C-reactive Protein - Full text - MIT Libraries
S Black, I Kushner, D Samols - J Biol Chem, 2004 - jbc.org
... In addition to C/EBP binding sites, the proximal promoter region of the
CRP gene contains binding sites for STAT3 and Rel proteins. ...
Cited by 7 - Web Search - jbc.org - ncbi.nlm.nih.gov

Transcription factor c-Rel enhances C-reactive protein expression by facilitating the binding of C/ … - Full text - MIT Libraries
A Agrawal, D Samols, I Kushner - Mol Immunol, 2003 - ncbi.nlm.nih.gov
... level. In Hep3B cells, the transcription factors C/EBPbeta, STAT3, and
Rel p50 have been shown to participate in this process. AC ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

IL-6 rescues the hyporesponsiveness of c-Rel deficient B cells independent of Bcl-xL, Mcl-1, and Bcl … - Full text - MIT Libraries
JR Tumang, CY Hsia, W Tian, JF Bromberg, HC Liou - Cellular Immunology, 2002 - ncbi.nlm.nih.gov
... Interleukin-6; MCL1 protein; Neoplasm Proteins; Proto-Oncogene Proteins c-bcl-2;
Proto-Oncogene Proteins c-rel; RNA, Messenger; Stat3 protein; Trans-Activators; ...
Cited by 5 - Web Search

Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages - Full text - MIT Libraries
S Sanjabi, A Hoffmann, HC Liou, D Baltimore, ST … - J. Biol. Chem, 2005 - dx.doi.org
... Home page F. Hoentjen, RB Sartor, M. Ozaki, and C. Jobin STAT3 regulates NF ... and J.
MJ Derry Specific NEMO mutations impair CD40-mediated c-Rel activation and B ...
Cited by 71 - Web Search - pnas.org - pubmedcentral.nih.gov - smbs.buffalo.edu - all 8 versions »

The Rel family member P50 mediates cytokine-induced C-reactive protein expression by a novel … - Full text - MIT Libraries
H Cha-Molstad, A Agrawal, D Zhang, D Samols, I … - J. Immunol, 2000 - jimmunol.org
... 3B cells is induced by IL-6, acting through C/EBP isoforms and STAT3. ... activates the
NF- B system, we explored the effects of overexpressed Rel family members ...
Cited by 26 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Three-dimensional structure of the Stat3 homodimer bound to DNA - Full text - MIT Libraries
S Becker, B Groner, CW Muller - Nature, 1998 - nature.com
... This difference may be due to the number of direct base contacts: Stat3 contacts
only ... on DNA: the dimer- ization domains of STAT protein and Rel proteins sit ...
Cited by 21 - Web Search

… by IL-6 requires synergistic interaction of CCAAT/enhancer binding protein beta (C/EBP beta) and Rel … - Full text - MIT Libraries
A Agrawal, H Cha-Molstad, D Samols, I Kushner - J Immunol, 2001 - jimmunol.org
... 1996. STAT3 participates in transcriptional activation of the C-reactive protein
gene by ... The rel family member p50 mediates cytokine-induced C-reactive protein ...
Cited by 30 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

The STAT3 DNA-Binding Domain Mediates Interaction with NF-{kappa} B p65 and Inducible Nitric Oxide … - Full text - MIT Libraries
Z Yu, BC Kone - J Am Soc Nephrol, 2004 - jasn.org
... NF- B/Rel complexes differs among different cell types and in response to different
stimuli, it is possible that the function of activated STAT3 is regulated ...
Cited by 2 - Web Search - jasn.org - jasn.org - ncbi.nlm.nih.gov - all 5 versions »

Transcription factors as targets for cancer therapy - Full text - MIT Libraries
JE Darnell - Nature Reviews Cancer, 2002 - nature.com
... References 36-38 provide evidence of the importance of STAT3 in clinical cancer. |
PubMed | ISI | ChemPort |. 39. Perkins, ND The Rel/NF- B family: friend and ...
Cited by 64 - Web Search - audreyli.com - radiationbiology.dk - liv.med.utoronto.ca - all 8 versions »

STAT3 is constitutively activated in Hodgkin cell lines - Full text - MIT Libraries
D Kube, U Holtick, M Vockerodt, T Ahmadi, B Haier, … - Blood, 2001 - bloodjournal.org
... NEOPLASIA. STAT3 is constitutively activated in Hodgkin cell lines. ... 19-21 The activation
by IL-6 is mainly associated with the tyrosine phosphorylation of STAT3. ...
Cited by 28 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible … - Full text - MIT Libraries
YU Zhiyuan, W ZHANG, C Bruce - Biochem. J, 2002 - biochemj.org
... 97 Signal transducers and activators of transcription 3 (STAT3) inhibits ... STAT3
is principally expressed in the kidney, liver and spleen. ...
Cited by 23 - View as HTML - Web Search - biochemj.org - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

STAT3 regulates NF-{kappa} B recruitment to the IL-12p40 promoter in dendritic cells - Full text - MIT Libraries
F Hoentjen, RB Sartor, M Ozaki, C Jobin - Blood, 2005 - bloodjournal.org
... Another potential mechanism could involve STAT3 signaling interference with chromatin
remodeling ... remodeling of nucleosome 1, which contains the Rel and CCAAT ...
Cited by 6 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

c-Rel regulation of the cell cycle in primary mouse B lymphocytes - Full text - MIT Libraries
CY Hsia, S Cheng, AM Owyang, SF Dowdy, HC Liou - International Immunology, 2002 - intimm.oupjournals.org
... c-Rel regulation of the cell cycle in primary mouse B lymphocytes. ... Keywords: antigen
receptor, B cell, c-Rel knockout, cyclin, NF- B. Introduction. ...
Cited by 16 - Web Search - intimm.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Three-dimensional structure of the Stat3 bold beta homodimer bound to DNA
S BECKER, B GRONER, CW MUeLLER - nature.com
... may be due to the number of direct base contacts: Stat3 contacts only two ... differently
on DNA: the dimerization domains of STAT protein and Rel proteins sit ...
Web Search - nature.com

Leptin signaling in the hypothalamus during chronic central leptin infusion - Full text - MIT Libraries
R Pal, A Sahu - Endocrinology, 2003 - endo.endojournals.org
... Key words: leptin, leptin receptor, p-STAT3, DNA binding activity, SOCS3, leptin
resistance ... 5). In addition, p-STAT3 levels on day 16 were significantly ...
Cited by 4 - Web Search - dx.doi.org - endo.endojournals.org - ncbi.nlm.nih.gov - all 5 versions »

NF-{kappa} B/Rel Participation in the Lymphokine-Dependent Proliferation of T Lymphoid Cells - Full text - MIT Libraries
A Mora, J Youn, A Keegan, M Boothby - J Immunol, 2001 - jimmunol.org
... The evidence that the I B/NF- B/Rel system can regulate receptor capacitation ... through
different Janus kinases (Jak2 and Tyk2) and Stat proteins (Stat3 and Stat4 ...
Cited by 18 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Regulation of IL-6 signaling by p53: STAT3-and STAT5-masking in p53-Val135-containing human hepatoma … - Full text - MIT Libraries
RJ Rayanade, MI Ndubuisi, JD Etlinger, PB Sehgal - J. Immunol, 1998 - jimmunol.org
... induced STAT-masking, although in reverse, is the unmasking of p65 (Rel-A)
immunofluorescence ... of a reduction in the pool of DNA-binding-competent STAT3 in the ...
Cited by 16 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Endothelial cells require Stat3 for protection against endotoxin-induced inflammation - Full text - MIT Libraries
A Kano, MJ Wolfgang, Q Gao, J Jacoby, GX Chai, W … - The Journal of Experimental Medicine - jem.org
... We investigated the role of STAT3 cytokine signaling within endothelium to better
understand ... and induce a primary immune response using the NF- B Rel family, c ...
Cited by 6 - Web Search - dx.doi.org - intl.jem.org - ncbi.nlm.nih.gov

PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells - Full text - MIT Libraries
S Sun, BM Steinberg - Journal of General Virology, 2002 - vir.sgmjournals.org
... Barkett, M. & Gilmore, TD (1999). Control of apoptosis by Rel/NF-kappaB transcription
factors. Oncogene 18, 6910-6924.[Medline]. ... Stat3 as an oncogene. ...
Cited by 5 - Web Search - jgv.sgmjournals.org - arc.ucla.edu - ncbi.nlm.nih.gov - all 7 versions »

Analysis of the activation status of Akt, NFjB, and Stat3 in human diffuse gliomas - Full text - MIT Libraries
H Wang, H Wang, W Zhang, HJ Huang, WSL Liao, GN … - Laboratory Investigation, 2004 - nature.com
... and Stat3 in human diffuse gliomas ... In contrast, only focal immunoreactivity
for phospho-Stat3 was observed in o9% of high-grade gliomas. ...
Cited by 5 - View as HTML - Web Search - nature.com - ncbi.nlm.nih.gov

… Protein by IL-6 Requires Synergistic Interaction of CCAAT/Enhancer Binding Protein (C/EBP) and Rel …
A Agrawal, H Cha-Molstad, D Samols, I Kushner - jimmunol.org
... STAT3 has also been found to participate in transducing the effects of IL-6 on ... The
Rel protein/NF- B family of transcription factors is known to be activated ...
Cited by 1 - Web Search

Stat3 Activation in Acute Lung Injury - Full text - MIT Libraries
H Gao, RF Guo, CL Speyer, J Reuben, TA Neff, LM … - The Journal of Immunology, 2004 - jimmunol.org
... The following Abs were purchased from Santa Cruz Biotechnology: Stat3 (C-20), p65
(C-20), p50 (19), c-Rel (C), RelB (C-19), p52 (K-27), and normal rabbit IgG ...
Cited by 3 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Cutting Edge: IL-10-Independent STAT3 Activation by Toxoplasma gondii Mediates Suppression of IL-12 … - Full text - MIT Libraries
BA Butcher, L Kim, AD Panopoulos, SS Watowich, PJ … - The Journal of Immunology, 2005 - jimmunol.org
... also disrupts intracellular signaling cascades including NF- B/Rel, STAT1, and ...
IL-10R ligation that triggers JAK1 activation and recruitment of STAT3 (9). JAK1 ...
Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Activation of NF-B and STAT3 in Rat Oval Cells During 2-Acetylaminofluorene/Partial Hepatectomy- … - Full text - MIT Libraries
A Sanchez, VM Factor, IS Schroeder, P Nagy, SS … - HEPATOLOGY, 2004 - doi.wiley.com
Page 1. Activation of NF- B and STAT3 in Rat Oval Cells ... In contrast,
phosphorylation of STAT3 was detected only in OV1 high cells. ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

STAT3 Inhibits Transcription of the Inducible Nitric Oxide Synthase Gene By Interacting with NF-kB
Z Yu, W Zhang, BC Kone - biochemj.org
... STAT3 Inhibits Transcription of the Inducible Nitric Oxide Synthase Gene ... Running
Title: STAT3 inhibits inducible nitric oxide synthase induction in mesangial ...
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Gfi-1 und Pias3 als Antagonisten bei der Stat3 Signaltransduktion
E des Doktorgrades, B Roedel - miless.uni-essen.de
Page 1. Gfi-1 und Pias3 als Antagonisten bei der Stat3 Signaltransduktion ... zelluläre
Verteilung von aktiviertem Stat3 2.9.1 Pias3 GFP und aktiviertes Stat3 sind ...
View as HTML - Web Search - deposit.ddb.de

A phosphatidylinositol 3-kinase–phosphodiesterase 3 B–cyclic AMP pathway in hypothalamic action … - Full text - MIT Libraries
AZ Zhao, JN Huan, S Gupta, R Pal, A Sahu, S Fig - Nature Neuroscience, 2002 - nature.com
... of IRS1-associated PI3K by ∼3.7 times (leptin, 372 ± 50 rel- ative %; control ... Leptin
induces Jak2 and Stat3 phosphorylation, and stimu- lates DNA binding ...
Cited by 25 - Web Search - nature.com - ncbi.nlm.nih.gov

Overexpressed nuclear factor-kappaB can participate in endogenous C-reactive protein induction, and … - Full text - MIT Libraries
A Agrawal, H Cha-Molstad, D Samols, I Kushner - Immunology, 2003 - blackwell-synergy.com
... In transactivation studies of constructs containing the proximal 157 bp of the CRP
promoter, we have found that overexpressed STAT3, C/EBP , and Rel p50 are ...
Cited by 8 - Web Search - ncbi.nlm.nih.gov

BD™ TransFactor Kits Data Sheet
TISOF BD, TKITT FACTORS, PP THP, PP THP - clontech.com
... c-Rel GGGGTATTTCC Polyclonal b 1:500 Yes Yes 6 RelB GGGGTATTTCC Polyclonal b
1:2,000 Yes Yes 6 STAT3 TTCTGGGAATT Polyclonal b 1:500 Yes Yes 19 ...
View as HTML - Web Search

Interferon alpha/beta Promotes Cell Survival by Activating Nuclear Factor kappa B through … - Full text - MIT Libraries
CH Yang, A Murti, SR Pfeffer, JG Kim, DB Donner, … - J Biol Chem, 2001 - jbc.org
... induction of potent cell survival signals through signaling dependent on STAT3,
PI-3K ... Institute, Frederick, MD) for providing a panel of anti-Rel antibodies, E ...
Cited by 46 - Web Search - jbc.org - ncbi.nlm.nih.gov

NF-kappa B inhibits transcription of the H-K-ATPase alpha 2-subunit gene: role of histone … - Full text - MIT Libraries
W Zhang, BC Kone - Am J Physiol Renal Physiol, 2004 - ajprenal.physiology.org
... Polyclonal antibodies recognizing NF- B p65, p52, p50, c-Rel, and STAT3
were from Santa Cruz Biotechnology (Santa Cruz, CA). Anti ...
Web Search - ajprenal.physiology.org

Volume 108: Issue 4
A Agrawal, H Cha-Molstad, D Samols, I Kushner - blackwellpublishing.com
... CRP promoter, we found that signal transducer and activator of transcription-3
(STAT3) and C/EBPb -mediated IL-6-induced transcription and that Rel p50 acted ...
Cached - Web Search

GEArray S Series Human Immunology Signaling Pathways Gene Array: AR-SAHS-605
FG Grouping, A Molecules, I ICAM, CS Molecules, C … - eurogentec.com
... JAK and STAT Proteins: JAK1, JAK2, JAK3, STAT1, STAT2, STAT3, STAT4, STAT5A ... Rel /
NFκB / IκB Family: NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIL1, NFKBIL2, NFRKB, REL ...
View as HTML - Web Search - eurogentec.be

The Role of C/EBP Isoforms in the Control of Inflammatory and Native Immunity Functions - Full text - MIT Libraries
V Poli - J Biol Chem, 1998 - jbc.org
... II IL-6REs, which bind the cytokine-inducible transcription factors Stat3 and Stat1 ...
interaction requires the integrity of both the NF- B rel homology domain ...
Cited by 116 - Web Search - jbc.org - journal-inflammation.com

E-mail: awmlee@ umich. edu
CM Rohde, J Schrum, WML Angel - sitemaker.umich.edu
... 5 decreased SFK binding, receptor phosphorylation and activity and Stat3
phosphorylation (32). ... CSF-1-stimulated phosphorylation of Stat3 was markedly reduced ...
View as HTML - Web Search

Stat 3 Dimerization Regulated by Reversible Acetylation of a Single Lysine Residue - Full text - MIT Libraries
Z Yuan, Y Guan, D Chatterjee, YE Chin - Science, 2005 - sciencemag.org
... S6). Crystal analysis revealed that STAT (Stat1 and Stat3), nuclear factor NF- B
(Rel A), and p53 bind DNA in a similar topology (2, 3). In p53, C-terminal ...
Cited by 4 - Web Search - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

Nuclear factor κ B is activated in myelodysplastic bone marrow cells - Full text - MIT Libraries
P McFadden… - haematologica, 2002 - haematologica.it
... consensus sites for Stat3, Stat5, and NFκB. Nuclear extracts from sample 11 were
pre- incubated with antibodies specific for p50, p65, p52, c-Rel, and RelB. ...
View as HTML - Web Search - haematologica.org

NOD 2 is a negative regulator of Toll-like receptor 2–mediated T helper type 1 responses - Full text - MIT Libraries
T Watanabe, A Kitani, PJ Murray, W Strober - Nature Immunology, 2004 - nature.com
... c-Rel regulates interleukin 12 p70 expression in CD8 + dendritic cells by ... of IL-12p40
causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice ...
Cited by 47 - Web Search - dmbr.ugent.be - mcb.berkeley.edu - ncbi.nlm.nih.gov - all 5 versions »

Interferon/Promotes Cell Survival by Activating Nuclear Factor B through Phosphatidylinositol 3- … - Full text - MIT Libraries
CH Yang, A Murti, SR Pfeffer, JG Kim, DB Donner, … - J Biol Chem, 2001 - intl.jbc.org
... STAT3, PI-3K, and Akt are indispensable for IFN-de- pendent cell survival
(antiapoptotic) signals ... Anti-Rel and IB antibodies were generously provided by ...
Cited by 4 - Web Search - cmdr.ubc.ca - cmdr.ubc.ca

Prevention of hepatic apoptosis and embryonic lethality in RelA/TNFR-1 double knockout mice - Full text - MIT Libraries
ME Rosenfeld, L Prichard, N Shiojiri, N Fausto - Am J Pathol, 2000 - ajp.amjpathol.org
... (RelA #SC-372X, p50 #SC-114X, p52 #SC-298X, c-Rel #SC-70X, and Stat3 #SC-482X)
were added to indicated samples for an additional 30 minutes. ...
Cited by 41 - Web Search - ajp.amjpathol.org - ncbi.nlm.nih.gov

TNF-a mediates SDF-1a-induced NF-kB activation and cytotoxic effects in primary astrocytes - Full text - MIT Libraries
Y Han, T He, DR Huang, CA Pardo, RM Ransohoff - J Clin Invest, 2001 - pubmedcentral.nih.gov
... Rabbit anti Erk2 MAPK, anti NF-kB (p50, p52, p65, c-Rel, and Rel-B), anti IkB-a,
anti IkB-b, anti-STAT3, anti SDF-1a, and anti-CXCR4 were purchased from Santa ...
Cited by 4 - Web Search

Interferon {alpha} Activates NF-{kappa} B in JAK1-deficient Cells through a TYK2-dependent Pathway - Full text - MIT Libraries
CH Yang, A Murti, WJ Valentine, Z Du, LM Pfeffer - J. Biol. Chem, 2005 - jbc.org
... Upon JAK-mediated tyrosine phosphorylation, the STATs (STAT1, STAT2, and STAT3)
dimerize and ... Dimers of the various Rel proteins (p50, p52, c-Rel, v-Rel, RelA ...
Web Search - jbc.org - ncbi.nlm.nih.gov

Thrombopoietin Regulates Bcl-xL Gene Expression through Stat 5 and Phosphatidylinositol 3-Kinase … - Full text - MIT Libraries
K Kirito, T Watanabe, K Sawada, H Endo, K Ozawa, N … - J Biol Chem, 2002 - intl.jbc.org
... Antisera for p50, p65, and c-Rel of NF- B subunits were purchased from ... Antisera against
Stat3 and Stat5 for the supershift assay were purchased from Santa Cruz ...
Cited by 16 - Web Search - intl.jbc.org - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

IFN/promotes cell survival by activating NF-B - Full text - MIT Libraries
CH Yang, A Murti, SR Pfeffer, L Basu, JG Kim, LM … - Proc Natl Acad Sci USA, 2000 - pnas.org
... in 3T3, IEC-6, CaKi, HepG2, and HT1080 cells, p50–c-Rel complexes were ... On their tyrosine
phosphorylation, IFN-activated STATs (STAT1–STAT3) dimerize and ...
Cited by 3 - Web Search - pubmedcentral.nih.gov

Composite regulatory elements: structure, function and classification.
S Receptor, HMG NF-kB, ETS SRF c-fos - Regulation - gene-regulation.com
... 1998) Coordinate transactivation of the interleukin-2 CD28 response element by
c-Rel and ATF ... of the C/EBPdelta gene in hepatocytes is mediated by Stat3 and Sp1. ...
Cached - Web Search - Get it from MIT Libraries

CpG DNA induces IgG class switch DNA recombination by activating human B cells through an innate … - Full text - MIT Libraries
B He, X Qiao, A Cerutti - J. Immunol, 2004 - jimmunol.org
... by incubating reaction mixtures with 1 µl of a DNA-binding inhibiting/supershifting
Ab to p65, c-Rel, Rel-B, p50, p52, STAT1, STAT2, STAT3, STAT6, IRF1, IRF9 ...
Cited by 5 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Activation of the Janus kinase 3-STAT5a pathway after CD40 triggering of human monocytes but not of … - Full text - MIT Libraries
P Revy, C Hivroz, G Andreu, P Graber, C Martinache … - J Immunol, 1999 - jimmunol.org
... Rabbit polyclonal Abs against Jak3, p65 (Rel-A), c-Rel, STAT1 (p84/p91), STAT2 ... The
antiphosphotyrosine Ab 4G10 and the anti-STAT3 Ab were purchased from Upstate ...
Cited by 13 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 6 versions »

核因子-κB 与炎症性肠病
李军华, 于皆平, 何小飞 - wjgnet.com
... NF-κB and Rel proteins: evolu- tionarily conserved mediators of immune ... Stat3 and
NF-kappaB activation pre- vents apoptosis in pancreatic carcinogenesis. ...
View as HTML - Web Search - wjgnet.com - wjgnet.com - wjgnet.com

The p50 Subunit of NF-{kappa} B Associates with the NF-IL6 Transcription Factor - Full text - MIT Libraries
KP LeClair, MA Blanar, PA Sharp - Proceedings of the National Academy of Sciences - pnas.org
... page, J Am Soc Nephrol Home page Z. Yu and BC Kone The STAT3 DNA-Binding ... Interaction
of CCAAT/Enhancer Binding Protein {{beta}} (C/EBP{{beta}}) and Rel p50 J ...
Cited by 124 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Regulation of Bcl-xL: a little bit of this and a little bit of STAT
JM Grad, XR Zeng, LH Boise - Curr Opin Oncol, 2000 - co-oncology.com
... Zushi S, Shinomura Y, Kiyohara T, et al.: STAT3 mediates the survival signal in ... Rayet
B, Gelinas C: Aberrant rel/nfkb genes and activity in human cancer. ...
Cited by 59 - Web Search - co-oncology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries