Impaired IgG Production in Mice Deficient for Heat Shock Transcription Factor 1 - Full text - MIT Libraries
S Inouye, H Izu, E Takaki, H Suzuki, M Shirai, Y … - J Biol Chem, 2004 - jbc.org
... It was revealed that expression levels of STAT1 and STAT3 and levels of phosphorylated
forms were similar in wild-type and HSF1-null spleen cells in response ...
Cited by 1 - Web Search - jbc.org - ncbi.nlm.nih.gov

Heat shock proteins and regulation of cytokine expression
Y Xie, CM Cahill, A Asea, PE Auron, SK Calderwood - Infectious Diseases in Obstetrics and Gynecology, 1999 - doi.wiley.com
... member NF-IL6 is strongly impli- cated as a major target for HSF1(Xie Y ... In addition,
other factors involved in cytokine expression, such as STAT3, CREB, and AP-1 ...
Cited by 8 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Progress IN Molecular Biology
G St, P Krakow - mol.uj.edu.pl
... promoters. In the case of α 2M gene transcription STAT3 and NF-κB compete for binding
to enhancer elements composed of overlapping binding sites. ...
View as HTML - Web Search - biotka.mol.uj.edu.pl

Thrombin Regulates Vascular Smooth Muscle Cell Growth and Heat Shock Proteins via the JAK-STAT … - Full text - MIT Libraries
NR Madamanchi, S Li, C Patterson, MS Runge - J Biol Chem, 2001 - jbc.org
... STAT binding domain of the Hsp70 promoter, whereas STAT1 and STAT3 are the ... also contain
binding sites for the stress-activated transcription factor, HSF1 (50). ...
Cited by 32 - Web Search - jbc.org - ncbi.nlm.nih.gov

Implication of BRG 1 and cdk 9 in the STAT 3-mediated activation of the p 21 waf 1 gene - Full text - MIT Libraries
S Giraud, A Hurlstone, S Avril, O Coqueret - Oncogene, 2004 - nature.com
Page 1. Implication of BRG1 and cdk9 in the STAT3-mediated activation of the p21waf1
gene ... Keywords: STAT3; chromatin; acetylation; p21waf1 Introduction ...
Cited by 2 - Web Search - nature.com - ncbi.nlm.nih.gov

Post-translational modification by the small ubiquitin-related modifier SUMO has big effects on …
G Gill - Curr. Opin. Genet. Dev, 2003 - genetics.biol.ttu.edu
... factors is also regulated by SUMO-modification including Sp3, HSF1, and TEL ... B, Rao
X, Jay P, Berta P, Shuai K: Specific inhibition of Stat3 signal transduction ...
Cited by 32 - View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

HSF-1 Interacts with Ral-binding Protein 1 in a Stress-responsive, Multiprotein Complex with HSP 90 … - Full text - MIT Libraries
Y Hu, NF Mivechi - J Biol Chem, 2003 - jbc.org
... this interaction appears to also be a negative regulator of HSF1 transcriptional
activity. ... Similarly, activated Ral-GTPase leads to phosphorylation of Stat3 (22 ...
Cited by 11 - Web Search - jbc.org - ncbi.nlm.nih.gov

Noncovalent SUMO-1 Binding Activity of Thymine DNA Glycosylase(TDG) Is Required for Its SUMO-1 … - Full text - MIT Libraries
H Takahashi, S Hatakeyama, H Saitoh, KI Nakayama - J Biol Chem, 2005 - jbc.org
... Transcription factors such as p53, HSF1, and HSF2 are activated by SUMO-1 ... Recombinant
His 6 -tagged Myc-STAT3 (negative control) was expressed in Sf21 cells ...
Cited by 1 - Web Search - jbc.org - ncbi.nlm.nih.gov

Cellular response to oxidative stress: Signaling for suicide and survival - Full text - MIT Libraries
JL Martindale, NJ Holbrook - Journal of Cellular Physiology, 2002 - doi.wiley.com
... The induction of Hsp in response to stress is mediat- ed largely through
transcriptional activation via heat shock transcription factor 1 (HSF1) (reviewed ...
Cited by 159 - Web Search - ncbi.nlm.nih.gov

SUMO wrestling with type 1 diabetes - Full text - MIT Libraries
CY Wang - J Mol Med, 2005 - springerlink.com
... Thus, while PIAS1 and PIAS3 bind STAT1 and STAT3, respectively, and inhibit ... tran-
scriptional level by stress-inducible heat shock factors (ie, HSF1 and HSF2 ...
Web Search

Transcription factor Sp 3 is silenced through SUMO modification by PIAS 1 - Full text - MIT Libraries
A Sapetschnig, G Rischitor, H Braun, A Doll, M … - The EMBO Journal, 2002 - embojournal.npgjournals.com
... In the case of HSF1 and HSF2, SUMO-1 modification was shown to result in ... of various
transcription factors, namely STAT1 (Liu et al., 1998), STAT3 (Chung et al ...
Cited by 67 - Web Search - nature.com - emboj.org - imt.uni-marburg.de - all 8 versions »

5a-Androstane-3a, 17b-diol activates pathway that resembles the epidermal growth factor responsive …
RA Zimmerman, I Dozmorov, EH Nunlist, Y Tang, X Li … - Prostate Cancer and Prostatic Diseases, 2004 - nature.com
... of several heat shock proteins (HSP; HSPs 27 (X54079), 40 (D49547), 70 (X51757),
and 75 (U12595)), heat shock transcription factor 1 (HSF1; M64673), and cell ...
Cited by 1 - Web Search

Nuclear and unclear functions of SUMO - Full text - MIT Libraries
JS Seeler, A Dejean - Nature Reviews Molecular Cell Biology, 2003 - nature.com
... The phosphorylation of a specific serine residue of HSF1 precedes sumoylation, thereby
providing an excellent example for the interplay between two types of ...
Cited by 98 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Abstracts of the 2nd International Symposium on Molecular Diagnostics and Skin Gene Therapy - Full text - MIT Libraries
I Session, II Session, IV Session, V Session, VI … - J Gene Med, 2003 - doi.wiley.com
... Therefore, we investigated the protein expression of Stat3 and Stat5 via Western
blot analysis and observed a constitutive level of these proteins in primary ...
Web Search

Octamer and Sox Elements Are Required for Transcriptional cis Regulation of Nanog Gene Expression - Full text - MIT Libraries
T Kuroda, M Tada, H Kubota, H Kimura, S Hatano, H … - Mol Cell Biol, 2005 - mcb.asm.org
... mouse cytosolic chaperonin CCT subunit genes by heat shock factors HSF1 and HSF2. ...
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality ...
Cited by 3 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov

5 alpha-Androstane-3 alpha, 17 bold italic beta-diol activates pathway that resembles the epidermal …
RA Zimmerman, I Dozmorov, EH Nunlist, Y Tang, X Li … - Prostate Cancer and Prostatic Diseases, 2004 - nature.com
... In contrast, expression of IL-6, BAD, HSF1, and HSP40 was more ... 6 differentially
regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK ...
Web Search - nature.com

Statistical methods for joint data mining of gene expression and DNA sequence database
MD Curran, H Liu, F Long, N Ge - SIGKDD Explorations Special Issue on Microarray Data Mining, 2003 - portal.acm.org
... OCT-x OCT1 -- OCT_C 42.1% STAT1 STAT3 -- STAT_C 71.8% NF-kappaB NF-kappaB (p65)
c-Rel NFkcR_C 77.9% ... MEIS1 TGIF -- MsTGIF_C 5.6% HSF1 HSF2 -- HSF_C 71.4% ...
Cited by 3 - Web Search - acm.org - portal.acm.org

Axonal defects in mouse models of motoneuron disease - Full text - MIT Libraries
S Jablonka, S Wiese, M Sendtner - Journal of Neurobiology, 2004 - doi.wiley.com
... an impaired ability to activate the heat shock transcription factor HSF1 (Batulan
et ... a signaling intermediate (Wiese et al., 2001), but not Stat3, a signaling ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Signaling specificity - Full text - MIT Libraries
PBO Tan, SK Kim - protein. Science - ww2.mcgill.ca
... A few targets of MAP kinase signaling that are commonly expressed in different
tissues include ELK1, SAP, NET and HSF1 (Refs 3, 34, 35). ...
Cited by 66 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

How Stat 1 mediates constitutive gene expression: a complex of unphosphorylated Stat 1 and IRF 1 … - Full text - MIT Libraries
M Chatterjee-Kishore, KL Wright, JP Ting, GR Stark - The EMBO Journal, 2000 - embojournal.npgjournals.com
... Stat1 and Stat3 have been found to be associated in the cytoplasm of unstimulated
cells (Haan et al., 2000) and HSF1 associates specifically with Stat1 in ...
Cited by 72 - Web Search - nature.com - emboj.org - medschool.mc.vanderbilt.edu - all 9 versions »

Tomato Heat Stress Transcription Factor HsfB1 Represents a Novel Type of General Transcription … - Full text - MIT Libraries
K Bharti, P von Koskull-Doering, S Bharti, P Kumar … - Plant Cell, 2004 - plantcell.org
... In support of the basic structural differences between class A and class B HSFs,
only class A HSFs were found to replace the yeast Hsf1 in its survival ...
Cited by 5 - Web Search - pubmedcentral.nih.gov - uni-frankfurt.de - dx.doi.org - all 13 versions »

Mechanisms of the development of androgen independence in prostate cancer - Full text - MIT Libraries
A So, M Gleave, A Hurtado-Col, C Nelson - World Journal of Urology, 2005 - springerlink.com
... biological ligands, and is regulated in part by transcription factor HSF1 (heat
shock ... N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Genes and proteins governing the cellular sensitivity to HSP90 inhibitors: a mechanistic perspective
A Maloney, PA Clarke, P Workman - Curr. Cancer Drug Targets, 2003 - ingentaconnect.com
... both HSP90 and caveolin-1 have been shown to be STAT3 accessory proteins ... through
activation of the transcription factor heat shock factor 1 (HSF1), which under ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

MNK 1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method … - Full text - MIT Libraries
R Fukunaga, T Hunter - The EMBO Journal, 1997 - embojournal.npgjournals.com
... Other clones were heat shock transcription factor-1 (HSF1) (Rabindran et al., 1991 ),
topoisomerase II- (Jenkins et al., 1992 ), the guanine nucleotide ...
Cited by 240 - Web Search - emboj.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Identification and Functional Characterization of Novel Thioredoxin Systems
AE Damdimopoulos - diss.kib.ki.se
... 2 O 2 is a potent activator of the STAT factors STAT1 and STAT3, and the STAT
kinases JAK2 and TYK2[102]. Furthermore, ... factor 1 (HSF1). ...
Web Search

Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics- an update
L Neckers, K Neckers - Expert Opinion on Emerging Drugs, 2005 - dx.doi.org
... cell line HMC-1.1, harbouring a single Val560Gly mutation, causes both the level
and activity of KIT and downstream signalling molecules AKT and STAT3 to be ...
Web Search - ingentaconnect.com - ashley-pub.com - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

A statistical analysis of the TRANSFAC database.
GB Fogel, DG Weekes, G Varga, ER Dow, AM Craven, … - Biosystems, 2005 - natural-selection.com
Page 1. BioSystems xxx (2005) xxx–xxx A statistical analysis of the TRANSFAC database
Gary B. Fogel a , Dana G. Weekes a , Gabor Varga b , Ernst R. Dow b , ...
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Genetic abnormalities in prostate cancer
S Shulka, GT MacLennan, SR Marengo, AD Seftel, MI … - Curr Genom, 2004 - ingentaconnect.com
Page 1. Current Genomics, 2004, 5, 67-83 67 1389-2029/04 $45.00+.00 ©2004 Bentham
Science Publishers Ltd. Genetic Abnormalities in Prostate Cancer ...
Cited by 1 - Web Search

[BOOK] Function of PIAS proteins in steroid receptor-dependent signaling
N Kotaja - 2002 - ethesis.helsinki.fi
... PIAS3 (protein inhibitor of activated Stat3) was demonstrated to interact with
Stat3 and inhibit Stat3-dependent signaling (Chung et al. 1997). ...
View as HTML - Web Search - Get it from MIT Libraries - Library Search

SUMO and ubiquitin in the nucleus: different functions, similar mechanisms? - Full text - MIT Libraries
G Gill - Genes & Development, 2004 - genesdev.org
Institution: Google Indexer Sign In as Individual. GENES &
DEVELOPMENT 18:2046-2059, 2004 ISSN 0890-9369/ $5.00 ...
Cited by 26 - Web Search - dx.doi.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

HSP90 FACTS & LITERATURE
HS PROTEIN - cgr.harvard.edu
... Overexpression of Hsp90 in NIH 3T3 cells retards cell cycle and blocks Hsf1 (Zhao
et ... In membrane rafts in complexes with caveolin-1 and Stat3; GA blocks ...
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Heat stress response in plants: a complex game with chaperones and more than twenty heat stress … - Full text - MIT Libraries
SK Baniwal, K Bharti, KY Chan, M Fauth, A Ganguli, … - J. Biosci, 2004 - ias.ac.in
Page 1. 471 Keywords. Chaperones; heat stress transcription factors;
plant heat stress response; thermotolerance _____ ...
View as HTML - Web Search - uni-frankfurt.de - ijmm.org - ijp-online.com - all 6 versions »

Androgens and prostate cancer - Full text - MIT Libraries
AI So, A Hurtado-Coll, ME Gleave - World Journal of Urology, 2003 - springerlink.com
Page 1. TOPIC PAPER Alan I. So Æ Antonio Hurtado-Coll Æ Martin E. Gleave
Androgens and prostate cancer Received: 14 October 2003 ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Structural and functional characterisation of the mouse annexin A9 promoter.
M Chlystun, A Markoff, V Gerke - Biochimica et Biophysica Acta, 2004 - ulb.ac.be
... Muscle initiator sequence (+) GATA-binding factor 1 (+) Heat shock factor 1; HSF1 (+)
pGL3B-S3 Signal transducer and activator of transcription 3; STAT3 (+) ...
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THE ROLE OF LIGAND IN THE INTERACTION OF ANDROGEN RECEPTOR WITH DNA AND COACTIVATORS
U Karvonen - ethesis.helsinki.fi
Page 1. Helsinki University Biomedical Dissertations No 30 THE ROLE OF LIGAND IN
THE INTERACTION OF ANDROGEN RECEPTOR WITH DNA AND COACTIVATORS Ulla Karvonen ...
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