Unique gene expression signatures of independently-derived human embryonic stem cell lines - Full text - MIT Libraries
MJ Abeyta, AT Clark, RT Rodriguez, MS Bodnar, RA … - Human Molecular Genetics, 2004 - hmg.oupjournals.org
... Moreover, the genes GP130, STAT3, FOXD3, H19, FGF4, CD34, RUNX1, VEGFR2 (KDR, FLK1)
and KIT, expressed in adult stem cell and mESC populations, were absent in ...
Cited by 15 - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Signalling in stem cells - Full text - MIT Libraries
LE Heasley, BE Petersen - EMBO Reports, 2004 - emboreports.npgjournals.com
... targeting approaches in ES cells, indicating the crucial requirement of Foxd3 for
ES ... can maintain ES-cell self-renewal independently of LIF and Stat3 (Mitsui et ...
Cited by 2 - Web Search - nature.com - nature.com - ncbi.nlm.nih.gov

Human Embryonic Stem Cells: Frontiers in Basic Research and Generation of Cell Technologies( …
OF Gordeeva - Russian Journal of Developmental Biology, 2004 - springerlink.com
... specific differences in the expression of genes, such as vimentin, β-III-tubulin,
α- fetoprotein, eomesodermin, HEB, ARNT, FoxD3, gp130, STAT3, CD34, etc. ...
Web Search - kluweronline.com - ingentaconnect.com

The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells - Full text - MIT Libraries
K Mitsui, Y Tokuzawa, H Itoh, K Segawa, M Murakami … - Cell, 2003 - ucsf.edu
... by stat3 inactivation, indicating crosstalk between the ... Differentiation of ES cells
was in- tors, Sox2 (Avilion et al., 2003) and FoxD3 (Hanna et al., ...
Cited by 119 - View as HTML - Web Search - biology.ccsu.edu - pharm.cwru.edu - cellbio.duke.edu - all 14 versions »

Identification of two distinct transactivation domains in the pluripotency sustaining factor nanog - Full text - MIT Libraries
GJ Pan, DQ Pei, DQ PEI - Cell Res, 2003 - cell-research.com
... R. The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to ... renewal
of pluri- potent embryonic stem cells is mediated via activation of STAT3. ...
Cited by 2 - View as HTML - Web Search - cell-research.com - ncbi.nlm.nih.gov

The neurotrophin-receptor-related protein NRH 1 is essential for convergent extension movements - Full text - MIT Libraries
N Sasai, Y Nakazawa, T Haraguchi, Y Sasai - Nature Cell Biology, 2004 - nature.com
Sasai, N., Mizuseki, K. & Sasai, Y. Requirement of FoxD3-class signaling for neural
crest ... Stat3 controls cell movements during zebrafish gastrulation. Dev. ...
Cited by 1 - Web Search - nature.com - ncbi.nlm.nih.gov

Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells - Full text - MIT Libraries
I Chambers, D Colby, M Robertson, J Nichols, S Lee … - Cell, 2003 - note.cellbio.duke.edu
... expressing chimeric GCSFR-gp130 variant molecules in which the Stat3 binding sites ...
including Oct4 and two transcription factors, Sox2 and FoxD3, identified as ...
Cited by 133 - View as HTML - Web Search - biology.ccsu.edu - fhcrc.org - all 7 versions »

Self-renewal vs. Differentiation of Mouse Embryonic Stem Cells - Full text - MIT Libraries
KS O'Shea - BIOLOGY OF REPRODUCTION, 2004 - biolreprod.org
... inhibitory Stat3 promotes the differentiation of ES cells [23], rather than causing ...
containing protein NANOG [25-27], the SRY family member Sox2 [28], Foxd3 ...
Cited by 1 - Web Search - biolreprod.org - ncbi.nlm.nih.gov

Full Text View - Full text - MIT Libraries
KS O'Shea - Biology of Reproduction - bioone.org
... Somewhat surprisingly, overexpression of an inhibitory STAT3 promotes the
differentiation of ES ... 27], the SRY family member Sox2 [28], Foxd3 (previously Genesis ...
Web Search - bioone.org

Identification of Developmental Pluripotency Associated 5 Expression in Human Pluripotent Stem Cells - Full text - MIT Libraries
SK Kim, MR Suh, HS Yoon, JB Lee, SK Oh, SY Moon, … - Stem Cells, 2005 - stemcells.alphamedpress.org
... and Stat3 each interact with various cofactors and regulate the expression of multiple
target genes [2]. Two other transcription factors, Sox2 and FoxD3, have ...
Web Search - dx.doi.org - stemcells.alphamedpress.org - ncbi.nlm.nih.gov

