The DNA-binding specificity of SOX 9 and other SOX proteins - Full text - MIT Libraries
S Mertin, SG McDowall, VR Harley - Nucleic Acids Research, 1999 - nar.oupjournals.org
... Furthermore, the related HMG domains of SOX9 and Sox17 have similar optimal binding
sites that differ from those of SRY and Sox5, suggesting that SOX factors ...
Cited by 50 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 7 versions »

Cloning and characterization of SOX5, a new member of the human SOX gene family - Full text - MIT Libraries
VM Wunderle, R Critcher, A Ashworth, PN Goodfellow - Genomics, 1996 - ncbi.nlm.nih.gov
... with the SRY HMG box and named Sox (Sry-related HMG box) in mouse and SOX in human
has been identified from various organisms. We have cloned SOX5, a new ...
Cited by 23 - Web Search

The Sry-related HMG box-containing gene Sox6 is expressed in the adult testis and developing nervous … - Full text - MIT Libraries
F Connor, E Wright, P Denny, P Koopman, A Ashworth - Nucleic Acids Res, 1995 - nar.oupjournals.org
... box- containing, SRY-related gene Sox6 from mouse. The deduced protein sequence
of Sox6 has considerable homology with that of the previously determined Sox5 ...
Cited by 46 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

The transcription factors L-Sox5 and Sox6 are essential for cartilage formation - Full text - MIT Libraries
P Smits, P Li, J Mandel, Z Zhang, JM Deng, RR … - Dev. Cell, 2001 - ingentaconnect.com
... full text options. Abstract: L-Sox5 and Sox6 are highly identical Sry-related
transcription factors coexpressed in cartilage. Whereas ...
Cited by 59 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Testis Expression of Hormone-sensitive Lipase Is Conferred by a Specific Promoter That Contains Four … - Full text - MIT Libraries
R Blaise, J Grober, P Rouet, G Tavernier, D … - J Biol Chem, 1999 - jbc.org
... oligonucleotides. The mSRY/Sox oligonucleotide contains an AACAAT sequence with
high affinity for mouse SRY, Sox5, and Sox6 (27, 28, 38-40). ...
Cited by 12 - Web Search - dx.doi.org - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

Expression of testis specific ankyrin repeat and SOCS box-containing 17 gene.
JH GUO, H SAIYIN, YH WEI, S CHEN, L CHEN, G BI, LJ … - Archives of Andrology, 2004 - dx.doi.org
... Among these sites, some have been identified to be involved in sex determination
or development; for instance, the sites of SRY, SOX5, CREBP, and ER. ...
Web Search - taylorandfrancis.metapress.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

… and recovery of chondrocyte-specific phenotype in culture involves Sry-type high-mobility-group box … - Full text - MIT Libraries
DG Stokes, G Liu, R Dharmavaram, D Hawkins, S … - Biochem J, 2001 - bj.portlandpress.com
... GAPDH, glyceraldehyde-3-phosphate dehydrogenase; polyHEMA, poly-(2-hydroxyethyl
methacrylate); SOX, Sry-type high-mobility-group box; L-SOX5, long-form SOX5 ...
Cited by 20 - View as HTML - Web Search - biochemj.org - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway
V Lefebvre, RR Behringer, B de Crombrugghe - Osteoarthritis Cartilage, 2001 - ncbi.nlm.nih.gov
... The transcription factors L-Sox5, Sox6, and Sox9 bound and cooperatively activated
this enhancer in vitro. They belong to the Sry-related family of HMG box DNA ...
Cited by 14 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Induction of the Sry-related factor SOX6 contributes to bone morphogenetic protein-2-induced … - Full text - MIT Libraries
R Fernandez-Lloris, F Vinals, T Lopez-Rovira, V … - Mol Endocrinol, 2003 - ub.es
... bovine serum; GST, glutathione-S-transferase; HMG, high- mobility group; L-SOX5,
alternatively spliced long form of SOX5; RA, retinoic acid; SOX, Sry-type HMG ...
Cited by 4 - View as HTML - Web Search - mend.endojournals.org - mend.endojournals.org - ncbi.nlm.nih.gov

Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of … - Full text - MIT Libraries
P De Santa Barbara, N Bonneaud, B Boizet, M … - Mol Cell Biol, 1998 - mcb.asm.org
... Finally, of the two SOX proteins, SRY and SOX9, that have been identified as ... specific
HMG domain transcription factors such as Sox2 (1, 52), Sox5 (7), and TCF ...
Cited by 142 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Identification of a novel Sry-related gene and its germ cell-specific expression - Full text - MIT Libraries
E Osaki, Y Nishina, J Inazawa, NG Copeland, DJ … - Nucleic Acids Research, 1999 - nar.oupjournals.org
... a novel subgroup H: A, SRY; B, Sox1-3 and 14, zebrafish Sox19, Dichaete (fishhook);
C, Sox4, 11, 19 and 22, mouse Sox12, rainbow trout Sox24; D, Sox5, 6 and 13 ...
Cited by 13 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 7 versions »

Cloning and characterisation of the Sry-related transcription factor gene Sox 8 - Full text - MIT Libraries
GE Schepers, M Bullejos, BM Hosking, P Koopman - Nucleic Acids Research, 2000 - nar.oupjournals.org
... two other Sox genes have been implicated in these processes, namely Sry, the mammalian
Y ... or some degree of functional redundancy, as suggested for Sox5 and Sox6 ...
Cited by 18 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Identification and characterization of the human long form of Sox5 (L-SOX5) gene - Full text - MIT Libraries
T Ikeda, J Zhang, T Chano, A Mabuchi, A Fukuda, H … - Gene, 2002 - ingentaconnect.com
... Sry-type HMG box) group of transcription factors, which is defined by a high-mobility
group (HMG) DNA-binding domain, is categorized into six subfamilies. Sox5 ...
Cited by 3 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Sry and Sox9: mammalian testis-determining genes - Full text - MIT Libraries
P Koopman - Cell Mol Life Sci, 1999 - springerlink.com
... 1999 Sry and Sox9: mammalian testis-determining genes P. Koopman ... known to
be downstream from Sry in this cascade is Abstract. Sry ...
Cited by 66 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Cloning and functional analysis of the Sry-related HMG box gene, Sox18 - Full text - MIT Libraries
BM Hosking, JR Wyeth, DJ Pennisi, SC Wang, P … - Gene, 2001 - ncbi.nlm.nih.gov
... The Sox gene family (Sry like HMG box gene) is characterised by a conserved DNA ... binding
domain in exactly the same position as that found in the Sox5, -13 and ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov

Induction of the Sry-related factor SOX6 contributes to BMP-2-induced chondroblastic differentiation …
JL Rosa, F Ventura - mend.endojournals.org
... [4]. Sry-type HMG box proteins form a subfamily of DNA-binding proteins with a 79 ...
determination and skeleton formation [5, 6]. Transcripts for Sox9, L-Sox5 (an ...
Web Search

Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in … - Full text - MIT Libraries
P Smits, P Dy, S Mitra, V Lefebvre - The Journal of Cell Biology - jcb.org
... Sox5 and Sox6 encode Sry-related transcription factors that redundantly
promote early chondroblast differentiation. Using mouse ...
Cited by 2 - Web Search - idp.med.ufl.edu - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

… and spermatid cell lines by transcription factor binding to SRY (sex-determining region Y), CAAT … - Full text - MIT Libraries
LS MORRISON, AR PIEROTTI - Biochem. J, 2003 - biochemj.org
... The SRY/Sox proteins have been shown to form dimers with several co-factors but
Sox5/Sox6 dimers have also been reported to co-operatively activate the ...
Cited by 1 - View as HTML - Web Search - biochemj.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Turning on the male – SRY, SOX 9 and sex determination in mammals - Full text - MIT Libraries
KC Knower, S Kelly, VR Harley, F Alert - Cytogenetic and Genome Research, 2003 - content.karger.com
... 000074336 Turning on the male – SRY, SOX9 and sex determination in mammals ... no
direct downstream targets of SRY have yet been identified. ...
Cited by 9 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions »

Sry and Sox9 expression during canine gonadal sex determination assayed by quantitative reverse …
VN MEYERS-WALLEN - Mol Reprod Dev, 2003 - doi.wiley.com
... Sry and Sox9 Expression During Canine Gonadal ... However, the regulation of Sry
expression and the downstream targets of Sry are unknown. ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

NiceProt View of Swiss-Prot: P35710
S None - expasy.cbr.nrc.ca
... Li P., de Crombrugghe B.; "A new long form of Sox5 (L-Sox5), Sox6 and ... DNA binding
and bending properties of the post-meiotically expressed Sry-related protein ...
Cached - Web Search

NiceProt View of Swiss-Prot: P40645
S Synonym - expasy.cbr.nrc.ca
... Ito M., Kabeno S., Shiba T., Yamashita S.; "A gene that is related to SRY and is ...
Japan] Lefebvre V., Li P., de Crombrugghe B.; "A new long form of Sox5 (L-Sox5 ...
Cached - Web Search

The genetic basis for skeletal diseases - Full text - MIT Libraries
E Zelzer, BR Olsen - Nature, 2003 - nature.com
... dysplasia are caused by mutations in and around the SRY-related gene ... of the chondrocyte
differentiation pathway and is required for expression of Sox5 and Sox6 ...
Cited by 21 - Web Search - nature.com - weizmann.ac.il - ncbi.nlm.nih.gov

SOX genes: architects of development
HM Prior, MA Walter - Mol. Med, 1996 - ncbi.nlm.nih.gov
... Like SRY, SOX genes play important roles in chordate development. ... Nuclear Proteins;
Sox11 protein; Sox3 protein; Sox5 protein; Sox6 protein, mouse; Transcription ...
Cited by 28 - Web Search - Get it from MIT Libraries

Regulatory mechanisms in the pathways of cartilage and bone formation
B de Crombrugghe, V Lefebvre, K Nakashima - Curr Opin Cell Biol, 2001 - cb207.med.harvard.edu
... Li P, de Crombrugghe B: A new long form of Sox5 (L-Sox5), Sox6 and ... Denny P, Swift
S, Connor F, Ashworth A: An SRY-related gene expressed during spermatogenesis ...
Cited by 62 - View as HTML - Web Search - cbi.pku.edu.cn - ingentaconnect.com - all 7 versions »

Hypaxial Muscle Migration during Primary Myogenesis in Xenopus laevis - Full text - MIT Libraries
B Martin, RM Harland - Developmental Biology, 2001 - ingentaconnect.com
... in the migrating muscle precursor population, including neural cell adhesion molecule
(NCAM), Xenopus kit related kinase (Xkrk1), and Xenopus SRY box 5 (sox5). ...
Cited by 6 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

[CITATION] TheSox-13Gene: Structure, Promoter Characterization, and Chromosomal Localization
J Roose, W Korver, R de Boer, J Kuipers, J …
Web Search

cDNA characterization and high resolution mapping of the human SOX20 gene - Full text - MIT Libraries
M Vujic, T Rajic, PN Goodfellow, M Stevanovic - Mamm Genome, 1998 - springerlink.com
... Oosterwegel M, van Norren K, Clevers H (1993) Sox-4, an Sry-like HMG ... Critcher R,
Ashworth A, Goodfellow PN (1996) Cloning and characterisation of SOX5, a new ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

Spatially Precise DNA Bending Is an Essential Activity of the Sox 2 Transcription Factor - Full text - MIT Libraries
P Scaffidi, ME Bianchi - J Biol Chem, 2001 - jbc.org
... 10 8 M indicates a quite strong DNA binding activity, comparable with that observed
for other HMG box transcription factors, such as SRY, LEF1, and Sox5 (8, 20 ...
Cited by 15 - Web Search - jbc.org - southalabama.edu - ncbi.nlm.nih.gov

Regulation of Human COL9A1 Gene Expression - Full text - MIT Libraries
P Zhang, SA Jimenez, DG Stokes - J. Biol. Chem, 2003 - jbc.org
... of the Sry-type HMG box (SOX) 1 family of transcription factors with a specific
region of the intronic enhancer (5-8). Three SOX factors, L-SOX5, SOX6, and SOX9 ...
Cited by 8 - Web Search - jbc.org - ncbi.nlm.nih.gov

Chromosome assignment of eight SOX family genes in chicken - Full text - MIT Libraries
A Kuroiwa, M Uchikawa, Y Kamachi, H Kondoh, C … - Cytogenetic and Genome Research, 2002 - content.karger.com
... The seven SOX genes, SOX1, SOX2, SOX3, SOX5, SOX10, SOX14 and SOX21 were localized
to ... domain, which has more than 50% amino acid similarity to the SRY HMG-box ...
Cited by 7 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions »

Diversification pattern of the HMG and SOX family members during evolution - Full text - MIT Libraries
S Soullier, P Jay, F Poulat, JM Vanacker, P Berta, … - J Mol Evol, 1999 - springerlink.com
... For the first time our analysis clearly identi- fied the SOX subfamily as structured
in six groups of genes named SOX5/6, SRY, SOX2/3, SOX14, SOX4/22, and SOX9 ...
Cited by 26 - Web Search - ncbi.nlm.nih.gov

Effectors of mammalian telomere dysfunction: a comparative transcriptome analysis using mouse models - Full text - MIT Libraries
S Franco, A Canela, P Klatt, MA Blasco - Carcinogenesis, 2005 - carcin.oxfordjournals.org
... a limited number of transcription factors that can be grouped into two functional
classes: (i) the Sry/Sox family of transcription factors (Sry, Sox5, Sox9 and ...
Web Search - ncbi.nlm.nih.gov

Extracellular Matrix Gene Regulation.
K Okazaki, LJ Sandell - Clinical Orthopaedics and Related Research, 2004 - corronline.com
... Additional Sry-related transcriptional factors, such as L-Sox5 and Sox6,
are also involved in chondrogenesis. They form homo-dimers ...
Cited by 1 - Web Search - corronline.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Extreme Evolutionary Conservation of CaSox4 Gene* in Alligator sinensis
J Zheng, M Zhu - RUSSIAN JOURNAL OF GENETICS, 2003 - springerlink.com
... of SRY, which is the mammalian testis- determining gene [1]. Besides SRY, some Sox ...
Sox3 transcripts were detected in the mouse genital ridge [3]. Sox5 and Sox6 ...
Web Search - kluweronline.com

Sequence-specific High Mobility Group Box Factors Recognize 10-12-Base Pair Minor Groove Motifs - Full text - MIT Libraries
M van Beest, D Dooijes, M van de Wetering, S … - J Biol Chem, 2000 - jbc.org
... The other proteins are closely related family members for which the structure (Lef1
and Sry) or the binding site (Rox1 and Sox5) has been elucidated. ...
Cited by 13 - Web Search - jbc.org - ncbi.nlm.nih.gov

Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators
M Wilson, P Koopman - Curr Opin Genet Dev, 2002 - imb.uq.edu.au
... SOX5 SOX6 Coiled-coil domains col2A1 Chondrocytes [49] ... SRY Androgen receptor
HMG N/D Sertoli cells / Wolffian duct [26] (not-coexpressed) ...
Cited by 41 - View as HTML - Web Search - imb.uq.edu.au - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

Toward understanding the functions of the two highly related Sox 5 and Sox 6 genes - Full text - MIT Libraries
V Lefebvre - Journal of Bone and Mineral Metabolism, 2002 - springerlink.com
... L-Sox5 and Sox6 are two highly identical proteins of the Sox D subfamily. They feature
a typical Sry-related HMG box DNA-binding domain and a unique coiled ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov

Expression of Sox transcription factors in the developing mouse pancreas - Full text - MIT Libraries
O Lioubinski, M Muller, M Wegner, M Sander - Dev. Dyn, 2003 - doi.wiley.com
... Although Sry, Sox1, Sox2, and Sox3 were not detected, transcripts for Sox7, Sox15 ...
We next examined the expression domains of Sox11, Sox4, Sox13, Sox5, Sox9, Sox8 ...
Cited by 6 - Web Search - devcell.bio.uci.edu - ncbi.nlm.nih.gov

A new long form of Sox 5(L-Sox 5), Sox 6 and Sox 9 are coexpressed in chondrogenesis and … - Full text - MIT Libraries
V Lefebvre, P Li, B de Crombrugghe - The EMBO Journal, 1998 - embojournal.npgjournals.com
... et al., 1998 ) also feature a similar coiled-coil domain and their HMG domain is
much more similar to those of L-Sox5 and Sox6 than to those of Sry, Sox9 and ...
Cited by 144 - Web Search - nature.com - emboj.org - ncbi.nlm.nih.gov - all 7 versions »

HMG-box sequences from microbats homologous to the human SOX30 HMG-box
M Bullejos, RD de la Guardia, MJL Barragan, A … - Genetica, 2001 - kluweronline.com
... testis and its function is still uncertain as the most abundant Sry transcripts
are ... is the case of Sox17, found in pre-meiotic spermatogonia, and Sox5 and Sox6 ...
Web Search - springerlink.com

Structure, mapping, and expression of human SOX 18 - Full text - MIT Libraries
DJ Pennisi, KM James, B Hosking, GEO Muscat, P … - Mammalian Genome, 2000 - springerlink.com
... campomelic dysplasia are caused by mutations in and around the SRY-related gene ... R,
Ashworth A, Goodfellow PN (1996) Cloning and characterisation of SOX5, a new ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov

Pituitary adenylate cyclase-activating polypeptide gene expression regulated by a testis-specific … - Full text - MIT Libraries
PB Daniel, JF Habener - Endocrinology, 2000 - endo.endojournals.org
... Of particular interest are binding sites for SOX5, a member of the SRY-related high
mobility group box family of DNA-binding factors, that is coexpressed with ...
Cited by 12 - Web Search - dx.doi.org - endo.endojournals.org - ncbi.nlm.nih.gov

Floppy SOX: mutual induced fit in HMG (high-mobility group) box-DNA recognition - Full text - MIT Libraries
MA Weiss - Mol. Endocrinol, 2001 - mend.endojournals.org
... The minor wing of Sox5 unfolds with a midpoint of 34 C whereas the major wing unfolds
with a midpoint of 46 C (36). Analogous studies of the free SRY HMG box ...
Cited by 14 - Web Search - mend.endojournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Sox 5 and Sox 6 are required for notochord extracellular matrix sheath formation, notochord cell … - Full text - MIT Libraries
P Smits, V Lefebvre - Development, 2003 - dev.biologists.org
... Sox5 and Sox6 encode Sry-related HMG box transcription factors that act redundantly
to promote chondroblast differentiation in all cartilages of the mouse ...
Cited by 11 - Web Search - dx.doi.org - dev.biologists.org - ncbi.nlm.nih.gov

EXPRESSION OF HUMAN ESTROGEN RECEPTOR α {alpha} GENE IS REGULATED BY PROMOTER F IN MG-63 …
E LAMBERTINI, L PENOLAZZI, S GIORDANO, L DEL SENNO … - biochemj.org
... box and potential regulatory elements for many transcription factors including
Cbfa1, GATA-1, SOX5, SRY, AP1 and CP2. It is able ...
View as HTML - Web Search

SOX9 is a potent activator of the chondrocyte-specific enhancer of the proa1 (II) collagen gene - Full text - MIT Libraries
V Lefebvre, W Huang, VR Harley, PN Goodfellow, B … - Mol. Cell. Biol, 1997 - mcb.asm.org
... SRY and SOX proteins bind to (A/T)(A/T)CAA(A/ T)G motifs in the minor ... Vectors encoding
full-length mouse Sox4 and Sox5 were generated in the same way with full ...
Cited by 189 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

COG-2, a Sox domain protein necessary for establishing a functional vulval-uterine connection in … - Full text - MIT Libraries
W Hanna-Rose, M Han - Development, 1999 - dev.biologists.org
... to the HMG box of the mammalian sex determining factor SRY (Laudet et al., 1993).
COG-2 is most similar to the group D Sox domain proteins Sox5 and Sox6 (Fig. ...
Cited by 32 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Expression of the human oestrogen receptor-alpha gene is regulated by promoter F in MG-63 … - Full text - MIT Libraries
E Lambertini, L Penolazzi, S Giordano, L Del Senno … - Biochem. J, 2003 - biochemj.org
... includingCbfa1[OSE2(osteoblast-specificelement)corebinding factor], GATA-1
[(A/T)GATA(A/G) binding protein], Sox5 [sex- determining region Y (SRY)-type HMG ...
Cited by 2 - View as HTML - Web Search - biochemj.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Sex-determining region Y-related protein SOX13 is a diabetes autoantigen expressed in pancreatic … - Full text - MIT Libraries
H Kasimiotis, MA Myers, A Argentaro, S Mertin, S … - Diabetes, 2000 - diabetes.diabetesjournals.org
... 5 GG GGT TA ACGTCCGCGG TA AT CTGG TAGA 3 ) containing the SRY/SOX protein ... Among mammals,
the SOX13 HMG domain sequence shows 90% identity to SOX5 and Sox6 (Fig ...
Cited by 19 - Web Search - diabetes.diabetesjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov