Identification of a portable repression domain and an E1A-responsive activation domain in Pax4: a … - Full text - MIT Libraries
Y Fujitani, Y Kajimoto, T Yasuda, TA Matsuoka, H … - Mol Cell Biol, 1999 - mcb.asm.org
... DNA-bound transcription factors such as TBP, USF, ATF2/CRE-BP1, Sp1, and c ... To
investigate whether E1A activates the Pax4 TAD through a similar mechanism, the ...
Cited by 16 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

The REST-mediated transcriptional repression requires the inhibition of Sp1
V Plaisance, G Niederhauser, F Azzouz, V Lenain, … - jbc.org
... inhibition of Sp1 Valérie Plaisance, Guy Niederhauser, Fayçal Azzouz, Vincent
Lenain, ... Running title: REST inhibits the Sp1-mediated activation ...
Web Search - jbc.org

Regulatory Sequence Analysis of Coclustering Genes
A TFBS - ahavj.ahajournals.org
... AP2+SP1, 11/52=21, 5/29=17, 2/11=18, 3/6=50, 5/16=31, 1/3=33, 0/4=0, 3/9=67,
0/1=0, 0/1=0. ... ATF+HFH3+PAX4, 0/52=0, 0/29=0, 0/11=0, 3/6=50, 1/16=6, 0/3=0, 0/4=0, ...
Web Search

Fundamentals of Transcription Factors and Their Impact on Pancreatic Development and Cancer
JAKR Urrutia - Pancreatology, 2003 - content.karger.com
... Sp1 activator embryogenesis 9, 10 ... Isl-1 activator development of endocrine pancreas
26, 27 Pax4 repressor beta and delta cell development 28, 29 ...
Web Search - content.karger.com

Regulation of ATP-sensitive Potassium Channel Subunit Kir 6. 2 Expression in Rat Intestinal Insulin- … - Full text - MIT Libraries
T Hashimoto, T Nakamura, H Maegawa, Y Nishio, K … - J Biol Chem, 2005 - jbc.org
... pancreatic -cells (4, 27), we performed EMSA with anti-MafA, Pax4, and Pax6 ... Next,
we performed a supershift assay using anti-Sp1 and anti-Sp3 antibodies (Fig. ...
Web Search - jbc.org - ncbi.nlm.nih.gov

Transcription Factors in Islet Development and Physiology: Role of PDX-1 in Beta-Cell Function - Full text - MIT Libraries
P Cancer, G Expression, E Tumors - Ann. NY Acad. Sci, 2004 - annalsnyas.org
... 1 (containing the LIM-domain), 5 the paired domain (PD) proteins Pax4 6 and ... 70 whereas
in the human it coactivates with both HNF-1 and SP1 transcription factors ...
Web Search - annalsnyas.org

Developmental biology of gastrin and somatostatin cells in the antropyloric mucosa of the stomach - Full text - MIT Libraries
LI Larsson - Microscopy Research and Technique, 2000 - doi.wiley.com
... phenotype as determined by transcription factors like Pdx-1, Pax4, Pax6, and ... rich
gERE element is known to bind the ubiquitous transcription factor Sp1 and addi ...
Cited by 12 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Fluid shear stress induces endothelial KLF2 gene expression through a defined promoter region
JP Huddleson, S Srinivasan, N Ahmad, JB Lingrel - Biol. Chem, 2004 - degruyter.com
... bp region (-342 to -157 bp) containing all of the Egr-1 and Sp1 binding sites ... These
are loosely defined consensus sequences for Hand1/E47, Oct1, Pax4, and Pax6 ...
Cited by 1 - Web Search - extenza-eps.com - degruyter.de - ijp-online.com - all 10 versions »

The Transcriptional Repressor Nkx6. 1 Also Functions as a DNA Context-Dependent Transcriptional … - Full text - MIT Libraries
T Iype, DG Taylor, SM Ziesmann, JC Garmey, H … - Molecular Endocrinology, 2004 - mend.endojournals.org
... the paired-homeodomain factor Pax4 directly binds to the pax4 promoter and represses ...
binding proteins such as the SP1-like and/or Krüppel-like factors (36). ...
Cited by 1 - Web Search - mend.endojournals.org

Evaluation of the microsomal glutathione S-transferase 3( MGST 3) locus on 1 q 23 as a Type 2 … - Full text - MIT Libraries
F Thameem, X Yang, PA Permana, JK Wolford, C … - Human Genetics, 2003 - springerlink.com
... 2), but the area surrounding the transcription start site has an elevated GC content
(54%) and contains two SP1 binding sites ... 2000) and Pax4 (Xu and Murphy 2000 ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

TranSignal TM GR-TF Interaction Arrays
PU Manual - panomics.com
... AP-1 (1) AP-1 (1) CREB (1) CREB (1) GA T A GA T A NF A T c NF A T c Pit 1 Pit 1
Sp1 Sp1 TR TR 1 AP-1 (1) AP-1 (1) CREB (1) CREB (1) GA T A GA T A NF A T c NF A ...
View as HTML - Web Search - biocat.de

Structural and functional characterization of the human PAX7 5 0-flanking regulatory region - Full text - MIT Libraries
YV Syagailo, O Okladnova, E Reimer, M Graessle, R … - Gene, 2002 - uni-wuerzburg.de
... described TATA- less human PAX2 and mouse Pax4 gene regulatory regions (Stayner
et al., 1998; Brink et al., 2001). Several potential binding sites for Sp1, AP-2 ...
Cited by 2 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

The Transcriptional Repressor Nkx6. 1 Also Functions as a Deoxyribonucleic Acid Context-Dependent … - Full text - MIT Libraries
T Iype, DG Taylor, SM Ziesmann, JC Garmey, H … - Molecular Endocrinology - mend.endojournals.org
... onset diabetes of the young transcription factors control the human PAX4 promoter ...
Kaczynski J, Cook T, Urrutia R 2003 Sp1- and Kruppel-like transcription factors ...
Cited by 2 - Web Search - mend.endojournals.org - ncbi.nlm.nih.gov

TranSignal TM Protein/DNA Arrays
PU Manual, MA MA1014 - panomics.com
... AP-1 (1) AP-1 (1) CREB (1) CREB (1) GA T A GA T A NF A T c NF A T c Pit 1 Pit 1
Sp1 Sp1 TR TR 1 AP-1 (1) AP-1 (1) CREB (1) CREB (1) GA T A GA T A NF A T c NF A ...
View as HTML - Web Search - biocat.de

Genome-wide prediction and analysis of function-specific transcription factor binding sites - Full text - MIT Libraries
F Long, H Liu, C Hahn, P Sumazin, MQ Zhang, A … - In Silico Biology, 2004 - iospress.metapress.com
... SP1 01(M00008) 38.50% GRGGCRGGGW MAZR 01(M00491) 38.03% NSGGGGGGGGMCN HOXA4 Q2(M00640)
34.98% AWAATTRG CRX Q4(M00623) 34.28% YNNYTAATCYCMN PAX4 02(M00377) 34.19 ...
Cited by 1 - Web Search - bioinfo.de - bioinfo.de - ncbi.nlm.nih.gov

cAMP Response Element-Binding Protein, Activating Transcription Factor-4, and Upstream Stimulatory … - Full text - MIT Libraries
JL Steiger, S Bandyopadhyay, DH Farb, SJ Russek - J Neurosci, 2004 - jneurosci.org
... enhancer-2; MOK2, ribonucleoprotein-associated zinc finger protein; MZF1, myeloid
zinc finger protein-1; PAX4, paired box factor-4; SP1, stimulatory protein-1 ...
Cited by 2 - Web Search - dx.doi.org - jneurosci.org - ncbi.nlm.nih.gov

A statistical analysis of the TRANSFAC database.
GB Fogel, DG Weekes, G Varga, ER Dow, AM Craven, … - Biosystems, 2005 - natural-selection.com
... 01 N-Myc OCT1 02 Octamer factor 1 OCT1 03 Octamer factor 1 OCT1 04 Octamer factor
1 OCT1 Q6 Octamer factor 1 P300 01 p300 PAX3 B Pax3 binding sites PAX4 01 Pax ...
View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Regulation of the pancreatic pro-endocrine gene neurogenin3 - Full text - MIT Libraries
JC Lee, SB Smith, H Watada, J Lin, D Scheel, J … - Diabetes, 2001 - diabetes.diabetesjournals.org
... the ngn3-null mice fail to express islet transcription factors isl1, pax4, pax6,
and ... not be accessible to the general transcription factors such as SP1 and NFY ...
Cited by 34 - Web Search - diabetes.diabetesjournals.org - ncbi.nlm.nih.gov

Transcriptional regulation of the human PAX 6 gene promoter. - Full text - MIT Libraries
ZP Xu, GF Saunders - J Biol Chem, 1997 - jbc.org
... in Pax1 and Pax9) or with a full-length (as in Pax3, Pax4, Pax6, and ... promoter region
(at bases 452 to +166), including single binding sites for Sp1 protein (at ...
Cited by 13 - Web Search - jbc.org - ncbi.nlm.nih.gov

Redox Control of Signal Transduction, Gene Expression and Cellular Senescence
F Esposito, R Ammendola, R Faraonio, T Russo, F … - Neurochemical Research, 2004 - springerlink.com
... binding domains is particularly sensitive to redox changes; thiol groups of the
cysteine involved in the zinc-finger motif of the Sp1 transcriptional factor ...
Cited by 2 - Web Search - kluweronline.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

TranSignal™ Protein/DNA Arrays
PU Manual - panomics.com
... AP-1 (1) AP-1 (1) CREB (1) CREB (1) G ATA G ATA N FAT c N FAT c Pit 1 Pit 1 Sp1
Sp1 TR TR 1 AP-1 (1) AP-1 (1) CREB (1) CREB (1) G ATA G ATA N FAT c N FAT c Pit ...
View as HTML - Web Search - panomics.com

PAX genes in development and disease: The role of PAX2 in urogenital tract development
MR Eccles, S He, M Legge, R Kumar, J Fox, C Zhou, … - Int J Dev Biol, 2002 - ijdb.ehu.es
... patches, hearing loss sensorineural hearing loss Splotch (-/-) Deficient muscle
and neuromuscular development, hypopigmentation PAX4 - - Pax4 knockout (+/-) No ...
Cited by 5 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - ijdb.ehu.es - Get it from MIT Libraries

Six family genesÐstructure and function as transcription factors and their roles in development - Full text - MIT Libraries
K Kawakami, S Sato, H Ozaki, K Ikeda - BioEssays - doi.wiley.com
... In the same study, three Sp1 binding sites and two negative regulatory elements
were identified in the promoter region of the mouse Six5 gene which were ...
Cited by 55 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Expression of a novel zinc-finger cDNA, IA-1, is associated with rat AR42J cells differentiation …
M Zhu, MB Breslin, MS Lan - Pancreas, 2002 - pancreasjournal.com
... family including Pdx-1/IPF-1 (3-5), Isl-1 (6), Pax4/6 (7-9 ... Three clustered Sp1 sites
are required for efficient transcription of the TATA-less promoter of the ...
Cited by 5 - Web Search - pancreasjournal.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Pax3 and the splotch mutations: structure, function, and relationship to teratogenesis, including …
AF Machado, LJ Martin, MD Collins - Curr. Pharm. Design, 2001 - ingentaconnect.com
... Pax4 knockout [225] ... 5'-flanking sequence of PAX3 revealed potential binding sites
for a variety of transcription factors including AP-1, AP-2, SP1, TFIID, PEA3 ...
Cited by 7 - Web Search - bentham.org - bentham.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

The PAX6 gene is activated by the basic helix–loop–helix transcription factor NeuroD/BETA2 - Full text - MIT Libraries
E Marsich, A Vetere, M Di Piazza, G Tell, S … - Biochem J, 2003 - bj.portlandpress.com
... 4]. During embryogenesis, PAX genes exhibit highly restricted temporal and spatial
expression patterns [4]. Two members of the PAX gene family, PAX4 and PAX6 ...
Cited by 4 - View as HTML - Web Search - biochemj.org - biochemj.org - ncbi.nlm.nih.gov - all 5 versions »

The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial … - Full text - MIT Libraries
A Krapp, M Knofler, B Ledermann, K Burki, C Berney … - Genes Dev, 1998 - genesdev.org
... Mice lacking Pax4 fail to develop mature insulin- and somatostatin-producing cells
(Sosa-Pineda 1997 ), while those lacking Pax6 are deficient for glucagon ...
Cited by 98 - Web Search - genesdev.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

2004 Claude Bernard Lecturer
CR Kahn - springerlink.com
... evidence for interaction with a region on chromosome 7 containing the PAX4 gene. ...
at unravelling the role of the TGFbeta pathway and the SP1/XKLF transcription ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

TranSignal TM Protein/DNA Arrays
CS Version - panomics.com
... AP-1 (1) AP-1 (1) CREB (1) CREB (1) G ATA G ATA N FAT c N FAT c Pit 1 Pit 1 Sp1
Sp1 TR TR 1 AP-1 (1) AP-1 (1) CREB (1) CREB (1) GA T A GA T A N FAT c N FAT c ...
View as HTML - Web Search

The Development of Beta-cell Mass: Recent Progress and Potential Role of GLP-1 - Full text - MIT Libraries
DA Stoffers - Hormone and Metabolic Research, 2004 - thieme-connect.com
... conserved regions are functionally important binding sites for Sp1, Sp3, Hepatocyte ...
Paired homeodomain factors Pax4 and Pax6 also regulate the relative numbers ...
Cited by 2 - Web Search - thieme-connect.com - ncbi.nlm.nih.gov

Aberrant regulation of human intestinal proglucagon gene expression in the NCI-H716 cell line - Full text - MIT Libraries
X Cao, G Flock, C Choi, DM Irwin, DJ Drucker - Endocrinology, 2003 - glucagon.com
... 3 (forward) and 5 -AAAAGC- GAAAACACGGAATTACA-3 (reverse); Pax4, 5 -GGGTCTGGTTTTC- ...
transcription from the G (i2) gene promoter through multiple Sp1 sites in the ...
Cited by 4 - View as HTML - Web Search - dx.doi.org - endo.endojournals.org - ncbi.nlm.nih.gov

Conserved and muscle group-specific gene expression patterns shape postnatal development of the … - Full text - MIT Libraries
G Cheng, AP Merriam, B Gong, P Leahy, S Khanna, JD … - Physiological Genomics, 2004 - physiolgenomics.physiology.org
... less frequently (eg, Sp1, 31%; Msx1, 23%; Pou2f1, 23%; Usf, 8%, Myog, 6%, and ... enriched
genes (eg, Pax4, 62%; Pitx2, 15%; Nkx2.5, 13.5%; Supplementary Table 6). ...
Web Search - dx.doi.org - ncbi.nlm.nih.gov - ijmm.org - all 5 versions »

Regulation of gene promoters of hypothalamic peptides
JPH Burbach - Front Neuroendocrinol, 2002 - www-unix.oit.umass.edu
... These include the homeodomain proteins Isl-1 [73], Pdx-1 (also termed Idx-1,
STF-1, Ipf-1) [72,89,105], Pbx, [46], Prep-1 [46], Pax4 [128], and Pax6 [5,115]. ...
Cited by 3 - View as HTML - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

BMC Genomics - Full text - MIT Libraries
S Nelander, E Larsson, E Kristiansson, R Maansson, … - BMC Genomics, 2005 - biomedcentral.com
... M00264:Staf 3: Neural tissues <2.5% 99 M00189:AP-2 <2.5% 115 M00196:Sp1
<2.5% 141 M00256:NRSF <10% 75 M00243:Egr-1 4: Lymphocytes ...
View as HTML - Web Search

Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity - Full text - MIT Libraries
B Kammandel, K Chowdhury, A Stoykova, S Aparicio, … - Dev. Biol, 1999 - fbmc.fcen.uba.ar
... sequences for various basal promoter elements, such as a conserved TATA-like se-
quence (AATATTT), three CCAAT boxes, and consensus binding sites for Sp1 and Ap ...
Cited by 66 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

BMC Genomics - Full text - MIT Libraries
J Besco, A Frostholm, MC Popesco, AHM Burghes, A … - BMC Genomics, 2001 - biomedcentral.com
Page 1. ...
View as HTML - Web Search - dx.doi.org - pubmedcentral.nih.gov - bmc.ub.uni-potsdam.de - all 9 versions »

Abstracts of Papers Submitted to the American Pancreatic Association
S by a grant from Solvay, C Pharmaceutical, GA … - Pancreas, 2001 - pancreasjournal.com
... Our laboratory studies the role of Sp1-like zinc finger proteins in the regulation
of normal and neoplastic cell growth in the exocrine pancreas. ...
Web Search

Bibliography Current World Literature
E Tumors - Current Opinion in Oncology, 2005 - co-oncology.com
... Am J Surg Pathol 2004, 28:417. Collombat P, Mansouri A, HecksherSorensen J, et al:
Opposing actions of Arx and Pax4 in endocrine pancreas development. ...
Web Search