Activation of Stem-Cell Specific Genes by HOXA9 and HOXA10 Homeodomain Proteins in CD34 Human Cord …
CM Ferrell, ST Dorsam, H Ohta, RK Humphries, MK … - stemcells.alphamedpress.org
... with myeloid differentiation are inhibited by HOXA9 and/or HOXA10. Tip60 is a
60-kDa Tat – interactive protein that normally represses STAT3 and is involved ...
Web Search - dx.doi.org - stemcells.alphamedpress.org

Rapid Generation of de novo Biological Pathways from Large-Scale Gene Expression Data Using the …
DC Siu - ingenuity.com
... FLI1 SYK HDAC6 (In Network 1.Data not shown) MBP MEIS1 HOXA9 PBX1 PBX2 ... STAT3, STAT5A,
IRF1, Alpha tubulin, PLCG2, GAB2, DOK1, CBLB, MAP4K1, SHC1, BLNK, Tubulin ...
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Transcriptional regulation during myelopoiesis
N Lenny, JJ Westendorf, SW Hiebert - Mol Biol Rep, 1997 - springerlink.com
... AML patient samples and cell lines while G-CSF activated STAT3 in nor ... HOXA9 is expressed
in normal CD34 + marrow cells, particularly fractions enriched for GM ...
Cited by 41 - Web Search - kluweronline.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Identification of CCR2, flotillin, and gp49B genes as new G-CSF targets during neutrophilic …
S Iida, T Kohro, T Kodama, S Nagata, R Fukunaga - Journal of Leukocyte Biology, 2005 - jleukbio.org
... R., Wistinghausen, B., Takeshita, K., DePinho, RA, Levy, DE (2002) STAT3 is a ... Text];
Calvo, KR, Sykes, DB, Pasillas, M., Kamps, MP (2000) Hoxa9 immortalizes a ...
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Estrogen-regulated Conditional Oncoproteins: Tools to Address Open Questions in Normal Myeloid Cell …
DB Sykes, MP Kamps - Leukemia & Lymphoma, 2003 - dx.doi.org
... cells (differentiation arrested by Hoxb8 or v-Myb, dominant-negative STAT3 [41 ... define
mechanisms of differentiation arrest by oncoproteins such as Hoxa9, Mll-Enl ...
Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Inhibition of Granulocyte Differentiation by G Cyclins D2 and D3 but not D1 - Full text - MIT Libraries
J Kato, CJ Sherr - Proceedings of the National Academy of Sciences - pnas.org
... Mbeta 2 (CD11b/CD18) Expression by Cytokines Is Regulated by Stat3-dependent Activation
of ... by SCF: Potential mechanisms of cooperativity with Hoxa9 in myeloid ...
Cited by 105 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Mechanisms controlling pathogenesis and survival of leukemic stem cells - Full text - MIT Libraries
CT Jordan, ML Guzman - Oncogene, 2004 - nature.com
... the preleukemic mutations result in genomic instability and/or increased self-renewal
(eg HoxA9). ... pathways such as Flt3, Ras, PI3 kinase, NF-kB, Stat3/5, and ...
Cited by 3 - Web Search - biochem.northwestern.edu - ncbi.nlm.nih.gov

Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice - Full text - MIT Libraries
LZ He, C Tribioli, R Rivi, D Peruzzi, PG Pelicci, … - Proc Natl Acad Sci USA, 1997 - dx.doi.org
... and Y. Kanakura Opposing effects of PML and PML/RARalpha on STAT3 activity Blood ...
blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9 PNAS, May 28 ...
Cited by 126 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Targeted ubiquitination of CDT 1 by the DDB 1–CUL 4 A–ROC 1 ligase in response to DNA damage - Full text - MIT Libraries
J Hu, CM McCall, T Ohta, Y Xiong - Nature Cell Biology, 2004 - nature.com
... CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein ...
Ulane, CM, Rodriguez, JJ, Parisien, JP & Horvath, CM STAT3 ubiquitylation and ...
Cited by 4 - Web Search - nature.com - cyan.kku.edu - ncbi.nlm.nih.gov

Demonstration of Permanent Factor-Dependent Multipotential (Erythroid/Neutrophil/Basophil) … - Full text - MIT Libraries
JS Greenberger, MA Sakakeeny, RK Humphries, CJ … - J. Biol. Chem, 2004 - pnas.org
... CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein ...
Longmore, and SS Watowich Cytokine Signaling through Stat3 Activates Integrins ...
Cited by 176 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Transcriptional Control of the Cell Cycle in Mammary Gland Development and Tumorigenesis
RD Coletta, P Jedlicka, A Gutierrez-Hartmann, HL … - Journal of Mammary Gland Biology and Neoplasia, 2004 - springerlink.com
... While the role of the HOXA9 paralog has been estab- lished in leukemias (35 ... There
are seven STAT genes in mammals (STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B ...
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Dimerization: a versatile switch for oncogenesis - Full text - MIT Libraries
CW So, ML Cleary - Blood, 2004 - bloodjournal.org
... leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways. ...
of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. ...
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Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem …
E Passegue, CH Jamieson, LE Ailles, IL Weissman - Proceedings of the National Academy of Sciences - pnas.org
... acts, at least in part, via activation of the transcription factor STAT3, an essential ...
Expression of some of the Hox genes, such as HoxB4 and HoxA9, has been ...
Cited by 42 - Web Search - 171.66.122.165 - biol.sc.edu - olemiss.edu - all 10 versions » - Get it from MIT Libraries

An Overview of Translocation-Related Oncogenesis in the Chronic Myeloid Leukaemias
BJ Bain - Acta Haematologica, 2002 - content.karger.com
... a cell line has been shown to result in activation of STAT1, STAT3 and STAT5 ... This
translocation usually results in formation of a NUP98-HOXA9 fusion gene but ...
Cited by 3 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

The Kinetic Status of Hematopoietic Stem Cell Subpopulations Underlies a Differential Expression of … - Full text - MIT Libraries
R Manfredini, R Zini, S Salati, M Siena, E … - Stem Cells, 2005 - stemcells.alphamedpress.org
... cycle progression of HSCs and progenitor cells acting through STAT1/STAT3 activation
[22]. ... Among them, HOXA5, HOXA9, HOXA10, HOXB2, HOXB5, Meis1, and PBX2 are ...
Web Search - dx.doi.org - stemcells.alphamedpress.org - ncbi.nlm.nih.gov

G ENETIC P ROFILE OF A CUTE M YELOID L EUKEMIA - Full text - MIT Libraries
C Mecucci, R Rosati, R La Starza - Reviews in Clinical & Experimental Hematology, 2002 - blackwell-synergy.com
... The leukemogenic potential of NUP98/HOXA9 protein was tested in vitro by ... proliferation
of c-kit mutant leukemic clones, such as STAT3 and phosphatidylinositol-3 ...
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Chromosomal Translocations in Hematologic Malignancies
CG Brunstein, SJ Dylla, CM Verfaillie - Current Genomics, 2002 - ingentaconnect.com
... 142]. HOXA9 and HOXA10 are highly expressed in early myeloid precursors,
but have low expression in differentiated CD34 - cells. ...
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Comparative genomics provides evidence for an ancient genome duplication event in sh
JS Taylor, Y Van de Peer, I Braasch, A Meyer - Phil. Trans. R. Soc. Lond. B, 2001 - journals.royalsoc.ac.uk
Page 1. Comparative genomics provides evidence for an ancient genome duplication
event in sh John S. Taylor, Yves Van de Peer, Ingo Braasch and Axel Meyer * ...
Cited by 102 - Web Search - evolutionsbiologie.uni-konstanz.de - mit.edu - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

The Epigenomic Viewpoint on Cellular Differentiation of Myeloid Progenitor Cells as it Pertains to …
VE Sollars - Current Genomics, 2005 - ingentaconnect.com
... Krosl, J., Thorsteinsdottir, U., Baban, S., Buchberg, AM., Sauvageau G. Hoxa9
transforms primary ... IL-6 induces expression of the Fli-1 proto-oncogene via STAT3. ...
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Altered differentiation in acute myeloid leukemias; Role of ERG and FUS-ERG fusion protein
MC Doarn - 2005 - kb.osu.edu
... include the translocation (t) between chromosomes 8 and 21 AML1/ETO, t(15;17) PML-
RARα, t(9;11) AF9-MLL, t(7;11) Nup98-HOXA9, and t(16;21)(p11;q22) FUS-ERG ...
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AC Ward, DM Loeb 2, AA Soede-Bobok, IP Touw and AD Friedman 2
G Factors - Leukemia, 2000 - nature.com
... 141 Both HoxA9 and HoxA10 are highly expressed in human CD34 + cells,
but are down-regulated during myeloid development. 19,142 ...
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Targeted transcriptional repression of Gfi 1 by GFI 1 and GFI 1 B in lymphoid cells - Full text - MIT Libraries
LL Doan, SD Porter, Z Duan, MM Flubacher, D … - Nucleic Acids Research, 2004 - nar.oupjournals.org
... that such factors may include NFAT, IRF2, GATA proteins, E4BP4/NFIL3, HoxA9,
SP-1 ... Moroy,T. (2000) The zinc finger protein Gfi-1 can enhance STAT3 signaling by ...
Cited by 5 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 7 versions »

A stable human-derived packaging cell line for production of high titer retrovirus/vesicular … - Full text - MIT Libraries
DS Ory, BA Neugeboren, RC Mulligan - J. Biol. Chem, 2004 - dx.doi.org
Vol. 93, Issue 21, 11400-11406, October 15, 1996. This paper was presented
at a colloquium entitled "Genetic Engineering of Viruses ...
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Blood First Edition Paper, prepublished online November 2, 2004; DOI 10.1182/blood-2004-09-3459
P Isolation, GGE Analysis - uni-ulm.de
... gene family, only HoxA9 was expressed, with lower expression in EP and higher ... within
the STAT family, Stat3 and Stat4 expression was stronger in GMP while ...
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The granulocytic inducer C/EBP a inactivates the myeloid master regulator PU. 1: possible role in …
AMK und Poliklinik, III am Klinikum Grosshadern - edoc.ub.uni-muenchen.de
... regulation is necessary for progression of erythropoiesis HOXA9 important role ... STAT3
essential for gp130-mediated induction of proliferation, differentiation ...
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Genetic programs regulating HSC specification, maintenance and expansion - Full text - MIT Libraries
J Lessard, A Faubert, G Sauvageau - Oncogene, 2004 - nature.com
... Interestingly, HSCs engineered to overexpress an activated form of STAT3 (STAT3c)
behave similarly to those transduced with Hoxb4, potentially suggesting the ...
Web Search - ncbi.nlm.nih.gov

The gene encoding the transcriptional regulator Yin Yang 1 (YY1) is a myeloid transforming gene … - Full text - MIT Libraries
SJ Erkeland, M Valkhof, C Heijmans-Antonissen, R … - Blood, 2003 - bloodjournal.org
... Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes. ...
STAT3-mediated differentiation and survival and of myeloid cells in response to ...
Cited by 9 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Prospective isolation and global gene expression analysis of the erythrocyte colony-forming unit ( … - Full text - MIT Libraries
G Terszowski, C Waskow, P Conradt, D Lenze, J … - Blood, 2005 - bloodjournal.org
... Within the homeobox domain gene family, only HoxA9 was expressed, with lower ... Finally,
within the STAT family, Stat3 and Stat4 expressions were stronger in GMPs ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

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MR Baer, LA Pixley, LA Ford… - Current Opinion in Oncology, 2002 - co-oncology.com
... J, Nakamura T, Croce CM, et al.: Upregulation of Meis1 and HoxA9 in acute ... Schuringa
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Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias - Full text - MIT Libraries
CW So, M Lin, PM Ayton, EH Chen, ML Cleary - Cancer Cell, 2003 - rkblab.biochem.uci.edu
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Exploitation of stem cell plasticity - Full text - MIT Libraries
E Martin-Rendon, SM Watt - Transfusion Medicine, 2003 - blackwell-synergy.com
... mouse embryo and murine ES cells independently of the LIF/Stat3 pathway has ...
Overexpression of HoxA9 in HSCs induces stem cell expansion (Thorsteinsdottir et ...
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Novel transcription factors in human CD34 antigen-positive hematopoietic cells - Full text - MIT Libraries
I Gomes, TT Sharma, S Edassery, N Fulton, BG Mar, … - Blood, 2002 - bloodjournal.org
... Transcription Hs.321677 STAT3 Signal transducer and activator of
transcription 3 (acute-phase response factor) 17q21 437.5 VH W ...
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Focus on Cellular Biochemistry
N Belgareh, V Doye - Protoplasma, 1999 - springerlink.com
... Grouping Nameb (mass) Cloning method c Homolog a Localization Motifs References
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L Benboubker, H Watier, A Carion, MT Georget, I … - Current Opinion in Hematology, 2002 - co-hematology.com
... et al.: The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at ... NG, Hirokawa
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MD Boyano, MD GarciaVazquez, T LopezMichelena, J … - Current Opinion in Hematology, 2001 - co-hematology.com
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... Blood 2004, 104:2307-2314. • Dorsam ST, Ferrell CM, Dorsam GP, et al.: The
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The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases - Full text - MIT Libraries
XJ Yang - Nucleic Acids Research, 2004 - nar.oupjournals.org
... TIP60 not only functions as a transcriptional co-repressor for TEL (119) and STAT3
(151), but also as a coactivator for androgen receptor (152,153), NF- B (154 ...
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Univ. of Pennsylvania-Electronic Theses and Dissertations
AS Agbe-Davies, K Aker, LM Anderson, R Anisfeld, … - repository.upenn.edu
Univ. of Pennsylvania - Electronic Theses and Dissertations.
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