Targeting STAT3 affects melanoma on multiple fronts
M Kortylewski, R Jove, H Yu - Cancer and Metastasis Reviews, 2005 - springerlink.com
... to restore p53 function and induce tumor regression, increasing endogenous p53
expression by either overexpressing HOXA5 [83] or targeting STAT3 results in ...
Web Search - ingentaconnect.com

The STATs of cancer—new molecular targets come of age - Full text - MIT Libraries
H Yu, R Jove - Nat Rev Cancer, 2004 - nature.com
... 22. Hirano, T., Ishihara, K. & Hibi, M. Roles of STAT3 in mediating the cell growth,
differentiation and survival signals relayed through the IL-6 family of ...
Cited by 51 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Transcriptional regulation during myelopoiesis
N Lenny, JJ Westendorf, SW Hiebert - Mol Biol Rep, 1997 - springerlink.com
... patient samples and cell lines while G-CSF activated STAT3 in nor ... For example, antisense
oligonucleotides against HOXA5 simultaneously inhibited myeloid colony ...
Cited by 41 - Web Search - kluweronline.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Normal growth and development in the absence of hepatic insulin-like growth factor I - Full text - MIT Libraries
S Yakar, JL Liu, B Stannard, A Butler, D Accili, B … - Developmental Biology, 1999 - dx.doi.org
... Takeda, S. Akira, T. Ogino, K. Irani, and M. Ozaki Stat3 protects against ... L. Gan,
TG Unterman, A. Prochiantz, and A. Trembleau Hoxa5 overexpression correlates ...
Cited by 288 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Transcriptional Control of the Cell Cycle in Mammary Gland Development and Tumorigenesis
RD Coletta, P Jedlicka, A Gutierrez-Hartmann, HL … - Journal of Mammary Gland Biology and Neoplasia, 2004 - springerlink.com
... of the cell cycle, as well as apopto- sis, the ability of the HOXA5 protein to ... There
are seven STAT genes in mammals (STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B ...
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The Kinetic Status of Hematopoietic Stem Cell Subpopulations Underlies a Differential Expression of … - Full text - MIT Libraries
R Manfredini, R Zini, S Salati, M Siena, E … - Stem Cells, 2005 - stemcells.alphamedpress.org
... of interferon-gamma due to phosphorylation of Stat1 and Stat3. ... Constitutive HOXA5
expression inhibits erythropoiesis and increases myelopoiesis from human ...
Web Search - dx.doi.org - stemcells.alphamedpress.org - ncbi.nlm.nih.gov

Comparative genomics provides evidence for an ancient genome duplication event in sh
JS Taylor, Y Van de Peer, I Braasch, A Meyer - Phil. Trans. R. Soc. Lond. B, 2001 - journals.royalsoc.ac.uk
Page 1. Comparative genomics provides evidence for an ancient genome duplication
event in sh John S. Taylor, Yves Van de Peer, Ingo Braasch and Axel Meyer * ...
Cited by 102 - Web Search - evolutionsbiologie.uni-konstanz.de - mit.edu - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

The intracrine hypothesis and intracellular peptide hormone action - Full text - MIT Libraries
RN Re - BioEssays, 2003 - doi.wiley.com
... analogue of LHRH)/LHRH Receptor Insulin/Nuclear Insulin Receptor Homeodomain protein
feed-back loops and intracrine interactions Hoxb-4/Hoxb-4 HOXA5/HOXA Gene ...
Cited by 10 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Activation of Stem-Cell Specific Genes by HOXA9 and HOXA10 Homeodomain Proteins in CD34 Human Cord …
CM Ferrell, ST Dorsam, H Ohta, RK Humphries, MK … - stemcells.alphamedpress.org
... Tip 60 is a co-repressor for STAT3. ... Constitutive HOXA5 expression inhibits
erythropoiesis and increases myelopoiesis from human hematopoietic progenitors. ...
Web Search - dx.doi.org - stemcells.alphamedpress.org

Analysis of the Protein Kinase B–Forkhead box O signaling pathway
APJ van den Heuvel - igitur-archive.library.uu.nl
Page 1. Analysis of the Protein Kinase B – Forkhead box O signaling pathway Analyse
van de proteine kinase B – Forkhead box O signaleringsroute ...
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Human stanniocalcin-2 exhibits potent growth suppressive properties in transgenic mice independent … - Full text - MIT Libraries
AD Gagliardi, EYW Kuo, S Raulic, GF Wagner, GE … - Am J Physiol Endocrinol Metab, 2004 - ajpendo.physiology.org
Page 1. FINAL ACCEPTED VERSION E-00268-2004.R2 Gagliardi et al. STC-2 and
Growth Restriction Human stanniocalcin-2 exhibits potent ...
Cited by 1 - Web Search - ajpendo.physiology.org - ncbi.nlm.nih.gov

AC Ward, DM Loeb 2, AA Soede-Bobok, IP Touw and AD Friedman 2
G Factors - Leukemia, 2000 - nature.com
... 141 HoxA5 is also expressed during early myelopoiesis – inhi- bition of HoxA5
expression with antisense oligonucleotides inhibited granulocytic and monocytic ...
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The Androgen Receptor Gene is Preferentially Hypermethylated in Follicular Non-Hodgkin’s Lymphomas - Full text - MIT Libraries
H Yang, CM Chen, P Yan, TH Huang, H Shi, M Burger, … - Clin Cancer Res, 2003 - 140.120.130.112
... NM_006497 HIC-1 17p13.3 Hypermethylated in cancer 1 NM_019102 HOXA5 7p15 Homeo box
A5, mRNA NM_002412 MGMT 10q26 O-6-methylguanine-DNA-methyltransferase ...
Cited by 3 - View as HTML - Web Search - clincancerres.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Rapid Generation of de novo Biological Pathways from Large-Scale Gene Expression Data Using the …
DC Siu - ingenuity.com
... STAT3, STAT5A, IRF1, Alpha tubulin, PLCG2, GAB2, DOK1, CBLB, MAP4K1, SHC1, BLNK ... HOXA5,
PBX1, HOXB7, HOXC8, PKNOX1, ISL1, NEUROG3, SST, COL5A2, REN, HOXB6, HOXB1 ...
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The granulocytic inducer C/EBP a inactivates the myeloid master regulator PU. 1: possible role in …
AMK und Poliklinik, III am Klinikum Grosshadern - edoc.ub.uni-muenchen.de
... HOXA5 several lines of evidence indicate that HOXA5 gene expression ... STAT3 essential
for gp130-mediated induction of proliferation, differentiation and survival ...
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Exploitation of stem cell plasticity - Full text - MIT Libraries
E Martin-Rendon, SM Watt - Transfusion Medicine, 2003 - blackwell-synergy.com
... embryo and murine ES cells independently of the LIF/Stat3 pathway has ... induces stem
cell expansion (Thorsteinsdottir et al., 2002), whereas HoxA5 and HoxA10 ...
Cited by 4 - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov

Supplementary Data ‘Stemness’: Transcriptional Profiling of Embryonic and Adult Stem Cells
M Ramalho-Santos, S Yoon, Y Matsuzaki, RC Mulligan … - intl.sciencemag.org
... and 10. Of these genes, the highest ranking are HoxA10 (65 th , LCB=6.9)
and HoxA5 (172 nd , LCB=4.4). Although the significance ...
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Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias - Full text - MIT Libraries
CW So, M Lin, PM Ayton, EH Chen, ML Cleary - Cancer Cell, 2003 - rkblab.biochem.uci.edu
... Their only shared features are coiled-coil domains, which are required genes (including
HoxA5, A7, A9, and A10) and Hox cofactors Meis1 and Meis3. ...
Cited by 24 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov