Increased dosage of Runx1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2 mice - Full text - MIT Libraries
M Yanagida, M Osato, N Yamashita, H Liqun, B Jacob … - Oncogene, 2005 - nature.com
... activation of STAT3 together with the overexpression of Runx1 may lead to dysregulation
of cyclin D1 or cyclin D3, since both STAT3 and RUNX1 binding sites are ...
Web Search - nature.com - ncbi.nlm.nih.gov

Oligo GEArray® Human Hematopoietic Stem Cells and Hematopoiesis Microarray
S Conditions - search.cosmobio.co.jp
... HOXB4, IFI16, IL31RA, IRF4, IRF8, KLF6, LEF1, MAFB, MYC, NCOA6, NFYA, NOTCH1, NOTCH2,
NOTCH4, PAX5, RBPSUH, RHOH, RUNX1, SCAND1, STAT1, STAT3, STAT4, TAL1, VAV1 ...
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RNA interference as a potential tool in the treatment of leukaemia
A Borkhardt, O Heidenreich - Expert Opinion on Biological Therapy, 2004 - extenza-eps.com
... Expression of the RUNX1–CBFA2T1 fusion gene predominantly blocks differentiation ...
has a differentiation-supportive and antiproliferative role, STAT3 and -5 ...
Web Search - ashley-pub.com - dx.doi.org - ingentaconnect.com - all 8 versions »

Association of the T allele of an intronic single nucleotide polymorphism in the colony stimulating … - Full text - MIT Libraries
A Zapata-Velandia, SS Ng, R Brennan, N Simonsen, M … - Journal of Immune Based Therapies and Vaccines, 2004 - dx.doi.org
... These data suggest that a signaling pathway involving G alpha i2, Stat3 and CSF1R
is ... of the A2033T SNP near a binding site for the transcription factor, RUNX1. ...
Web Search - pubmedcentral.nih.gov - jibtherapies.com - citebase.eprints.org - all 9 versions »

Journal of Immune Based Therapies and Vaccines - Full text - MIT Libraries
NR Simonsen, M Gastanaduy, J Zabaleta, JJ Lentz, … - Journal of Immune Based Therapies and Vaccines, 2004 - bmc.ub.uni-potsdam.de
... the CSF1R gene that was located 77 base pairs downstream from a Runx1 binding site ...
cascade linking the G alpha i2 receptor to the transcription factor Stat3. ...
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AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34 cells, allowing nerve growth …
JC Mulloy, V Jankovic, M Wunderlich, R Delwel, J … - pnas.org
... ETO (RUNX1-CBFA2T1) [t(8;21)], RUNX1/MDS/EVI1 [t(3;21)], ETV6-RUNX1 [t(12 ... were prepared
and analyzed by Western blot for the level of ERK, AKT, STAT3, and STAT5 ...
Web Search - dx.doi.org - dx.doi.org - pnas.org

Report on the ‘Expert Workshop on the Biology of Chromosome 21: towards gene-phenotype … - Full text - MIT Libraries
K Gardiner, MT Davisson, M Pritchard, D Patterson, … - Cytogenetic and Genome Research, 2005 - content.karger.com
... Principal classes include transcription fac- tors (FOXO1A, STAT3, CREB1 and GLI)
and, from his ... The chromosome 21 gene, RUNX1, is a frequent target of leu- kemia ...
Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions »

A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and … - Full text - MIT Libraries
RJ Chan, SA Johnson, Y Li, MC Yoder, GS Feng, GS … - Blood, 2003 - bloodjournal.org
... 35-37 and runx1 38 knock-out mice. ... which little is known. Based on the findings
that phospho-Stat3 is necessary to maintain ES cells in an ...
Cited by 7 - Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov

Granulocyte Colony-Stimulating Factor Receptors on CD34 Cells in Patients with Myelodysplastic …
A KIMURA, TA SULTANA - Leukemia & Lymphoma, 2004 - dx.doi.org
... in the constitutive phosphorylation of signaling substrates (Jak2, Stat3, ERK1 and
2 ... we have shown somatically acquired point mutations of AML/RUNX1 gene in ...
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Mutagenesis of the Runt Domain Defines Two Energetic Hot Spots for Heterodimerization with the Core … - Full text - MIT Libraries
L Zhang, Z Li, J Yan, P Pradhan, T Corpora, MD … - J Biol Chem, 2003 - jbc.org
... RUNX1 and CBFB are required for hematopoiesis and are frequently targeted by ... of
DNA-binding transcription factors, whose other members include STAT3 , p53, NF B ...
Cited by 3 - Web Search - intl.jbc.org - jbc.org - ncbi.nlm.nih.gov

Bone morphogenetic proteins in vertebrate hematopoietic development - Full text - MIT Libraries
A Snyder, ST Fraser, MH Baron, N York, N York, RC … - Journal of Cellular Biochemistry, 2004 - doi.wiley.com
... It is tempting to speculate that BMP4 signaling may induce expression of Runx1 in
the ... inhibitory factor (LIF) acts through the gp130 receptor and STAT3, and in ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

The Kasumi-1 cell line: a t (8; 21)-kit mutant model for acute myeloid leukemia
L Larizza, I Magnani, A Beghini - Leukemia & Lymphoma, 2005 - dx.doi.org
... KIT Asn822Lys tyrosine phosphorylation and downstream JNK and STAT3 effectors in ...
gene located on chromosome 21, (also called CBFA2, RUNX1, PEBP2A), encoding ...
Cited by 1 - Web Search - taylorandfrancis.metapress.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Molecular Mechanisms of Megakaryocyte Differentiation - Full text - MIT Libraries
H Schulze, RA Shivdasani - Seminars in Thrombosis and Hemostasis, 2004 - thieme-connect.com
... Michaud J, Wu F, Osato M. In vitro analyses of known and novel RUNX1/AML1 mutations ...
4045-4052 68 Kirito K, Osawa M, Morita H. A functional role of Stat3 in in ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

Energetic and Functional Contribution of Residues in the Core Binding Factor beta(CBFbeta) Subunit … - Full text - MIT Libraries
YY Tang, J Shi, L Zhang, A Davis, J Bravo, AJ … - J Biol Chem, 2000 - jbc.org
... The plasmids expressing the Runx1 and CBF fusion proteins were cotransformed into
a ... CBF heterodimer bound to DNA, based on comparison to the STAT3 ·DNA co ...
Cited by 14 - Web Search - cs.dartmouth.edu - jbc.org - ncbi.nlm.nih.gov

Unique gene expression signatures of independently-derived human embryonic stem cell lines - Full text - MIT Libraries
MJ Abeyta, AT Clark, RT Rodriguez, MS Bodnar, RA … - Human Molecular Genetics, 2004 - hmg.oupjournals.org
... Moreover, the genes GP130, STAT3, FOXD3, H19, FGF4, CD34, RUNX1, VEGFR2 (KDR, FLK1)
and KIT, expressed in adult stem cell and mESC populations, were absent in ...
Cited by 15 - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

TRANSCRIPTION FACTORS
OFB CELLS - doi.wiley.com
... II TRANSCRIPTION FACTORS AND THE MYELOID LINEAGE 85 6 RUNX1(AML1) and CBFB: Genes
Required for the Development of All Definitive Hematopoietic Lineages 87 ...
Web Search

Analysis of the interaction of TIP60β and PIN1 with the ets family transcription factor ETV6
CD Zhang - edoc.ub.uni-muenchen.de
... leukemias with an ETV6/RUNX1 fusion gene a deletion of the ... et al., 2003). TIP60
interacts with STAT3 and represses STAT3-mediated gene expression. ...
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CCAAT/Enhancer-binding Proteins(C/EBP) beta and delta Activate Osteocalcin Gene Transcription and … - Full text - MIT Libraries
S Gutierrez, A Javed, DK Tennant, M van Rees, M … - J Biol Chem, 2002 - jbc.org
... and osteogenic genes (13, 14, 23, 42-44), whereas PPAR and Stat3 interactions with ...
and - and Runx2 in osteoblasts (29, 30, 46) and C/EBP -Runx1 protein-protein ...
Cited by 39 - Web Search - ncbi.nlm.nih.gov

RET/PTC-induced gene expression in thyroid PCCL3 cells reveals early activation of genes involved in …
E Puxeddu, JA Knauf, MA Sartor, N Mitsutake, EP … - Endocrine-Related Cancer, 2005 - journals.endocrinology.org
... Gstt1), signal transduction (Socs3, Nf1, Jak2, Cpg21, Dusp6, Socs1, Stat1, Stat3,
Cish) and transcription (Nr4a1, Junb, Hfh1, Runx1, Foxe1). ...
View as HTML - Web Search - erc.endocrinology-journals.org - journals.endocrinology.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

