Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the … - Full text - MIT Libraries
KC Chung, I Gomes, D Wang, LF Lau, MR Rosner - Mol Cell Biol, 1998 - mcb.asm.org
... Previous studies have shown that the pip92 SRE can interact with recombinant SRF
and Elk1 proteins at the CArG and Ets binding sites, respectively, forming a ...
Cited by 37 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Molecular characterization of the B-box protein-protein interaction motif of the ETS-domain … - Full text - MIT Libraries
Y Ling, JH Lakey, CE Roberts, AD Sharrocks - The EMBO Journal, 1997 - embojournal.npgjournals.com
... Ternary complexes were formed between SRF, Elk1-168 and the c-fos SRE in the
presence of increasing amounts of B-box competitor peptide. ...
Cited by 39 - Web Search - emboj.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Cleavage of the Serum Response Factor during Death Receptor-induced Apoptosis Results in an … - Full text - MIT Libraries
C Bertolotto, JE Ricci, F Luciano, B Mari, JC … - J Biol Chem, 2000 - jbc.org
... This observation agrees with earlier studies demonstrating the requirement of SRF
for Elk1 binding to SRE motif (8). Moreover, since the anti-Elk1 antibody did ...
Cited by 22 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Net-b, a Ras-insensitive factor that forms ternary complexes with serum response factor on the serum … - Full text - MIT Libraries
A Giovane, P Sobieszczuk, A Ayadi, SM Maira, B … - Mol Cell Biol, 1997 - mcb.asm.org
... lane 1). CI migrated at the same level as SRF and SRF plus Net-b, and CII migrated
at the same level as SRF plus Sap1a and SRF plus Elk1 (compare with Fig. ...
Cited by 18 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov - all 5 versions »

Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein … - Full text - MIT Libraries
J Shipley, D Sheer, S Dalton, R Treisman, K Patel - Genomics, 1994 - ncbi.nlm.nih.gov
... SAP1 was identified by a genetic screen for proteins interacting with SRF expressed
in yeast, and SAP2 by its homology with SAP1; ELK1 was previously ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov

Expression of immediate early gene pip 92 during anisomycin-induced cell death is mediated by the … - Full text - MIT Libraries
KC Chung, SM Kim, S Rhang, LF Lau, I Gomes, YS Ahn - European Journal of Biochemistry, 2000 - content.febsjournal.org
... anisomycin-induced pip92 expression Previous studies have shown that SRE present
in the pip92 promoter can interact with recombinant SRF and Elk1 proteins at ...
Cited by 10 - Cached - Web Search - ejbiochem.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 7 versions »

Novel nuclear target for thrombin: activation of the Elk1 transcription factor leads to chemokine … - Full text - MIT Libraries
QJ Li, S Vaingankar, FM Sladek, M Martins-Green - Blood, 2000 - bloodjournal.org
... Thus, the work presented here strongly supports the previous proposition
that Elk1 can function independently of SRF/SRE. 50 , 58. ...
Cited by 15 - Web Search - bloodjournal.org - bloodjournal.org - ncbi.nlm.nih.gov - all 5 versions »

Rapid electrical and delayed molecular signals regulate the serum response element after nerve … - Full text - MIT Libraries
H Lin, J Bao, JS Ying, ET Walters, RT Ambron - Journal of Neurobiology, 2003 - doi.wiley.com
... phase. The Transcription Complex That Binds to the SRE in the Rapid Phase
in Aplysia and Mouse Consists of an SRF and Elk1 Does ...
Cited by 10 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Synergistic Activation of the Serum Response Element-Dependent Pathway by Hepatitis B Virus X … - Full text - MIT Libraries
T Goto, N Kato, H Yoshida, M Otsuka, M Moriyama, Y … - The Journal of Infectious Diseases, 2003 - journals.uchicago.edu
... Neither HBx nor LHDAg increased SRF and Elk1 binding to SRE. ... A supershifted band
was generated by the addition of an antibody directed against SRF or Elk1. ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Mechanisms Responsible for the Promoter-specific Effects of Myocardin - Full text - MIT Libraries
J Zhou, BP Herring - J Biol Chem, 2005 - jbc.org
... It has recently been reported that growth signals can repress smooth muscle-specific
genes by triggering the displacement of myocardin from SRF by ELK1, an ets ...
Cited by 2 - Web Search - jbc.org - ncbi.nlm.nih.gov

Mitogen regulated induction of FRA-1 proto-oncogene is controlled by the transcription factors … - Full text - MIT Libraries
P Adiseshaiah, S Peddakama, Q Zhang, DV … - Oncogene, 2005 - nature.com
... The FRA-1 promoter is occupied by SRF, Elk1, CREB and ATF proteins in vivo. ... SRF,
Elk1, ATF1 and CREB regulate TPA-inducible FRA-1 transcription. ...
Web Search - nature.com - ncbi.nlm.nih.gov

FLI 1 and EWS-FLI 1 function as ternary complex factors and ELK 1 and SAP 1 a function as ternary … - Full text - MIT Libraries
DK Watson, L Robinson, DR Hodge, I Kola, TS Papas, … - Oncogene, 1997 - nature.com
... Localization of the FLI1 domain required for interaction with SRF ELK1 and SAP1a
contain three regions of sequence similarity: (1) the amino-terminal DNA ...
Cited by 41 - Web Search - nature.com - ncbi.nlm.nih.gov

SRF binding to SRE in the rat heart: influence of age
XG Lu, G Azhar, L Liu, H Tsou, JY Wei - Journals of Gerontology Series A: Biological Sciences and … - biomed.gerontologyjournals.org
... SRE is the site of attachment of the 67- kDa protein serum response factor (SRF)
and several accessory proteins (Elk1, SAP1, SAP2/NET), termed the ternary ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

SRF-dependent gene expression is required for PI 3-kinase-regulated cell proliferation - Full text - MIT Libraries
S Poser, S Impey, K Trinh, Z Xia, DR Storm - The EMBO Journal, 2000 - embojournal.npgjournals.com
... Elk1 phosphorylation (Figure 4F). Similarly, expression of DN MEK attenuated
transactivation of Gal4–Elk1 (Figure 4G) but was without effect on Gal4–SRF. ...
Cited by 24 - Web Search - nature.com - emboj.org - ncbi.nlm.nih.gov - all 7 versions »

Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl K562 … - Full text - MIT Libraries
JF Dorsey, JM Cunnick, SM Mane, J Wu - Blood, 2002 - bloodjournal.org
... in K562 cells. The c-fos SRE binds a ternary complex consisting of serum
response factor (SRF) and Elk1/TCF. 40 Phosphorylation of ...
Cited by 11 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

L’ENDOCRINOLOGIE: DES MECANISMES MOLECULAIRES A LA SANTE PUBLIQUE
A Enjalbert - medecine/sciences, 1999 - ist.inserm.fr
... Cette régulation court-circuite les cascades de kinases impliquées dans la répon-
se au calcium d’autres facteurs com- me CREB ou SRF/Elk1. ...
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Large Isoform of Hepatitis Delta Antigen Activates Serum Response Factor-associated Transcription - Full text - MIT Libraries
T Goto, N Kato, SK Ono-Nita, H Yoshida, M Otsuka, … - J Biol Chem, 2000 - intl.jbc.org
... LHDAg Activates the SRE-dependent Pathway through SRF, Not Elk1-- LHDAg activated
not only the SRF-dependent pathway but also the SRE-dependent pathway. ...
Cited by 7 - Web Search - jbc.org - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

… transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF … - Full text - MIT Libraries
B Cen, A Selvaraj, RC Burgess, JK Hitzler, Z Ma, … - Mol Cell Biol, 2003 - mcb.asm.org
... well with SRE activation, since only the N250 and basic region deletion mutants
abolished SRF binding in ... (E) Cells were transfected with GAL4-ELK1 and the ...
Cited by 15 - Web Search - pubmedcentral.nih.gov - columbia.edu - dx.doi.org - all 7 versions »

Structural organization of the human Elk1 gene and its processed pseudogene Elk2 - Full text - MIT Libraries
T Yamauchi, M Toko, M Suga, T Hatakeyama, M Isobe - DNA Res, 1999 - dna-res.kazusa.or.jp
... ELK1 has 143 amino acids shorter than the full-length protein; it lacks part of
the ELK1 DNA binding domain (A-box) and the entire SRF interaction domain (B-box ...
Cited by 2 - View as HTML - Web Search - dna-res.kazusa.or.jp - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL … - Full text - MIT Libraries
A Selvaraj, R Prywes - BMC Molecular Biology, 2004 - biomedcentral.com
... However, binding of dominant negative MKL1 to SRF could titrate other SRF complexing
proteins such as the TCF factors Elk1 and SAP-1/2, since they all bind to ...
Cited by 4 - Cached - Web Search - dx.doi.org - pubmedcentral.nih.gov - citebase.eprints.org - all 7 versions »

Decisions, Decisions... SRF Coactivators and Smooth Muscle Myogenesis - Full text - MIT Libraries
MW Majesky - Circ Res, 2003 - circres.ahajournals.org
... of the association of SRF with a family of Ets domain-containing transcription factors
called ternary complex factors (TCFs). TCFs, including Elk1, SAP1, and ...
Cited by 5 - Web Search - ahavj.ahajournals.org - intl-circres.ahajournals.org - ncbi.nlm.nih.gov

The Ets family of transcription factors
B WASYLYK, SL HAHN, A GIOVANE - European Journal of Biochemistry, 1993 - blackwell-synergy.com
... specifically bound by the DNA sequence specifically bound by Ets proteins; SRF,
serum-response ... et al., 1991), PEA3 (PEA3 MOUSE, Xin et al., 1992), Elk1 +2 (ELK ...
Cited by 379 - Web Search - content.febsjournal.org - ejbiochem.org - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex - Full text - MIT Libraries
M Hassler, TJ Richmond - The EMBO Journal, 2001 - embojournal.npgjournals.com
... The B-box dominates SAP-1–SRF interactions in the structure of the ternary
complex. ... 2. Structure of the SAP-1–SRF–DNA ternary complex. ...
Cited by 34 - Web Search - nature.com - emboj.org - pubmedcentral.nih.gov - all 6 versions »

Regulation of life and death by the zinc finger transcription factor Egr-1 - Full text - MIT Libraries
G Thiel, G Cibelli - Journal of Cellular Physiology, 2002 - doi.wiley.com
... Ternary complex factors are the proteinsElk1,Sap1orSap2thatmustbothcontactDNA and
bind to SRF to exhibit biological activity. Elk1 is phosphorylated by the c ...
Cited by 47 - Web Search - ncbi.nlm.nih.gov

Funktionelle Charakterisierung des Lipopeptids MALP-2 aus Mycoplasma fermentans als neues mukosales …
D der Naturwissenschaften - opus.tu-bs.de
... CREB ATF-1 CRE - Neuronale Aktivität - Differenzierung von Neuronen P
P Elk1 SRF SRE P P P ... P P Elk1 SRF SRE Elk1 SRF SRE P P P ...
Web Search

BMC Bioinformatics - Full text - MIT Libraries
T Wattarujeekrit, PK Shah, N Collier - BMC Bioinformatics, 2004 - biomedcentral.com
... P P P Grb2 Sos Ras Raf-1 MEK MEK P P P P MAPK P P MAPK SRF Elk1 SRF P Elk1 HYP HYP
exon splice alter express encode translate decrease inhibit signal begin ...
View as HTML - Web Search - research.nii.ac.jp - bmc.ub.uni-potsdam.de - cling.gu.se

Regulation of Serum Response Factor-Dependent Gene Expression by Proteasome Inhibitors - Full text - MIT Libraries
N Sandbo, Y Qin, S Taurin, DK Hogarth, B Kreutz, … - Mol Pharmacol, 2005 - molpharm.aspetjournals.org
... incubated with or without 3 µM MG132 for 2 h, lysed, and the cleared cell lysates
were analyzed by Western blotting with antibodies against SRF, Elk1, YY1, c ...
Web Search - molpharm.org - molpharm.org - ncbi.nlm.nih.gov - all 5 versions »

Myocardin/MKL family of SRF coactivators: Key regulators of immediate early and muscle specific gene … - Full text - MIT Libraries
B Cen, A Selvaraj, R Prywes, A Selvaraj, R Prywes, … - Journal of Cellular Biochemistry, 2004 - doi.wiley.com
... p62TCF, which binds to SRF and to a short sequence element on the 5 0 flank of the
c-fos SRE. p62TCF, encoded by the three ets-related factors Elk1, SAP1, and ...
Cited by 5 - Web Search - ijmm.org - ncbi.nlm.nih.gov

Dual role for mitogen-activated protein kinase (Erk) in insulin-dependent regulation of Fra-1 … - Full text - MIT Libraries
TW Hurd, AA Culbert, KJ Webster, JM Tavare - Biochem J, 2002 - biochemj.org
... SRE) within the c- fos promoter which binds a heterodimer between serum response
factor (SRF) and Elk1 [5, 6]. Elk1, and the related ...
Cited by 1 - View as HTML - Web Search

Full record
S Ahalya, P Ron - doaj.org
... expressed immediate early genes, the two sets of SRF binding proteins that regulate
its activity are the TCF family of proteins that include Elk1, SAP1 and ...
Cached - Web Search - doaj.org

Nuclear translocation of the SRF co-activator MAL in cortical neurons: role of RhoA signalling. - Full text - MIT Libraries
A Tabuchi, M Estevez, JA Henderson, R Marx, J … - Journal of Neurochemistry, 2005 - blackwell-synergy.com
... SRF can be activated by binding to co-activators from the TCF family, such as Elk1,
or members of the myocardin/MKL family, which includes MAL, also called MKL1 ...
Web Search - ncbi.nlm.nih.gov

Net, a new ets transcription factor that is activated by Ras
A Giovane, A Pintzas, SM Maira, P Sobieszczuk, B … - Genes Dev, 1994 - genesdev.org
... of the protein and form ternary complexes with the serum response factor SRF on
the fos serum response element, SRE. However, Net differs from Elk1 and SAP1 in ...
Cited by 107 - Web Search - genesdev.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Positive and negative regulatory elements in the upstream region of the rat Cu/Zn-superoxide … - Full text - MIT Libraries
MS Chang, HY Yoo, HM Rho - Biochem. J, 1999 - biochemj.org
... These observations in HepG2 cells imply that the function of Elk1 in SOD1 transcription
as an enhancer is independent of the effect of an Elk1–SRF interaction ...
Cited by 7 - View as HTML - Web Search - biochemj.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Regulation of the Human c-fos Gene: X-ray Structure of the SAP-1, SRF, DNA Ternary Complex
DN ETH - e-collection.ethbib.ethz.ch
... 14435 Regulation of the Human c-fos Gene: X-ray Structure of the SAP-1, SRF, ... protein
complex at the SRE comprising a homo-dimer of serum response factor (SRF) ...
View as HTML - Web Search - e-collection.ethbib.ethz.ch

Intracellular Calcium Mobilization Induces Immediate Early Gene pip 92 via Src and Mitogen-activated … - Full text - MIT Libraries
KC Chung, JY Sung, W Ahn, H Rhim, TH Oh, MG Lee, … - J Biol Chem, 2001 - jbc.org
... have shown that serum response element (SRE) present in the pip92 promoter can interact
with recombinant serum response factor (SRF) and Elk1 proteins forming ...
Cited by 5 - Web Search - jbc.org - ncbi.nlm.nih.gov

The Extracellular Signal-Regulated Protein Kinases Erk1/Erk2 Stimulate Expression and Biological …
K Kaufmann, K Bach, G Thiel - Biol Chem, 2001 - degruyter.com
... Ternary complex factors are the proteins Elk1, Sap1 or Sap2, that contact DNA and
also have to bind to the SRF in order to exhibit biological activity. ...
Cited by 15 - Web Search - extenza-eps.com - degruyter.de - ncbi.nlm.nih.gov - all 8 versions » - Get it from MIT Libraries

Cell cycle-regulated transcription of the CLB2 gene is dependent on Mcm1 and a ternary complex … - Full text - MIT Libraries
M Maher, F Cong, D Kindelberger, K Nasmyth, S … - Mol. Cell. Biol, 1995 - mcb.asm.org
... This is similar to the recruitment of ternary complex factors by the mammalian
counterpart of Mcm1, the serum response factor SRF (7, 29). ...
Cited by 36 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Computational analysis of composite regulatory elements - Full text - MIT Libraries
P Qiu, W Ding, Y Jiang, JR Greene, L Wang - Mammalian Genome, 2002 - springerlink.com
... 24.7 NF1 NFY 490.5 Oct-1 TCF11 123.3 MEF2 TATA 45.9 ELK1 SP1 24.6 CREB XBP1
454.6 SRF YY1 123.0 MZF1 NFKB 45.6 CDP PBX1 24.3 CEBPB ...
Cited by 10 - Web Search - ncbi.nlm.nih.gov

Regulation of c-fos induction in lens epithelial cells by 12 (S) HETE-dependent activation of PKC - Full text - MIT Libraries
RK Seth, MS Haque, PS Zelenka - Invest. Ophthalmol. Vis. Sci, 2001 - iovs.org
... 7 Phosphorylated Elk1 binds the serum response element (SRE) of the c-fos promoter
in association with the serum response factor (SRF) dimer 6 and ...
Cited by 7 - Web Search - iovs.org - ncbi.nlm.nih.gov

Corticotropin-releasing factor triggers neurite outgrowth of a catecholaminergic immortalized neuron … - Full text - MIT Libraries
G Cibelli, P Corsi, G Diana, F Vitiello, G Thiel - European Journal of Neuroscience, 2001 - ingentaconnect.com
... A complex of Elk1 and SRF interacts with the serum response element. Transcriptional
activation is dependent upon the phosphorylation of Elk1. ...
Cited by 18 - Web Search - ncbi.nlm.nih.gov

CREB/CBP and SRE-interacting transcriptional regulators are fast on-off switches: duration of … - Full text - MIT Libraries
S Chawla, H Bading - Journal of Neurochemistry, 2001 - blackwell-synergy.com
... the duration of calcium transients controls CREB- and TCF/SRF-mediated transcription,
we ... Our attempt to study the regulation of TCF Elk1 phosphorylation failed ...
Cited by 13 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

The cellular and molecular response of cardiac myocytes to mechanical stress
J Sadoshima, S Izumo - Annu Rev Physiol, 1997 - physiol.annualreviews.org
... SEK, stress-activated protein kinase kinase; SRE, serum response element; SRF, serum
response ... been shown to phosphorylate the C-terminal region of Elk1/p62 TCF ...
Cited by 266 - Web Search - physiol.annualreviews.org - phyto.annualreviews.org - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Sequence-specific targeting of nuclear signal transduction pathways by homeodomain proteins - Full text - MIT Libraries
DA Grueneberg, KJ Simon, K Brennan, M Gilman - Mol. Cell. Biol, 1995 - mcb.asm.org
... retains a limited ability to bind endogenous SRF in the absence of Phox1 and perhaps
reflecting the ability of Elk1 to interact cooperatively with SRF (49). ...
Cited by 33 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Ets 转录因子家族在发育和肿瘤发生中作用的研究进展
张健, 高福禄, 刘芝华 - Biol Chem, 2003 - wjgnet.com
... 级联反应的底物 ＭＡＰＫ级联反应可以使ＥＬＫ１磷酸化之后ＥＬＫ１
和ＳＲＦ 共同作用激活ｃ－ｆｏｓ的启动子 ...
View as HTML - Web Search - wjgnet.com - wjgnet.com - wjgnet.com

Regulation of the Cell-specific Calcitonin/Calcitonin Gene-related Peptide Enhancer by USF and the … - Full text - MIT Libraries
TJ Viney, TW Schmidt, W Gierasch, AW Sattar, RE … - J Biol Chem, 2004 - jbc.org
... antisera against HNF-3 (Fig. 2) or eight other factors (C/EBP- , C/EBP- ,
Ets-1, Ets-2, c-Rel, SRF, Elk1, Hmx3) (data not shown). ...
Cited by 1 - Web Search - jbc.org - ncbi.nlm.nih.gov

Elk-1 knock-out mice engineered by Flp recombinase-mediated cassette exchange - Full text - MIT Libraries
F Cesari, V Rennekampff, K Vintersten, L Giang … - genesis, 2004 - doi.wiley.com
... TCFs interact with SRF at serum response el- ements (SREs) of immediate early genes ...
We previously generated an Elk-1 null allele (Elk1-137) in murine embryonic ...
Cited by 3 - Web Search - uni-tuebingen.de - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Annotating significant pairs of transcription factor binding sites in regulatory DNA - Full text - MIT Libraries
K Rateitschak, T Mueller, M Vingron - In Silico Biol, 2004 - iospress.metapress.com
... AP1,TM 1.6 NRF1,NRF1 2.4 NRF1,NRF1 2.3 ARNT,ATF 1.4 CS,ELK1 2.3 NFE2,NFE2 2.3
SRF,SRF 1.4 SP3,TAXCREB 2.2 CJ,ATF6 2.0 CJ,MAX 1.2 CREB,ARNT 2.1 MAX,ARNT 2.0 ...
Cited by 1 - Web Search - bioinfo.de - bioinfo.de - ncbi.nlm.nih.gov

Negative Regulation of ERK and Elk by Protein Kinase B Modulates c-fos Transcription - Full text - MIT Libraries
I Galetic, SM Maira, M Andjelkovic, BA Hemmings - J Biol Chem, 2003 - jbc.org
... PKB Suppresses TCF-dependent Transcription-- The c-fos SRE is constitutively occupied
by an SRF dimer, which recruits monomeric TCFs, Elk1, Sap1, or Sap2/ERP ...
Cited by 5 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Reporter Gene Assay Systems for the Investigation of G-protein-coupled Receptors
MC Dinger, AG Beck-Sickinger - Enzyme - doi.wiley.com
... factor. Only in combination with the ternary complex factor (TCF/Elk1)
can SRF bind to SRE and activate gene transcription. Both ...
Web Search

Serum response factor: discovery, biochemistry, biological roles and implications for tissue injury … - Full text - MIT Libraries
J Chai, AS Tarnawski - J. Physiol. Pharmacol, 2002 - jpp.krakow.pl
... Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by
SRF. ... Raf and fibroblast growth factor phospho- rylate Elk1 and activate the ...
Cited by 25 - View as HTML - Web Search - jpp.krakow.pl - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov