition of viral replication
6 and DNA poly- merases 10 and activation of the transcription factor Sp1 ...
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Complex Transcriptional Effects of p63 Isoforms: Identification of Novel Activation and Repression … - Full text - MIT Libraries
P Ghioni, F Bolognese, PHG Duijf, H van Bokhoven, … - Mol Cell Biol, 2002 - mcb.asm.org
... Lack of homozygously inactivated p73 in single-copy MYCN primary neuroblastomas ...
Different members of the Sp1 multigene family exert opposite transcriptional ...
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Proliferate and survive: cell division cycle and apoptosis in human neuroblastoma - Full text - MIT Libraries
A Borriello, R Roberto, F Della Ragione, A … - Haematologica, 2002 - haematologica.org
... of the p27 Kip1 gene is constitutive, and analysis of the p27 Kip1 promoter
demonstrated that it is controlled by the ubiquitous transcription factor Sp1. ...
Cited by 17 - View as HTML - Web Search - haematologica.it - haematologica.org - ncbi.nlm.nih.gov - all 10 versions »

The Problem of Information for the Theory of Evolution
R Truman - theapologiaproject.org
Page 1. The Problem of Information for the Theory of Evolution Has Tom Schneider
Really Solved It? Royal Truman © 2001 Dr. Royal Truman, Ph.D., Germany. ...
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Analysis of gene expression in the bovine corpus luteum through generation and characterisation of …
OM Casey, R Fitzpatrick, JO McInerney, DG Morris, … - Biochimica et Biophysica Acta, 2004 - bioinf.may.ie
... A cDNA encoding a cofactor required for Sp1 transcription activation was
also identified. Significantly, Sp1 is known to interact ...
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Identification of Target Genes of Oncogenic Transcription Factors (44425)
KE Boyd, PJ Farnham - ingentaconnect.com
Page 1. MINIREVIEW Identification of Target Genes of Oncogenic Transcription
Factors (44425) K ATHRYN E. B OYD AND P EGGY J. F ARNHAM 1 ...
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Basic helix-loop-helix proteins bind to TrkB and p21 (Cip1) promoters linking differentiation and … - Full text - MIT Libraries
Y Liu, M Encinas, JX Comella, M Aldea, C Gallego - Mol. Cell. Biol, 2004 - pubmedcentral.nih.gov
... 1999. Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21
WAF1/CIP1 during NGF-mediated neuronal differentiation. Oncogene 18:2872-2882. ...
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Differential regulation of the N-myc proto-oncogene by RORa and RVR, two orphan members of the … - Full text - MIT Libraries
I Dussault, V GIGUERE - Mol. Cell. Biol, 1997 - mcb.asm.org
... the N-myc gene has a single major promoter that contains a TATA box and Sp1 and
AP2 ... Lo- calization of regulatory elements controlling human MYCN expression. ...
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BMC Cancer - Full text - MIT Libraries
M Raponi, RT Belly, JE Karp, JE Lancet, D Atkins, … - BMC Cancer, 2004 - biomedcentral.com
Page 1. ...
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Genomic organization and refined mapping of the mouse-dystrobrevin gene
NY Loh, HJ Ambrose, LM Guay-Woodford, S DasGupta, … - springerlink.com
... Two potential Sp1-binding sites were identified within 100 bp upstream of the 5 ... The
syntenic region encom- passes the genes SDC1, APOB, MYCN, POMC, ODC1, ID2 ...
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Identifizierung genetischer Laesionen in der Progression und Metastasierung von Bronchialkarzinomen
PDD hcH Meyer, PDJP Rabe, P Saumweber, PDD … - edoc.hu-berlin.de
... Page 13. 13 von MYCN und MYCL lediglich in Kleinzellern vor. ... Dabei ist lediglich
bei den Regionen 1p32 (MYCL), 2p25 (MYCN), 8q24 (MYC) und 11q13 (CycD1) das ...
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The c-MYC oncoprotein as a treatment target in cancer and other disorders of cell growth
S Pelengaris, M Khan - Expert Opinion on Therapeutic Targets, 2003 - dx.doi.org
... Proteins involved in transcriptional regulation, such as MIZ-1, interact with the
CTD of c-MYC, whereas SP1 interacts with the central region of c-MYC. ... SP1 ...
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Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps
WJ Murphy, G Bourque, G Tesler, P Pevzner, SJ O' … - Human Genomics, 2003 - ingentaconnect.com
Page 1. Reconstructing the genomic architecture of mammalian ancestors using
multispecies comparative maps William J. Murphy, 1 * Guillaume ...
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E2F-1 Regulates the Expression of a Subset of Target Genes during Skeletal Myoblast Hypertrophy - Full text - MIT Libraries
S Data, VS Cart - J. Biol. Chem, 2004 - jbc.org
... have been determined for some E2F-1 target genes such as MYCN (68), and ... at the specific
promoter, including transcription factors, such as Sp1 (69), chromatin ...
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Pathology and molecular genetics of oligodendroglial tumors - Full text - MIT Libraries
C Hartmann, W Mueller, A Deimling - Journal of Molecular Medicine, 2004 - springerlink.com
Page 1. J Mol Med (2004) 82:638–655 DOI 10.1007/s00109-004-0565-9 GU EST E DI TO
RR EVI EW Christian Hartmann · Wolf Mueller · Andreas von Deimling ...
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In vivo retinal gene expression in early diabetes - Full text - MIT Libraries
AM Joussen, S Huang, V Poulaki, K Camphausen, WD … - Invest Ophthalmol Vis Sci, 2001 - iovs.org
... Fulda, S, Lutz, W, Schwab, M, Debatin, KM (1999) MycN sensitizes neuroblastoma cells ...
1 beta is mediated through stress-activated MAP kinases and Sp1 sites in ...
Cited by 17 - Web Search - iovs.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Gastrointestinal stromal tumors(GISTs) with KIT and PDGFRA mutations have distinct gene expression … - Full text - MIT Libraries
S Subramanian, RB West, CL Corless, W Ou, BP Rubin … - Oncogene, 2004 - nature.com
... Hs.183109 1.0221565 4.02053 MYCN V-myc myelocytomatosis viral related oncogene ... TLE3
Transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov

Bibliography Current World Literature
E Tumors - Current Opinion in Oncology, 2005 - co-oncology.com
... Burkhart CA, Cheng AJ, Madafiglio J, et al: Effects of MYCN antisense oligonucleotide
administration on tumorigenesis in a murine model of neuroblastoma. ...
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Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review)
F CHANG, LS STEELMAN, JG SHELTON, JT LEE, PM … - Signal transduction - 147.52.72.117
... human fibroblasts (202). c-Myc could downregulate p21 Cip1 by sequestering
its transcription activator Sp1 (187). However, Ets-1 ...
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Control of growth and differentiation of human neuronal and hematopoietic tumour cells via Myc/Max/ …
C Cetinkaya - diss-epsilon.slu.se
Page 1. 1 Control of growth and differentiation of human neuronal and hematopoietic
tumour cells via Myc/Max/Mad- network proteins Cihan Cetinkaya ...
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