Dimerization: a versatile switch for oncogenesis - Full text - MIT Libraries
CW So, ML Cleary - Blood, 2004 - bloodjournal.org
... leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways ...
N. The role of a Runt domain transcription factor AML1/RUNX1 in leukemogenesis ...
Cited by 5 - Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov

Regulation of skeletal development by the Runx family of transcription factors - Full text - MIT Libraries
T Komori - Journal of Cellular Biochemistry, 2005 - doi.wiley.com
... Runx1 determines commitment to the hematopoietic cell lineage and Runx2
determines commitment to the osteoblastic lineage. Cbfb ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

Runt Domain Factor(Runx)-dependent Effects on CCAAT/ Enhancer-binding Protein delta Expression and … - Full text - MIT Libraries
TL McCarthy, C Ji, Y Chen, KK Kim, M Imagawa, Y … - J Biol Chem, 2000 - jbc.org
... signal transducers and activators of transcription 3 (APRE/STAT3) and Sp1 (16 ... results
that demonstrated physical interactions between the homologues Runx1 and C ...
Cited by 26 - Web Search - jbc.org - ncbi.nlm.nih.gov

Divergence and convergence of TGF-b/BMP signaling - Full text - MIT Libraries
K Miyazono, K Kusanagi, H Inoue - J. Cell Physiol, 2001 - doi.wiley.com
... Runx1/2/3 Smad1,2,3,5 MH2, MH1 ... factors that interact with BR-Smads (Miyazono, 2001)
but it has been shown that BR-Smads indirectly interact with STAT3 through a ...
Cited by 135 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

The‘definitive’(and‘primitive’) guide to zebrafish hematopoiesis - Full text - MIT Libraries
AJ Davidson, LI Zon - Oncogene, 2004 - nature.com
... cbfb Core binding factor — Blake et al. (2000) runx1 Core binding factor Morphant
Kalev-Zylinska et al. (2002) ... (1998) stat3 STAT — Oates et al. (1999) ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

ANGIOGENESIS
H Identification - rndsystems.com
... that the hematopoietic and endothelial lineages express a number of genes in common,
such as CD34, VEGF R2 (also known as Flk-1 and KDR), SCL, Runx1 and GATA-1 ...
View as HTML - Web Search - rndsystems.com - woongbee.com - rndsystems.com

Enforced Activation of STAT 5 A Facilitates the Generation of Embryonic Stem-Derived Hematopoietic … - Full text - MIT Libraries
JJ Schuringa, K Wu, G Morrone, MAS Moore - Stem Cells, 2004 - stemcells.alphamedpress.org
... early hematopoietic cells, which involves a lack of STAT3 activation [28 ... hematopoietic
progenitors, whereas this population is absent in runx1/AML1 –/– EBs ...
Web Search - dx.doi.org - stemcells.alphamedpress.org - ncbi.nlm.nih.gov

BASL abstracts - Full text - MIT Libraries
D Schuppan, C Trautwein - Gut, 2003 - dx.doi.org
... 011 EXPRESSION OF TIMP-1 IN HEPATIC STELLATE CELLS IS REGULATED BY THE ANTAGONISTIC
EFFECTS OF THE RUNX1 AND RUNX2 TRANSCRIPTION FACTORS M. Bertrand, MPJ Arthur ...
Web Search - gut.bmjjournals.com - gut.bmjjournals.com

The role of the AML1 transcription factor in leukemogenesis
RB Lorsbach, JR Downing - Int J Hematol, 2001 - cardenjennings.metapress.com
... Key words: AML1; Runx1;Acute leukemia; ETO;AML1-ETO ... several other structurally related
DNA-binding proteins including p53, NF- B, NFAT, STAT1, and STAT3 [10,11 ...
Cited by 7 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Update in childhood acute myeloid leukemia: recent developments in the molecular basis of disease …
JJ Clark, FO Smith, RJ Arceci… - Curr Opin Hematol, 2003 - co-hematology.com
... Further characterization of the RUNX1-ETO fusion in 19 pediatric AML samples showed ...
both the signal transducer and activator of transcription 3 (STAT3) and the ...
Cited by 4 - Web Search - co-hematology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Genomic approaches for reconstructing gene networks
NH Lee - Pharmacogenomics, 2005 - futuremedicine.com
Page 1. 10.1517/14622416.6.3.245 © 2005 Future Medicine Ltd ISSN 1462-2416
Pharmacogenomics (2005) 6(3), 245-258 245 R EVIEW For ...
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Novel transcription factors in human CD34 antigen-positive hematopoietic cells - Full text - MIT Libraries
I Gomes, TT Sharma, S Edassery, N Fulton, BG Mar, … - Blood, 2002 - bloodjournal.org
... Transcription Hs.321677 STAT3 Signal transducer and activator of transcription 3 ...
Hs.129914 RUNX1 Runt-related transcription factor 1 (acute myeloid leukemia 1 ...
Cited by 3 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

A stable human-derived packaging cell line for production of high titer retrovirus/vesicular … - Full text - MIT Libraries
DS Ory, BA Neugeboren, RC Mulligan - J. Biol. Chem, 2004 - dx.doi.org
Vol. 93, Issue 21, 11400-11406, October 15, 1996. This paper was presented
at a colloquium entitled "Genetic Engineering of Viruses ...
Cited by 320 - Web Search - pnas.org - ncbi.nlm.nih.gov - adsabs.harvard.edu - all 6 versions »

Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem …
E Passegue, CH Jamieson, LE Ailles, IL Weissman - Proceedings of the National Academy of Sciences - pnas.org
... acts, at least in part, via activation of the transcription factor STAT3, an essential ...
AML-1 gene (AML1 also known as CBFA2, PEBP2 B, and RUNX1) on chromosome ...
Cited by 42 - Web Search - 171.66.122.165 - biol.sc.edu - olemiss.edu - all 10 versions » - Get it from MIT Libraries

Past, present, and future of HPV research: highlights from the 19th International Papillomavirus …
LL Villa, HU Bernard, M Kast, A Hildesheim, G … - Virus Res 89, 2002 - upload.mcgill.ca
... that HPV-18 transcription could be stimulated by IL-6 in a STAT3 dependent manner ...
of HPV-8 is regulated by p53, the interferon regulating factor-5, RUNX1, and a ...
Cited by 2 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Hematopoietic perturbation in zebrafish expressing a tel-jak2a fusion.
SM Onnebo, MM Condron, DO McPhee, GJ Lieschke, AC … - Experimental Hematology, 2005 - eanimal.snu.ac.kr
... Tyrosine-dependent and independent mechanisms of STAT3 activation by the human ... Runx1
is required for zebrafish blood and vessel development and expression of a ...
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AML1 interconnected pathways of leukemogenesis
J Michaud, HS Scott, R Escher - Cancer Invest, 2003 - taylorandfrancis.metapress.com
... The official designation for AML1 is RUNX1 (the Human Gene Nomenclature ... Transcription
activators STAT3 d Signal transducer and acti- vator of transcription 3 ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

The Kinetic Status of Hematopoietic Stem Cell Subpopulations Underlies a Differential Expression of … - Full text - MIT Libraries
R Manfredini, R Zini, S Salati, M Siena, E … - Stem Cells, 2005 - stemcells.alphamedpress.org
... CD34 + cells, because TPO response genes, such as HOXB4, CBFß, Runx1, Nfe-2 ... progression
of HSCs and progenitor cells acting through STAT1/STAT3 activation [22 ...
Web Search - dx.doi.org - stemcells.alphamedpress.org - ncbi.nlm.nih.gov

The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases - Full text - MIT Libraries
XJ Yang - Nucleic Acids Research, 2004 - nar.oupjournals.org
... functions as a transcriptional co-repressor for TEL (119) and STAT3 (151), but ... Both
MOZ and MORF physically and functionally interact with Runx1 and Runx2 (161 ...
Cited by 14 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

The Theoretical Basis of Transcriptional Therapy of Cancer: Can it Be Put Into Practice? - Full text - MIT Libraries
AM Melnick, K Adelson, JD Licht - Journal of Clinical Oncology, 2005 - jco.org
... of t(8;21) M2 AML, CBFß-MYH11 of inv(16) M4eo AML, and TEL-RUNX1 of t ... A duplex DNA
decoy for the STAT3 transcription factor that can be directly injected into ...
Cited by 1 - Web Search - dx.doi.org - jco.org - ncbi.nlm.nih.gov

The ETS-family transcription factor, PU. 1, is necessary for the maintenance of fetal liver … - Full text - MIT Libraries
HG Kim, CG De Guzman, CS Swindle, CV Cotta, L … - Blood, 2004 - bloodjournal.org
... 15-18 The absence of definitive hematopoiesis in the Runx1 and CBF knockouts ... 2
(CD11b/CD18) expression by cytokines is regulated by Stat3-dependent activation ...
Cited by 3 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Microarray analysis of epigenetic silencing of gene expression in the KAS-6/1 multiple myeloma cell … - Full text - MIT Libraries
C Pompeia, DR Hodge, C Plass, YZ Wu, VE Marquez, … - Cancer Res, 2004 - cancerres.aacrjournals.org
Page 1. [CANCER RESEARCH 64, 3465–3473, May 15, 2004] Microarray Analysis of Epigenetic
Silencing of Gene Expression in the KAS-6/1 Multiple Myeloma Cell Line ...
Cited by 8 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Altered differentiation in acute myeloid leukemias; Role of ERG and FUS-ERG fusion protein
MC Doarn - 2005 - kb.osu.edu
Page 1. Altered Differentiation in Acute Myeloid Leukemias; Role of ERG
and FUS-ERG Fusion Protein A Senior Honors Thesis Presented ...
View as HTML - Web Search - kb.osu.edu

Production of high-titer helper-free retroviruses by transient transfection - Full text - MIT Libraries
WS PEAR, GP NOLAN, ML SCOTT, D BALTIMORE - Proc. Nat. Acad. Sci, 1993 - pnas.org
... Home page BA Hug, N. Ahmed, JA Robbins, and MA Lazar A Chromatin Immunoprecipitation
Screen Reveals Protein Kinase C{beta} as a Direct RUNX1 Target Gene J. Biol ...
Cited by 1223 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - adsabs.harvard.edu - all 5 versions »

Bibliography Current World Literature
Y Alamanos, NG Papadopoulos, PV Voulgari… - Current Opinion in Rheumatology, 2005 - co-rheumatology.com
... U, Traupe H, Burkhardt H, et al.: Lack of evidence for genetic association to RUNX1
binding site at ... Sano S, Chan K, Carbajal S, et al.: Stat3 links activated ...
Web Search

Genetic programs regulating HSC specification, maintenance and expansion - Full text - MIT Libraries
J Lessard, A Faubert, G Sauvageau - Oncogene, 2004 - nature.com
... et al., 1996; Lacaud et al., 2002) (also known as RUNX1/CBFA2 and ... Interestingly,
HSCs engineered to overexpress an activated form of STAT3 (STAT3c) behave ...
Web Search - ncbi.nlm.nih.gov

Regulatory mechanisms of osteoblast and osteoclast differentiation - Full text - MIT Libraries
T Katagiri, N Takahashi - Oral Diseases, 2002 - blackwell-synergy.com
... differentiation through the formation of a complex between Smad1 and STAT3, bridged
by ... Hanai et al (1999) showed that R-Smads interact with Runx1/Runx2/Runx3. ...
Cited by 28 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

BASL Meeting 2003
F Liver - basl.org.uk
... CARE SD Ryder, GP Aithal, M Holmes, M Burroughs, N Wright ■ Functional interaction
between the transcription factors JunD and Runx1: Implications for the ...
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Identification and characterization of two types of erythroid progenitors that express GATA-1 at … - Full text - MIT Libraries
N Suzuki, N Suwabe, O Ohneda, N Obara, S Imagawa, … - Ann. NY Acad. Sci, 2005 - bloodjournal.org
Page 1. Suzuki et al . Identification and characterization of two types of
erythroid progenitors that express GATA-1 at distinct levels ...
Cited by 8 - Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov - all 5 versions »

Ras GTPase Chemi ELISA Kit
AMN America, AM Europe, AM Japan - activemotif.com
... TransAM™Kits Format Catalog No. TransAM™ AML-1/Runx1 1 x 96 rxns 47396 5 x 96 rxns
47896 ... TransAM™ STAT3 1 x 96 rxns 45196 5 x 96 rxns 45696 Page 16. ...
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Gene Targeting and Transgenic Strategies for the Analysis of Hematopoietic Development in the Mouse
HKA Mikkola, SH Orkin - Methods Mol Med, 2005 - neurosci.humanapress.com
... (2002) Runx1 expression marks long-term repopulating hematopoietic stem cells
in the midgestation mouse embryo. Immunity 16, 661–672. 30. ...
Web Search - journals.humanapress.com - biomed.humanapress.com - ncbi.nlm.nih.gov - Get it from MIT Libraries