PPAR {alpha} Activators Inhibit Vascular Endothelial Growth Factor Receptor-2 Expression by … - Full text - MIT Libraries
M Meissner, M Stein, C Urbich, K Reisinger, G … - Circulation Research, 2004 - circresaha.org
... Coimmunoprecipitation of Sp1/PPARa For Sp1 immunoprecipitation, 5x10 6 cells were
lysed in cold buffer containing 50 mmol/L Tris-HCl (pH 7.6), 150 mmol/L NaCl ...
Cited by 2 - Cached - Web Search - circres.ahajournals.org - ahavj.ahajournals.org - ncbi.nlm.nih.gov - all 7 versions »

Characterization of the 5 Regulatory Region of the Mouse Angiopoietin-like Protein 4
K Yoshida, M Ono, R Koishi, H Furukawa - Veterinary Research Communications, 2004 - kluweronline.com
... was found to be TATA-less and to contain numerous potential cis-acting elements
(eg AP1, AP2, C/EBP and SP1). Moreover, a few potential PPARa response elements ...
Cited by 1 - Web Search - springerlink.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Transcriptional Regulation of Energy Substrate Metabolism in Normal and Hypertrophied Heart - Full text - MIT Libraries
R Tian - Current Science, 2003 - current-reports.com
... a/relinoid X receptor a (PPARa/RXRa),and activation of chicken ovalbumin upstream
promoter transcription factor (COUP-TF), and transcription factors Sp1 and Sp3 ...
Cited by 3 - Web Search - current-reports.com - ncbi.nlm.nih.gov

Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth - Full text - MIT Libraries
JJ Lehman, DP Kelly - Heart Fail. Rev, 2002 - springerlink.com
... pressure overload of the ventricle, with a concurrent decline in the nuclear protein
level of PPARa. Collectively, these results identify COUP-TF, Sp1, and Sp3 ...
Cited by 21 - Web Search - kluweronline.com - ncbi.nlm.nih.gov

Role of redox-regulated transcription factors in inflammation, aging and age-related diseases
Y Lavrovsky, B Chatterjee, RA Clark, AK Roy - Exp Gerontol, 2000 - aging.pharm.pusan.ac.kr
... They also demonstrated that NF-kB and Sp1 can interact in vivo (Rippe et al ... The
pro-inflammatory agent leukotriene B 4 (LTB 4 ) is a natural ligand for PPARa. ...
Cited by 49 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

Peroxisome proliferator activated receptor delta genotype in relation to cardiovascular risk factors … - Full text - MIT Libraries
J Skogsberg, AD McMahon, F Karpe, A Hamsten, CJ … - Journal of Internal Medicine, 2003 - ingentaconnect.com
... in human monocytic cells and in Sp1 deficient Drosophila cells [9]. In addition,
evidence was obtained for an interaction with the PPARA L162V polymorphism ...
Cited by 3 - Web Search

Forum Review
RA DAYNES, E ENIOUTINA, DC JONES - ANTIOXIDANTS & REDOX SIGNALING, 2003 - dx.doi.org
... Recently, the peroxisome proliferator-activated receptor-a (PPARa) has been evaluated
for its effects on inflammatory and adaptive immune processes. ...
Web Search - liebertonline.com - liebertonline.com - path.utah.edu

Molecular regulation of the chondrocyte phenotype - Full text - MIT Libraries
MB Goldring - J Musculoskelet Neuronal Interact, 2002 - ismni.org
... Functional binding motifs for Sp1 family members 27,30,31 , E-box-binding, bHLH
pro- teins 32 , and the zinc finger protein 33 , have been identified in the ...
Cited by 1 - View as HTML - Web Search - ncbi.nlm.nih.gov

Energy biogenesis: one key for coordinating two genomes
M Sardiello, G Tripoli, A Romito, C Minervini, L … - Trends Genet, 2005 - biologia.uniba.it
... In mammals, nuclear respiratory factor 1 and 2 (NRF1, NRF2), peroxisome proliferative
activated receptor a (PPARa and Sp1 tran- scription factor have been ...
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Structure of the mouse peroxisome proliferator activated receptor alpha gene - Full text - MIT Libraries
KL Gearing, A Crickmore, JA Gustafsson - Biochem Biophys Res Commun, 1994 - ncbi.nlm.nih.gov
... The DNA binding domain of PPARa consists of two exons, each encoding one of ... The 5'
flanking region is GC rich and contains several putative SP1 binding sites. ...
Cited by 25 - Web Search

Cloning and characterization of the rat cytochrome P450 4F5 (CYP4F5) gene - Full text - MIT Libraries
X Cui, HW Strobel - Gene, 2002 - www-bmb.med.uth.tmc.edu
... with the Sp1 sites are the most striking features identified in this ... clofibrate can
induce CYP4A subfamily expression through activating the PPARa (Aldridge et ...
Cited by 4 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Nuclear activators and coactivators in mammalian mitochondrial biogenesis
RC Scarpulla - Biochim Biophys Acta, 2002 - fmtm.br
... NRF-1, NRF-2 and Sp1 are the most prevalent factors associated with ... For example,
genes of the fatty acid oxidation pathway rely upon PPARa for expression [99 ...
Cited by 45 - View as HTML - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Clustering analysis of proteins in fat regulation
Z Luo, CA Kulikowski, I Muchnik - Proceedings of the First Asia-Pacific bioinformatics …, 2003 - portal.acm.org
... 5. Transcription factors: GR, VDR, TR, RAR, RXR, RORa, ERRa, LXR, PPARa, PPARß,
PPAR?, PPARd ... p300, p42, Hox, CBP/p300, c-fos, c-jun, NCO2, RAC3, SP1, aP2, SRC-1 ...
Web Search - portal.acm.org

The gene encoding acyl-CoA binding protein is subject to metabolic regulation by both SREBP and …
MB Sandberg, M Bloksgaard, D Duran-Sandoval, C … - jbc.org
... gene through binding sites for SREBP and the auxiliary factors Sp1 and nuclear ... in
rodent hepatocytes is subject to dual metabolic regulation by PPARa and SREBP ...
Web Search - jbc.org

REGULAR ARTICLES
MR Pump, CTC Lymphoma, MC Lines, C by Yohimbine - ingentaconnect.com
... 113 Role of the Sp1 Response Element in Transcription of the Human ... 353 Stimulation
of PPARa Promotes Epidermal Keratinocyte Differenciation In Vivo LaÂszlo ...
Web Search

Dietary polyunsaturated fatty acid regulation of hepatic gene transcription
DB Jump - Scandinavian Journal of Nutrition, 2002 - taylorandfrancis.metapress.com
... observa- tion suggests that brate action may extend beyond the PPARa regulatory
network ... with ancillary transcription factors, like NF-Y and:or Sp1, which bind ...
Web Search

Dietary polyunsaturated fatty acid regulation of hepatic gene transcription
DB Jump - Scandinavian Journal of Nutrition, 2002 - dx.doi.org
... observa- tion suggests that brate action may extend beyond the PPARa regulatory
network ... with ancillary transcription factors, like NF-Y and:or Sp1, which bind ...
Web Search - ingentaconnect.com

High evolutionary rates in nuclear genes of squamates
S Hughes, D Mouchiroud - J molec Evol, 2001 - springerlink.com
... pk 432 0.0208 0.0215 − 0.9494 NS ppara 642 0.0144 0.0053 + 0.1011 NS ... Snakes and
chicken comparisons are also given Comparisons dKa a RRT b Ka sp1 c Ka sp2 c ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Inhibition of Endogenous Thyroid Hormone Receptor- and Peroxisome Proliferator-Activated Receptor- …
ML Yang, TS Huang, Y Lee, TH Chen, SY Chen, FJ Lu - Thyroid, 2002 - dx.doi.org
... against various TRa, TRb (Affinity BioReagents, Golden, CO), PPARa or PPARb ... or goat
immunoglobulin G (IgG) (Santa Cruz) and antibody against Sp1 protein (Santa ...
Web Search - liebertonline.com - liebertonline.com

