Prevention of hepatic apoptosis and embryonic lethality in RelA/TNFR-1 double knockout mice - Full text - MIT Libraries
ME Rosenfeld, L Prichard, N Shiojiri, N Fausto - Am J Pathol, 2000 - ajp.amjpathol.org
... Because STAT3 was active in RelA -/- mice during liver development, it appears that
a functional NF- B complex is not required for STAT3 activation in the ...
Cited by 41 - Web Search - ajp.amjpathol.org - ncbi.nlm.nih.gov

STAT3 regulates NF-{kappa} B recruitment to the IL-12p40 promoter in dendritic cells - Full text - MIT Libraries
F Hoentjen, RB Sartor, M Ozaki, C Jobin - Blood, 2005 - bloodjournal.org
... Interestingly, STAT3 directly interacted with RelA and suppressed IL-1 and
LPS/interferon- -induced inducible nitric oxide synthase (iNOS) gene expression ...
Cited by 6 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality - Full text - MIT Libraries
K Takeda, K Noguchi, W Shi, T Tanaka, M Matsumoto, … - Proc. Natl. Acad. Sci. USA, 1997 - dx.doi.org
... Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. ... No
viable Stat3-deficient mice could be obtained from heterozygote intercross. ...
Cited by 273 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Distinct regions of the granulocyte colony-stimulating factor receptor are required for tyrosine … - Full text - MIT Libraries
SE Nicholson, U Novak, SF Ziegler, JE Layton - Blood, 1995 - bloodjournal.org
... preincubated with an excess of unlabeled probe or antibodies to either Stat1 or
Stat3. ... teins and blotting with G-CSF-R antiserum shows the rela- tive receptor ...
Cited by 61 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Multiple signaling pathways induced by granulocyte colony-stimulating factor involving activation of … - Full text - MIT Libraries
SS Tian, P Tapley, C Sincich, RB Stein, J Rosen, P … - Blood, 1996 - bloodjournal.org
... and/or STAT3 activation, we do not detect major differences in either the time course
of STAT activation or shifts in the G-CSF dose-response curve rela- tive ...
Cited by 49 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Factors secreted by human neuroblastoma mediated doxorubicin resistance by activating STAT3 and … - Full text - MIT Libraries
A Rebbaa, PM Chou, BL Mirkin - Mol. Med, 2001 - muse.jhu.edu
... The direct rela- tionship between Stat3 and Bcl-x L was demonstrated by in vitro
experiments showing the ability of this transcription factor to interact with ...
Cited by 8 - Web Search - muse.jhu.edu - molmed.org - ncbi.nlm.nih.gov

PIAS 3 Suppresses NF-{kappa} B-mediated Transcription by Interacting with the p 65/RelA Subunit - Full text - MIT Libraries
HD Jang, K Yoon, YJ Shin, J Kim, SY Lee - J Biol Chem, 2004 - jbc.org
... using the Rel homology domain (RHD) of the p65 subunit (RelA) of NF ... bait, led to
the isolation of PIAS3, previously identified as a specific inhibitor of STAT3. ...
Cited by 2 - Web Search - jbc.org - ncbi.nlm.nih.gov

STAT3 is constitutively activated in Hodgkin cell lines - Full text - MIT Libraries
D Kube, U Holtick, M Vockerodt, T Ahmadi, B Haier, … - Blood, 2001 - bloodjournal.org
... NEOPLASIA. STAT3 is constitutively activated in Hodgkin cell lines. ... 19-21 The activation
by IL-6 is mainly associated with the tyrosine phosphorylation of STAT3. ...
Cited by 28 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

PIAS3 Suppresses NF-{kappa} B-mediated Transcription by Interacting with the p65/RelA Subunit - Full text - MIT Libraries
HD Jang, K Yoon, YJ Shin, J Kim, SY Lee - J. Biol. Chem, 2004 - dx.doi.org
... Rel homology domain (RHD) of the p65 subunit (RelA) of NF- B as bait, led to the
isolation of PIAS3, previously identified as a specific inhibitor of STAT3. ...
Web Search

Functional differences between STAT3 and STAT3 - Full text - MIT Libraries
TS Schaefer, LK Sanders, OK Park, D Nathans - Mol. Cell. Biol, 1997 - mcb.asm.org
... We then determined the rela- tive transcriptional activities of the active forms
of Stat3 , Stat3 , and 48 by measuring the CAT activity and binding of nuclear ...
Cited by 6 - Web Search

Analysis of the activation status of Akt, NFjB, and Stat3 in human diffuse gliomas - Full text - MIT Libraries
H Wang, H Wang, W Zhang, HJ Huang, WSL Liao, GN … - Laboratory Investigation, 2004 - nature.com
... Keywords: Akt; glioma; NFMkB; Stat3 ... 21–23 NFkB is a heterodimeric transcription
factor consisting predominantly of p65/RelA and p50 subunits. ...
Cited by 5 - View as HTML - Web Search - nature.com - ncbi.nlm.nih.gov

Reproductive hormone-induced, STAT3-mediated interleukin 6 action in normal and malignant human … - Full text - MIT Libraries
V Syed, G Ulinski, SC Mok, SM Ho - J Natl Cancer Inst, 2002 - jncicancerspectrum.oupjournals.org
... 429 and OVCA 432 cells were transiently transfected with the Dn-STAT3 vector or
the ... Rela- tive levels of IL-6 mRNA were then measured with semiquan- titative RT ...
Cited by 10 - Web Search - ncbi.nlm.nih.gov

Activation of NF-B and STAT3 in Rat Oval Cells During 2-Acetylaminofluorene/Partial Hepatectomy- … - Full text - MIT Libraries
A Sanchez, VM Factor, IS Schroeder, P Nagy, SS … - HEPATOLOGY, 2004 - doi.wiley.com
Page 1. Activation of NF- B and STAT3 in Rat Oval Cells ... In contrast,
phosphorylation of STAT3 was detected only in OV1 high cells. ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Induction of S100A9 gene expression by cytokine oncostatin M in breast cancer cells through the STAT … - Full text - MIT Libraries
C Li, F Zhang, M Lin, J Liu - Breast Cancer Research and Treatment, 2004 - springerlink.com
... induction by OM in dnStat3 cells suggest that other signaling path- ways may also
be involved and may play a rela- tively minor role as compared to STAT3. ...
Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

2 Induction of S100A9 gene expression by cytokine oncostatin M in breast 3 cancer cells through the …
C Li, F Zhang, M Lin, J Liu - Breast Cancer Research and Treatment, 2004 - kluweronline.com
... 405 ways may also be involved and may play a rela- 406 tively minor role as compared
to STAT3. 407 Previous studies have demonstrated a transient 408 ...
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15-Deoxy-Δ 12, 14-PGJ 2 inhibits IL-6-induced Stat3 phosphorylation in lymphocytes - Full text - MIT Libraries
HJ Kim, YH Rho, SJ Choi, YH Lee, HJ Cheon, JW Um, … - EXPERIMENTAL and MOLECULAR MEDICINE, 2005 - e-emm.org
... P Stat3 - Stat3 IL 6 - C 15d - - P Stat3 - Stat3 - + + + + VA GF GF PD SB
C 15d Rela ti ve mR NA exp r es sio n Jurkat 0 0.4 0.8 1.2 D ...
View as HTML - Web Search - e-emm.org

[CITATION] growth factor stimulation, and ROS is known to activate Src and Jak family kinases (11, 23, 24). … - Full text - MIT Libraries
J EMBO - Science, 1993
... Thus, Rac1 may both localize STAT3 to kinase complexes and contribute to the acti ...
and density of fat droplets in the intestine and hypodermis rela- tive with ...
Web Search - grc.nia.nih.gov - x.biochem.nwu.edu - seroudelab.biology.queensu.ca - all 6 versions »

Molecular Targets for Therapy STAT3 is essential for Hodgkin lymphoma cell proliferation and is a …
U Holtick, M Vockerodt, D Pinkert, N Schoof, B … - Leukemia, 2005 - nature.com
... Evidence for an antiapoptotic function of STAT3. ... Constitutive nuclear factor-kappab-
RelA activation is required for proliferation and survival of Hodgkin's ...
Web Search - nature.com

Stat3 Inhibits-Globin Gene Expression in Erythroid Cells
HA Foley, SF Ofori-Acquah, A Yoshimura, S Critz, … - jbc.org
... The rela- tive luciferase activity was calculated as a ratio to that of ... Three expression
vectors Stat3 (pS3 ) and mutant Stat3 (pmS3 ) established in the base ...
Web Search - southalabama.edu

IL-18 Activates STAT3 in the Natural Killer Cell Line 92, Augments Cytotoxic Activity, and Mediates …
U Kalina, D Kauschat, N Koyama, H Nuernberger, K … - jimmunol.org
... of STAT3 was induced in IL-18-treated NK92 cells (Fig. ... CD95(Fas)-dependent or
perforin-dependent pathways (7–9). In view of its structural rela- tionship to ...
Web Search

Meeting Report Second International Conference on Signal Transduction, Croatia May 2000 - Full text - MIT Libraries
Z Dembic - Scandinavian Journal of Immunology, 2000 - blackwell-synergy.com
... regulator of cell growth and may curb the growth of malignant cells, whereas the
STAT3 deficiency stops ... NF- B is a dimer of two proteins p65(RelA) and p50. ...
Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Stat Acetylation--A Key Facet of Cytokine Signaling? - Full text - MIT Libraries
JJ O'Shea, Y Kanno, X Chen, DE Levy - Science, 2005 - sciencemag.org
... The nuclear transcription factor NF- B (RelA) is also acetylated by p300 and ... A similar
understanding of Stat3 modification is difficult to reconcile with the ...
Web Search - dx.doi.org - ncbi.nlm.nih.gov - all 4 versions »

STAT signaling is active during early mammalian development - Full text - MIT Libraries
SA Duncan, Z Zhong, Z Wen, JE Darnell - Developmental Dynamics, 1997 - doi.wiley.com
... Because we found that active Stat3 protein and mRNA were present at rela- tively
equal levels between E4.5 and E8.5, it seemed likely that Stat3 mediated ...
Cited by 31 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Session 3: Signalling in inflammatory and immune cells: cell surface to nucleus
M White, D Nelson, D Spiller, A Ihekwaba, D Kell, … - blackwell-synergy.com
... genes depended on oscillation persistence, involving cycles of RelA phos- phorylation ...
3.2 STAT3 is the dominant mediator of the anti- inflammatory effects of IL ...
Web Search - ingentaconnect.com

Proteasome- and p 53-dependent masking of signal transducer and activator of transcription(STAT) … - Full text - MIT Libraries
RJ Rayanade, K Patel, M Ndubuisi, S Sharma, S … - J Biol Chem, 1997 - jbc.org
... 20-30 min after IL-6 addition, (ii) was transient in that STAT3 and STAT5 ... that a
loss of immunostaining was not observed for STAT1, STAT4, STAT6, RelA (p65), C ...
Cited by 17 - Web Search - jbc.org - ncbi.nlm.nih.gov

Mutagenesis by reversible promoter insertion to study the activation of NF-{kappa} B - Full text - MIT Libraries
ES Kandel, T Lu, Y Wan, MK Agarwal, MW Jackson, GR … - Proc Natl Acad Sci US A, 2005 - pnas.org
... 35 clone, treated with vector or Cre, were compared by using RT-PCR, with primers
that anneal within the insert and within exon 3 of relA. Stat3 primers were ...
Web Search - dx.doi.org - pnas.org - ncbi.nlm.nih.gov

NF-< img border='0' src='/__chars/kappa/black/med/base/glyph. gif' align='bottom' alt='kappa'/> B … - Full text - MIT Libraries
MK Meffert, JM Chang, BJ Wiltgen, MS Fanselow, D … - Nature Neuroscience, 2003 - nature.com
... of p62 nucleoporin in angiotensin II-induced nuclear translocation of STAT3 in brain ...
lethality and liver degeneration in mice lacking the RelA component of NF ...
Cited by 25 - Web Search - baltimorelab.caltech.edu - fanselowlab.psych.ucla.edu - ncbi.nlm.nih.gov - all 7 versions »

The SOCS proteins: a new family of negative regulators of signal transduction
SE Nicholson, DJ Hilton - J Leukoc Biol, 1998 - jleukbio.org
... to SOCS-1 and CIS, SOCS-2 and SOCS-3 contain a rela- tively short ... seems to be regulated
by STAT5 [11], whereas the use of dominant-negative STAT3 constructs sug ...
Cited by 50 - Web Search - jleukbio.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

Interferon alpha/beta Promotes Cell Survival by Activating Nuclear Factor kappa B through … - Full text - MIT Libraries
CH Yang, A Murti, SR Pfeffer, JG Kim, DB Donner, … - J Biol Chem, 2001 - jbc.org
... Mice that lack the RelA/p65 gene die embryonically from extensive apoptosis within ...
IFN receptor signaling through the STAT3 docking site on the IFNAR1 chain ...
Cited by 46 - Web Search - jbc.org - ncbi.nlm.nih.gov

Lessons from Genetically Engineered Animal Models. V. Knocking out genes to study liver regeneration … - Full text - MIT Libraries
N Fausto - Am J Physiol Gastrointest Liver Physiol, 1999 - ajpgi.physiology.org
... mice, despite the induction of TNF, NF B, IL-6, and STAT3 (14 ... recent experiments
with double transgenic mice that are deficient in both the relA (p65) component ...
Cited by 24 - Web Search - ajpgi.physiology.org - ncbi.nlm.nih.gov

A transcriptional corepressor of Stat1 with an essential LXXLL signature motif - Full text - MIT Libraries
B Liu, M Gross, J ten Hoeve, K Shuai - Mol. Cell. Biol, 2005 - dx.doi.org
... C. Levy, and E. Razin Interplay between MITF, PIAS3, and STAT3 in Mast ... Suppresses
NF-{kappa}B-mediated Transcription by Interacting with the p65/RelA Subunit J ...
Cited by 42 - Web Search - pnas.org - pubmedcentral.nih.gov - bions.hanyang.ac.kr - all 8 versions »

Constitutive activity of signal transducer and activator of transcription 3 protein in acute myeloid … - Full text - MIT Libraries
M Benekli, Z Xia, KA Donohue, LA Ford, LA Pixley, … - Blood, 2002 - bloodjournal.org
... Isoforms and rela- tive levels of STAT proteins were deter- mined by immunoblotting.
Constitutive STAT3 activity was detected in samples from 28 (44%) patients ...
Cited by 14 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Activation of STAT Transcription Factors in Oncogenic Tyrosine Kinase Signaling
R Garcia, R Jove, R Jove, F Alert - Journal of Biomedical Science, 1998 - content.karger.com
... ligand, and the ‘profile’ of activated STATs (ie the rela- tive stoichiometry of
various ... Some STAT family members, for exam- ple, STAT1 and STAT3, can both ...
Cited by 95 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

GEArray S Series Human Immunology Signaling Pathways Gene Array: AR-SAHS-605
FG Grouping, A Molecules, I ICAM, CS Molecules, C … - eurogentec.com
... JAK and STAT Proteins: JAK1, JAK2, JAK3, STAT1, STAT2, STAT3, STAT4, STAT5A ... IκB Family:
NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIL1, NFKBIL2, NFRKB, REL, RELA, RELB. ...
View as HTML - Web Search - eurogentec.be

Interferon/Promotes Cell Survival by Activating Nuclear Factor B through Phosphatidylinositol 3- … - Full text - MIT Libraries
CH Yang, A Murti, SR Pfeffer, JG Kim, DB Donner, … - J Biol Chem, 2001 - intl.jbc.org
... Mice that lack the RelA/p65 gene die embry- onically from extensive apoptosis ... IFN
receptor signaling through the STAT3 docking site on the IFNAR1 chain leads ...
Cited by 4 - Web Search - cmdr.ubc.ca - cmdr.ubc.ca

Regulatory Effect of SOCS on NF-B Activity in Murine Monocytes/Macrophages
SH Park, KE Kim, HY Hwang, TY Kim - DNA and Cell Biology, 2003 - dx.doi.org
... activities of interferons (Song et al., 1998) and inhibitionof STAT3 phos- phorylation ...
could account for the differencein their effects on RelA activation. ...
Cited by 2 - Web Search - liebertonline.com - liebertonline.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Stat 6 activation and Th2 cell proliferation driven by CD 28 signals - Full text - MIT Libraries
S Oki, N Otsuki, T Kohsaka, M Azuma - European Journal of Immunology, 2000 - doi.wiley.com
... Stat3, anti-phosphotyrosine or anti-CD28 Ab ... Data are present as mean % induction
of rela- tive luciferase unit (RLU) of five separate experiments, when the RLU ...
Cited by 10 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

IL-10 gene deficient mice lack TGF-beta/Smad signaling and fail to inhibit NF-kappa B-mediated pro- …
A Shkoda, SC Kim, PA Ruiz, RB Sartor, D Haller, A … - doi.wiley.com
... Accordingly, wild type IEC expressed phosphorylated NF-kappa B subunit RelA (p65)
and phosphorylated Smad2 only at day 7 after bacterial colonization, whereas E ...
Web Search

Signal Transducer and Activator of Transcription-3 Activation Contributes to High Tissue Inhibitor … - Full text - MIT Libraries
R Lai, GZ Rassidakis, LJ Medeiros, L Ramdas, AH … - American Journal of Pathology, 2004 - ajp.amjpathol.org
... We further evaluated the rela- tionship between TIMP1 expression and STAT3 acti-
vation in 43 ALCL tumors (19 ALK and 24 ALK ) using immunohistochemistry and a ...
Cited by 3 - Web Search - ajp.amjpathol.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Role of aromatase in sex steroid action
ER Simpson - J Mol Endocrinol, 2000 - journals.endocrinology.org
... are not contiguous, and the nature of the interaction between STAT3, the glucocorticoid ...
of breast cancer in postmenopausal women is the rela- tionship between ...
Cited by 24 - View as HTML - Web Search - journals.endocrinology.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Analyses of Hepatocellular Proliferation in a Mouse Model of-1-Antitrypsin Deficiency - Full text - MIT Libraries
DA Rudnick, Y Liao, JK An, LJ Muglia, DH … - HEPATOLOGY, 2004 - doi.wiley.com
... Regenerating liver (*4 hours or **30 minutes after partial hepatectomy) served as
positive controls for phospho-STAT3 and phospho-p42/44 ... (A) Rela- tive hepatic 1 ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Bacterial pathogens modulate an apoptosis differentiation program in human neutrophils - Full text - MIT Libraries
SD Kobayashi, KR Braughton, AR Whitney, JM Voyich, … - Proceedings of the National Academy of Sciences, USA, 2003 - pnas.org
... IRF1, MX1, and ADAR, and transcription factors that play key roles in IFN signaling
and cell fate, including STAT1, STAT3, STAT5B, STAT6, JAK1, RELA, and RELB ...
Cited by 22 - Web Search - 171.66.122.165 - pubmedcentral.nih.gov - math.unm.edu - all 9 versions »

[PS] EVALUATING RADIO NEWS INTONATION
AVS MODELLING - ikp.uni-bonn.de
... DISC HEAR STAT3 STAT4 Description Sample ... categories for syntactic functions correspond
to classical terminology, which makes the annotations rela- tively theory ...
View as HTML - Web Search - mariawolters.net

IL-2-Mediated Cell Cycle Progression and Inhibition of Apoptosis Does Not Require NF-{kappa} B or … - Full text - MIT Libraries
M Iacobelli, F Rohwer, P Shanahan, JA Quiroz, KL … - J Immunol, 1999 - jimmunol.org
... PhosphoPlus SAPK/JNK (Thr 183 /Tyr 185 ) Ab Kit, New England Biolabs, Beverley,
MA), phosphorylated and total STAT3 (PhosphoPlus Stat3 (Tyr 705 ... 1141), RelA (no ...
Cited by 9 - Web Search - jimmunol.org - sci.sdsu.edu - ncbi.nlm.nih.gov - all 7 versions »

Novel Anti-inflammatory Effects of the Inhaled Corticosteroid Fluticasone Propionate During Lung … - Full text - MIT Libraries
E Cazes, J Giron-Michel, S Baouz, C Doucet, F … - J Immunol, 2001 - jimmunol.org
... Abs were obtained from New England Biolabs (Beverly, MA); the anti-STAT3 Ab, the ...
was performed by incubating the protein extracts with 1 µl of RelA-, RelB-, c ...
Cited by 5 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 6 versions »

Cytokine G-protein signaling crosstalk in cardiomyocytes: Attenuation of Jak-STAT activation by …
GW Booz, JNE Day, R Speth, KM Baker - Molecular and Cellular Biochemistry, 2002 - kluweronline.com
... LIF- induced ERK 1 and 2 activation in cardiomyocytes is rela- tively modest and ...
that other mechanisms contributed to the reduction of LIF-induced STAT3 Y 705 ...
Cited by 3 - Web Search - springerlink.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

TIMP-1 expression in anaplastic large cell lymphoma is usually restricted to macrophages and only … - Full text - MIT Libraries
R Rust, T Blokzijl, G Harms, M Lim, L Visser, WA … - J Pathol, 2005 - ingentaconnect.com
... no clear rela- tionship was observed between IL-6, IL-10 or TGF- β1, and the induction
of TIMP-1 in ALCL. More- over, mRNA levels for STAT3 were similar in ALK ...
Web Search - ncbi.nlm.nih.gov

Biology of Aromatase in the Mammary Gland
ER Simpson - Journal of Mammary Gland Biology and Neoplasia, 2000 - springerlink.com
... This fact is of clinical importance since corpulent women are rela- tively protected ...
results in the rapid phosphorylation of tyrosine residues on STAT3 on but ...
Web Search - kluweronline.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

EFEITO DA PILOCARPINA NA REGENERA O HEP ICA P HEPATECTOMIA PARCIAL EM RATOS.
AN Kalil, D Sperb, E Lichtenfels - scielo.br
... de peso e maior diminui da umidade hep ca em rela a dosagem ... 4. CRESSMAN, DE;
DIAMOND, RH; TAUB, R.- Rapid activatin of the Stat3 transcription complex ...
Cached - Web Search - scielo.br

High Glucose Enhances Interleukin-6-induced Vascular Endothelial Growth Factor 165 Expression via … - Full text - MIT Libraries
K Omori, K Naruishi, F Nishimura, H Yamada- … - J Biol Chem, 2004 - perio6.dent.okayama-u.ac.jp
... was calculated and expressed as a ratio to that of STAT3 protein expression ... The rela-
tive densities of amplified cDNA encoding VEGF165 (B) and VEGF121 (C) were ...
Cited by 1 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov