Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation - Full text - MIT Libraries
S Diehl, CW Chow, L Weiss, A Palmetshofer, T … - J. Exp. Med, 2002 - intl.jem.org
... The JAK/STAT3 and the mitogen-activated protein (MAP) kinase/C/EBP are the two ... activity
by IL-6 appears to be due to the induction of NFATc2 expression since ...
Cited by 18 - Web Search - dx.doi.org - jem.org - ncbi.nlm.nih.gov - all 5 versions »

Calcium-dependent Activation of Interleukin-21 Gene Expression in T Cells - Full text - MIT Libraries
HP Kim, LL Korn, AM Gamero, WJ Leonard - J. Biol. Chem, 2005 - jbc.org
... IL-15) or Stat6 (IL-4), IL-21 preferentially activates Stat1 and Stat3 (2, 4 ... NFATc2
knock-out mice were a gift from LH Glimcher (Harvard School of Public Health ...
Web Search - jbc.org

Galectin-1 is a Novel Factor that Regulates Myotube Growth in Regenerating Skeletal Muscles
K Kami, E Senba - Current Drug Targets, 2005 - ingentaconnect.com
... regulated kinase 1 and 2: JAK, Janus tyrosine kinase; STAT3, signal transducer and ...
in a pathway regulated by the calcium-regulated transcription factor NFATC2. ...
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GEArray S Series Human Immunology Signaling Pathways Gene Array: AR-SAHS-605
FG Grouping, A Molecules, I ICAM, CS Molecules, C … - eurogentec.com
... JAK and STAT Proteins: JAK1, JAK2, JAK3, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B,
STAT6, TYK2. ... NFAT Family Members: NFATC1, NFATC2, NFATC3, NFATC4, NFAT5. ...
View as HTML - Web Search - eurogentec.be

Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down- … - Full text - MIT Libraries
HM Craig, MW Pandori, JC Guatelli - Cell, 1998 - dx.doi.org
... Federico Human immunodeficiency virus type 1 (HIV-1) Nef activates STAT3 in primary ...
of the Human CD3gamma Gene That Differentially Bind NFATc1, NFATc2, and NF ...
Cited by 92 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Biology of IL-21 and the IL-21 receptor - Full text - MIT Libraries
DS Mehta, AL Wurster, MJ Grusby - Immunological Reviews, 2004 - blackwell-synergy.com
... NFATc2 was determined to be essential to promote transcription, likely directing ...
transducers and activators of transcription 1 (Stat1), Stat3, Stat4, and Stat5 ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

A Member of the C/EBP Family, NF-IL6ss, Forms a Heterodimer and Transcriptionally Synergizes with NF … - Full text - MIT Libraries
S Kinoshita, S Akira, T Kishimoto - Proceedings of the National Academy of Sciences - pnas.org
... Rounds, E. Serfling, RJ Davis, J. Anguita, and M. Rincon Induction of NFATc2 Expression
by ... of the C/EBPdelta Gene in Hepatocytes Is Mediated by Stat3 and Sp1 ...
Cited by 90 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

IL-6 Plays a Unique Role in Initiating c-Maf Expression during Early Stage of CD4 T Cell Activation - Full text - MIT Libraries
Y Yang, J Ochando, A Yopp, JS Bromberg, Y Ding - The Journal of Immunology, 2005 - jimmunol.org
... We show that Stat3 binds the c-maf promoter in CD4 T cells after IL-6 stimulation,
and also transactivates the c-maf promoter in reporter gene assays. ...
Cited by 1 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Workshop J Signal Transduction and Gene Regulation
T Brdicka, N Brdickova, M Imrich, B Schraven, V … - ingentaconnect.com
Page 1. 1 Institute of Molecular Genetics, Academy of Sciences of the Czech
Republic, Prague, Czech Republic and 2 Institute of Immunology ...
Web Search

Quantitative trait loci that harbor genes regulating muscle size in(MRL/MPJ × SJL/J) F 2 mice - Full text - MIT Libraries
G Masinde, X Li, W Gu, M Hamilton-Ulland, S Mohan, … - Functional & Integrative Genomics, 2002 - springerlink.com
... 11, even though chromosome 11 has strong candi- date genes like Stat3, Stat5a and ...
of the growth of multinucleated muscle cells by an NFATC2-dependent pathway. ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov

Cytokines and transcription factors that regulate T helper cell differentiation: new players and new …
D Agnello, CS Lankford, J Bream, A Morinobu, M … - J Clin Immunol, 2003 - springerlink.com
... Although Stat1, Stat3, Stat4, and Stat5 have all been reported to be activated by
IL-12, Stat4 appears to be the major player in IL-12-induced responses (61, 62 ...
Cited by 29 - Web Search - kluweronline.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

The IL-6R {alpha} chain controls lung CD4 CD25 Treg development and function during allergic airway … - Full text - MIT Libraries
A Doganci, T Eigenbrod, N Krug, GT De Sanctis, M … - J. Clin. Invest, 2005 - jci.org
... CD4 + spleen T cells via activation of the transcription factor NFATc2, thereby
polarizing ... activation of Src and JAK, which in turn phosphorylate STAT3 (19-23 ...
Cited by 1 - Web Search - pubmedcentral.nih.gov - pubmedcentral.nih.gov - jci.org

Transcriptional regulatory cascades controlling plasma cell differentiation - Full text - MIT Libraries
KI Lin, C Tunyaplin, K Calame - Immunological Reviews, 2003 - blackwell-synergy.com
... Reljic et al. (21) also presented data suggesting that STAT3 could overcome
BCL-6 repression of Blimp-1. As BCL-6 and STAT3 share similar consensus binding ...
Cited by 8 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

IL-6 signal transduction and its physiological roles: the signal orchestration model - Full text - MIT Libraries
D Kamimura, K Ishihara, T Hirano - Rev Physiol Biochem Pharmacol, 2003 - springerlink.com
... using a knock-in mouse strain defective in STAT3 autoregulation (Narimatsu ... of activated
T cells) transcriptional activity by increasing the levels of NFATc2. ...
Cited by 10 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Signaling pathways in Th2 development - Full text - MIT Libraries
KA Mowen, LH Glimcher - Immunological Reviews, 2004 - blackwell-synergy.com
... Jak2, and Tyk2 by IL-6 induces tyrosine phosphorylation of Stat3 and to a ... upregulation
of nuclear factor (NF) for activated T cells c2 (NFATc2) and inhibits ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov

Cutting edge: Transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase - Full text - MIT Libraries
EM Rainio, J Sandholm, PJ Koskinen - J. Immunol, 2002 - jimmunol.org
... Furthermore, a detailed analysis of NFATc2 has revealed that in addition to 13 serine ...
1999. Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle ...
Cited by 17 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 6 versions »

Heat Shock Protein 60 Inhibits Th1-Mediated Hepatitis Model via Innate Regulation of Th1/Th2 … - Full text - MIT Libraries
A Zanin-Zhorov, R Bruck, G Tal, S Oren, H Aeed, R … - The Journal of Immunology, 2005 - jimmunol.org
... been characterized: NFATc, NFATp, NFAT3, and NFAT4 (also called NFATc1, NFATc2,
NFATc4, and ... the level of the in situ activation of STAT1 and STAT3 appears to ...
Cited by 2 - Web Search - jimmunol.org - weizmann.ac.il - ncbi.nlm.nih.gov - all 6 versions »

Lineage commitment in the immune system: the T helper lymphocyte grows up
LH Glimcher, KM Murphy - Immunology, 2000 - genesdev.org
... 1998 ). Although IL-12 activates Stat1 and Stat3 as well as Stat4, only Stat4 is
required for Th1 ... Each of these sites bind NFATc1 and NFATc2 (Timmerman et al. ...
Cited by 148 - Web Search - genesdev.org - cbr.med.harvard.edu - ncbi.nlm.nih.gov - Get it from MIT Libraries

REGULATORY MECHANISMS THAT DETERMINE THE DEVELOPMENT AND FUNCTION OF PLASMA CELLS - Full text - MIT Libraries
KL Calame, KI Lin, C Tunyaplin - Annual Review of Immunology, 2003 - immunol.annualreviews.org
... Indeed, enforced expression of Bcl-6 inhibits plasma cell differentiation,
possibly by inhibiting the activity of STAT3 (109). Pax5. ...
Cited by 38 - Web Search - phyto.annualreviews.org - nutr.annualreviews.org - ncbi.nlm.nih.gov - all 6 versions »

Regulation of plasma-cell development - Full text - MIT Libraries
M Shapiro-Shelef, K Calame - Nature Reviews Immunology, 2005 - nature.com
... both the peritoneal cavityand the spleen requires NFATc1 but is independent of NFATc2
(REF.120) .B1 cells haveconstitutively activated STAT3 (signal transducer ...
Cited by 1 - Web Search - immuneweb.xxmc.edu.cn - ncbi.nlm.nih.gov

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase - Full text - MIT Libraries
BL Bennett, DT Sasaki, BW Murray, EC O'Leary, ST … - Blood, 2005 - dx.doi.org
... page I. Ortega-Perez, E. Cano, F. Were, M. Villar, J. Vazquez, and JM Redondo
c-Jun N-terminal Kinase (JNK) Positively Regulates NFATc2 Transactivation through ...
Cited by 410 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

CD4+ T 细胞亚群的新认识及对炎症性肠病研究的指导
郑长青, 胡刚正 - wjgnet.com
... 中的作用被研究的较多． ＳＴＡＴ１ ＳＴＡＴ３ ＳＴＡＴ４
ＳＴＡＴ６ ｃ－ｍａｆＮＦＡＴ ＮＩＰ４５ ｆｏｓ ...
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Molecular mechanisms in T helper phenotype development
JD Farrar, SH Ranganath, KM Murphy - Springer Seminars in Immunopathology, 1999 - springerlink.com
... including SHP-1 [26, 27], PI3-kinase [99], CrkL and Cbl [4]. Fur- thermore, Stat2,
Stat3 and CrkL ... NFAT1 (NFATp, NFATc2), NFAT2 (NFATc, NFATcl) and NFAT4 (NFATc3 ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Kuo-I Lin Chainarong Tunyaplin Kathryn Calame - Full text - MIT Libraries
KI Lin - Immunological Reviews, 2003 - ingentaconnect.com
... 20 Immunological Reviews 194/2003 Page 3. germinal center reaction could proceed.
Reljic et al. (21) also presented data suggesting that STAT3 could overcome BCL ...
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Human Keratinocytes Respond to Interleukin-18: Implication for the Course of Chronic Inflammatory … - Full text - MIT Libraries
M Wittmann, R Purwar, C Hartmann, R Gutzmer, T … - J Invest Dermatol, 2005 - blackwell-synergy.com
Full Article. View/Print PDF article (265K). Download to reference manager.
The Journal of Investigative Dermatology Volume 124 Issue ...
Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Expression and activation of STAT and IRF family transcription factors in mononuclear leukocytes
A Lehtonen - ethesis.helsinki.fi
Page 1. Publications of the National Public Health Institute A 15 / 2004 Anne Lehtonen
Expression and activation of STAT and IRF family transcription ...
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Bibliography Current World Literature
M Benezra, N Chevallier, DJ Morrison… - Current Opinion in Oncology, 2003 - co-oncology.com
November 2003, 15:6 > Bibliography Current World Literature. < Previous | Next >. ...
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Cardiovascular Toxicology
F Myocardium, BCD Alive, C Death, D Cardiomyopathy … - Cardiovascular Toxicology, 2003 - neurosci.humanapress.com
... phenomena. The NFAT family of transcription factors consists of five family
members (NFATc1, NFATc2, NFATc3, NFATc4 and NFAT5 [TonEBP]). ...
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