Differential regulation of SF-1-cofactor interactions.
J Lund, B Borud, G Mellgren, R Aesoy, T Hoang, AL … - Endocr Res, 2002 - taylorandfrancis.metapress.com
... Transcription intermediary factor-2 has been reported to interact with and coactivate
the peroxisome proliferator-activated receptor a (PPARa) and g ... Sp1 has ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Increased expression of the lipocalin 24p3 as an apoptotic mechanism for MK886 - Full text - MIT Libraries
Z Tong, X Wu, JP Kehrer - Biochem J, 2003 - biochemj.org
... et al. [44] also reported that activation of PPARa decreased the ... the 24p3 gene, it
is possible the activation of PPAR interfere with the activity of sp1 or ...
Cited by 5 - View as HTML - Web Search - biochemj.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Nutrient and hormonal regulation of pyruvate kinase gene expression - Full text - MIT Libraries
K Yamada, T Noguchi - Biochem. J, 1999 - biochemj.org
... Sp1 may be involved in this regulation via its dephosphorylation, although the
carbohydrate ... of L-PK gene expression is observed even in PPARa-deficient mice [69 ...
Cited by 28 - Cached - Web Search - biochemj.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic … - Full text - MIT Libraries
H Shimano - Prog Lipid Res, 2001 - lipid.umin.ne.jp
... composed of NF-Y site, E-box, sterol-regulatory element, and Sp1 site were ... for choles-
terol catabolism, SREBP-1 for fatty acid synthesis, and PPARa for fatty ...
Cited by 62 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Cardiovascular disease genetics: a long and winding road
JM Ordovas - Curr Opin Lipidol, 2003 - co-lipidology.com
... to CETP mass and high density lipoprotein cholesterol levels: role of Sp1/Sp3 in ...
Association between the PPARA L162V polymorphism and plasma lipid levels: the ...
Cited by 9 - Web Search - co-lipidology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Toucan: deciphering the cis-regulatory logic of coregulated genes - Full text - MIT Libraries
S Aerts, G Thijs, B Coessens, M Staes, Y Moreau, B … - Nucleic Acids Research, 2003 - nar.oupjournals.org
... The detection of SP1 is not surprising since it is a general promoter element. ... approach),
like HEN (or STAF) and HSF for the muscle group and PPARA, SRY, MIF1 ...
Cited by 52 - Web Search - pubmedcentral.nih.gov - nar.oxfordjournals.org - csb.yale.edu - all 9 versions »

SUBJECT AND TITLE INDEX FOR VOLUME 115
N Puri, JM Gardner, MH Brilliant, DSA Transport, … - ingentaconnect.com
... in vitro, 1152 Hairless gene mutations, human, 761 mouse, PPARa activators, 361
Hapten ... corneocyte lipid envelope, 765 lamellar, transglutaminase 1 Sp1 site, 113 ...
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Cyclopentenone Prostaglandins: New Insights on Biological Activities and CellularTargets
DS Straus, CK Glass - Key words, 2001 - doi.wiley.com
Page 1. Cyclopentenone Prostaglandins: New Insights on Biological Activities
and CellularTargets Daniel S. Straus, 1 Christopher K. Glass 2 ...
Cited by 105 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Ligands of peroxisome proliferator-activated receptor-g increase the generation of vascular …
A Jozkowicz, J Dulak, E Piatkowska, W Placha, A … - actabp.pl
... steroid hormones and vitamin D [1]. In mammals, the PPAR family consists of three
subtypes of pro- teins encoded by separate genes: PPARa, PPARg, and PPARd. ...
View as HTML - Web Search - actabp.pl

Workshop: Intravital Microscopy and Live Cell Imaging in Angiogenesis Research
SS Bolz, U Pohl - springerlink.com
Page 1. Workshop: Intravital Microscopy and Live Cell Imaging in Angiogenesis
Research Friday, July 18, 2003, 09.00À12.30 L1 Application ...
Web Search - kluweronline.com

Age-related phenotypes in the staggerer mouse expand the ROR· nuclear receptor’s role beyond the …
CI Jarvis, B Staels, B Brugg, Y Lemaigre-Dubreuil, … - Mol Cell Endocrinol, 2002 - npa.snv.jussieu.fr
... Here, the RORE site has been shown to lie between two Sp1 binding sites ... receptors
such as the glucocorticoid receptor (Auphan et al., 1995), PPARa and PPARg ...
Cited by 16 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

Enzymes and receptors in the leukotriene cascade - Full text - MIT Libraries
JZ Haeggstrom, A Wetterholm - Cell. Mol. Life Sci, 2002 - springerlink.com
... It has features typical of a housekeeping gene with no TATA or CAAT box, although
atypical in that it is not GC rich and lacks Sp1/Egr-1 sites. ...
Cited by 10 - Web Search - ncbi.nlm.nih.gov

Resveratrol: Preventing properties against vascular alterations and ageing
D Delmas, B Jannin, N Latruffe - Molecular Nutrition & Food Research, 2005 - doi.wiley.com
... estrogens which can upregulate eNOS by increasing promoter activity and enhancing
the binding activity of the transcription factor Sp1, resveratrol increases ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Regulation of cytochrome P450 (CYP) genes by nuclear receptors - Full text - MIT Libraries
P Honkakoski, M Negishi - Biochem. J, 2000 - biochemj.org
... Both PPARa and PPARg are able to activate the CYP4A6 promoter in transient
transfections ... a need for other transcription factors [250,268] such as Sp1 [253,260 ...
Cited by 109 - Cached - Web Search - cmbi.kun.nl - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Promoter activity and regulation of the corneal CYP 4 B 1 gene by hypoxia - Full text - MIT Libraries
V Mastyugin, A Mezentsev, WX Zhang, S Ashkar, MW … - Journal of Cellular Biochemistry, 2004 - doi.wiley.com
Page 1. Journal of Cellular Biochemistry 91:1218–1238 (2004) Promoter Activity
and Regulation of the Corneal CYP4B1 Gene by Hypoxia ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

PPAR Functions as a Prostacyclin Receptor in Blastocyst Implantation
C Endocrinol, OB Phys, OB Phys - Clin. Endocrinol - obgyn.wustl.edu
... receptor; cAMP elevation; IP Fertile 36 Ppara PPAR ; ligand-dependent
transcription factor; Fertile 31 nuclear receptor for PGI ...
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6. Control genico de la expresion del citocromo P-450 en el higado
RJ ATIENZA - ranf.com
... CYP2D6 HNF4 & COUP-TFI Cairns-W, et al. (1996) J-Biol-Chem 271:25269-76 CYP2D5
C/EBPb & Sp1 Lee-YH, et al. (1994) Mol-Cell-Biol 14:1383-94 ...
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Quantitative Trait Loci for Hypercalciuria in a Rat Model of Kidney Stone Disease - Full text - MIT Libraries
RR Hoopes Jr, R Reid, S Sen, C Szpirer, P Dixon, … - J Am Soc Nephrol, 2003 - jasn.org
... Cd80 (A), co-localized with D11Rat8 and D11Got46, respectively, and of Ppara (B),
co ... G, Marynen P, Cassiman JJ, Wiese R, DeLuca HF: The Sp1 transcription factor ...
Cited by 3 - Web Search - jasn.org - jasn.org - ncbi.nlm.nih.gov - all 5 versions »

Polyunsaturated fatty acids inhibit fatty acid synthase and spot-14-protein gene expression in … - Full text - MIT Libraries
M Foretz, F Foufelle, P Ferre - Biochem J, 1999 - biochemj.org
... 14], and (iiii) that the effects were not mediated by the PPARa [32 ... The binding of
Sp1, a zinc-finger transcription factor, and upstream stimulatory factor ('USF ...
Cited by 10 - Cached - Web Search - biochemj.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Theoretical Biology and Medical Modelling - Full text - MIT Libraries
E Shelest, E Wingender - Theoretical Biology and Medical Modelling, 2005 - bmc.ub.uni-potsdam.de
... could be predicted from the fact that they may constitute well-known composite elements,
like those containing NF-κB and C/EBP or NF-κB and Sp1 binding sites ...
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Large-scale collection and characterization of promoters of human and mouse genes - Full text - MIT Libraries
Y Suzuki, R Yamashita, M Shirota, Y Sakakibara, J … - Silico Biol, 2004 - iospress.metapress.com
... V$POU1F1 Q6 POU1F1 0.985 0.979 329 202 10 V$PPARA 01 PPARalpha/RXR-alpha 0.899
0.863 6 4 0 V$PTF1BETA Q6 PTF1-beta 1 0.991 9 8 0 V$RORA1 01
Cited by 2 - Web Search - bioinfo.de - bioinfo.de - ncbi.nlm.nih.gov

Impaired Ras membrane-association and activation in PPARα knockout mice following partial …
MD Wheeler, OM Smutney, JF Check, I Rusyn, R … - ajpgi.physiology.org
... exposure, was observed. Competition assay using excess unlabeled DNA oligo blunted
PPARa ... For example, there are PPAR, retinoid X receptor, Sp1 and CREB ...
Web Search - ajpgi.physiology.org

Lipids in Health and Disease - Full text - MIT Libraries
A Berger, DM Mutch, JB German, MA Roberts - Lipids in Health and Disease, 2002 - gdrs-intranet.ath.cx
... In the liver, groups of genes were linked to the transcription factors PPARa, HNFa,
and SREBP-1; transcription factors known to control lipid metabolism. ...
View as HTML - Web Search - bmc.ub.uni-potsdam.de - bmc.ub.uni-potsdam.de - lipidworld.com

1. Thursday 27 September (am): Rheumatoid Arthritis and Systemic Diseases - Full text - MIT Libraries
POFR ARTHRITIS - Clin Rheumatol, 2001 - springerlink.com
Page 1. Abstracts 1. Thursday 27 September (am): Rheumatoid Arthritis and Systemic
Diseases STATE OF THE ART MOLECULES MARKERS ASSOCIATED ...
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Communications Communications Communications
AD Kits, AA Kit, TF Assays, C Tissue, M from … - chemicon.com
Page 1. www.chemicon.com Communications Communications Communications
O n y our mouse ,get set … Shop! See page 18 for details ...
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Dual Role of Oxidized LDL on the NF-KappaB Signaling Pathway
F Robbesyn, R Salvayre, A Negre-Salvayre - Free Radical Research, 2004 - dx.doi.org
... [75 – 77] PPARa and PPARg ... This family, belonging to the zinc-finger family of DNA
binding proteins, consists of four proteins designed Sp1 (specific protein 1 ...
Cited by 3 - Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

The Vitamin D Response Element of the Involucrin GeneMediates its Regulation by 1, 25- … - Full text - MIT Libraries
DD Bikle, D Ng, Y Oda, K Hanley, K Feingold, Z Xie - Journal of Investigative Dermatology, 2002 - jidonline.org
... keratinocytes • vitamin D receptor • vitamin D response element • PPARa • LXR •
P ... region transcriptional activator elements - a role for Sp1 and AP1 ...
Cited by 7 - Web Search - blackwell-synergy.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Drug transport proteins in the liver - Full text - MIT Libraries
KN Faber, M Muller, PL Jansen - Adv Drug Deliv Rev, 2003 - nutrigene.4t.com
Page 1. Advanced Drug Delivery Reviews 55 (2003) 107–124 www.elsevier.com/locate/
drugdeliv Drug transport proteins in the liver a b a , * ...
Cited by 17 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Regulation of cholesterol synthesis by oleic and palmitic acid in keratinocytes - Full text - MIT Libraries
W Siefken, H Hoppner, IR Harris - Experimental Dermatology, 2000 - ingentaconnect.com
... differen- tiation is stimulated by activators of the nuclear hormone receptor PPARa. ...
HB, Osborne T F. Domains of transcrip- tion factor Sp1 required for ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

Suppression of Vitamin D Receptor and Induction of Retinoid X Receptor a Expression During Squamous …
S Segaert, M Garmyn, H Degreef, R Bouillon - ingentaconnect.com
... cytes might facilitate the action of nuclear receptors such as PPARa and FXR ...
transcription factors, known to be expressed in keratinocytes such as Sp1, C/EBP ...
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A statistical analysis of the TRANSFAC database.
GB Fogel, DG Weekes, G Varga, ER Dow, AM Craven, … - Biosystems, 2005 - natural-selection.com
... AAGTT not AAGT PPARA 01 PPAR/RXR heterodimers Core should be AAAGGT not
AAAG VMYB 02 v-Myb Core should be AACGG not AACG MYT1 01 ...
View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries