Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial … - Full text - MIT Libraries
DL Silver, DJ Montell - Cell, 2001 - pharmacology.cwru.edu
... the et al., 2001; Huang et al., 2000). Activated STAT3 is rest of the follicle
cells form a nearly uniform cuboidal sufficient to ...
Cited by 49 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

What does Stat3 do - Full text - MIT Libraries
DE Levy, CK Lee - J. Clin. Invest, 2002 - dx.doi.org
... relating to other Stat family members has been somewhat laid to rest due to the
restricted phenotypes observed in knockout mice, Stat3 remains something of an ...
Cited by 54 - Web Search - jci.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Steel factor induces serine phosphorylation of Stat3 in human growth factor-dependent myeloid cell … - Full text - MIT Libraries
A Gotoh, H Takahira, C Mantel, S Litz-Jackson, HS … - Blood, 1996 - bloodjournal.org
... with anti-Stat3 Ab. One half of each immunoprecipi- tate was separated by 7.5%
SDS-PAGE and blots were visualized by autoradiography. The rest of ...
Cited by 27 - Web Search - bloodjournal.org - bloodjournal.org - ncbi.nlm.nih.gov

STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma - Full text - MIT Libraries
C Brender, M Nielsen, K Kaltoft, G Mikkelsen, Q … - Blood, 2001 - bloodjournal.org
... with a dominant negative STAT3 (DNA binding mutant) or wild-type STAT3, and
transfectants ... out by initial separation of the DNA polymerase from the rest of the ...
Cited by 25 - Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov - all 5 versions »

Three-dimensional structure of the Stat3 homodimer bound to DNA - Full text - MIT Libraries
S Becker, B Groner, CW Muller - Nature, 1998 - nature.com
... in Stat1 to Stat4 and critical for sequence-specific recognition in Stat3—is a ... of
the SH2 domain indicates that it is not rigidly attached to the rest of the ...
Cited by 21 - Web Search

Analysis of Stat3 (signal transducer and activator of transcription 3) dimerization by fluorescence … - Full text - MIT Libraries
AK Kretzschmar, MC Dinger, C Henze, K Brocke- … - Biochem J, 2004 - biochemj.org
... N1 and pEYFP-N1 (Clontech), resulting in a linker between Stat3 (or its ... purchased
from Clontech (Heidelberg, Germany), T4 DNA ligase and rest- riction enzymes ...
Cited by 7 - View as HTML - Web Search - dx.doi.org - biochemj.org - ncbi.nlm.nih.gov - all 5 versions »

Activation of Stat3 Transcription Factor by Herpesvirus Saimiri STP-A Oncoprotein - Full text - MIT Libraries
YH Chung, NH Cho, MI Garcia, SH Lee, P Feng, JU … - J Virol, 2004 - pubmedcentral.nih.gov
... Src has been shown to interact with Stat3 and to activate Stat3 to induce ... STPs have
transforming and tumor-inducing activities independent of the rest of the ...
Cited by 4 - Web Search - jvi.asm.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Supporting Information
B Evaluation - pnas.org
... The rest of the compounds were purchased from corresponding vendors. ... in Tables
3-5, STA-21 (STA-021) demonstrated strong and selective inhibition to the Stat3. ...
Web Search

Aberrant Stat3 Signaling by Interleukin-4 in Malignant Glioma Cells: Involvement of IL-13R {alpha} 2 - Full text - MIT Libraries
SO Rahaman, MA Vogelbaum, SJ Haque - Cancer Research, 2005 - cancerres.aacrjournals.org
... Twenty-five percent of the precleared chromatin were kept for input control and
the rest was immunoprecipitated with either anti-Stat3 rabbit polyclonal ...
Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

Three-dimensional structure of the Stat3 bold beta homodimer bound to DNA
S BECKER, B GRONER, CW MUeLLER - nature.com
... in Stat1 to Stat4 and critical for sequence-specific recognition in Stat3—is a ... of
the SH2 domain indicates that it is not rigidly attached to the rest of the ...
Web Search - nature.com

It takes nerve to dampen inflammation - Full text - MIT Libraries
CN Metz, KJ Tracey - Nature Immunology, 2005 - nature.com
... pathway of the tyrosine kinase Jak2 and the transcription factor STAT3, which is ...
component of the parasympathetic nervous system (known for its 'rest and digest ...
Web Search

Suppression of G-CSF-mediated Stat signalling by IL-3
RA Steinman, A Iro - Leukemia, 1999 - nature.com
... At base, immunoblots of extracts for Stat3 expression are shown. (b) Dose dependence
of IL-3 suppression of G-CSF-induced Stat3 binding. After rest cells were ...
Cited by 10 - Web Search - nature.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Cytokines: IL-20—a new effector in skin inflammation - Full text - MIT Libraries
BE Rich, TS Kupper - Curr Biol, 2001 - jpkc.bjmu.cn
... both upregulated in proliferation and differentiation; psoriasis activates Stat3;
receptor also on ... a self-repairing physical barrier to keep the rest of the ...
Cited by 13 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

JAK 2/STAT 3, Not ERK 1/2, Mediates Interleukin-6-induced Activation of Inducible Nitric-oxide … - Full text - MIT Libraries
X Yu, RH Kennedy, SJ Liu - J Biol Chem, 2003 - jbc.org
... Thus, we examined whether the JAK2/STAT3 and/or ERK1/2 pathways are involved in ... The
amplitude of PRP30 and PRP60 relative to that of pre-rest steady state is ...
Cited by 12 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

lal-1: a differentially expressed novel gene during proliferation in liver regeneration and in … - Full text - MIT Libraries
MA Della Fazia, D Piobbico, D Bartoli, M Castelli, … - Genes to Cells, 2002 - genestocellsonline.org
... Background : During liver regeneration,95% of the rest- ing hepatocytes enter in
G1/S phase ... It has been shown that the DNA- binding activity of Stat3,NF-kB,AP ...
Cited by 1 - Web Search - blackwell-synergy.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Modulation of Brain Gene Expression during Sleep and Wakefulness A Review of Recent Findings - Full text - MIT Libraries
G Tononi, C Cirelli - Neuropsychopharmacology, 2001 - nature.com
... Related to rlf NGFI-A Related to SNF2/SW12 NGFI-B N-Ras Stat3 ... Rest deprivation in
Drosophila is associated with an increased expression of arylalky- lamine N ...
Cited by 16 - Web Search - nature.com - ncbi.nlm.nih.gov

STAT 3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase … - Full text - MIT Libraries
Q Zhang, HY Wang, M Marzec, PN Raghunath, T … - Proceedings of the National Academy of Sciences, 2005 - pnas.org
... of the binding, we performed mutational analysis of the identified STAT3 binding
sites ... M2 mutants, both TT and AA dimers were replaced, whereas the rest of the ...
Web Search - dx.doi.org - ncbi.nlm.nih.gov - all 4 versions »

Epigenetic control of neural stem cell fate
J Hsieh, FH Gage - Curr. Opin. Genet. Dev, 2004 - utsouthwestern.edu
... and ChIP assays, the authors postulated a model wherein the NRSE dsRNA interacted
with REST–NRSF and ... (a) Changes in DNA methylation at the Stat3 binding site ...
Cited by 6 - View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Two distinct signaling pathways in hair cycle induction: Stat 3-dependent and-independent pathways - Full text - MIT Libraries
S Sano, M Kira, S Takagi, K Yoshikawa, J Takeda, S … - Proceedings of the National Academy of Sciences - pnas.org
... an epidermal derivative that undergoes cycles of growth, involution, and rest. ... We
previously established keratinocyte-specific Stat3-disrupted mice, by which ...
Cited by 14 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Impaired response to interferon-alpha/bold beta and lethal viral disease in human STAT1 deficiency - Full text - MIT Libraries
S Dupuis, E Jouanguy, S Al-Hajjar, C Fieschi, IZ … - Nature Genetics, 2003 - nature.com
... 705-STAT3 (9131; New England Biolabs) or a rabbit antibody against STAT3 (sc7179;
Santa ... Then, 48 h later, infection in the rest of the sample was stopped, and ...
Cited by 42 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Tissue Regeneration: Hair Follicle as a Model
S Sano, J Takeda, K Yoshikawa, S Itami - Journal of Investigative Dermatology, 2001 - blackwell-synergy.com
... Thus, analyses of these mice reveal that Stat3 in keratinocytes contributes to ...
derivative that undergoes cycles of growth, regression, and rest, referred to as ...
Cited by 2 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Assessment of Stem Cell Markers During Long-Term Culture of Mouse Embryonic Stem Cells
A Berrill, HL Tan, SC Wuang, WJ Fong, ABH Choo, … - Cytotechnology, 2004 - kluweronline.com
... The withdrawal of LIF induces differentiation but not cell-cycle ar- rest. Therefore
it is possible that STAT3 could still regulate the differentiated ES cells ...
Web Search - springerlink.com

Ciliary neurotrophic factor and stress stimuli activate the Jak-STAT pathway in retinal neurons and … - Full text - MIT Libraries
WM Peterson, Q Wang, R Tzekova, SJ Wiegand - J Neurosci, 2000 - jneurosci.org
... results not shown). In the rest of the retina, total STAT3 immunoreactivity
was similar to that of untreated eyes. Our results suggest ...
Cited by 51 - Web Search - jneurosci.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Cardiomyocyte-restricted knockout of STAT 3 results in higher sensitivity to inflammation, cardiac … - Full text - MIT Libraries
JJ Jacoby, A Kalinowski, MG Liu, SS Zhang, Q Gao, … - Proceedings of the National Academy of Sciences - pnas.org
... results also indicate that the deletion of one allele of STAT3 rather than ... their
cardiac function was restricted to that obtained by echocardiography at rest. ...
Cited by 9 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Gastrointestinal Stem Cells I. Pancreatic stem cells - Full text - MIT Libraries
B Soria, FJ Bedoya, F Martin - Am J Physiol Gastrointest Liver Physiol, 2005 - ajpgi.physiology.org
... In the rest of the organs, they transdifferentiate (green) to -cells. ... Receptor
activation triggers the JAK/STAT3 proliferative pathway. ...
Web Search - ajpgi.physiology.org

Teammate effects on pay - Full text - MIT Libraries
AE Letters - Applied Economics Letters, 2004 - dx.doi.org
... based on an assessment of how well the player will fit in with the rest of the ... Constant
14.506 a – – (1.463) R 2 0.609 F-stat1 0.34 F-stat2 3.13 b F-stat3 ...
Web Search - taylorandfrancis.metapress.com

Muscle-derived interleukin-6: possible biological effects - Full text - MIT Libraries
BK Pedersen, A Steensberg, P Schjerling - The Journal of Physiology, 2001 - jphysiol.org
... contractions of one hind leg, while the other leg remained at rest. ... JAKs), which
then phosphorylate signal transducer and activator of transcription 3 (STAT3). ...
Cited by 53 - Web Search - blackwell-synergy.com - jp.physoc.org - ncbi.nlm.nih.gov

[CITATION] Targeted inhibition of Stat 3 with a decoy oligonucleotide abrogates head and neck cancer cell … - Full text - MIT Libraries
PL Leong, GA Andrews, DE Johnson, KF Dyer, S Xi, … - Proceedings of the National Academy of Sciences, 2003
... The Stat3 decoy sequence was 5'-CATTTCCCGTAAATC-3', 3'GTAAAGGGCATTTAC-5' and the ...
sequence was 5'-CATTTCCTTAAATC-3', 3'-GTAAAGGGAATTTAG-5' (for the rest of the ...
Cited by 21 - Web Search - pnas.org - pubmedcentral.nih.gov - dx.doi.org - all 7 versions »

Identification of two distinct transactivation domains in the pluripotency sustaining factor nanog - Full text - MIT Libraries
GJ Pan, DQ Pei, DQ PEI - Cell Res, 2003 - cell-research.com
... The rest of nanog contains no apparent homology to any known proteins ... both positively
and negatively[1-3]. In addition, transcription factors STAT3 has also ...
Cited by 2 - View as HTML - Web Search - cell-research.com - ncbi.nlm.nih.gov

Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural … - Full text - MIT Libraries
J Hsieh, K Nakashima, T Kuwabara, E Mejia, FH Gage - Proceedings of the National Academy of Sciences - pnas.org
... histone deacetylase; VPA, valproic acid; TSA, trichostatin A; NRSF/REST,
neuron-restrictive ... 2; IGF-1, insulin-like growth factor 1; STAT3, signal transducer ...
Cited by 1 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Fes Tyrosine Kinase Promotes Survival and Terminal Granulocyte Differentiation of Factor-dependent … - Full text - MIT Libraries
J Kim, Y Ogata, RA Feldman - J Biol Chem, 2003 - jbc.org
... 5'-TGCAGATTGCGCAATCTGCA-3, antisense 5'-TGCAGATTGCGCAATCTGCA-3'; STAT3-SIE (sis ... of
this Fes act -expressing population, whereas the rest exhibited intermediate ...
Cited by 7 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

A Novel Sequence in the Coiled-coil Domain of Stat 3 Essential for Its Nuclear Translocation - Full text - MIT Libraries
J Ma, T Zhang, V Novotny-Diermayr, ALC Tan, X Cao - J Biol Chem, 2003 - jbc.org
... after EGF treatment (Fig. 3B). The rest mutants, on the other hand, behaved
like the wild-type Stat3. This result indicated that ...
Cited by 10 - Web Search - jbc.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Molecular and anatomical determinants of central leptin resistance - Full text - MIT Libraries
H Muenzberg, MG Myers - Nature Neuroscience, 2005 - nature.com
... of leptin resistance act on signaling pathways other than STAT3 and that ... or other
cytokines), as compared with the relative protection afforded the rest of the ...
Web Search - uni-marburg.de - nature.com - ncbi.nlm.nih.gov

Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, … - Full text - MIT Libraries
Q Gao, MJ Wolfgang, S Neschen, K Morino, TL … - Proc Natl Acad Sci US A, 2004 - pubmedcentral.nih.gov
... able to maintain their body temperature throughout the cold challenge, STAT3 N-/-
and ... C and were able to stabilize this temperature throughout the rest of the ...
Cited by 14 - Web Search - dx.doi.org - pnas.org - ncbi.nlm.nih.gov - all 6 versions »

Leptin and TGF-[beta] synergistically regulate VIP cytokine response element transcription. - Full text - MIT Libraries
E Jones, A Symes - Neuroreport, 2000 - neuroreport.com
... Stat3 binds to a Stat site at the 5' end of the VIP CyRE (G3 ... strongly activates Stat
signaling, and may have little effect on signaling to the rest of the CyRE. ...
Cited by 1 - Web Search - neuroreport.com - ncbi.nlm.nih.gov

Photoperiodic Regulation of Leptin Sensitivity in the Siberian Hamster, Phodopus sungorus, Is … - Full text - MIT Libraries
A Tups, C Ellis, KM Moar, TJ Logie, CL Adam, JG … - Endocrinology, 2004 - endo.endojournals.org
... receptor by inhibition of STAT3 phosphorylation. ... (LD-REST, n=12) such that
the group mean body weight tracked that of the SD hamsters. ...
Cited by 1 - Web Search - cgi-host.uni-marburg.de - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Functional Genomics of Sleep and Circadian Rhythm - Full text - MIT Libraries
C Cirelli - J Appl Physiol, 2002 - jap.physiology.org
... of sleep loss (7). They include CHOP, IER5, NGFI-B, N-ras, and Stat3. ... BiP mRNA levels
are induced after periods of spontaneous activity or rest deprivation in ...
Cited by 1 - Web Search - jap.physiology.org

Stage- and site-specific DNA demethylation during neural cell development from embryonic stem cells - Full text - MIT Libraries
K Shimozaki, M Namihira, K Nakashima, T Taga - Journal of Neurochemistry, 2005 - blackwell-synergy.com
... DNA demethylation and the maintenance of DNA methylation of the STAT3 binding site ...
Recently, it was reported that the zinc-finger factor REST/NRSF can mediate ...
Web Search - ncbi.nlm.nih.gov

STAT proteins are activated by ciliary neurotrophic factor in cells of central nervous system origin - Full text - MIT Libraries
P Rajan, AJ Symes, JS Fink - Journal of Neuroscience Research, 1996 - doi.wiley.com
... activation of the VIP gene is mediated by the CyRE, to which activated Statla and
Stat3 proteins bind (Symes et ... rest, n = 3. Data are presented as mean * SEM. ...
Cited by 21 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

[CITATION] MEDICAL SCIENCES
Q Zhang, HY Wang, M Marzec, PN Raghunath, T …
Web Search

Molecular Pathways of Regeneration and Repair after Liver Transplantation - Full text - MIT Libraries
KM Olthoff - World Journal of Surgery, 2002 - springerlink.com
... The parenchymal cells are nor- mally at rest during the G 0 -phase, with ... NF- B) and
signal transduction and activators of transcription 3 (STAT3) are induced ...
Cited by 13 - Web Search - ncbi.nlm.nih.gov

Expression of cytokine signal transduction components in the postnatal mouse retina
K Do Rhee, XJ Yang - molvis.org
... 24 h of birth were considered as postnatal day 0 (P0) animals, and the rest were
staged ... antibodies against Jak2 (C-20), Tyk2 (C-20), STAT1 (E-23), STAT3 (K-15 ...
Cited by 5 - View as HTML - Web Search - molvis.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Genetic variations in the interleukin-12/interleukin-23 receptor (b1) chain, and implications for IL … - Full text - MIT Libraries
E Van de Vosse, EG Lichtenauer-Kaligis, JT van … - Immunogenetics, 2003 - springerlink.com
... 1995), although direct interaction between STAT1, STAT3 or STAT5 and either of ... The
rest have nucleotide substitutions or deletions resulting in either splicing ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Multiple signaling pathways mediate LIF-induced skeletal muscle satellite cell proliferation - Full text - MIT Libraries
EE Spangenburg, FW Booth, FW Booth, MO Columbia - Am J Physiol Cell Physiol, 2002 - ajpcell.physiology.org
... JAK2-STAT3 signaling pathway, suggesting that this may be an important ... physical
inactivity associated with aging, bed rest, limb immobilization, space flight ...
Cited by 13 - Web Search - intl-ajpcell.physiology.org - intl-ajpcell.physiology.org - ncbi.nlm.nih.gov - all 5 versions »

IL-6 signaling by STAT 3 participates in the change from hyperplasia to neoplasia in NRP-152 and NRP … - Full text - MIT Libraries
B Barton, T Murphy, P Adem, R Watson, R Irwin, H … - BMC Cancer, 2001 - biomedcentral.com
... determine if IL-6 was the activating ligand for phosphorylation of STAT3, we examined
IL ... 9 clones were highly-positive for IL-6, while the rest expressed little ...
Cited by 6 - Cached - Web Search - dx.doi.org - pubmedcentral.nih.gov - citebase.eprints.org - all 7 versions »

Insulin Increases the Abundance of the Growth Hormone Receptor in Liver and Adipose Tissue of … - Full text - MIT Libraries
RP Rhoads, JW Kim, BJ Leury, LH Baumgard, N … - J Nutr, 2004 - nutrition.org
... abundance of intracellular mediators of GH actions (JAK2, STAT5, or STAT3) remained
unaffected. ... from adipose tissue and their oxidative use by the rest of the ...
Web Search - nutrition.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

A niche for adult neural stem cells
F Doetsch - Curr Opin Genet Dev, 2003 - mrrc.npi.ucla.edu
... At later developmental stages, the STAT3 element is demethylated and the cells can
dif ... as the Type II sodium channel are repressed by binding of REST/NRSF and ...
Cited by 27 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

The West African Power Pool & Optimal Long-Term Planning Of International Transmission With A Free- …
FT Sparrow, BH Bowen, S Dakar - ECOWAS Power Pool Conference, Dakar, Senegal, March, 2001 - engineering.purdue.edu
... the 20-year horizon. Benin and Togo become major wheelers of electricity
to Ghana and the rest of the region. Guinea becomes an ...
Cited by 1 - View as HTML - Web Search - engineering.purdue.edu

Role of Phosphatidylinositol-3 Kinase in Regulation of Differential Sensitivity of Melanoma Cells to …
MA Krasil'nikov, EV Luzai, AM Scherbakov, VA … - Biochemistry(Moscow), 2004 - springerlink.com
... Our data indicate that PI3K and STAT3 can be considered as components of one and ...
The level of protein activities after withdrawal of hormone A rest is to be ...
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Single cell profiling of potentiated phospho-protein networks in cancer cells - Full text - MIT Libraries
JM Irish, R Hovland, PO Krutzik, OD Perez, O … - Cell, 2004 - facsdragon.com
... unique cancer network profiles that correlated with ports suggest that STATs, such
as Stat3 and Stat5, are ... phosphorylated Stat1, Stat3, Stat5, Stat6, p38, and ...
Cited by 21 - View as HTML - Web Search - imm.med.ncku.edu.tw - ncbi.nlm.nih.gov