Requirement for Foxd 3 in maintaining pluripotent cells of the early mouse embryo - Full text - MIT Libraries
LA Hanna, RK Foreman, IA Tarasenko, DS Kessler, PA … - Genes & Development, 2002 - genesdev.org
... RESEARCH PAPER Requirement for Foxd3 in maintaining pluripotent cells of the
early mouse embryo. ... Expression of Foxd3 in early mouse embryos. ...
Cited by 31 - Web Search - genesdev.org - pubmedcentral.nih.gov - dx.doi.org - all 8 versions »

Differential roles for SOX 15 and SOX 2 in transcriptional control in mouse embroyonic stem cells - Full text - MIT Libraries
M Maruyama, T Ichisaka, M Nakagawa, S Yamanaka - Journal of Biological Chemistry, 2005 - jbc.org
... Several transcription factors are essential for maintaining pluripotency, including
Stat3 (7, 8), Oct3/4 (9, 10), Nanog (11, 12), FoxD3 (13), and Sox2 (14). ...
Web Search - jbc.org - ncbi.nlm.nih.gov

Stemness, fusion and renewal of hematopoietic and embryonic stem cells - Full text - MIT Libraries
S Constantinescu - J. Cell. Mol. Med, 2003 - jcmm.ro
... Taken together these results sug- gest that Nanog and STAT3 may have common tar ... potency
include Nanog, Oct4 and two Oct4 partners, Sox2 and FoxD3, which are ...
View as HTML - Web Search - jcmm.ro - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Turning germ cells into stem cells
PJ Donovan, MP de Miguel - Curr Opin Genet Dev, 2003 - biochem.northwestern.edu
... in [82]); the STAT3 transcriptional activator (reviewed in [83]); the HMG-box protein
SOX2 [84 ]; the forkhead tran- scriptional regulator FoxD3 [85 ]; and ...
Cited by 12 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

TRANSGENESIS AND GENE TARGETING
EG ENGINEERS - kcl.ac.uk
... Maintenance of the pluripotent epiblast of postimplantation embryos requires Oct4,
Sox2, and FoxD3 In the ES cell Oct4, Sox2, Stat3, and Nanog are essential ...
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Mini-Review
MES Cell - stemcell.com
... LIF/gp130/Stat3 pathway. 10,11 Other factors proposed to have a role in maintaining
“stemness” include Sox2 (SRY-related HMG box 2) and FoxD3 (forkhead box ...
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Self-renewal of teratocarcinoma and embryonic stem cells - Full text - MIT Libraries
I Chambers, A Smith - Oncogene, 2004 - nature.com
... These studies used a chimaeric STAT3-estrogen receptor that could be dimerized by ...
Sox2/FoxD3 Two transcription factors that may interact with Oct4 and for ...
Cited by 12 - Web Search - era.lib.ed.ac.uk - ncbi.nlm.nih.gov

The Transcriptome Profile of Human Embryonic Stem Cells as Defined by SAGE - Full text - MIT Libraries
M Richards, SP Tan, JH Tan, WK Chan, A Bongso - Stem Cells, 2004 - intl-stemcells.alphamedpress.org
... the existence of distinct transcripts that matched to genes like FOXD3 and GBX2 ... Genes
studied were POU5F1, SOX2, REX1 HESX1, DNMT3B, ERH, STAT3, LIF, LIFR, IL6ST ...
Cited by 23 - Web Search - dx.doi.org - stemcells.alphamedpress.org - ncbi.nlm.nih.gov - all 6 versions »

Human embryonic stem cells express a unique set of microRNAs - Full text - MIT Libraries
M SUH, Y Lee, JY Kim, SK Kim, SH Moon, JY Lee, KY … - Developmental Biology, 2004 - plaza1.snu.ac.kr
... Stat3 each interact with various cofactors and regulate the expression of multiple
target genes (Niwa, 2001). Two other transcription factors, Sox2 and FoxD3, ...
Cited by 13 - View as HTML - Web Search - ncbi.nlm.nih.gov

Orphan Nuclear Receptor LRH-1 Is Required To Maintain Oct4 Expression at the Epiblast Stage of … - Full text - MIT Libraries
P Gu, B Goodwin, CKC Arthur, X Xu, DA Wheeler, RR … - Mol Cell Biol, 2005 - mcb.asm.org
... the early mouse embryo is controlled by several key transcription factors such as
Oct4, Sox2, Foxd3, Nanog, and signaling molecules such as STAT3, FGF4, FGF4 ...
Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov

Characterization and culture of human embryonic stem cells - Full text - MIT Libraries
LM Hoffman, MK Carpenter - Nature Biotechnology, 2005 - nature.com
... undifferentiated state, and include those encoding Oct4, DNMT3B, Sox2 and FoxD3
40 . ... cells have been shown to require activation of the gp130/STAT3 pathway to ...
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Transcriptome Profiling of Human and Murine ESCs Identifies Divergent Paths Required to Maintain the … - Full text - MIT Libraries
CL Wei, T Miura, P Robson, SK Lim, XQ Xu, MYC Lee, … - Stem Cells, 2005 - stemcells.alphamedpress.org
... revealed that besides LIFR, transcripts for gp130 and Stat3 were easily ... conditions,
while other differences—such as those in FoxD3—represent allelic ...
Cited by 1 - Web Search - dx.doi.org - stemcells.alphamedpress.org - ncbi.nlm.nih.gov

Oct-3/4 Maintains the Proliferative Embryonic Stem Cell State via Specific Binding to a Variant … - Full text - MIT Libraries
M Nishimoto, S Miyagi, T Yamagishi, T Sakaguchi, H … - Mol Cell Biol, 2005 - mcb.asm.org
... Requirement for FoxD3 in maintaining pluripotent cells of the early mouse embryo. ...
STAT3 activation is sufficient to maintain an undifferentiated state of mouse ...
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Correlation of Murine Embryonic Stem Cell Gene Expression Profiles with Functional Measures of … - Full text - MIT Libraries
L Palmqvist, CH Glover, L Hsu, M Lu, B Bossen, JM … - Stem Cells, 2005 - stemcells.alphamedpress.org
... However, the onset of the decrease was later than for Stat3 (between 18 and ... The
abundance of FoxD3, a gene expressed early in mouse embryonic development, also ...
Web Search - dx.doi.org - stemcells.alphamedpress.org - ncbi.nlm.nih.gov

A slug, a fox, a pair of sox: Transcriptional responses to neural crest inducing signals
E Heeg-Truesdell, C LaBonne - Birth Defects Research Part C Embryo Today Reviews, 2004 - doi.wiley.com
... 2004. © 2004 Wiley-Liss, Inc. Key words: neural crest; c-myc; Wnt; BMP;
FGF; Notch; Slug; Snail; Sox; Msx-1; Pax-3; FoxD3 Elizabeth ...
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Human STELLAR, NANOG, and GDF 3 Genes Are Expressed in Pluripotent Cells and Map to Chromosome 12 p … - Full text - MIT Libraries
AT Clark, RT Rodriguez, MS Bodnar, MJ Abeyta, MI … - Stem Cells, 2004 - intl-stemcells.alphamedpress.org
... Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo. ...
STAT3 activation is sufficient to maintain an undifferentiated state of mouse ...
Cited by 9 - Web Search - dx.doi.org - stemcells.alphamedpress.org - ncbi.nlm.nih.gov - all 5 versions »

Issues in Development
VP KALE - dx.doi.org
... and only a limited number of genes like Oct-4, Fgf-4, H2a2, Foxd3, Nanog, and ...
LIF/STAT3 signaling fails to maintain self-renewal of human embry- onic stem cells ...
Web Search - liebertonline.com - liebertonline.com

The intracrine hypothesis and intracellular peptide hormone action - Full text - MIT Libraries
RN Re - BioEssays, 2003 - doi.wiley.com
... p53/Mdm2/p63 p53/Maspin p53/angiotensinogen (precursor of angiotensinII ) p53/VEGF
p53/IGFBP 3 p63 isoform (p51A)/VEGF p63 isoform (p71L)/VEGF FoxD3 (XFD-6 ...
Cited by 10 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

S tem C ells
UMESC Lines - stemcells.nih.gov
... is capable of maintaining mouse ES cell self-renewal independent of the LIF/Stat3
pathway associated with transcription factors such as Oct-4, Sox2,and FoxD3. ...
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Earlier expression of the transcription factor HFH-11 B diminishes induction of p 21 CIP 1/WAF 1 … - Full text - MIT Libraries
X Wang, NJ Hung, RH Costa - Hepatology, 2001 - dx.doi.org
Page 1. Earlier Expression of the Transcription Factor HFH-11B Diminishes Induction
of p21 CIP1/WAF1 Levels and Accelerates Mouse Hepatocyte ...
Cited by 23 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - all 4 versions »

Regenerative Biology and Medicine: An Overview
DL Stocum - cellscience.com
... Recently, a LIF/STAT3-independent transcription factor, Nanog, has been discovered
that ... IA, Kessler DS, Labosky PA (2002) Requirement for Foxd3 in maintaining ...
Cached - Web Search

Embryonic Stem Cells: Prospects for Developmental Biology and Cell Therapy - Full text - MIT Libraries
AM Wobus, KR Boheler - Physiol. Rev, 2005 - physrev.physiology.org
... 4, Nanog, BMP-dependent SMAD, and LIF-dependent JAK/STAT3 signaling pathways. A:
transcription factors, such as Oct3/4, Nanog, Sox2, and FoxD3, control early ...
Web Search - med.unc.edu - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Exploitation of stem cell plasticity - Full text - MIT Libraries
E Martin-Rendon, SM Watt - Transfusion Medicine, 2003 - blackwell-synergy.com
... A novel factor, Nanog, that promotes pluripotency and self-renewal in the mouse
embryo and murine ES cells independently of the LIF/Stat3 pathway has also been ...
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